Header

UZH-Logo

Maintenance Infos

Spontaneous progression of cutaneous angiomatosis to an infiltrative sarcoma-like tumour in a bull


Ruetten, M; Hauser, M; Nuss, K (2014). Spontaneous progression of cutaneous angiomatosis to an infiltrative sarcoma-like tumour in a bull. New Zealand Veterinary Journal, 62(4):221-225.

Abstract

CASE HISTORY: A 5-month-old valuable Red Holstein bull presented with a cutaneous mass on the fetlock of the right hind limb. The mass was removed and histologically diagnosed as a benign angiomatosis. Four months later, the mass reoccurred on the same leg.
PATHOLOGICAL FINDINGS: The first excision biopsy consisted of numerous blood vessels of different diameters and wall thicknesses. Often, the smaller vessels were oriented around a larger, vein-like vessel. The endothelial cells were elongated with small oval to elongated nuclei with dense chromatin. Following recurrence, the mass showed clear signs of infiltrative growth, including solid bundles of cells, increased polymorphism and round to oval nuclei with coarse chromatin and distinctive nucleoli. The neoplastic cells were immunohistochemically positive for von Willebrand Factor (vWF).
DIAGNOSIS: Angiomatosis with focal progression to an infiltrative growing sarcoma-like tumour.
CLINICAL RELEVANCE: This case represents the progression of a benign vascular proliferation, often considered as a reactive process, into a more aggressively behaving neoplasm. The clinical behaviour and histopathological morphology were strikingly similar to previous cases described in human and veterinary medicine.

Abstract

CASE HISTORY: A 5-month-old valuable Red Holstein bull presented with a cutaneous mass on the fetlock of the right hind limb. The mass was removed and histologically diagnosed as a benign angiomatosis. Four months later, the mass reoccurred on the same leg.
PATHOLOGICAL FINDINGS: The first excision biopsy consisted of numerous blood vessels of different diameters and wall thicknesses. Often, the smaller vessels were oriented around a larger, vein-like vessel. The endothelial cells were elongated with small oval to elongated nuclei with dense chromatin. Following recurrence, the mass showed clear signs of infiltrative growth, including solid bundles of cells, increased polymorphism and round to oval nuclei with coarse chromatin and distinctive nucleoli. The neoplastic cells were immunohistochemically positive for von Willebrand Factor (vWF).
DIAGNOSIS: Angiomatosis with focal progression to an infiltrative growing sarcoma-like tumour.
CLINICAL RELEVANCE: This case represents the progression of a benign vascular proliferation, often considered as a reactive process, into a more aggressively behaving neoplasm. The clinical behaviour and histopathological morphology were strikingly similar to previous cases described in human and veterinary medicine.

Statistics

Altmetrics

Downloads

1 download since deposited on 20 May 2014
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2014
Deposited On:20 May 2014 15:20
Last Modified:08 Dec 2017 05:41
Publisher:New Zealand Veterinary Association
ISSN:0048-0169
Publisher DOI:https://doi.org/10.1080/00480169.2013.871194
PubMed ID:24313281

Download