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Leukemia Inhibitory Factor Signaling in Degenerating Retinas


Agca, C; Grimm, C (2014). Leukemia Inhibitory Factor Signaling in Degenerating Retinas. Advances in Experimental Medicine and Biology, 801:389-394.

Abstract

Degeneration of cells in the retina is a hallmark of various inherited and acquired blinding diseases in humans. One of the most challenging problems to establish successful treatments for these diseases is to understand the molecular mechanisms that result in retinal degeneration and to identify endogenous rescue pathways which support cell survival. In many mouse models for retinal degeneration, expression of LIF in glial cells in response to a disease condition is crucial for the activation of an elaborate protective system. This mini review will summarize the findings that are related to LIF signaling and discuss the neuroprotective effects of LIF in different animal models.

Abstract

Degeneration of cells in the retina is a hallmark of various inherited and acquired blinding diseases in humans. One of the most challenging problems to establish successful treatments for these diseases is to understand the molecular mechanisms that result in retinal degeneration and to identify endogenous rescue pathways which support cell survival. In many mouse models for retinal degeneration, expression of LIF in glial cells in response to a disease condition is crucial for the activation of an elaborate protective system. This mini review will summarize the findings that are related to LIF signaling and discuss the neuroprotective effects of LIF in different animal models.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2014
Deposited On:11 Apr 2014 13:33
Last Modified:05 Apr 2016 17:49
Publisher:Springer
ISSN:0065-2598
Publisher DOI:https://doi.org/10.1007/978-1-4614-3209-8_49
PubMed ID:24664722

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