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Number of items: 41.

Pecqueur, L; Duellberg, C; Dreier, B; Jiang, Q; Wang, C; Plückthun, A; Surrey, T; Gigant, B; Knossow, M (2012). A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 109(30):12011-12016.

Mignot, I; Pecqueur, L; Dorléans, A; Karuppasamy, M; Ravelli, R B G; Dreier, B; Plückthun, A; Knossow, M; Gigant, B (2012). Design and Characterization of Modular Scaffolds for Tubulin Assembly. Journal of Biological Chemistry, 287(37):31085-31094.

Alfarano, P; Varadamsetty, G; Ewald, C; Parmeggiani, F; Pellarin, R; Zerbe, O; Plückthun, A; Caflisch, A (2012). Optimization of designed armadillo repeat proteins by molecular dynamics simulations and NMR spectroscopy. Protein Science, 21(9):1298-1314.

Martin-Killias, P; Stefan, N; Rothschild, S; Plückthun, A; Zangemeister-Wittke, U (2011). A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity. Clinical Cancer Research, 17(1):100-110.

Boersma, Y L; Chao, G; Steiner, D; Wittrup, K D; Plückthun, A (2011). Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling. Journal of Biological Chemistry, 286(48):41273-41285.

Boersma, Y L; Plückthun, A (2011). DARPins and other repeat protein scaffolds: advances in engineering and applications. Current Opinion in Biotechnology, 22(6):849-857.

Stefan, N; Martin-Killias, P; Wyss-Stoeckle, S; Honegger, A; Zangemeister-Wittke, U; Plückthun, A (2011). DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency. Journal of Molecular Biology, 413(4):826-43.

Münch, R C; Mühlebach, M D; Schaser, T; Kneissl, S; Jost, C; Plückthun, A; Cichutek, K; Buchholz, C J (2011). DARPins: an efficient targeting domain for lentiviral vectors. Molecular Therapy, 19(4):686-693.

Dodevski, I; Plückthun, A (2011). Evolution of three human GPCRs for higher expression and stability. Journal of Molecular Biology, 408(4):599-615.

Dreier, B; Mikheeva, G; Belousova, N; Parizek, P; Boczek, E; Jelesarov, I; Forrer, P; Plückthun, A; Krasnykh, V (2011). Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targeting. Journal of Molecular Biology, 405(2):410-426.

Stevens, G B; Krüger, M; Latychevskaia, T; Lindner, P; Plückthun, A; Fink, H-W (2011). Individual filamentous phage imaged by electron holography. European Biophysics Journal, 40(10):1197-1201.

Dreier, B; Plückthun, A (2011). Ribosome display: a technology for selecting and evolving proteins from large libraries. Methods in Molecular Biology, 687:283-306.

Zahnd, C; Sarkar, C A; Plückthun, A (2010). Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution. Protein Engineering Design and Selection : PEDS, 23(4):175-184.

Schaefer, J V; Honegger, A; Plückthun, A (2010). Construction of scFv fragments from hybridoma or spleen cells by PCR assembly. In: Kontermann, R; Dübel, S. Antibody Engineering. Berlin Heidelberg: Springern-Verlag, 21-44.

Theurillat, J P; Dreier, B; Nagy-Davidescu, G; Seifert, Burkhardt; Behnke, S; Zürrer-Härdi, U; Ingold, F; Plückthun, A; Moch, H (2010). Designed ankyrin repeat proteins: a novel tool for testing epidermal growth factor receptor 2 expression in breast cancer. Modern Pathology, 23(9):1289-1297.

Zahnd, C; Kawe, M; Stumpp, M T; de Pasquale, C; Tamaskovic, R; Nagy-Davidescu, G; Dreier, B; Schibli, R; Binz, H K; Waibel, R; Plückthun, A (2010). Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size. Cancer Research, 70(4):1595-1605.

Plückthun, A (2010). HIV: Antibodies with a split personality. Nature, 467(7315):537-538.

Schaefer, J V; Plückthun, A (2010). Improving expression of scFv fragments by co-expression of periplasmic chaperones. In: Kontermann, R; Dübel, S. Antibody Engineering. Berlin Heidelberg: Springern-Verlag, 345-361.

Brient-Litzler, E; Plückthun, A; Bedouelle, H (2010). Knowledge-based design of reagentless fluorescent biosensors from a designed ankyrin repeat protein. Protein Engineering Design and Selection : PEDS, 23(4):229-241.

Schaefer, J V; Lindner, P; Plückthun, A (2010). Miniantibodies. In: Kontermann, R; Dübel, S. Antibody Engineering. Berlin Heidelberg, Germany: Springern-Verlag, 85-99.

Wetzel, S K; Ewald, C; Settanni, G; Jurt, S; Plückthun, A; Zerbe, O (2010). Residue-resolved stability of full-consensus ankyrin repeat proteins probed by NMR. Journal of Molecular Biology, 402(1):241-258.

