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Number of items: 75.

Ranganathan, Anirudh; Heine, Philipp; Rudling, Axel; Plückthun, Andreas; Kummer, Lutz; Carlsson, Jens (2017). Ligand discovery for a peptide-binding GPCR by Structure-based screening of fragment- and lead-like chemical libraries. ACS Chemical Biology, 12(3):735-745.

Anders, Ulrike; Schaefer, Jonas V; Hibti, Fatima-Ezzahra; Frydman, Chiraz; Suckau, Detlev; Plückthun, Andreas; Zenobi, Renato (2017). SPRi-MALDI MS: characterization and identification of a kinase from cell lysate by specific interaction with different designed ankyrin repeat proteins. Analytical and Bioanalytical Chemistry, 409(7):1827-1836.

Syafrizayanti; Lueong, Smiths S; Di, Cuixia; Schaefer, Jonas V; Plückthun, Andreas; Hoheisel, Jörg D (2017). Personalised proteome analysis by means of protein microarrays made from individual patient samples. Scientific Reports, 7:39756.

Ernst, Patrick; Plückthun, Andreas (2017). Advances in the design and engineering of peptide-binding repeat proteins. Biological Chemistry, 398(1):23-29.

Nasr, Mahmoud L; Baptista, Diego; Strauss, Mike; Sun, Zhen-Yu J; Grigoriu, Simina; Huser, Sonja; Plückthun, Andreas; Hagn, Franz; Walz, Thomas; Hogle, James M; Wagner, Gerhard (2017). Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nature Methods, 14(1):49-52.

Verdurmen, Wouter P R; Mazlami, Marigona; Plückthun, Andreas (2017). A Biotin Ligase-Based Assay for the Quantification of the Cytosolic Delivery of Therapeutic Proteins. Methods in Molecular Biology, 1575:223-236.

Goricanec, David; Stehle, Ralf; Egloff, Pascal; Grigoriu, Simina; Plückthun, Andreas; Wagner, Gerhard; Hagn, Franz (2016). Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding. Proceedings of the National Academy of Sciences of the United States of America, 113(26):E3629-E3638.

Bender, Ruben R; Muth, Anke; Schneider, Irene C; Friedel, Thorsten; Hartmann, Jessica; Plückthun, Andreas; Maisner, Andrea; Buchholz, Christian J (2016). Receptor-targeted nipah virus glycoproteins improve cell-type selective gene delivery and reveal a preference for membrane-proximal cell attachment. PLoS Pathogens, 12(6):e1005641.

Batyuk, Alexander; Wu, Yufan; Honegger, Annemarie; Heberling, Matthew M; Plückthun, Andreas (2016). DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography. Journal of Molecular Biology, 428(8):1574-1588.

Schütz, Marco; Batyuk, Alexander; Klenk, Christoph; Kummer, Lutz; de Picciotto, Seymour; Gülbakan, Basri; Wu, Yufan; Newby, Gregory A; Zosel, Franziska; Schöppe, Jendrik; Sedlák, Erik; Mittl, Peer R E; Zenobi, Renato; Wittrup, K Dane; Plückthun, Andreas (2016). Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools. Journal of Molecular Biology, 428(6):1272-1289.

Hansen, Simon; Tremmel, Dirk; Madhurantakam, Chaithanya; Reichen, Christian; Mittl, Peer R E; Plückthun, Andreas (2016). Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity. Journal of the American Chemical Society, 138(10):3526-3532.

Jones, Tim D; Carter, Paul J; Plückthun, Andreas; et al (2016). The INNs and outs of antibody nonproprietary names. mAbs, 8(1):1-9.

Reichen, Christian; Madhurantakam, Chaithanya; Hansen, Simon; Grütter, Markus G; Plückthun, Andreas; Mittl, Peer R E (2016). Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects. Acta Crystallographica. Section D: Structural Biology, 72(Pt 1):168-175.

Klenk, Christoph; Ehrenmann, Janosch; Schütz, Marco; Plückthun, Andreas (2016). A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution. Scientific Reports, 6:21294.

Reichen, Christian; Hansen, Simon; Forzani, Cristina; Honegger, Annemarie; Fleishman, Sarel J; Zhou, Ting; Parmeggiani, Fabio; Ernst, Patrick; Madhurantakam, Chaithanya; Ewald, Christina; Mittl, Peer R E; Zerbe, Oliver; Baker, David; Caflisch, Amedeo; Plückthun, Andreas (2016). Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition. Journal of Molecular Biology, 428(22):4467-4489.

