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Association of dopamine D3-receptor gene variants with neuroleptic induced akathisia in schizophrenic patients - A generalization of Steen's study on DRD3 and tardive dyskinesia


Eichhammer, P; Albus, M; Borrmann-Hassenbach, M; Schoeler, A; Putzhammer, A; Frick, Ulrich; Klein, H E; Rohrmeier, T (2000). Association of dopamine D3-receptor gene variants with neuroleptic induced akathisia in schizophrenic patients - A generalization of Steen's study on DRD3 and tardive dyskinesia. American Journal of Medical Genetics. Part C: Seminars in Medical Genetics, 96:187-191.

Abstract

Neuroleptic induced akathisia is a common and distressful extrapyramidal side effect of antipsychotic treatment. A significant proportion of the variability of its development has been left unexplained and has to be attributed to individual susceptibility. Since hereditary factors have been discussed in the etiology of acute akathisia (AA), part of the individual susceptibility might be of genetic origin. Moreover, AA is regarded as a forerunner of tardive dyskinesia, a drug-induced chronic movement disorder, which may be associated with homozygosity for the Ser9Gly variant of the DRD3 gene. Considering expression studies, which demonstrated functional variants of DRD3 polymorphisms, we investigated whether homozygosity for the Ser9Gly variant of the DRD3 gene is associated with AA. Homozygosity for the Ser9Gly variant of the DRD3 gene was connected to an 88% incidence of AA as compared with a considerably lower 46.9% incidence of AA in schizophrenic patients nonhomozygous for the 2-2 allele (exact P = 0.0223).

Abstract

Neuroleptic induced akathisia is a common and distressful extrapyramidal side effect of antipsychotic treatment. A significant proportion of the variability of its development has been left unexplained and has to be attributed to individual susceptibility. Since hereditary factors have been discussed in the etiology of acute akathisia (AA), part of the individual susceptibility might be of genetic origin. Moreover, AA is regarded as a forerunner of tardive dyskinesia, a drug-induced chronic movement disorder, which may be associated with homozygosity for the Ser9Gly variant of the DRD3 gene. Considering expression studies, which demonstrated functional variants of DRD3 polymorphisms, we investigated whether homozygosity for the Ser9Gly variant of the DRD3 gene is associated with AA. Homozygosity for the Ser9Gly variant of the DRD3 gene was connected to an 88% incidence of AA as compared with a considerably lower 46.9% incidence of AA in schizophrenic patients nonhomozygous for the 2-2 allele (exact P = 0.0223).

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Swiss Research Institute for Public Health and Addiction
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2000
Deposited On:06 Aug 2014 11:22
Last Modified:08 Dec 2017 04:59
Publisher:Wiley-Blackwell
ISSN:1552-4868
Publisher DOI:https://doi.org/10.1002/(SICI)1096-8628(20000403)96:2<187::AID-AJMG13>3.0.CO;2-8
PubMed ID:10893495

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