UZH-Logo

Maintenance Infos

Browse by Creators - Zurich Open Repository and Archive

Navigate back| Up a level
Export as
Number of items: 113.

Markkanen, E; van Loon, B; Ferrari, E; Parsons, J L; Dianov, G L; Hübscher, U (2012). Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 109(2):437-442.

Hübscher, U; Maga, G (2011). DNA replication and repair bypass machines. Current Opinion in Chemical Biology, 15(5):627-635.

Eger, S; Castrec, B; Hübscher, U; Scheffner, M; Rubini, M; Marx, A (2011). Generation of a mono-ubiquitinated PCNA mimic by click chemistry. ChemBioChem, 12(18):2807-2812.

Villani, G; Hübscher, U; Gironis, N; Parkkinen, S; Pospiech, H; Shevelev, I; di Cicco, G; Markkanen, E; Syväoja, J E; Tanguy Le Gac, N (2011). In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta. Journal of Biological Chemistry, 286(37):32094-32104.

Meerang, M; Ritz, D; Paliwal, S; Garajova, Z; Bosshard, M; Mailand, N; Janscak, P; Hübscher, U; Meyer, H; Ramadan, K (2011). The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nature Cell Biology, 13(11):1376-1382.

Markkanen, E; van Loon, B; Ferrari, E; Hübscher, U (2011). Ubiquitylation of DNA polymerase λ. FEBS Letters, 585(18):2826-2830.

DNA Polymerases Discovery,Characterizations and Functions in Cellular DNA Transactions. Edited by: Hübscher, U; Spadari, S; Villani, G; Maga, G (2010). Singapure, Singapure: World Scientific Publishing Co. PTE. Ltd..

van Loon, B; Markkanen, E; Hübscher, U (2010). Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine. DNA Repair, 9(6):604-616.

Hübscher, U (2009). DNA Replication Fork Proteins. In: Vengrova, S; Dalgaard, J Z. DNA Replication Methods and Protocols. Totowa, NJ , USA: Humana Press.

van Loon, B; Hübscher, U (2009). An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(43):18201-18206.

van Loon, B; Ferrari, E; Hübscher, U (2009). Isolation of recombinant DNA elongation proteins. Methods in Molecular Biology, 521:345-359.

Maga, G; van Loon, B; Crespan, E; Villani, G; Hübscher, U (2009). The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1. Journal of Biological Chemistry, 284(21):14267-1475.

Maga, G; Hübscher, U (2008). Repair and Translesion DNA Polymerases as Anticancer Drug Targets. Anti-Cancer Agents in Medicinal Chemistry, 8(4):431-447.

Belousova, E A; Crespan, E; Lebedeva, N A; Rechunova, N J; Hübscher, U; Maga, G; Lavrik, O I (2008). Photoreactive DNA Probes as a Tool for Studying the Translesion Synthesis System in Mammalian Cell Extracts. Medicinal Chemistry, 4(2):155-162.

Wimmer, U; Ferrari, E; Hunziker, P; Hübscher, U (2008). Control of DNA polymerase lambda stability by phosphorylation and ubiquitination during the cell cycle. EMBO Reports, 9(10):1027-1033.

Crespan, M; Cancio, E; Spadari, S; Hübscher, U; Maga, G (2008). Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the “primer grip” region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. Biochemical Pharmacology, 76(2):156-168.

Selak, N; Bachrati, C Z; Shevelev, I; Dietschy, T; van Loon, B; Jacob, A; Hübscher, U; Hoheisel, J D; Hickson, I D; Stagljar, I (2008). The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta. Nucleic Acids Research, 36(16):5166-5179.

Gembka, A; Smirnova, E; Hübscher, U (2008). The checkpoint sensors, the 9-1-1 complex and the Rad17-RF-C2-5 complex: at the crossroads of DNA damage checkpoint and DNA repair. In: Maga, G; Hübscher, U; Villani, G; Baldacci, G. DNA Replication, Repair and Recombination at the Crossroad Between Genome Integrity and Genomic Instability : A Biochemical Perspective. Kerala: Research Signpost, 77-86.

