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Reaktion von 3-Dimethylamino-2,2-dimethyl-2H-azirin mit 6-Methyluracil; Kristallstruktur der Reaktionsprodukte


Dähler, Marlise; Prewo, Roland; Bieri, Jost H; Heimgartner, Heinz (1982). Reaktion von 3-Dimethylamino-2,2-dimethyl-2H-azirin mit 6-Methyluracil; Kristallstruktur der Reaktionsprodukte. Helvetica Chimica Acta, 65:2302-2312.

Abstract

Reaction of 3-Dimethylamino-2,2-dimethyl-2H-azirine with 6-Methyluracil;
Crystal Structure of the Products
The reaction of 3-dimethylamino-2,2-dimethyl-2H-azirine (1) with 6-methyl- uracil (4) in 2-propanol at 80° yields the 4H-imidazole derivative 5 as the main product. This reaction is similar to the previously reported ones with heterocyclic compounds containing the sequence NH-CO-NH-CO. In the presence of water, 5 is easily hydrolyzed to 6. The structures of 5 and 6 have been established by X-ray crystallography.

Abstract

Reaction of 3-Dimethylamino-2,2-dimethyl-2H-azirine with 6-Methyluracil;
Crystal Structure of the Products
The reaction of 3-dimethylamino-2,2-dimethyl-2H-azirine (1) with 6-methyl- uracil (4) in 2-propanol at 80° yields the 4H-imidazole derivative 5 as the main product. This reaction is similar to the previously reported ones with heterocyclic compounds containing the sequence NH-CO-NH-CO. In the presence of water, 5 is easily hydrolyzed to 6. The structures of 5 and 6 have been established by X-ray crystallography.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:German
Date:1982
Deposited On:24 Jul 2014 07:23
Last Modified:21 Nov 2017 17:24
Publisher:Wiley-Blackwell
ISSN:0018-019X
Funders:Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, F. Hoffmann-La Roche & Co. AG, Basel

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