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Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis


Abramowski, Pierre; Steinbach, Karin; Zander, Axel R; Martin, Roland (2014). Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 274(1-2):111-24.

Abstract

The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression in lymphoid organs and the central nervous system; however, edelfosine did not induce global apoptosis. Edelfosine improved the disease course and led to reduced frequencies of CD4(+) T cells infiltrating into the central nervous system. Our data suggest edelfosine as an interesting treatment candidate for multiple sclerosis.

Abstract

The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression in lymphoid organs and the central nervous system; however, edelfosine did not induce global apoptosis. Edelfosine improved the disease course and led to reduced frequencies of CD4(+) T cells infiltrating into the central nervous system. Our data suggest edelfosine as an interesting treatment candidate for multiple sclerosis.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Date:15 September 2014
Deposited On:23 Oct 2014 11:28
Last Modified:27 Apr 2017 21:29
Publisher:Elsevier
ISSN:0165-5728
Publisher DOI:https://doi.org/10.1016/j.jneuroim.2014.07.007
PubMed ID:25086877

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