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Late antibody-mediated rejection by de novo donor HLA-DP-specific antibody after renal transplantation: A case report


Cippà, Pietro E; Gaspert, Ariana; Etter, Christoph; Guenduez, Zehra; Ferrari-Lacraz, Sylvie; Rüsi, Barbara; Fehr, Thomas (2014). Late antibody-mediated rejection by de novo donor HLA-DP-specific antibody after renal transplantation: A case report. Human Immunology, 75(5):462-465.

Abstract

The role of donor HLA-DP-specific antibodies after renal transplantation is controversial, and only preformed HLA-DP-specific antibodies have been shown to mediate rejection. Here we present a case of late humoral rejection mediated by de novo donor HLA-DP-specific antibodies in a non-sensitized recipient. This unique case demonstrates the pathogenic role of de novo anti-DP antibodies and suggests that HLA-DP matching might be relevant for renal transplantation.

Abstract

The role of donor HLA-DP-specific antibodies after renal transplantation is controversial, and only preformed HLA-DP-specific antibodies have been shown to mediate rejection. Here we present a case of late humoral rejection mediated by de novo donor HLA-DP-specific antibodies in a non-sensitized recipient. This unique case demonstrates the pathogenic role of de novo anti-DP antibodies and suggests that HLA-DP matching might be relevant for renal transplantation.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2014
Deposited On:30 Oct 2014 12:35
Last Modified:05 Apr 2016 18:27
Publisher:Elsevier
ISSN:0198-8859
Publisher DOI:https://doi.org/10.1016/j.humimm.2014.02.008
PubMed ID:24530822

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