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Sicherheitsaspekte der Folsäure für die Gesamtbevölkerung


Eichholzer, Monika; Lüthy, J; Moser, U; Stähelin, H B; Gutzwiller, Felix (2002). Sicherheitsaspekte der Folsäure für die Gesamtbevölkerung. Praxis, 91(1-2):7-16.

Abstract

Periconceptional use of folic acid reduces the risk of neural tube defects considerably. In Switzerland, implementation of these findings could be improved through fortification of a staple food with folic acid. The present paper reviews possible hazards associated with high intake of folic acid in the general population. Among the potential safety issues are interaction between folic acid and zinc, interaction between folic acid and drugs (phenytoin, methotrexate etc.) and hypersensitivity to folic acid. Of main concern are adverse effects of folic acid in cobalamin deficiency. Solutions are discussed.

Abstract

Periconceptional use of folic acid reduces the risk of neural tube defects considerably. In Switzerland, implementation of these findings could be improved through fortification of a staple food with folic acid. The present paper reviews possible hazards associated with high intake of folic acid in the general population. Among the potential safety issues are interaction between folic acid and zinc, interaction between folic acid and drugs (phenytoin, methotrexate etc.) and hypersensitivity to folic acid. Of main concern are adverse effects of folic acid in cobalamin deficiency. Solutions are discussed.

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Other titles:Safety aspects of folic acid for the general population
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:9 January 2002
Deposited On:23 Jul 2014 14:17
Last Modified:05 Apr 2016 17:58
Publisher:Hans Huber
ISSN:1661-8157
Publisher DOI:https://doi.org/10.1024/0369-8394.91.1.7
PubMed ID:11824146

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