Kramer, M A; Wetzel, S K; Plückthun, A; Mittl, P R E; Grütter, M G (2010). Structural determinants for improved stability of designed ankyrin repeat proteins with a redesigned C-capping module. Journal of Molecular Biology, 404(3):381-391.

Kawe, M; Horn, U; Plückthun, A (2009). Facile promoter deletion in Escherichia coli in response to leaky expression of very robust and benign proteins from common expression vectors. Microbial Cell Factories, 8:8.

Plückthun, A (2009). Alternative scaffolds: Expanding the options of antibodies. In: Little, M. Recombinant antibodies for immunotherapy. New York, US: Cambridge University Press, 243-271.

Veesler, D; Dreier, B; Blangy, S; Lichière, J; Tremblay, D; Moineau, S; Spinelli, S; Tegoni, M; Plückthun, A; Campanacci, V; Cambillau, C (2009). Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1: comparison of DARPin and camelid VHH binding mode. Journal of Biological Chemistry, 284(44):30718-30726.

Winkler, J; Martin-Killias, P; Plückthun, A; Zangemeister-Wittke, U (2009). EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins. Molecular Cancer Therapeutics, 8(9):2674-2683.

Milovnik, P; Ferrari, D; Sarkar, C A; Plückthun, A (2009). Selection and characterization of DARPins specific for the neurotensin receptor 1. Protein Engineering Design and Selection : PEDS, 22(6):357-366.

Kügler, M; Stein, C; Schwenkert, M; Saul, D; Vockentanz, L; Huber, T; Wetzel, S K; Scholz, O; Plückthun, A; Honegger, A; Fey, G H (2009). Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework. Protein Engineering Design and Selection : PEDS, 22(3):135-147.

Honegger, A; Malebranche, A D; Röthlisberger, D; Plückthun, A (2009). The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains. Protein Engineering Design and Selection : PEDS, 22(3):121-134.

Steiner, D; Forrer, P; Plückthun, A (2008). Efficient selection of DARPins with sub-nanomolar affinities using SRP phage display. Journal of Molecular Biology, 382(5):1211-1227.

Sarkar, C A; Dodevski, I; Kenig, M; Dudli, S; Mohr, A; Hermans, E; Plückthun, A (2008). Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(39):14808-14813.

Frey, D; Huber, T; Plückthun, A; Grütter, M G (2008). Structure of the recombinant antibody Fab fragment f3p4. Acta Crystallographica. Section D, Biological Crystallography, 64(Pt 6):636-643.

Wetzel, S K; Settanni, G; Kenig, M; Binz, H K; Plückthun, A (2008). Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins. Journal of Molecular Biology, 376(1):241-257.

Merz, T; Wetzel, S K; Firbank, S; Plückthun, A; Grütter, M G; Mittl, P R E (2008). Stabilizing ionic interactions in a full-consensus ankyrin repeat protein. Journal of Molecular Biology, 376(1):232-240.

Interlandi, G; Wetzel, S K; Settanni, G; Plückthun, A; Caflisch, A (2008). Characterization and further stabilization of designed ankyrin repeat proteins by combining molecular dynamics simulations and experiments. Journal of Molecular Biology, 375(3):837-854.

Parmeggiani, F; Pellarin, R; Larsen, A P; Varadamsetty, G; Stumpp, M T; Zerbe, O; Caflisch, A; Plückthun, A (2008). Designed armadillo repeat proteins as general peptide-binding scaffolds: consensus design and computational optimization of the hydrophobic core. Journal of Molecular Biology, 376(5):1282-1304.

Röthlisberger, D; Honegger, A; Plückthun, A (2005). Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability. Journal of Molecular Biology, 347(4):773-789.

Ott, D; Neldner, Y; Cèbe, R; Dodevski, I; Plückthun, A (2005). Engineering and functional immobilization of opioid receptors. Protein Engineering Design and Selection : PEDS, 18(3):153-160.

Röthlisberger, D; Pos, K M; Plückthun, A (2004). An antibody library for stabilizing and crystallizing membrane proteins - selecting binders to the citrate carrier CitS. FEBS Letters, 564(3):340-348.

Ott, D; Frischknecht, R; Plückthun, A (2004). Construction and characterization of a kappa opioid receptor devoid of all free cysteines. Protein Engineering Design and Selection : PEDS, 17(1):37-48.

Waibel, R; Alberto, R; Willuda, J; Finnern, R; Schibli, R; Stichelberger, A; Egli, A; Abram, U; Mach, J P; Plückthun, A; Schubiger, P A (1999). Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex. Nature Biotechnology, 17(9):897-901.

This list was generated on Tue Oct 24 13:58:45 2017 CEST.