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Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1


Sospedra, Mireia; Schippling, Sven; Yousef, Sara; Jelcic, Ilijas; Bofill-Mas, Silvia; Planas, Raquel; Stellmann, Jan-Patrick; Demina, Viktoria; Cinque, Paola; Garcea, Robert; Croughs, Therese; Girones, Rosina; Martin, Roland (2014). Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1. Clinical Infectious Diseases, 59(11):1588-1592.

Abstract

Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.

Abstract

Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:11 September 2014
Deposited On:23 Oct 2014 11:24
Last Modified:03 Aug 2017 18:59
Publisher:Oxford University Press
ISSN:1058-4838
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/cid/ciu682
PubMed ID:25214510

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