El-Andaloussi, N; Valovka, T; Toueille, M; Hassa, P O; Gehrig, P; Covic, M; Hübscher, U; Hottiger, M O (2007). Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen. FASEB Journal, 21(1):26-34.

Crespan, E; Hübscher, U; Maga, G (2007). Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. Nucleic Acids Research, 35(15):5173-5181.

Maga, G; Amacker, M; Hübscher, U; Gosselin, G; Imbach, J L; Mathé, C; Faraj, A; Sommadossi, J P; Spadari, S (2006). Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy. Nucleosides, Nucleotides and Nucleic Acids, 18(4-5):795-805.

El-Andaloussi, N; Valovka, T; Toueille, M; Steinacher, R; Focke, F; Gehrig, P; Covic, M; Hassa, P O; Schär, P; Hübscher, U; Hottiger, M O (2006). Arginine methylation regulates DNA polymerase beta. Molecular Cell, 22(1):51-62.

Blasius, M; Shevelev, I V; Jolivet, E; Sommer, Suzanne; Hübscher, U (2006). DNA polymerase X from Deinococcus radiodurans possesses a structure-modulated 3'-->5' exonuclease activity involved in radioresistance. Molecular Microbiology, 60(1):165-176.

Maga, G; Shevelev, I V; Villani, G; Spadari, S; Hübscher, U (2006). Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. Nucleic Acids Research, 34(5):1405-1415.

Sharma, S; Sommers, J A; Gary, R K; Friedrich-Heineken, E; Hübscher, U; Brosh, R M (2005). The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Research, 33(21):6769-6781.

Friedrich-Heineken, E; Toueille, M; Tännler, B; Bürki, C; Ferrari, E; Hottiger, M O; Hübscher, U (2005). The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity. Journal of Molecular Biology, 353(5):980-989.

Cancio, R; Silvestri, R; Ragno, R; Artico, M; De Martino, G; La Regina, G; Crespan, E; Zanoli, S; Hübscher, U; Spadari, S; Maga, G (2005). High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme. Antimicrobial Agents and Chemotherapy, 49(11):4546-4554.

Frouin, I; Toueille, M; Ferrari, E; Shevelev, I V; Hübscher, U (2005). Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen. Nucleic Acids Research, 33(16):5354-5361.

Locatelli, G A; Di Santo, R; Crespan, E; Costi, R; Roux, A; Hübscher, U; Shevelev, I V; Blanca, G; Villani, G; Spadari, S; Maga, G (2005). Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. Molecular Pharmacology, 68(2):538-550.

Crespan, E; Zanoli, S; Khandazhinskaya, A; Shevelev, I V; Jasko, M; Alexandrova, L; Kukhanova, M; Blanca, G; Villani, G; Hübscher, U; Spadari, S; Maga, G (2005). Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. Nucleic Acids Research, 33(13):4117-4127.

Locatelli, G A; Savio, M; Forti, L; Shevelev, I V; Ramadan, K; Stivala, L A; Vannini, V; Hübscher, U; Spadari, S; Maga, G (2005). Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. Biochemical Journal, 389(2):259-268.

Smirnova, E; Toueille, M; Markkanen, E; Hübscher, U (2005). The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery. Biochemical Journal, 389(1):13-17.

Henneke, G; Flament, D; Hübscher, U; Querellou, J; Raffin, J P (2005). The hyperthermophilic euryarchaeota Pyrococcus abyssi likely requires the two DNA polymerases D and B for DNA replication. Journal of Molecular Biology, 350(1):53-64.

Boudsocq, F; Benaim, P; Canitrot, Y; Knibiehler, M; Ausseil, F; Capp, J P; Bieth, A; Long, C; David, B; Shevelev, I V; Frierich-Heinecken, E; Hübscher, U; Amalric, F; Massiot, G; Hoffmann, J S; Cazaux, C (2005). Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta. Molecular Pharmacology, 67(5):1485-1492.

Maga, G; Ramadan, K; Locatelli, G A; Shevelev, I V; Spadari, S; Hübscher, U (2005). DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. Journal of Biological Chemistry, 280(3):1971-1981.