Ahmad, Shoeb; Pecqueur, Ludovic; Dreier, Birgit; Hamdane, Djemel; Aumont-Nicaise, Magali; Plückthun, Andreas; Knossow, Marcel; Gigant, Benoît (2016). Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin. Scientific Reports, 6:28922.

Schütz, Marco; Schöppe, Jendrik; Sedlák, Erik; Hillenbrand, Matthias; Nagy-Davidescu, Gabriela; Ehrenmann, Janosch; Klenk, Christoph; Egloff, Pascal; Kummer, Lutz; Plückthun, Andreas (2016). Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts. Scientific Reports, 6:21508.

Hanauer, Jan Rh; Gottschlich, Lisa; Riehl, Dennis; Rusch, Tillmann; Koch, Vivian; Friedrich, Katrin; Hutzler, Stefan; Prüfer, Steffen; Friedel, Thorsten; Hanschmann, Kay-Martin; Münch, Robert C; Jost, Christian; Plückthun, Andreas; Cichutek, Klaus; Buchholz, Christian J; Mühlebach, Michael D (2016). Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors. Molecular Therapy - Oncolytics, 3:16003.

Tamaskovic, Rastislav; Schwill, Martin; Nagy-Davidescu, Gabriela; Jost, Christian; Schaefer, Dagmar C; Verdurmen, Wouter P R; Schaefer, Jonas V; Honegger, Annemarie; Plückthun, Andreas (2016). Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk. Nature Communications, 7:11672.

Merten, Hannes; Brandl, Fabian; Plückthun, Andreas; Zangemeister-Wittke, Uwe (2015). Antibody-drug conjugates for tumor targeting-novel conjugation chemistries and the promise of non-igg binding proteins. Bioconjugate Chemistry, 26(11):2176-2185.

Bradbury, Andrew R M; Plückthun, Andreas (2015). Getting to reproducible antibodies: the rationale for sequenced recombinant characterized reagents. Protein Engineering, Design & Selection, 28(10):303-305.

Fleishman, Sarel J; Plückthun, Andreas (2015). Editorial overview: Protein design and evolution-new protein architectures, evolutionary fine-tuning and analysis. Current Opinion in Structural Biology, 33:v-vi.

König, Iwo; Zarrine-Afsar, Arash; Aznauryan, Mikayel; Soranno, Andrea; Wunderlich, Bengt; Dingfelder, Fabian; Stüber, Jakob C; Plückthun, Andreas; Nettels, Daniel; Schuler, Benjamin (2015). Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells. Nature Methods, 12(8):773-779.

Sedlák, Erik; Schaefer, Jonas V; Marek, Jozef; Gimeson, Peter; Plückthun, Andreas (2015). Advanced analyses of kinetic stabilities of iggs modified by mutations and glycosylation. Protein Science, 24(7):1100-1113.

Ewald, Christina; Christen, Martin T; Watson, Randall P; Mihajlovic, Maja; Zhou, Ting; Honegger, Annemarie; Plückthun, Andreas; Caflisch, Amedeo; Zerbe, Oliver (2015). A combined NMR and computational approach to investigate peptide binding to a designed armadillo repeat protein. Journal of Molecular Biology, 427(10):1916-1933.

Bradbury, Andrew M; Plückthun, Andreas (2015). Antibodies: validate recombinants once. Nature, 520(7547):295.

Egloff, Pascal; Deluigi, Mattia; Heine, Philipp; Balada, Stefanie; Plückthun, Andreas (2015). A cleavable ligand column for the rapid isolation of large quantities of homogeneous and functional neurotensin receptor 1 variants from E. coli. Protein Expression and Purification, 108:106-114.

Friedel, Thorsten; Hanisch, Lydia J; Muth, Anke; Honegger, Annemarie; Abken, Hinrich; Plückthun, Andreas; Buchholz, Christian J; Schneider, Irene C (2015). Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv. Protein Engineering, Design & Selection, 28(4):93-106.

Oude Blenke, Erik; Klaasse, Gruson; Merten, Hannes; Plückthun, Andreas; Mastrobattista, Enrico; Martin, Nathaniel I (2015). Liposome functionalization with copper-free "click chemistry". Journal of Controlled Release, 202:14-20.

Hillenbrand, Matthias; Schori, Christian; Schöppe, Jendrik; Plückthun, Andreas (2015). Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution. Proceedings of the National Academy of Sciences of the United States of America, 112(11):E1181-E1190.

