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Frequency of eprinomectin resistance in gastrointestinal nematodes of goats in canton Berne, Switzerland


Murri, Sarah; Knubben-Schweizer, Gabriela; Torgerson, Paul R; Hertzberg, Hubertus (2014). Frequency of eprinomectin resistance in gastrointestinal nematodes of goats in canton Berne, Switzerland. Veterinary Parasitology, 203(1-2):114-119.

Abstract

tEprinomectin (EPN) is a member of the avermectin class of compounds and the onlyanthelmintic registered for goats in Switzerland with a zero milk withdrawal period. Theaim of the present study was to identify the actual efficacy of EPN in an area with a higherdensity of goat enterprises. Forty-three randomly chosen farms from canton Berne wereinvestigated. At least eight goats were investigated on every farm. Conditions for inclusionin the study were the absence of anthelmintic treatment during the previous six weeksand a pooled faecal sample showing a mean faecal egg count (FEC) higher than 600 epgfaeces. Pre- and 14–16 days post-treatment samples were individually collected directlyfrom the rectum. Animals were treated with the recommended dose of EPN (1 mg/kg bodyweight) after taking the pre-treatment samples. Efficacy of EPN was tested with the faecalegg count reduction test (FECRT) and faecal cultures were performed on every farm frompooled faeces samples before and after treatment. Additionally the farmers completed aquestionnaire. None of the gastrointestinal nematode populations of the 43 investigatedfarms were susceptible to EPN at the required level. The mean egg count reduction was40%. None of the typical risk factors, such as production type, stocking rate, animal trafficand quarantine measures showed an association with the level of eprinomectin resistance.It can be concluded with 80% certainty that the prevalence of EPN resistance on goat farmsis at least 95% in canton Berne.

Abstract

tEprinomectin (EPN) is a member of the avermectin class of compounds and the onlyanthelmintic registered for goats in Switzerland with a zero milk withdrawal period. Theaim of the present study was to identify the actual efficacy of EPN in an area with a higherdensity of goat enterprises. Forty-three randomly chosen farms from canton Berne wereinvestigated. At least eight goats were investigated on every farm. Conditions for inclusionin the study were the absence of anthelmintic treatment during the previous six weeksand a pooled faecal sample showing a mean faecal egg count (FEC) higher than 600 epgfaeces. Pre- and 14–16 days post-treatment samples were individually collected directlyfrom the rectum. Animals were treated with the recommended dose of EPN (1 mg/kg bodyweight) after taking the pre-treatment samples. Efficacy of EPN was tested with the faecalegg count reduction test (FECRT) and faecal cultures were performed on every farm frompooled faeces samples before and after treatment. Additionally the farmers completed aquestionnaire. None of the gastrointestinal nematode populations of the 43 investigatedfarms were susceptible to EPN at the required level. The mean egg count reduction was40%. None of the typical risk factors, such as production type, stocking rate, animal trafficand quarantine measures showed an association with the level of eprinomectin resistance.It can be concluded with 80% certainty that the prevalence of EPN resistance on goat farmsis at least 95% in canton Berne.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Parasitology
04 Faculty of Medicine > Institute of Parasitology

05 Vetsuisse Faculty > Chair in Veterinary Epidemiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
600 Technology
Language:English
Date:2014
Deposited On:22 May 2014 09:32
Last Modified:14 Feb 2018 21:16
Publisher:Elsevier
ISSN:0304-4017
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.vetpar.2014.02.052
PubMed ID:24661808

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