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Diagnostic performance and additional value of elastosonography in focal breast lesions: statistical correlation between size-dependant strain index measurements, multimodality-BI-RADS score, and histopathology in a clinical routine setting


Ebner, Lukas; Bonel, Harald M; Huber, Adrian; Ross, Steffen G; Christe, Andreas (2014). Diagnostic performance and additional value of elastosonography in focal breast lesions: statistical correlation between size-dependant strain index measurements, multimodality-BI-RADS score, and histopathology in a clinical routine setting. ISRN Radiology, 2014:ID 396368-8pp.

Abstract

Objective. To evaluate the diagnostic benefit of real-time elastography (RTE) in clinical routine. Strain indices (SI) for benign and malignant tumors were assessed. Methods. 100 patients with 110 focal breast lesions were retrieved. Patients had mammography (MG), ultrasound (US), and, if necessary, MRI. RTE was conducted after ultrasound. Lesions were assessed with BI-RADS for mammography and ultrasound. Diagnosis was established with histology or follow-up. Results. SI for BI-RADS 2 was . Higher SI was observed for BI-RADS 3 lesions. SI of BI-RADS 4 and 5 lesions were significantly higher and . 31 malignant tumors exhibited an average SI of ; SI of benign lesions was ( value ). ROC analysis threshold was >3.8 for malignant disease. Sensitivity of sonography was 90.3% (specificity 78.5%). RTE showed a sensitivity of 87.1% (specificity 79.7%). Accuracy of all modalities combined was 96.8%. In BI-RADS 3 lesions RTE was able to detect all malignant lesions (sensitivity 100%, specificity 92.9%, and accuracy 93.9%). Conclusions. RTE increased sensitivity and specificity for breast cancer detection when used in combination with ultrasound.

Abstract

Objective. To evaluate the diagnostic benefit of real-time elastography (RTE) in clinical routine. Strain indices (SI) for benign and malignant tumors were assessed. Methods. 100 patients with 110 focal breast lesions were retrieved. Patients had mammography (MG), ultrasound (US), and, if necessary, MRI. RTE was conducted after ultrasound. Lesions were assessed with BI-RADS for mammography and ultrasound. Diagnosis was established with histology or follow-up. Results. SI for BI-RADS 2 was . Higher SI was observed for BI-RADS 3 lesions. SI of BI-RADS 4 and 5 lesions were significantly higher and . 31 malignant tumors exhibited an average SI of ; SI of benign lesions was ( value ). ROC analysis threshold was >3.8 for malignant disease. Sensitivity of sonography was 90.3% (specificity 78.5%). RTE showed a sensitivity of 87.1% (specificity 79.7%). Accuracy of all modalities combined was 96.8%. In BI-RADS 3 lesions RTE was able to detect all malignant lesions (sensitivity 100%, specificity 92.9%, and accuracy 93.9%). Conclusions. RTE increased sensitivity and specificity for breast cancer detection when used in combination with ultrasound.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Legal Medicine
Dewey Decimal Classification:340 Law
610 Medicine & health
Language:English
Date:2014
Deposited On:14 Oct 2014 14:34
Last Modified:08 Dec 2017 07:28
Publisher:Hindawi Publishing Corporation
ISSN:2314-4084
Publisher DOI:https://doi.org/10.1155/2014/396368
Official URL:http://www.hindawi.com/journals/isrn/2014/396368/abs/

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