Verdurmen, Wouter P R; Luginbühl, Manuel; Honegger, Annemarie; Plückthun, Andreas (2015). Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems. Journal of Controlled Release, 200:13-22.

Bradbury, Andrew; Plückthun, Andreas (2015). Reproducibility: Standardize antibodies used in research. Nature, 518(7537):27-29.

Goldstein, Robert; Sosabowski, Jane; Livanos, Maria; Leyton, Julius; Vigor, Kim; Bhavsar, Gaurav; Nagy-Davidescu, Gabriela; Rashid, Mohammed; Miranda, Enrique; Yeung, Jenny; Tolner, Berend; Plückthun, Andreas; Mather, Stephen; Meyer, Tim; Chester, Kerry (2015). Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging. European Journal of Nuclear Medicine and Molecular Imaging, 42(2):288-301.

Salvati Manni, Livia; Zabara, Alexandru; Osornio, Yazmin M; Schöppe, Jendrik; Batyuk, Alexander; Plückthun, Andreas; Siegel, Jay S; Mezzenga, Raffaele; Landau, Ehud M (2015). Phase behavior of a designed cyclopropyl analogue of monoolein: implications for low-temperature membrane protein crystallization. Angewandte Chemie Internationale Edition, 54(3):1027-1031.

Plückthun, Andreas (2015). Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy. Annual Review of Pharmacology and Toxicology, 55:489-511.

Münch, Robert C; Muth, Anke; Muik, Alexander; Friedel, Thorsten; Schmatz, Julia; Dreier, Birgit; Trkola, Alexandra; Plückthun, Andreas; Büning, Hildegard; Buchholz, Christian J (2015). Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors. Nature Communications, 6:6246.

Stefan, Nikolas; Zimmermann, Martina; Simon, Manuel; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2014). Novel prodrug-like fusion toxin with protease-sensitive bioorthogonal PEGylation for tumor targeting. Bioconjugate Chemistry, 25(12):2144-2156.

Reichen, Christian; Madhurantakam, Chaithanya; Plückthun, Andreas; Mittl, Peer R E (2014). Crystal structures of designed armadillo repeat proteins: Implications of construct design and crystallization conditions on overall structure. Protein Science, 23(11):1572-1583.

Larrick, James W; Parren, Paul Whi; Huston, James S; Plückthun, Andreas; Bradbury, Andrew; Tomlinson, Ian M; Chester, Kerry A; Burton, Dennis R; Adams, Gregory P; Weiner, Louis M; Scott, Jamie K; Alfenito, Mark R; Veldman, Trudi; Reichert, Janice M (2014). Antibody engineering and therapeutics conference. mAbs, 6(5):1115-1123.

Yan, Junhong; Gu, Gucci Jijuan; Jost, Christian; Hammond, Maria; Plückthun, Andreas; Landegren, Ulf; Kamali-Moghaddam, Masood (2014). A universal approach to prepare reagents for DNA-assisted protein analysis. PLoS ONE, 9(9):e108061.

Hanenberg, Michael; McAfoose, Jordan; Kulic, Luka; Welt, Tobias; Wirth, Fabian; Parizek, Petra; Strobel, Lisa; Cattepoel, Susann; Späni, Claudia; Derungs, Rebecca; Maier, Marcel; Plückthun, Andreas; Nitsch, Roger M (2014). Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. Journal of Biological Chemistry, 289(39):27080-27089.

Schilling, Johannes; Schöppe, Jendrik; Sauer, Evelyn; Plückthun, Andreas (2014). Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W. Journal of Molecular Biology, 426(12):2346-2362.

Jost, Christian; Plückthun, Andreas (2014). Engineered proteins with desired specificity: DARPins, other alternative scaffolds and bispecific IgGs. Current Opinion in Structural Biology, 27:102-112.

Schilling, Johannes; Schöppe, Jendrik; Plückthun, Andreas (2014). From DARPins to LoopDARPins: novel LoopDARPin design allows the selection of low picomolar binders in a single round of ribosome display. Journal of Molecular Biology, 426(3):691-721.

Scholz, Oliver; Hansen, Simon; Plückthun, Andreas (2014). G-quadruplexes are specifically recognized and distinguished by selected designed ankyrin repeat proteins. Nucleic Acids Research, 42(14):9182-9194.

Scott, Daniel J; Kummer, Lutz; Egloff, Pascal; Bathgate, Ross A D; Plückthun, Andreas (2014). Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies. BBA - Biochimica et Biophysica Acta, 1838(11):2817-2824.