Crespan, E; Locatelli, G A; Cancio, R; Hübscher, U; Spadari, S; Maga, G (2005). Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz. Antimicrobial Agents and Chemotherapy, 49(1):342-349.

Ramadan, K; Shevelev, I V; Hübscher, U (2004). The DNA-polymerase-X family: controllers of DNA quality? Nature Reviews. Molecular Cell Biology, 5(12):43.

Maga, G; Blanca, G; Shevelev, I V; Frouin, I; Ramadan, K; Spadari, S; Villani, G; Hübscher, U (2004). The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. FASEB Journal, 18(14):1743-1745.

Blanca, G; Villani, G; Shevelev, I V; Ramadan, K; Spadari, S; Hübscher, U; Maga, G (2004). Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Biochemistry, 43(36):11605-11615.

Lecointe, F; Shevelev, I V; Bailone, A; Sommer, Suzanne; Hübscher, U (2004). Involvement of an X family DNA polymerase in double-stranded break repair in the radioresistant organism Deinococcus radiodurans. Molecular Microbiology, 53(6):1721-1730.

Toueille, M; Hübscher, U (2004). Regulation of the DNA replication fork: a way to fight genomic instability. Chromosoma, 113(3):113-125.

Toueille, M; El-Andaloussi, N; Frouin, I; Freire, R; Funk, D; Shevelev, I V; Friedrich-Heineken, E; Villani, G; Hottiger, M O; Hübscher, U (2004). The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair. Nucleic Acids Research, 32(11):3316-3324.

Ramadan, K; Shevelev, I V; Maga, G; Hübscher, U (2004). De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase. Journal of Molecular Biology, 339(2):395-404.

Locatelli, G A; Campiani, Giuseppe; Cancio, R; Morelli, E; Ramunno, A; Gemma, S; Hübscher, U; Spadari, S; Maga, G (2004). Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. Antimicrobial Agents and Chemotherapy, 48(5):1570-1580.

Friedrich-Heineken, E; Hübscher, U (2004). The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity. Nucleic Acids Research, 32(8):2520-2528.

Shevelev, I V; Blanca, G; Villani, G; Ramadan, K; Spadari, S; Hübscher, U; Maga, G (2003). Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Nucleic Acids Research, 31(23):6916-6925.

Bergoglio, V; Ferrari, E; Hübscher, U; Cazaux, C; Hoffmann, J S (2003). DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA. Journal of Molecular Biology, 331(5):1017-1023.

Henneke, G; Koundrioukoff, S; Hübscher, U (2003). Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Oncogene, 22(28):4301-4313.

Baldanti, F; Paolucci, S; Maga, G; Labo, N; Hübscher, U; Skoblov, A Y; Victorova, L; Spadari, S; Minoli, L; Gerna, G (2003). Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine. AIDS, 17(10):1568-1570.

Henneke, G; Friedrich-Heineken, E; Hübscher, U (2003). Flap endonuclease 1: a novel tumour suppresser protein. Trends in Biochemical Sciences, 28(7):384-390.

Blanca, G; Shevelev, I V; Ramadan, K; Villani, G; Spadari, S; Hübscher, U; Maga, G (2003). Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. Biochemistry, 42(24):7467-7476.

Tasara, T; Angerer, B; Damond, M; Winter, H; Dörhöfer, S; Hübscher, U; Amacker, M (2003). Incorporation of reporter molecule-labeled nucleotides by DNA polymerases. II. High-density labeling of natural DNA. Nucleic Acids Research, 31(10):2636-2646.

Blanca, G; Baldanti, F; Paolucci, S; Skoblov, A Y; Victorova, L; Hübscher, U; Gerna, G; Spadari, S; Maga, G (2003). Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. Journal of Biological Chemistry, 278(18):15469-15472.

Ramadan, K; Maga, G; Shevelev, I V; Villani, G; Blanco, L; Hübscher, U (2003). Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions. Journal of Molecular Biology, 328(1):63-72.

