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Liu, J; Bruhn, D; Lee, R B; Zheng, Z; Janusic, T; Shcherbakov, D; Scherman, M; Boshoff, H; Das, S; Raskesh, K; Waidyarachchi, S; Brewer, T; Garcia, B; Yang, L; Bollinger, J; Robertson, G; Meibohn, B; Lenaerts, A; Ainsa, J; Böttger, E C; Lee, R E (2017). The structure-activity relationships of Spectinamide antituberculosis agents; a dissection of ribosomal inhibition and native efflux avoidance contributions. ACS Infectious Diseases, 3(1):72-88.

Cambau, E; Viveiros, M; Machado, D; Raskine, L; Ritter, C; Tortoli, E; Matthys, V; Hoffner, S; Richter, E; Perez Del Molino, M L; Cirillo, D M; van Soolingen, D; Böttger, E C (2015). Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study. Journal of Antimicrobial Chemotherapy, 70(3):686-696.

Ritter, C; Lucke, K; Sirgel, F A; Warren, R W; van Helden, P D; Böttger, E C; Bloemberg, G V (2014). Evaluation of the AID TB Resistance Line Probe Assay for Rapid Detection of Genetic Alterations Associated with Drug Resistance in Mycobacterium tuberculosis Strains. Journal of Clinical Microbiology, 52(3):940-946.

Medizinische Mikrobiologie. Edited by: Kayser, F H; Böttger, E C; Deplazes, P; Haller, O; Roers, A (2014). Stuttgart: Georg Thieme Verlag.

Somoskovi, A; Helbling, P; Deggim, V; Hömke, R; Ritter, C; Böttger, E C (2014). Transmission of multidrug-resistant tuberculosis in a low-incidence setting, Switzerland, 2006 to 2012. Eurosurveillance, 19(11):4.

Sirgel, F A; Tait, M; Warren, R M; Streicher, E M; Böttger, E C; Van Helden, P D; Gey Van Pittius, N C; Coetzee, G; Hoosain, E Y; Chabula-Nxiweni, M; Hayes, C; Victor, T C; Trollip, A (2012). Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in mycobacterium tuberculosis. Microbial Drug Resistance, 18(2):193-197.

Streicher, E M; Bergval, I; Dheda, K; Böttger, E C; Gey van Pittius, N C; Bosman, M; Coetzee, G; Anthony, R M; van Helden, P D; Victor, T C; Warren, R M (2012). Mycobacterium tuberculosis population structure determines the outcome of genetics-based second-line drug resistance testing. Antimicrobial Agents and Chemotherapy, 56(5):2420-2427.

Fenner, L; Gagneux, S; Helbling, P; Battegay, M; Rieder, H L; Pfyffer, G E; Zwahlen, M; Furrer, H; Siegrist, H H; Fehr, J; Dolina, M; Calmy, A; Stucki, D; Jaton, K; Janssens, J P; Stalder, J M; Bodmer, T; Ninet, B; Böttger, E C; Egger, M (2012). Mycobacterium tuberculosis transmission in a country with low tuberculosis incidence: Role of immigration and HIV infection. Journal of Clinical Microbiology, 50(2):388-395.

Polsfuss, S; Bloemberg, G V; Giger, J; Meyer, V; Böttger, E C; Hombach, M (2011). A practical approach for reliable detection of AmpC Beta-Lactamase producing Enterobacteriaceae. Journal of Clinical Microbiology, 49(8):2798-2803.

Müller, B; Warren, R M; Williams, M; Böttger, E C; Gey Van Pittius, N C; Victor, T C (2011). Acquisition, transmission and amplification of drug-resistant tuberculosis. In: Donald, P R; Van Helden, P D. Antituberculosis Chemotherapy. Basel [etc.]: Karger, 96-104.

Rampini, S K; Bloemberg, G V; Keller, P M; Büchler, A C; Dollenmaier, G; Speck, R F; Böttger, E C (2011). Broad-range 16S rRNA gene polymerase chain reaction for diagnosis of culture-negative bacterial infections. Clinical Infectious Diseases, 53(12):1245-1251.