Simon, Manuel; Stefan, Nikolas; Borsig, Lubor; Plückthun, Andreas; Zangemeister-Wittke, Uwe (2014). Increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click PEGylation. Molecular Cancer Therapeutics, 13(2):375-385.

Reichen, Christian; Hansen, Simon; Plückthun, Andreas (2014). Modular peptide binding: from a comparison of natural binders to designed armadillo repeat proteins. Journal of Structural Biology, 185(2):147-162.

Brauchle, Michael; Hansen, Simon; Caussinus, Emmanuel; Lenard, Anna; Ochoa-Espinosa, Amanda; Scholz, Oliver; Sprecher, Simon G; Plückthun, Andreas; Affolter, Markus (2014). Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry. Biology Open, 3(12):1252-1261.

Watson, Randall P; Christen, Martin T; Ewald, Christina; Bumbak, Fabian; Reichen, Christian; Mihajlovic, Maja; Schmidt, Elena; Güntert, Peter; Caflisch, Amedeo; Plückthun, Andreas; Zerbe, Oliver (2014). Spontaneous self-assembly of engineered armadillo repeat protein fragments into a folded structure. Structure, 22(7):985-995.

Egloff, Pascal; Hillenbrand, Matthias; Klenk, Christoph; Batyuk, Alexander; Heine, Philipp; Balada, Stefanie; Schlinkmann, Karola M; Scott, Daniel J; Schütz, Marco; Plückthun, Andreas (2014). Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 111(6):E655-E662.

Kiuchi, Tai; Ortiz-Zapater, Elena; Monypenny, James; Matthews, Daniel R; Nguyen, Lan K; Barbeau, Jody; Coban, Oana; Lawler, Katherine; Burford, Brian; Rolfe, Daniel J; de Rinaldis, Emanuele; Dafou, Dimitra; Simpson, Michael A; Woodman, Natalie; Pinder, Sarah; Gillett, Cheryl E; Devauges, Viviane; Poland, Simon P; Fruhwirth, Gilbert; Marra, Pierfrancesco; Boersma, Ykelien L; Plückthun, Andreas; Gullick, William J; Yarden, Yosef; Santis, George; Winn, Martyn; Kholodenko, Boris N; Martin-Fernandez, Marisa L; Parker, Peter; Tutt, Andrew; Ameer-Beg, Simon M; Ng, Tony (2014). The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility. Science Signaling, 7(339):ra78.

Mann, Axel; Friedrich, Nikolas; Krarup, Anders; Weber, Jacqueline; Stiegeler, Emanuel; Dreier, Birgit; Pugach, Pavel; Robbiani, Melissa; Riedel, Tina; Moehle, Kerstin; Robinson, John A; Rusert, Peter; Plückthun, Andreas; Trkola, Alexandra (2013). Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors. Journal of Virology, 87(10):5868-5881.

Friedrich, Katrin; Hanauer, Jan R H; Prüfer, Steffen; Münch, Robert C; Völker, Iris; Filippis, Christodoulos; Jost, Christian; Hanschmann, Kay-Martin; Cattaneo, Roberto; Peng, Kah-Whye; Plückthun, Andreas; Buchholz, Christian J; Cichutek, Klaus; Mühlebach, Michael D (2013). DARPin-targeting of measles virus: unique bispecificity, effective oncolysis, and enhanced safety. Molecular Therapy, 21(4):849-859.

Dreier, Birgit; Honegger, Annemarie; Hess, Christian; Nagy-Davidescu, Gabriela; Mittl, Peer R E; Grütter, Markus G; Belousova, Natalya; Mikheeva, Galina; Krasnykh, Victor; Plückthun, Andreas (2013). Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters. Proceedings of the National Academy of Sciences of the United States of America, 110(10):E869-E877.

Scott, Daniel J; Plückthun, Andreas (2013). Direct molecular evolution of detergent-stable G protein-coupled receptors using polymer encapsulated cells. Journal of Molecular Biology, 425(3):662-677.

Schlinkmann, Karola M; Plückthun, Andreas (2013). Directed evolution of G-protein-coupled receptors for high functional expression and detergent stability. In: Conn, P Michael. G Protein Coupled Receptors Structure. Amsterdam: Elsevier, 67-97.

Simon, Manuel; Stefan, Nikolas; Plückthun, Andreas; Zangemeister-Wittke, Uwe (2013). Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy. Expert Opinion on Drug Delivery, 10(4):451-468.