Friedrich-Heineken, E; Henneke, G; Ferrari, E; Hübscher, U (2003). The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities. Journal of Molecular Biology, 328(1):73-84.

Henneke, G; Koundrioukoff, S; Hübscher, U (2003). Multiple roles for kinases in DNA replication. EMBO Reports, 4(3):252-256.

Maga, G; Villani, G; Ramadan, K; Shevelev, I V; Tanguy Le Gac, N; Blanco, L; Blanca, G; Spadari, S; Hübscher, U (2002). Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. Journal of Biological Chemistry, 277(50):48434-48440.

Henneke, G; Gueguen, Y; Flament, D; Azam, P; Querellou, J; Dietrich, J; Hübscher, U; Raffin, J P (2002). Replication factor C from the hyperthermophilic archaeon Pyrococcus abyssi does not need ATP hydrolysis for clamp-loading and contains a functionally conserved RFC PCNA-binding domain. Journal of Molecular Biology, 323(5):795-810.

Storici, F; Henneke, G; Ferrari, E; Gordenin, D A; Hübscher, U; Resnick, M A (2002). The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair. The EMBO Journal, 21(21):5930-5942.

Dahm, K; Hübscher, U (2002). Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block. Oncogene, 21(50):7710-7719.

Maga, G; Shevelev, I V; Ramadan, K; Spadari, S; Hübscher, U (2002). DNA polymerase theta purified from human cells is a high-fidelity enzyme. Journal of Molecular Biology, 319(2):359-369.

Ramadan, K; Shevelev, I V; Maga, G; Hübscher, U (2002). DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. Journal of Biological Chemistry, 277(21):18454-18458.

Frouin, I; Montecucco, A; Biamonti, G; Hübscher, U; Spadari, S; Maga, G (2002). Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. The EMBO Journal, 21(10):2485-2495.

Pascucci, B; Maga, G; Hübscher, U; Bjoras, M; Seeberg, E; Hickson, I D; Villani, G; Giordano, C; Cellai, L; Dogliotti, E (2002). Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins. Nucleic Acids Research, 30(10):2124-2130.

Shevelev, I V; Hübscher, U (2002). The 3' 5' exonucleases. Nature Reviews. Molecular Cell Biology, 3(5):364-376.

Ducoux, M; Urbach, S; Baldacci, G; Hübscher, U; Koundrioukoff, S; Christensen, J; Hughes, P (2001). Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. Journal of Biological Chemistry, 276(52):49258-49266.

Maga, G; Villani, G; Tillement, V; Stucki, M; Locatelli, G A; Frouin, I; Spadari, S; Hübscher, U (2001). Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 98(25):14298-14303.

Ziemienowicz, A; Konieczny, I; Hübscher, U (2001). Calf thymus Hsc70 and Hsc40 can substitute for DnaK and DnaJ function in protein renaturation but not in bacteriophage DNA replication. FEBS Letters, 507(1):11-15.

Tasara, T; Maga, G; Hottiger, M O; Hübscher, U (2001). HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other. FEBS Letters, 507(1):39-44.

Miller, J T; Ehresmann, B; Hübscher, U; Le Grice, S F (2001). A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis. Journal of Biological Chemistry, 276(29):27721-27730.

Missura, M; Buterin, T; Hindges, R; Hübscher, U; Kaspárková, J; Brabec, V; Naegeli, H (2001). Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair. The EMBO Journal, 20(23):3554-3564.

Tasara, T; Hottiger, M O; Hübscher, U (2001). Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation. Biological Chemistry, 382(7):993-999.

Hasan, S; Stucki, M; Hassa, P O; Imhof, R; Gehrig, P; Hunziker, P; Hübscher, U; Hottiger, M O (2001). Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Molecular Cell, 7(6):1221-1231.

Maga, G; Hübscher, U; Pregnolato, M; Ubiali, D; Gosselin, G; Spadari, S (2001). Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs. Antimicrobial Agents and Chemotherapy, 45(4):1192-1200.

Stucki, M; Jónsson, Z O; Hübscher, U (2001). In eukaryotic flap endonuclease 1, the C terminus is essential for substrate binding. Journal of Biological Chemistry, 276(11):7843-7849.