Akbergenov, R; Shcherbakov, D; Matt, T; Duscha, S; Meyer, Martin; Perez Fernandez, D; Pathak, R; Harish, S; Kudyba, I; Dubakka, S R; Silva, S; Ruiz Ruiz, M C; Salian, S; Vasella, A; Böttger, E C (2011). Decoding and deafness: two sides of a coin. In: Rodnina, M V; Wintermeyer, W; Green, R. Ribosomes: Structure, Function and Dynamics. Vienna, Austria: Springer Verlag, 249-261.

Peter-Getzlaff, S; Polsfuss, S; Poledica, M; Hombach, M; Giger, J; Böttger, E C; Zbinden, R; Bloemberg, G V (2011). Detection of AmpC beta-lactamase in Escherichia coli: comparison of three phenotypic confirmation assays and genetic analysis. Journal of Clinical Microbiology, 49(8):2924-2932.

Böttger, E C (2011). Drug resistance in mycobacterium tuberculosis: molecular mechanisms and laboratory susceptibility testing. In: Donald, P R; Van Helden, P D. Antituberculosis Chemotherapy. Basel [etc.]: Karger, 128-144.

Hobbie, S N; Kaiser, M; Schmidt, S; Shcherbakov, D; Janusic, T; Brun, R; Böttger, E C (2011). Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma. PLoS Neglected Tropical Diseases, 5(5):e1161.

Akbergenov, R; Shcherbakov, D; Matt, T; Duscha, S; Meyer, Martin; Wilson, D N; Böttger, E C (2011). Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrobial Agents and Chemotherapy, 55(10):4712-4717.

Tortoli, E; Böttger, E C; Fabio, A; Falsen, E; Gitti, Z; Grottola, A; Klenk, H P; Mannino, R; Mariottini, A; Messinò, M; Pecorari, M; Rumpianesi, F (2011). Mycobacterium europaeum sp. nov., a scotochromogenic species related to Mycobacterium simiae complex. International Journal of Systematic and Evolutionary Microbiology, 61(7):1606-1611.

Akshay, S; Bertea, M; Hobbie, S N; Oettinghaus, B; Shcherbakov, D; Böttger, E C; Akbergenov, R (2011). Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis. Antimicrobial Agents and Chemotherapy, 55(9):4096-4102.

Johansen, P; Fettelschoss, A; Amstutz, B; Selchow, P; Waeckerle-Men, Y; Keller, P; Deretic, V; Held, L; Kündig, T M; Böttger, E C; Sander, P (2011). Relief from zmp1-mediated arrest of phagosome maturation is associated with facilitated presentation and enhanced immunogenicity of mycobacterial antigens. Clinical and Vaccine Immunology : CVI, 18(6):907-913.

Rossi, F; Khanduja, J S; Bortoluzzi, A; Houghton, J; Sander, P; Güthlein, C; Davis, E O; Springer, B; Böttger, E C; Relini, A; Penco, A; Muniyappa, K; Rizzi, M (2011). The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action. Nucleic Acids Research, 39(16):7316-7328.

Böttger, E C (2011). The ins and outs of mycobacterium tuberculosis drug susceptibility testing: Themed review 'Therapeutic efficiency in the presence of resistance mechanisms: (when) to give-or not to give?'. Clinical Microbiology and Infection, 17(8):1128-1134.

Williams, A; Güthlein, C; Beresford, N; Böttger, E C; Springer, B; Davis, E O (2011). UvrD2 is essential in mycobacterium tuberculosis, but its helicase activity is not required. Journal of Bacteriology, 193(17):4487-4494.

van Ingen, J; de Lange, W C; Boeree, M J; Iseman, M D; Daley, C L; Heifets, L B; Böttger, E C; van Soolingen, D (2011). XDR tuberculosis. Lancet Infectious Diseases, 11(8):585.

Peter-Getzlaff, S; Lüthy, J; Voit, A; Bloemberg, G V; Böttger, E C (2010). Detection and identification of Mycobacterium spp. in clinical specimens by combining the Roche Cobas Amplicor Mycobacterium tuberculosis assay with Mycobacterium genus detection and nucleic acid sequencing. Journal of Clinical Microbiology, 48(11):3943-3948.

