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Prävalenz der Demenz in der Stadt Zürich


Gostynski, Michal; Ajdacic-Gross, Vladeta; Gutzwiller, Felix; Michel, Jean-Pierre; Herrmann, François (2002). Prävalenz der Demenz in der Stadt Zürich. Sozial- und Präventivmedizin, 47(5):330-335.

Abstract

OBJECTIVES: The purpose of the study was to estimate the prevalence rate of dementia (PRD) in relation to age, gender, and ApoE-genotype.
METHODS: The random sample consisted of 465 subjects aged 65 and more. The interview was conducted by means of the Canberra Interview for the Elderly. The genotyping of ApoE has been performed by a combination of the polymerase chain reaction and a gel electrophoresis separation.
RESULTS: The overall PRD amounted to 10.1% (95% CI 6.8-13.3%) and was higher among females (12.2%) than among males (4.9%). The gender difference was of borderline statistical significance (OR 2.17; 95% CI 0.97-4.84 adjusted for age, education level). PRD rose significantly with age. In contrast, the possession of one copy of ApoE-epsilon 4-allele was not associated with a higher risk of having dementia (OR 1.48; 95% CI 0.60-3.63 adjusted for age, gender, education level).
CONCLUSIONS: These results are consistent with the finding from other authors.

Abstract

OBJECTIVES: The purpose of the study was to estimate the prevalence rate of dementia (PRD) in relation to age, gender, and ApoE-genotype.
METHODS: The random sample consisted of 465 subjects aged 65 and more. The interview was conducted by means of the Canberra Interview for the Elderly. The genotyping of ApoE has been performed by a combination of the polymerase chain reaction and a gel electrophoresis separation.
RESULTS: The overall PRD amounted to 10.1% (95% CI 6.8-13.3%) and was higher among females (12.2%) than among males (4.9%). The gender difference was of borderline statistical significance (OR 2.17; 95% CI 0.97-4.84 adjusted for age, education level). PRD rose significantly with age. In contrast, the possession of one copy of ApoE-epsilon 4-allele was not associated with a higher risk of having dementia (OR 1.48; 95% CI 0.60-3.63 adjusted for age, gender, education level).
CONCLUSIONS: These results are consistent with the finding from other authors.

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Additional indexing

Other titles:Prevalence of dementia in the City of Zurich
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2002
Deposited On:14 Jul 2014 11:03
Last Modified:08 Dec 2017 06:27
Publisher:Springer
ISSN:0303-8408
Publisher DOI:https://doi.org/10.1007/PL00012643
PubMed ID:12512226

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