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Quantitative blood oxygenation level-dependent (BOLD) response of the left ventricular myocardium to hyperoxic respiratory challenge at 1.5 and 3.0 T


Winklhofer, Sebastian; Pazahr, Shila; Manka, Robert; Alkadhi, Hatem; Boss, Andreas; Stolzmann, Paul (2014). Quantitative blood oxygenation level-dependent (BOLD) response of the left ventricular myocardium to hyperoxic respiratory challenge at 1.5 and 3.0 T. NMR in Biomedicine, 27(7):795-801.

Abstract

The aim of this study was to quantify the response of the myocardial transverse relaxation times (ΔT2 *) to hyperoxic respiratory challenge (HRC) at different field strengths in an intra-individual comparison of healthy volunteers and in a patient with coronary artery disease. Blood oxygenation level-dependent (BOLD) cardiovascular MR (CMR) data were acquired in 10 healthy volunteers (five women, five men; mean age, 29 ± 3 years; range, 22-35 years) at 1.5 and 3.0 T. Medical air (21% O2 ), pure oxygen and carbogen (95% O2 , 5% CO2 ) were administered in a block-design temporal pattern to induce normoxia, hyperoxia and hyperoxic hypercapnia, respectively. Average T2 * times were derived from measurements by two independent and blind readers in 16 standard myocardial segments on three short-axis slices per patient. Inter- and intra-reader correlations of T2 * measurements were good [intra-class correlation coefficient (ICC) = 0.75 and ICC = 0.79, both p < 0.001]. During normoxia, the mean T2 * times were 29.9 ± 6.1 ms at 1.5 T and 27.1 ± 6.6 ms at 3.0 T. Both hyperoxic gases induced significant (all p < 0.01) T2 * increases (∆T2 * hyperoxia: 1.5 T, 12.7%; 3.0 T, 11.2%; hyperoxic hypercapnia: 1.5 T, 13.1%; 3.0 T, 17.7%). Analysis of variance (ANOVA) results indicated a significant (both p < 0.001) effect of the inhaled gases on the T2 * times at both 1.5 T (F = 17.74) and 3.0 T (F = 39.99). With regard to the patient imaged at 1.5 T, HRC induced significant T2 * increases during hyperoxia and hyperoxic hypercapnia in normal myocardial segments, whereas the T2 * response was not significant in ischemic segments (p > 0.23). The myocardial ∆T2 * response to HRC can reliably be imaged and quantified with BOLD CMR at both 1.5 and 3.0 T. During HRC, hyperoxia and hyperoxic hypercapnia induce a significant increase in T2 *, with ∆T2 * being largest at 3.0 T and during hyperoxic hypercapnia in normal myocardial segments. Copyright © 2014 John Wiley & Sons, Ltd.

Abstract

The aim of this study was to quantify the response of the myocardial transverse relaxation times (ΔT2 *) to hyperoxic respiratory challenge (HRC) at different field strengths in an intra-individual comparison of healthy volunteers and in a patient with coronary artery disease. Blood oxygenation level-dependent (BOLD) cardiovascular MR (CMR) data were acquired in 10 healthy volunteers (five women, five men; mean age, 29 ± 3 years; range, 22-35 years) at 1.5 and 3.0 T. Medical air (21% O2 ), pure oxygen and carbogen (95% O2 , 5% CO2 ) were administered in a block-design temporal pattern to induce normoxia, hyperoxia and hyperoxic hypercapnia, respectively. Average T2 * times were derived from measurements by two independent and blind readers in 16 standard myocardial segments on three short-axis slices per patient. Inter- and intra-reader correlations of T2 * measurements were good [intra-class correlation coefficient (ICC) = 0.75 and ICC = 0.79, both p < 0.001]. During normoxia, the mean T2 * times were 29.9 ± 6.1 ms at 1.5 T and 27.1 ± 6.6 ms at 3.0 T. Both hyperoxic gases induced significant (all p < 0.01) T2 * increases (∆T2 * hyperoxia: 1.5 T, 12.7%; 3.0 T, 11.2%; hyperoxic hypercapnia: 1.5 T, 13.1%; 3.0 T, 17.7%). Analysis of variance (ANOVA) results indicated a significant (both p < 0.001) effect of the inhaled gases on the T2 * times at both 1.5 T (F = 17.74) and 3.0 T (F = 39.99). With regard to the patient imaged at 1.5 T, HRC induced significant T2 * increases during hyperoxia and hyperoxic hypercapnia in normal myocardial segments, whereas the T2 * response was not significant in ischemic segments (p > 0.23). The myocardial ∆T2 * response to HRC can reliably be imaged and quantified with BOLD CMR at both 1.5 and 3.0 T. During HRC, hyperoxia and hyperoxic hypercapnia induce a significant increase in T2 *, with ∆T2 * being largest at 3.0 T and during hyperoxic hypercapnia in normal myocardial segments. Copyright © 2014 John Wiley & Sons, Ltd.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2014
Deposited On:13 May 2014 15:34
Last Modified:08 Dec 2017 05:30
Publisher:Wiley-Blackwell
ISSN:0952-3480
Publisher DOI:https://doi.org/10.1002/nbm.3119
PubMed ID:24737306

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