Shcherbakov, D; Akbergenov, R; Mattina, T; Sander, P; Andersson, D I; Böttger, E C (2010). Directed mutagenesis of Mycobacterium smegmatis 16S rRNA to reconstruct the in-vivo evolution of aminoglycoside resistance in Mycobacterium tuberculosis. Molecular Microbiology, 77(4):830-840.

Kayser, F H; Böttger, E C; Zinkernagel, R M; Haller, O; Eckert, J; Deplazes, P (2010). Medizinische Mikrobiologie: Taschenlehrbuch. Stuttgart: Thieme.

Böttger, E C (2010). Mutant A1555G mitochondrial 12S rRNA and aminoglycoside susceptibility. Antimicrobial Agents and Chemotherapy, 54(7):3073-3074; author reply 3074.

Kalapala, S K; Hobbie, S N; Böttger, E C; Shcherbakov, D (2010). Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines. PLoS ONE, 5(9):e11960.

Long, K S; Munck, C; Andersen, T B M; Schaub, M A; Hobbie, S N; Böttger, E C; Vester, B (2010). Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. Antimicrobial Agents and Chemotherapy, 54(11):4705-4713.

Keller, P M; Rampini, S K; Büchler, A C; Eich, G; Wanner, R M; Speck, R F; Böttger, E C; Bloemberg, G V (2010). Recognition of potentially novel human disease-associated pathogens by implementation of systematic 16S rRNA gene sequencing in the diagnostic laboratory. Journal of Clinical Microbiology, 48(9):3397-3402.

Ciardo, D E; Lucke, K; Imhof, A; Bloemberg, G V; Böttger, E C (2010). Systematic internal transcribed spacer sequence analysis for identification of clinical mold isolates in diagnostic mycology: a 5-year study. Journal of Clinical Microbiology, 48(8):2809-2813.

Matt, T; Akbergenov, R; Shcherbakov, D; Böttger, E C (2010). The ribosomal A-site: decoding, drug target and disease. Israel Journal of Chemistry, 50(1):60-70.

Böttger, E C; Springer, B (2009). Mycobacterium tuberculosis: drug resistance and genetic mechanisms - facts, artifacts and fallacies. In: Kaufmann, S H E; Walker, B. AIDS and tuberculosis: a deadly liaison. Weinheim: Wiley-VCH, 103-121.

Long, K S; Poehlsgaard, J; Hansen, L H; Hobbie, S N; Böttger, E C; Vester, B (2009). Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket. Molecular Microbiology, 71(5):1218-1227.

Güthlein, C; Wanner, R M; Sander, P; Davis, E O; Bosshard, M; Jiricny, J; Böttger, E C; Springer, B (2009). Characterisation of the mycobacterial NER system reveals novel functions of uvrD1 helicase. Journal of Bacteriology, 191(2):555-562.

Kayser, F H; Böttger, E C; Zinkernagel, R M; Haller, O; Eckert, J; Deplazes, P (2009). Microbiologie Médicale (Übersetzung der 11. Auflage). Paris: Flammarion.

Springer, B; Lucke, K; Calligaris-Maibach, R; Ritter, C; Böttger, E C (2009). Quantitative drug susceptibility testing of Mycobacterium tuberculosis by use of MGIT 960 and EpiCenter instrumentation. Journal of Clinical Microbiology, 47(6):1773-1780.

Collin, M P; Hobbie, S N; Böttger, E C; Vasella, A (2009). Synthesis and Evaluation of S- and C(1)-Substituted Analogues of Lincomycin. Helvetica Chimica Acta, 92(2):230-266.

Wanner, R M; Castor, D; Güthlein, C; Böttger, E C; Springer, B; Jiricny, J (2009). The uracil DNA glycosylase UdgB of Mycobacterium smegmatis protects the organism from the mutagenic effects of cytosine and adenine deamination. Journal of Bacteriology, 191(20):6312-6319.

Hobbie, S N; Subramanian, A; Kalapala, S K; Bruell, C M; Shcherbakov, D; Böttger, E C (2008). Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(52):20888-20893.

Springer, B; Calligaris-Maibach, R C; Ritter, C; Böttger, E C (2008). TB drug resistance in a low endemic area 2004 to 2006: semi-quantitative drug susceptibility testing and genotyping. Journal of Clinical Microbiology, 46(12):4064-4067.