Kummer, Lutz; Hsu, Chia-Wen; Dagliyan, Onur; Macnevin, Christopher; Kaufholz, Melanie; Zimmermann, Bastian; Dokholyan, Nikolay V; Hahn, Klaus M; Plückthun, Andreas (2013). Knowledge-based design of a biosensor to quantify localized ERK activation in living cells. Chemistry & Biology, 20(6):847-856.

Simon, Manuel; Frey, Raphael; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2013). Orthogonal assembly of a designed ankyrin repeat protein-cytotoxin conjugate with a clickable serum albumin module for half-life extension. Bioconjugate Chemistry, 24(11):1955-1966.

Gu, Gucci Jijuan; Friedman, Mikaela; Jost, Christian; Johnsson, Kai; Kamali-Moghaddam, Masood; Plückthun, Andreas; Landegren, Ulf; Söderberg, Ola (2013). Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation. New biotechnology, 30(2):144-152.

Scott, Daniel J; Kummer, Lutz; Tremmel, Dirk; Plückthun, Andreas (2013). Stabilizing membrane proteins through protein engineering. Current Opinion in Chemical Biology, 17(3):427-435.

Jost, Christian; Schilling, Johannes; Tamaskovic, Rastislav; Schwill, Martin; Honegger, Annemarie; Plückthun, Andreas (2013). Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2. Structure, 21(11):1979-1991.

Epa, V Chandana; Dolezal, Olan; Doughty, Larissa; Xiao, Xiaowen; Jost, Christian; Plückthun, Andreas; Adams, Timothy E (2013). Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2. PLoS ONE, 8(3):e59163.

Gigant, Benoît; Wang, Weiyi; Dreier, Birgit; Jiang, Qiyang; Pecqueur, Ludovic; Plückthun, Andreas; Wang, Chunguang; Knossow, Marcel (2013). Structure of a kinesin-tubulin complex and implications for kinesin motility. Nature Structural & Molecular Biology, 20(8):1001-1007.

Frei, Andreas P; Jeon, Ock-Youm; Kilcher, Samuel; Moest, Hansjoerg; Henning, Lisa M; Jost, Christian; Plückthun, Andreas; Mercer, Jason; Aebersold, Ruedi; Carreira, Erick M; Wollscheid, Bernd (2012). Direct identification of ligand-receptor interactions on living cells and tissues. Nature biotechnology, 30(10):997-1001.

Tamaskovic, Rastislav; Simon, Manuel; Stefan, Nikolas; Schwill, Martin; Plückthun, Andreas (2012). Designed Ankyrin Repeat Proteins (DARPins). Methods in Enzymology, 503:101-134.

Parizek, Petra; Kummer, Lutz; Rube, Peter; Prinz, Anke; Herberg, Friedrich W; Plückthun, Andreas (2012). Designed Ankyrin Repeat Proteins (DARPins) as Novel Isoform-Specific Intracellular Inhibitors of c-Jun N-Terminal Kinases. ACS Chemical Biology, 7(8):1356-1366.

Varadamsetty, Gautham; Tremmel, Dirk; Hansen, Simon; Parmeggiani, Fabio; Plückthun, Andreas (2012). Designed armadillo repeat proteins: library generation, characterization and selection of Peptide binders with high specificity. Journal of Molecular Biology, 424(1-2):68-87.

Schaefer, Jonas V; Plückthun, Andreas (2012). Engineering aggregation resistance in IgG by two independent mechanisms: lessons from comparison of Pichia pastoris and mammalian cell expression. Journal of Molecular Biology, 417(4):309-335.

Simon, Manuel; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2012). Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chemistry, 23(2):279-286.

Schlinkmann, Karola M; Hillenbrand, Matthias; Rittner, Alexander; Künz, Madeleine; Strohner, Ralf; Plückthun, Andreas (2012). Maximizing Detergent Stability and Functional Expression of a GPCR by Exhaustive Recombination and Evolution. Journal of Molecular Biology, 422(3):414-428.

Dreier, Birgit; Plückthun, Andreas (2012). Rapid selection of high-affinity binders using ribosome display. Methods in Molecular Biology, 805:261-286.

Plückthun, Andreas (2012). Ribosome Display: A Perspective. Methods in Molecular Biology, 805:3-28.

Madhurantakam, Chaithanya; Varadamsetty, Gautham; Grütter, Markus G; Plückthun, Andreas; Mittl, Peer R E (2012). Structure-based optimization of designed Armadillo-repeat proteins. Protein Science, 21(7):1015-1028.

This list was generated on Sun Jul 23 23:16:15 2017 CEST.