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Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα-/-) in vivo model


Eberle, Claudia; Niessen, Markus; Hemmings, Brian A; Tschopp, Oliver; Ament, Christoph (2014). Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα-/-) in vivo model. Archives of Physiology and Biochemistry, 120(3):91-98.

Abstract

CONTEXT: Type 2 diabetes and associated co-morbidities run epidemic waves worldwide. Since pathophysiological constellations are individual and display a wide spread of dysmetabolic profiles personalized health care assessments start to emerge. Therefore, we established a specific in silico assessment tool targeting metabolic characterizations individually.
MATERIALS AND METHODS: Values obtained from oral glucose and intraperitoneal insulin tolerance tests performed on pkbα(-/-) mice (KO) as well as age- and gender-matched controls (WT) were analysed using our established in silico model.
RESULTS: Generally, male pkbα(-/-) mice (KO) presented significantly increased insulin sensitivity at an age of 6 months compared with age-matched WTs (p = 0.036). Female KO and WT groups displayed improved glucose sensitivities compared with age-matched males (for WT p ≤ 0.011).
DISCUSSION AND CONCLUSION: Specific metabolic characterization should be assessed individually. Therefore, our in silico model enables novel insights inaugurating specific primary preventive strategies targeting individual metabolic profiling precisely.

Abstract

CONTEXT: Type 2 diabetes and associated co-morbidities run epidemic waves worldwide. Since pathophysiological constellations are individual and display a wide spread of dysmetabolic profiles personalized health care assessments start to emerge. Therefore, we established a specific in silico assessment tool targeting metabolic characterizations individually.
MATERIALS AND METHODS: Values obtained from oral glucose and intraperitoneal insulin tolerance tests performed on pkbα(-/-) mice (KO) as well as age- and gender-matched controls (WT) were analysed using our established in silico model.
RESULTS: Generally, male pkbα(-/-) mice (KO) presented significantly increased insulin sensitivity at an age of 6 months compared with age-matched WTs (p = 0.036). Female KO and WT groups displayed improved glucose sensitivities compared with age-matched males (for WT p ≤ 0.011).
DISCUSSION AND CONCLUSION: Specific metabolic characterization should be assessed individually. Therefore, our in silico model enables novel insights inaugurating specific primary preventive strategies targeting individual metabolic profiling precisely.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2014
Deposited On:26 Nov 2014 14:57
Last Modified:05 Apr 2016 18:23
Publisher:Informa Healthcare
ISSN:1381-3455
Publisher DOI:https://doi.org/10.3109/13813455.2014.911330
PubMed ID:24773499

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