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DNA Polymerases Discovery,Characterizations and Functions in Cellular DNA Transactions. Edited by: Hübscher, U; Spadari, S; Villani, G; Maga, G (2010). Singapure, Singapure: World Scientific Publishing Co. PTE. Ltd..

Crespan, M; Cancio, E; Spadari, S; Hübscher, U; Maga, G (2008). Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the “primer grip” region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. Biochemical Pharmacology, 76(2):156-168.

Maga, G; Amacker, M; Hübscher, U; Gosselin, G; Imbach, J L; Mathé, C; Faraj, A; Sommadossi, J P; Spadari, S (2006). Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy. Nucleosides, Nucleotides and Nucleic Acids, 18(4-5):795-805.

Maga, G; Shevelev, I V; Villani, G; Spadari, S; Hübscher, U (2006). Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. Nucleic Acids Research, 34(5):1405-1415.

Cancio, R; Silvestri, R; Ragno, R; Artico, M; De Martino, G; La Regina, G; Crespan, E; Zanoli, S; Hübscher, U; Spadari, S; Maga, G (2005). High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme. Antimicrobial Agents and Chemotherapy, 49(11):4546-4554.

Locatelli, G A; Di Santo, R; Crespan, E; Costi, R; Roux, A; Hübscher, U; Shevelev, I V; Blanca, G; Villani, G; Spadari, S; Maga, G (2005). Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. Molecular Pharmacology, 68(2):538-550.

Crespan, E; Zanoli, S; Khandazhinskaya, A; Shevelev, I V; Jasko, M; Alexandrova, L; Kukhanova, M; Blanca, G; Villani, G; Hübscher, U; Spadari, S; Maga, G (2005). Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. Nucleic Acids Research, 33(13):4117-4127.

Locatelli, G A; Savio, M; Forti, L; Shevelev, I V; Ramadan, K; Stivala, L A; Vannini, V; Hübscher, U; Spadari, S; Maga, G (2005). Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. Biochemical Journal, 389(2):259-268.

Maga, G; Ramadan, K; Locatelli, G A; Shevelev, I V; Spadari, S; Hübscher, U (2005). DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. Journal of Biological Chemistry, 280(3):1971-1981.

Crespan, E; Locatelli, G A; Cancio, R; Hübscher, U; Spadari, S; Maga, G (2005). Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz. Antimicrobial Agents and Chemotherapy, 49(1):342-349.

Maga, G; Blanca, G; Shevelev, I V; Frouin, I; Ramadan, K; Spadari, S; Villani, G; Hübscher, U (2004). The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. FASEB Journal, 18(14):1743-1745.

Blanca, G; Villani, G; Shevelev, I V; Ramadan, K; Spadari, S; Hübscher, U; Maga, G (2004). Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Biochemistry, 43(36):11605-11615.

Locatelli, G A; Campiani, Giuseppe; Cancio, R; Morelli, E; Ramunno, A; Gemma, S; Hübscher, U; Spadari, S; Maga, G (2004). Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. Antimicrobial Agents and Chemotherapy, 48(5):1570-1580.

Shevelev, I V; Blanca, G; Villani, G; Ramadan, K; Spadari, S; Hübscher, U; Maga, G (2003). Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Nucleic Acids Research, 31(23):6916-6925.

Baldanti, F; Paolucci, S; Maga, G; Labo, N; Hübscher, U; Skoblov, A Y; Victorova, L; Spadari, S; Minoli, L; Gerna, G (2003). Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine. AIDS, 17(10):1568-1570.

Blanca, G; Shevelev, I V; Ramadan, K; Villani, G; Spadari, S; Hübscher, U; Maga, G (2003). Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. Biochemistry, 42(24):7467-7476.

Blanca, G; Baldanti, F; Paolucci, S; Skoblov, A Y; Victorova, L; Hübscher, U; Gerna, G; Spadari, S; Maga, G (2003). Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. Journal of Biological Chemistry, 278(18):15469-15472.

Maga, G; Villani, G; Ramadan, K; Shevelev, I V; Tanguy Le Gac, N; Blanco, L; Blanca, G; Spadari, S; Hübscher, U (2002). Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. Journal of Biological Chemistry, 277(50):48434-48440.

Maga, G; Shevelev, I V; Ramadan, K; Spadari, S; Hübscher, U (2002). DNA polymerase theta purified from human cells is a high-fidelity enzyme. Journal of Molecular Biology, 319(2):359-369.

Frouin, I; Montecucco, A; Biamonti, G; Hübscher, U; Spadari, S; Maga, G (2002). Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. The EMBO Journal, 21(10):2485-2495.

Hubscher, U; Maga, G; Spadari, S (2002). Eukaryotic DNA polymerases. Annual Review of Biochemistry, 71:133-163.

Maga, G; Villani, G; Tillement, V; Stucki, M; Locatelli, G A; Frouin, I; Spadari, S; Hübscher, U (2001). Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 98(25):14298-14303.

Maga, G; Ramunno, A; Nacci, V; Locatelli, G A; Spadari, S; Fiorini, I; Baldanti, F; Paolucci, S; Zavattoni, M; Bergamini, A; Galletti, B; Muck, S; Hubscher, U; Giorgi, G; Guiso, G; Caccia, S; Campiani, G (2001). The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors. Journal of Biological Chemistry, 276(48):44653-44662.

Maga, G; Frouin, I; Spadari, S; Hubscher, U (2001). Replication protein A as a "fidelity clamp" for DNA polymerase alpha. Journal of Biological Chemistry, 276(21):18235-18242.

Maga, G; Hübscher, U; Pregnolato, M; Ubiali, D; Gosselin, G; Spadari, S (2001). Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs. Antimicrobial Agents and Chemotherapy, 45(4):1192-1200.

Maga, G; Stucki, M; Spadari, S; Hübscher, U (2000). DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Journal of Molecular Biology, 295(4):801.

Maga, G; Amacker, M; Hübscher, U; Gosselin, G; Imbach, J L; Mathé, C; Faraj, A; Sommadossi, J P; Spadari, S (1999). Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs. Nucleic Acids Research, 27(4):972-978.

Maga, G; Jónsson, Z O; Stucki, M; Spadari, S; Hübscher, U (1999). Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. Journal of Molecular Biology, 285(1):259-267.

Maga, G; Amacker, M; Ruel, N; Hübscher, U; Spadari, S (1997). Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions. Journal of Molecular Biology, 274(5):738-747.

This list was generated on Wed Jul 26 14:18:24 2017 CEST.