Hobi, R; Hübscher, U; Neftel, K; Alteri, E; Poncioni, B; Walker, M R; Woods-Cook, K; Schneider, P; Lazdins, J K (2001). Anti-HIV-1 activity in vitro of ceftazidime degradation products. Antiviral Chemistry & Chemotherapy, 12(2):109-118.

Stucki, M; Stagljar, I; Jónsson, Z O; Hübscher, U (2001). A coordinated interplay: proteins with multiple functions in DNA replication, DNA repair, cell cycle/checkpoint control, and transcription. Progress in Nucleic Acid Research and Molecular Biology, 65:261-298.

Rülicke, T; Hübscher, U (2000). Germ line transformation of mammals by pronuclear microinjection. Experimental Physiology, 85(6):859-601.

Henneke, G; Raffin, J P; Ferrari, E; Jónsson, Z O; Dietrich, J; Hübscher, U (2000). The PCNA from Thermococcus fumicolans functionally interacts with DNA polymerase delta. Biochemical and Biophysical Research Communications (BBRC), 276(2):600-6.

Koundrioukoff, S; Jónsson, Z O; Hasan, S; de Jong, R N; van der Vliet, P C; Hottiger, M O; Hübscher, U (2000). A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation. Journal of Biological Chemistry, 275(30):22882-22887.

Georlette, D; Jónsson, Z O; Van Petegem, F; Chessa, J; Van Beeumen, J; Hübscher, U; Gerday, C (2000). A DNA ligase from the psychrophile Pseudoalteromonas haloplanktis gives insights into the adaptation of proteins to low temperatures. FEBS Journal, 267(12):3502-3512.

Hübscher, U; Nasheuer, H P; Syväoja, J E (2000). Eukaryotic DNA polymerases, a growing family. Trends in Biochemical Sciences, 25(3):143-147.

Moggs, J G; Grandi, P; Quivy, J P; Jónsson, Z O; Hübscher, U; Becker, P B; Almouzni, G (2000). A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage. Molecular and Cellular Biology, 20(4):1206-1218.

Araújo, S J; Tirode, F; Coin, F; Pospiech, H; Syväoja, J E; Stucki, M; Hübscher, U; Egly, J M; Wood, R D (2000). Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK. Genes and Development, 14(3):349-359.

Maga, G; Stucki, M; Spadari, S; Hübscher, U (2000). DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Journal of Molecular Biology, 295(4):801.

Mossi, R; Keller, R C; Ferrari, E; Hübscher, U (2000). DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase alpha at a critical length. Journal of Molecular Biology, 295(4):803-814.

Schumacher, S B; Stucki, M; Hübscher, U (2000). The N-terminal region of DNA polymerase delta catalytic subunit is necessary for holoenzyme function. Nucleic Acids Research, 28(2):620-625.

Pascucci, B; Stucki, M; Jónsson, Z O; Dogliotti, E; Hübscher, U (1999). Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon. Journal of Biological Chemistry, 274(47):33696-33702.

Keller, R C; Mossi, R; Maga, G; Wellinger, R E; Hübscher, U; Sogo, J M (1999). Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA. Nucleic Acids Research, 27(17):3433-3437.

Stagljar, I; Hübscher, U; Barberis, A (1999). Activation of DNA replication in yeast by recruitment of the RNA polymerase II transcription complex. Biological Chemistry, 380(5):525-30.

Maga, G; Amacker, M; Hübscher, U; Gosselin, G; Imbach, J L; Mathé, C; Faraj, A; Sommadossi, J P; Spadari, S (1999). Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs. Nucleic Acids Research, 27(4):972-978.

Tasara, T; Amacker, M; Hübscher, U (1999). Intramolecular chimeras of the p51 subunit between HIV-1 and FIV reverse transcriptases suggest a stabilizing function for the p66 subunit in the heterodimeric enzyme. Biochemistry, 35(5):1633-1642.

Marx, A; Spichty, M; Amacker, M; Schwitter, U; Hübscher, U; Bickle, T A; Maga, G; Giese, B (1999). Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides. Chemistry & Biology, 6(2):111-116.

