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Deuel, J W; Schaer, C A; Boretti, F S; Opitz, L; Garcia-Rubio, I; Baek, J H; Spahn, D R; Buehler, P W; Schaer, D J (2016). Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response. Cell Death and Disease, 7:e2064.

Vallelian, F; Deuel, J W; Opitz, L; Schaer, C A; Puglia, M; Lönn, M; Engelsberger, W; Schauer, S; Karnaukhova, E; Spahn, D R; Stocker, R; Buehler, P W; Schaer, D J (2015). Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress. Cell Death and Differentiation, 22(4):597-611.

Boretti, F S; Baek, J H; Palmer, A F; Schaer, D J; Buehler, P W (2014). Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications. Frontiers in Physiology:5:385.

Schaer, C A; Deuel, J W; Bittermann, A G; Rubio, I G; Schoedon, G; Spahn, D R; Wepf, R A; Vallelian, F; Schaer, D J (2013). Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage. Cell Death and Differentiation, 20(11):1569-1579.

Schaer, D J; Buehler, P W; Alayash, A I; Belcher, J D; Vercellotti, G M (2013). Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood, 121(8):1276-1284.

Recher, M; Malipiero, U; Schaer, D J; Koedel, U; Pfister, H W; Birchler, T; Petrausch, U; Claus, H; Gast, H; Fontana, A (2013). Inhibition of meningitis-associated neutrophil apoptosis by TNF- depends on functional PI3-kinase in monocytes. Journal of Leukocyte Biology, 93(2):259-266.

Baek, J H; Zhou, Y; Harris, D R; Schaer, D J; Palmer, A F; Buehler, P W (2012). Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model. Toxicological Sciences, 127(2):567-581.

Kaempfer, T; Duerst, E; Gehrig, P; Roschitzki, B; Rutishauser, D; Grossmann, J; Schoedon, G; Vallelian, F; Schaer, D J (2011). Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression. Journal of Proteome Research, 10(5):2397-2408.

Schaer, D J; Alayash, A I (2010). Clearance and control mechanisms of hemoglobin from cradle to grave. Antioxidants and Redox Signaling, 12(2):181-184.

Vallelian, F; Schaer, C A; Kaempfer, T; Gehrig, P; Duerst, E; Schoedon, G; Schaer, D J (2010). Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity. Blood, 116(24):5347-5356.

Widmer, C C; Pereira, C P; Gehrig, P; Vallelian, F; Schoedon, G; Buehler, P W; Schaer, D J (2010). Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase. Antioxidants and Redox Signaling, 12(2):185-198.

Buehler, P W; D'Agnillo, F; Schaer, D J (2010). Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design. Trends in Molecular Medicine, 16(10):447-457.

Cusini, A; Günthard, H F; Stussi, G; Schwarz, U; Fehr, T; Grueter, E; Meerbach, A; Bossart, W; Schaer, D J; Rudiger, A (2010). Hemophagocytic syndrome caused by primary herpes simplex virus 1 infection: report of a first case. Infection, 38(5):423-426.

Pimenova, T; Pereira, C P; Gehrig, P; Buehler, P W; Schaer, D J; Zenobi, R (2010). Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin. Journal of Proteome Research, 9(8):4061-4070.

Pereira, C P; Bachli, E B; Schaer, D J; Schoedon, G (2010). Transcriptome analysis revealed unique genes as targets for the anti-inflammatory action of activated protein C in human macrophages. PLoS ONE, 5(10):e15352.

Biedermann, L; Schaer, D J; Montani, M; Speich, R; Müllhaupt, B (2009). Extensive chronic xanthogranulomatous intra-abdominal inflammation due to Mycoplasma hominis mimicking a malignancy: a case report. Journal of Medical Case Reports, 3:9211.

Buehler, P W; Abraham, B; Vallelian, F; Linnemayr, C; Pereira, C P; Cipollo, J F; Jia, Y; Mikolajczyk, M; Boretti, F S; Schoedon, G; Alayash, A I; Schaer, D J (2009). Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood, 113(11):2578-2586.

Pimenova, T; Pereira, C P; Schaer, D J; Zenobi, R (2009). Characterization of high molecular weight multimeric states of human haptoglobin and hemoglobin-based oxygen carriers by high-mass MALDI MS. Journal of Separation Science, 32(8):1224-1230.

Boretti, F S; Buehler, P W; D'Agnillo, F; Kluge, K; Glaus, T M; Butt, O I; Jia, Y; Goede, J; Pereira, C P; Maggiorini, M; Schoedon, G; Alayash, A I; Schaer, D J (2009). Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. Journal of Clinical Investigation, 119(8):2271-2280.

Vallelian, F; Pimenova, T; Pereira, C P; Abraham, B; Mikolajczyk, M G; Schoedon, G; Zenobi, R; Schaer, D J (2008). The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways. Free Radical Biology and Medicine, 45(8):1150-1158.

Schaer, C A; Vallelian, F; Imhof, A; Schoedon, G; Schaer, D J (2008). Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation. Journal of Leukocyte Biology, 83(2):325-333.

Gianella, S; Schaer, D J; Schwarz, U; Kurrer, M; Heppner, F L; Fehr, J; Seebach, J D (2008). Retinal microangiopathy and rapidly fatal cerebral edema in a patient with adult-onset Still's disease and concurrent macrophage activation syndrome. American Journal of Hematology, 83(5):424-427.

Buehler, P W; Vallelian, F; Mikolajczyk, M G; Schoedon, G; Schweizer, T; Alayash, A I; Schaer, D J (2008). Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways. Antioxidants and Redox Signaling, 10(8):1449-1462.

Pereira, C; Schaer, D J; Bachli, E B; Kurrer, M O; Schoedon, G (2008). Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(3):504-510.

This list was generated on Tue Jul 25 05:12:38 2017 CEST.