Peter-Getzlaff, S; Lüthy, J; Böddinghaus, B; Böttger, E C; Springer, B (2008). Development and evaluation of a molecular assay for detection of nontuberculous mycobacteria on the basis of the COBAS Amplicor platform. Journal of Clinical Microbiology, 46(12):4023-4028.

Wanner, R M; Güthlein, C; Springer, B; Böttger, E C; Ackermann, M (2008). Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choice. BMC Genomics, 9:249.

Kayser, F H; Böttger, E C; Zinkernagel, R M; Haller, O; Eckert, J; Deplazes, P (2008). Manuel de poche de microbiologie médicale. Paris: Flammarion Médecine-Sciences .

Böttger, E C; Springer, B (2008). Tuberculosis: drug resistance, fitness, and strategies for global control. European Journal of Pediatrics, 167(2):141-148.

Güthlein, C; Wanner, R M; Sander, P; Böttger, E C; Springer, B (2008). A mycobacterial smc null mutant is proficient in DNA repair and long-term survival. Journal of Bacteriology, 190(1):452-456.

Bruell, C M; Eichholz, C; Kubarenko, A; Post, V; Katunin, V I; Hobbie, S N; Rodnina, M V; Böttger, E C (2008). Conservation of bacterial protein synthesis machinery: initiation and elongation in Mycobacterium smegmatis. Biochemistry, 47(34):8828-8839.

Dora, C; Altwegg, M; Gerber, C; Böttger, E C; Zbinden, R (2008). Evaluation of conventional microbiological procedures and molecular genetic techniques for diagnosis of infections in patients with implanted orthopedic devices. Journal of Clinical Microbiology, 46(2):824-825.

Rampini, S K; Selchow, P; Keller, C; Ehlers, S; Böttger, E C; Sander, P (2008). LspA inactivation in Mycobacterium tuberculosis results in attenuation without affecting phagosome maturation arrest. Microbiology, 154(Pt 10):2991-3001.

Hobbie, S N; Bruell, C M; Akshay, S; Kalapala, S K; Shcherbakov, D; Böttger, E C (2008). Mitochondrial deafness alleles confer misreading of the genetic code. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(9):3244-3249.

Collin, M P; Hobbie, S N; Böttger, E C; Vasella, A (2008). Synthesis of 1,2,3-triazole analogues of lincomycin. Helvetica Chimica Acta, 91(10):1838-1848.

Keller, P M; Böttger, E C; Sander, P (2008). Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a natural recA mutant. BMC Microbiology, 8:120.

Hobbie, S N; Kalapala, S K; Akshay, S; Bruell, C M; Schmidt, S; Dabow, S; Vasella, A; Sander, P; Böttger, E C (2007). Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria. Nucleic Acids Research, 35(18):6086-6093.

Böttger, E C (2007). Antimicrobial agents targeting the ribosome: the issue of selectivity and toxicity - lessons to be learned. Cellular and Molecular Life Sciences, 64(7-8):791-795.

Hobbie, S N; Bruell, C; Kalapala, S; Akshay, S; Schmidt, S; Pfister, P; Böttger, E C (2006). A genetic model to investigate drug-target interactions at the ribosomal decoding site. Biochimie, 88(8):1033-1043.

Hobbie, S N; Pfister, P; Bruell, C; Sander, P; François, B; Westhof, E; Böttger, E C (2006). Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA. Antimicrobial Agents and Chemotherapy, 50(4):1489-1496.

Böttger, E C (2006). Mechanisms of mycobacterial drug resistance: implications for treatment and prevention strategies. Chemotherapie Journal, 15(2):23-28.

Böttger, E C (2006). The ribosome as a drug target. Trends in Biotechnology, 24(4):145-147.

Böttger, E C; Pletschette, M; Andersson, D (2005). Drug resistance and fitness in mycobacterium tuberculosis infection. Journal of Infectious Diseases, 191(5):823-824.

Springer, B; Sander, P; Sedlacek, L; Hardt, W D; Mizrahi, V; Schärer, P; Böttger, E C (2004). Lack of mismatch correction facilitates genome evolution in mycobacteria. Molecular Microbiology, 53(6):1601-1609.

