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Efficient purging of deleterious mutations in plants with haploid selfing


Szövényi, Peter; Devos, Nicolas; Weston, David J; Yang, Xiaohan; Hock, Zsofia; Shaw, A Jonathan; Shimizu, Kentaro K; McDaniel, Stuart; Wagner, Andreas (2014). Efficient purging of deleterious mutations in plants with haploid selfing. Genome Biology and Evolution, 6(5):1238-1252.

Abstract

In diploid organisms, selfing reduces the efficiency of selection in removing deleterious mutations from a population. This need not be the case for all organisms. Some plants, for example, undergo an extreme form of selfing known as intragametophytic selfing, which immediately exposes all recessive deleterious mutations in a parental genome to selective purging. Here we ask how effectively deleterious mutations are removed from such plants. Specifically, we study the extent to which deleterious mutations accumulate in a predominantly selfing and a predominantly outcrossing pair of moss species, using genome- wide transcriptome data. We find that the selfing species purge significantly more non- synonymous mutations, as well as a greater proportion of radical amino acid changes which alter physicochemical properties of amino acids. Moreover, their purging of deleterious mutation is especially strong in conserved regions of protein-coding genes. Our observations show that selfing need not impede but can even accelerate the removal of deleterious mutations, and do so on a genome-wide scale.

Abstract

In diploid organisms, selfing reduces the efficiency of selection in removing deleterious mutations from a population. This need not be the case for all organisms. Some plants, for example, undergo an extreme form of selfing known as intragametophytic selfing, which immediately exposes all recessive deleterious mutations in a parental genome to selective purging. Here we ask how effectively deleterious mutations are removed from such plants. Specifically, we study the extent to which deleterious mutations accumulate in a predominantly selfing and a predominantly outcrossing pair of moss species, using genome- wide transcriptome data. We find that the selfing species purge significantly more non- synonymous mutations, as well as a greater proportion of radical amino acid changes which alter physicochemical properties of amino acids. Moreover, their purging of deleterious mutation is especially strong in conserved regions of protein-coding genes. Our observations show that selfing need not impede but can even accelerate the removal of deleterious mutations, and do so on a genome-wide scale.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Systematic and Evolutionary Botany
07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
580 Plants (Botany)
Language:English
Date:2014
Deposited On:30 May 2014 11:27
Last Modified:08 Dec 2017 05:54
Publisher:Oxford University Press
ISSN:1759-6653
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/gbe/evu099
Official URL:http://gbe.oxfordjournals.org/content/early/2014/05/14/gbe.evu099.short

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