Maga, G; Jónsson, Z O; Stucki, M; Spadari, S; Hübscher, U (1999). Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. Journal of Molecular Biology, 285(1):259-267.

Shivji, M K; Ferrari, E; Ball, K; Hübscher, U; Wood, R D (1998). Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1. Oncogene, 17(22):2827-2835.

Perderiset, M; Maga, G; Piard, K; Francesconi, S; Tratner, I; Hübscher, U; Baldacci, G (1998). Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen. Biochemical Journal, 335(3):581-588.

Marx, A; Amacker, M; Stucki, M; Hübscher, U; Bickle, T A; Giese, B (1998). 4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase. Nucleic Acids Research, 26(17):4063-4069.

Stucki, M; Pascucci, B; Parlanti, E; Fortini, P; Wilson, S H; Hübscher, U; Dogliotti, E (1998). Mammalian base excision repair by DNA polymerases delta and epsilon. Oncogene, 17(7):835-843.

Mossi, R; Ferrari, E; Hübscher, U (1998). DNA ligase I selectively affects DNA synthesis by DNA polymerases delta and epsilon suggesting differential functions in DNA replication and repair. Journal of Biological Chemistry, 273(23):14322-14330.

von Janta-Lipinski, M; Costisella, B; Ochs, H; Hübscher, U; Hafkemeyer, P; Matthes, E (1998). Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. Journal of Medicinal Chemistry, 41(12):2040-2046.

Mossi, R; Hübscher, U (1998). Clamping down on clamps and clamp loaders--the eukaryotic replication factor C. FEBS Journal, 254(2):209-216.

Amacker, M; Hübscher, U (1998). Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases. Journal of Molecular Biology, 278(4):757-765.

Schurtenberger, P; Egelhaaf, S U; Hindges, R; Maga, G; Jónsson, Z O; May, R P; Glatter, O; Hübscher, U (1998). The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering. Journal of Molecular Biology, 275(1):123-132.

Maga, G; Amacker, M; Ruel, N; Hübscher, U; Spadari, S (1997). Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions. Journal of Molecular Biology, 274(5):738-747.

Jónsson, Z O; Hübscher, U (1997). Proliferating cell nuclear antigen: more than a clamp for DNA polymerases. BioEssays, 19(11):967-975.

Mossi, R; Jónsson, Z O; Allen, B L; Hardin, S H; Hübscher, U (1997). Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. Journal of Biological Chemistry, 272(3):1769-1776.

Jessberger, R; Schär, P; Robins, P; Ferrari, E; Riwar, B; Hübscher, U (1997). Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: up-regulation of DNA polymerase delta. Nucleic Acids Research, 25(2):289-296.

Lutz, M J; Held, H A; Hottiger, M O; Hübscher, U; Benner, S A (1996). Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet. Nucleic Acids Research, 24(7):1308-1313.

Amacker, M; Hottiger, M O; Hübscher, U (1995). Feline immunodeficiency virus reverse transcriptase: expression, functional characterization, and reconstitution of the 66- and 51-kilodalton subunits. Journal of Virology, 69(10):6273-6279.

Horlacher, J; Hottiger, M O; Podust, V N; Hübscher, U; Benner, S A (1995). Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 92(14):6329-6333.

Ziemienowicz, A; Zylicz, M; Floth, C; Hübscher, U (1995). Calf thymus Hsc70 protein protects and reactivates prokaryotic and eukaryotic enzymes. Journal of Biological Chemistry, 270(26):15479-15484.

Hoffmann, J S; Pillaire, M J; Maga, G; Podust, V N; Hübscher, U; Villani, G (1995). DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 92(12):5356-5360.

Hottiger, M O; Gramatikoff, K; Georgiev, O; Chaponnier, C; Schaffner, W; Hübscher, U (1995). The large subunit of HIV-1 reverse transcriptase interacts with beta-actin. Nucleic Acids Research, 23(5):736-741.

This list was generated on Tue Jul 25 14:13:54 2017 CEST.