Sander, P; Rezwan, M; Walker, B; Rampini, S K; Kroppenstedt, R M; Ehlers, S; Keller, C; Keeble, J R; Hagemeier, M; Colston, M J; Springer, B; Böttger, E C (2004). Lipoprotein processing is required for virulence of Mycobacterium tuberculosis. Molecular Microbiology, 52(6):1543-1552.

Sander, P; Böttger, E C; Springer, B; Steinmann, B; Rezwan, M; Stavropoulos, E; Colston, M J (2003). A recA deletion mutant of Mycobacterium bovis BCG confers protection equivalent to that of wild-type BCG but shows increased genetic stability. Vaccine, 21(27-30):4124-4127.

Durbach, S I; Springer, B; Machowski, E E; North, R J; Papavinasasundaram, K G; Colston, M J; Böttger, E C; Mizrahi, V (2003). DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis. Infection and Immunity, 71(2):997-1000.

Davis, E O; Springer, B; Gopaul, K K; Papavinasasundaram, K G; Sander, P; Böttger, E C (2002). DNA damage induction of recA in Mycobacterium tuberculosis independently of RecA and LexA. Molecular Microbiology, 46(3):791-800.

Sander, P; Springer, B; Prammananan, T; Sturmfels, A; Kappler, M; Pletschette, M; Böttger, E C (2002). Fitness cost of chromosomal drug resistance-conferring mutations. Antimicrobial Agents and Chemotherapy, 46(5):1204-1211.

Bange, F-C; Böttger, E C (2002). Improved decontamination method for recovering mycobacteria from patients with cystic fibrosis. European Journal of Clinical Microbiology and Infectious Diseases, 21(7):546-548.

Sander, P; Belova, L; Kidan, Y G; Pfister, P; Mankin, A S; Böttger, E C (2002). Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations. Molecular Microbiology, 46(5):1295-1304.

Raynaud, C; Papavinasasundaram, K G; Speight, R A; Springer, B; Sander, P; Böttger, E C; Colston, M J; Draper, P (2002). The functions of OmpATb, a pore-forming protein of Mycobacterium tuberculosis. Molecular Microbiology, 46(1):191-201.

Böttger, E C (2001). Drug-resistant tuberculosis. Lancet, 357(9264):1288-1289.

Springer, B; Sander, P; Sedlacek, L; Ellrott, K; Böttger, E C (2001). Instability and site-specific excision of integration-proficient mycobacteriophage L5 plasmids: development of stably maintained integrative vectors. International Journal of Medical Microbiology, 290(8):669-675.

Bange, F C; Brown, B A; Smaczny, C; Wallace Jr, R J; Böttger, E C (2001). Lack of transmission of mycobacterium abscessus among patients with cystic fibrosis attending a single clinic. Clinical Infectious Diseases, 32(11):1648-1650.

Springer, B; Kidan, Y G; Prammananan, T; Ellrott, K; Böttger, E C; Sander, P (2001). Mechanisms of streptomycin resistance: selection of mutations in the 16S rRNA gene conferring resistance. Antimicrobial Agents and Chemotherapy, 45(10):2877-2884.

Sander, P; Papavinasasundaram, K G; Dick, T; Stavropoulos, E; Ellrott, K; Springer, B; Colston, M J; Böttger, E C (2001). Mycobacterium bovis BCG recA deletion mutant shows increased susceptibility to DNA-damaging agents but wild-type survival in a mouse infection model. Infection and Immunity, 69(6):3562-3568.

Wilson, R W; Steingrube, V A; Böttger, E C; Springer, B; Brown-Elliott, B A; Vincent, V; Jost, K C; Zhang, Y; Garcia, M J; Chiu, S H; Onyi, G O; Rossmoore, H; Nash, D R; Wallace, R J (2001). Mycobacterium immunogenum sp. nov., a novel species related to mycobacterium abscessus and associated with clinical disease, pseudo-outbreaks and contaminated metalworking fluids: an international cooperative study on mycobacterial taxonomy. International Journal of Systematic and Evolutionary Microbiology, 51(Pt 5):1751-1764.

Xiong, L; Polacek, N; Sander, P; Böttger, E C; Mankin, A (2001). pKa of adenine 2451 in the ribosomal peptidyl transferase center remains elusive. RNA, 7(10):1365-1369.

This list was generated on Tue Sep 26 09:34:10 2017 CEST.