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Borna disease virus antigen distribution in naturally infected bicolored white-toothed shrews, Crocidura leucodon, supporting its role as reservoir host species


Puorger, Maria. Borna disease virus antigen distribution in naturally infected bicolored white-toothed shrews, Crocidura leucodon, supporting its role as reservoir host species. 2008, University of Zurich, Vetsuisse Faculty.

Abstract

Borna Disease is a severe, immunopathological disorder of the central nervous system, caused by infection with Borna Disease Virus (BDV). The main known naturally affected animal species in endemic areas in central Europe are horses and sheep[24].
In this study we present evidence of shrew mice (Crocidura leucodon) as a vector of BDV. The widespread presence of viral antigen and –RNA in the organs of this animal species without producing pathological lesions differs from the classical hosts such as equines, small ruminants and other domestic animals naturally infected with BDV.
The detection of BDV in the shrew mice was achieved by immunohistochemistry and by TaqMan® Real Time RT-PCR. RT-PCR mplification products were sequenced, and the sequences were compared with those from horses and sheep originating from the same geographical region, which had died from Borna Disease (BD).

Abstract

Borna Disease is a severe, immunopathological disorder of the central nervous system, caused by infection with Borna Disease Virus (BDV). The main known naturally affected animal species in endemic areas in central Europe are horses and sheep[24].
In this study we present evidence of shrew mice (Crocidura leucodon) as a vector of BDV. The widespread presence of viral antigen and –RNA in the organs of this animal species without producing pathological lesions differs from the classical hosts such as equines, small ruminants and other domestic animals naturally infected with BDV.
The detection of BDV in the shrew mice was achieved by immunohistochemistry and by TaqMan® Real Time RT-PCR. RT-PCR mplification products were sequenced, and the sequences were compared with those from horses and sheep originating from the same geographical region, which had died from Borna Disease (BD).

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Additional indexing

Item Type:Dissertation
Referees:Ehrensperger F, Nowotny N
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2008
Deposited On:13 Jan 2009 07:14
Last Modified:26 Jan 2017 08:42
Number of Pages:34

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