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Enchondroma of the nasal septum due to Ollier disease: A case report and review of the literature


Jacobi, Christian Manuel Claus; Hiranya, Egodage Samitha; Gay, Annietta; Holzmann, David; Kollias, Spyridon; Soyka, Michael (2015). Enchondroma of the nasal septum due to Ollier disease: A case report and review of the literature. Head and Neck, 37(3):E30-3.

Abstract

Background: Morbus Ollier is characterized by the presence of multiple enchondromas, i.e. benign intraosseous cartilaginous lesions. Although their manifestation in the limb bones is well described, only few cases with ENT involvement, primarily arising from the skull, have been reported. The malignant transformation toward slowly growing low-grade chondrosarcomas is the most severe form of progression. Methods: We report a unique case of a 54-year-old Ollier disease patient with an extensive nasal enchondroma apparently eroding the middle nasal concha and expanding to the lateral nasal wall that raised suspicion of malignant transformation. Results: Radiological and histological features of enchondromas can be controversial and appear to have limited sensitivity to exclude low-grade malignancy. The clinical symptoms play a decisive role in differentiation between enchondromas and low-grade chondrosarcomas. Conclusion: Surgery remains the only effective solution in removing an enchondroma and preventing the tendency toward malignant transformation. Head Neck, 2014.

Abstract

Background: Morbus Ollier is characterized by the presence of multiple enchondromas, i.e. benign intraosseous cartilaginous lesions. Although their manifestation in the limb bones is well described, only few cases with ENT involvement, primarily arising from the skull, have been reported. The malignant transformation toward slowly growing low-grade chondrosarcomas is the most severe form of progression. Methods: We report a unique case of a 54-year-old Ollier disease patient with an extensive nasal enchondroma apparently eroding the middle nasal concha and expanding to the lateral nasal wall that raised suspicion of malignant transformation. Results: Radiological and histological features of enchondromas can be controversial and appear to have limited sensitivity to exclude low-grade malignancy. The clinical symptoms play a decisive role in differentiation between enchondromas and low-grade chondrosarcomas. Conclusion: Surgery remains the only effective solution in removing an enchondroma and preventing the tendency toward malignant transformation. Head Neck, 2014.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neuroradiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2015
Deposited On:09 Jul 2014 12:32
Last Modified:13 May 2016 10:29
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1043-3074
Publisher DOI:https://doi.org/10.1002/hed.23783
PubMed ID:24890303

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