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Integrated CT-perfusion shows no meaningful correlation with PSA and pre-surgical Gleason score in patients with early prostate cancer


Huellner, Martin W; Mattei, Agostino; Ross, Steffen; Butea-Bocu, Marius; Vosbeck, Jürg; Pauli, Chantal; Diebold, Joachim; Seifert, Burkhardt; Strobel, Klaus; Veit-Haibach, Patrick (2014). Integrated CT-perfusion shows no meaningful correlation with PSA and pre-surgical Gleason score in patients with early prostate cancer. Clinical Imaging, 38(6):850-857.

Abstract

OBJECTIVES To analyze the correlation of computed tomography (CT) perfusion parameters blood flow (BF), blood volume (BV), and mean transit time (MTT) with presurgical prostate cancer data. METHODS Ninety-eight patients with biopsy-proven prostate cancer underwent a CT-perfusion scan of the prostate. MTT, BF, and BV were determined and correlated with prostate-specific antigen (PSA) level, tumor load and Gleason score of transrectal ultrasonography-guided biopsy specimens. RESULTS Mean BF was 41.3 ml/100 ml*min(-1), BV 5.2 ml/100 ml, MTT 8.7 s. Moderate correlations were observed between Gleason score and BF (0.35) and between PSA and BF (0.33) and BV (0.30). CONCLUSIONS CT-perfusion shows no valuable correlation with presurgical prostate cancer data.

Abstract

OBJECTIVES To analyze the correlation of computed tomography (CT) perfusion parameters blood flow (BF), blood volume (BV), and mean transit time (MTT) with presurgical prostate cancer data. METHODS Ninety-eight patients with biopsy-proven prostate cancer underwent a CT-perfusion scan of the prostate. MTT, BF, and BV were determined and correlated with prostate-specific antigen (PSA) level, tumor load and Gleason score of transrectal ultrasonography-guided biopsy specimens. RESULTS Mean BF was 41.3 ml/100 ml*min(-1), BV 5.2 ml/100 ml, MTT 8.7 s. Moderate correlations were observed between Gleason score and BF (0.35) and between PSA and BF (0.33) and BV (0.30). CONCLUSIONS CT-perfusion shows no valuable correlation with presurgical prostate cancer data.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Computed tomography; CT-perfusion; Prostate cancer; Biopsy; Gleason score
Language:English
Date:2014
Deposited On:27 Aug 2014 17:02
Last Modified:05 Apr 2016 18:21
Publisher:Elsevier
ISSN:0899-7071
Publisher DOI:https://doi.org/10.1016/j.clinimag.2014.07.011
PubMed ID:25168905

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