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Publications for Aguzzi, A

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Number of items: 417.

2017

Seredenina, T; Sorce, S; Herrmann, F R; Ma Mulone, X-J; Plastre, O; Aguzzi, A; Jaquet, V; Krause, K-H (2017). Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse. Translational Psychiatry, 7(8):e1206.

Sorce, Silvia; Stocker, Roland; Seredenina, Tamara; Holmdahl, Rikard; Aguzzi, Adriano; Chio, Adriano; Depaulis, Antoine; Heitz, Freddy; Olofsson, Peter; Olsson, Tomas; Duveau, Venceslas; Sanoudou, Despina; Skosgater, Sara; Vlahou, Antonia; Wasquel, Dominique; Krause, Karl-Heinz; Jaquet, Vincent (2017). NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: what is the evidence? Free Radical Biology & Medicine, 112:387-396.

Nuvolone, Mario; Paolucci, Marta; Sorce, Silvia; Kana, Veronika; Moos, Rita; Matozaki, Takashi; Aguzzi, Adriano (2017). Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling. PLoS ONE, 12(5):e0177876.

Wulf, Marie-Angela; Senatore, Assunta; Aguzzi, Adriano (2017). The biological function of the cellular prion protein: an update. BMC Biology, 15:34.

Nuvolone, Mario; Sorce, Silvia; Paolucci, Marta; Aguzzi, Adriano (2017). Extended characterization of the novel co-isogenic C57BL/6J Prnp$^{−/−}$ mouse line. Amyloid, 24(Suppl 1):36-37.

Ballmer, Boris A; Moos, Rita; Liberali, Prisca; Pelkmans, Lucas; Hornemann, Simone; Aguzzi, Adriano (2017). Modifiers of prion protein biogenesis and recycling identified by a highly-parallel endocytosis kinetics assay. Journal of Biological Chemistry, 292(20):8356-8368.

Nuvolone, Mario; Sorce, Silvia; Pelczar, Pawel; Rushing, Elisabeth; Lavatelli, Francesca; Rognoni, Paola; Valentini, Veronica; Palladini, Giovanni; Merlini, Giampaolo; Aguzzi, Adriano (2017). Regulated expression of amyloidogenic immunoglobulin light chains in mice. Amyloid, 24(Suppl 1):52-53.

Leske, Henning; Hornemann, Simone; Herrmann, Uli Simon; Zhu, Caihong; Dametto, Paolo; Li, Bei; Laferriere, Florent; Polymenidou, Magdalini; Pelczar, Pawel; Reimann, Regina Rose; Schwarz, Petra; Rushing, Elisabeth Jane; Wüthrich, Kurt; Aguzzi, Adriano (2017). Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein. PLoS ONE, 12(2):e0170503.

Nuvolone, Mario; Schmid, Nicolas; Miele, Gino; Sorce, Silvia; Moos, Rita; Schori, Christian; Beerli, Roger R; Bauer, Monika; Saudan, Philippe; Dietmeier, Klaus; Lachmann, Ingolf; Linnebank, Michael; Martin, Roland; Kallweit, Ulf; Kana, Veronika; Rushing, Elisabeth J; Budka, Herbert; Aguzzi, Adriano (2017). Cystatin F is a biomarker of prion pathogenesis in mice. PLoS ONE, 12(2):e0171923.

Kiessling, Michael K; Curioni-Fontecedro, Alessandra; Samaras, Panagiotis; Lang, Silvia; Scharl, Michael; Aguzzi, Adriano; Oldridge, Derek A; Maris, John M; Rogler, Gerhard (2017). Correction: Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma. PLoS ONE, 12(1):e0170851.

Bethge, Philipp; Carta, Stefano; Lorenzo, Dayra A; Egolf, Ladan; Goniotaki, Despoina; Madisen, Linda; Voigt, Fabian F; Chen, Jerry L; Schneider, Bernard; Ohkura, Masamichi; Nakai, Junichi; Zeng, Hongkui; Aguzzi, Adriano; Helmchen, Fritjof (2017). An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator. PLoS ONE, 12(6):e0179460.

Aguzzi, Adriano; Zhu, Caihong (2017). Microglia in prion diseases. Journal of Clinical Investigation:JCI90605.

2016

Frontzek, Karl; Pfammatter, Manuela; Sorce, Silvia; Senatore, Assunta; Schwarz, Petra; Moos, Rita; Frauenknecht, Katrin; Hornemann, Simone; Aguzzi, Adriano (2016). Neurotoxic antibodies against the prion protein do not trigger prion replication. PLoS ONE, 11(9):e0163601.

Sherman, M A; LaCroix, M; Amar, F; Larson, M E; Forster, C; Aguzzi, A; Bennett, D A; Ramsden, M; Lesne, S E (2016). Soluble Conformers of A and Tau Alter Selective Proteins Governing Axonal Transport. Journal of Neuroscience, 36(37):9647-9658.

Küffer, Alexander; Lakkaraju, Asvin K. K; Mogha, Amit; Petersen, Sarah C; Airich, Kristina; Doucerain, Cédric; Marpakwar, Rajlakshmi; Bakirci, Pamela; Senatore, Assunta; Monnard, Arnaud; Schiavi, Carmen; Nuvolone, Mario; Grosshans, Bianka; Hornemann, Simone; Bassilana, Frederic; Monk, Kelly R; Aguzzi, Adriano (2016). The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature, 536(7617):464-468.

Requena, Jesús R; Kristensson, Krister; Korth, Carsten; Zurzolo, Chiara; Simmons, Marion; Aguilar-Calvo, Patricia; Aguzzi, Adriano; Andreoletti, Olivier; Benestad, Sylvie L; Böhm, Reinhard; Brown, Karen; Calgua, Byron; del Río, José Antonio; Espinosa, Juan Carlos; Girones, Rosina; Godsave, Sue; Hoelzle, Ludwig E; Knittler, Michael R; Kuhn, Franziska; Legname, Giuseppe; Laeven, Paul; Mabbott, Neil; Mitrova, Eva; Müller-Schiffmann, Andreas; Nuvolone, Mario; Peters, Peter J; Raeber, Alex; Roth, Klaus; Schmitz, Matthias; Schroeder, Björn; Sonati, Tiziana; Stitz, Lothar; Taraboulos, Albert; Torres, Juan María; Yan, Zheng-Xin; Zerr, Inga (2016). The Priority position paper: protecting Europe´s food chain from prions. Prion, 10(3):165-181.

Zhu, Caihong; Herrmann, Uli S; Falsig, Jeppe; Abakumova, Irina; Nuvolone, Mario; Schwarz, Petra; Frauenknecht, Katrin; Rushing, Elisabeth J; Aguzzi, Adriano (2016). A neuroprotective role for microglia in prion diseases. Journal of Experimental Medicine, 213(6):1047-1059.

Aguzzi, Adriano; Altmeyer, Matthias (2016). Phase separation: linking cellular compartmentalization to disease. Trends in Cell Biology, 26(7):547-558.

Theocharides, Alexandre P; Lundberg, Pontus; Lakkaraju, Asvin K K; Lysenko, Veronika; Myburgh, Renier; Aguzzi, Adriano; Skoda, Radek C; Manz, Markus G (2016). Homozygous Calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency. Blood, 127(25):3253-3259.

Haybaeck, Johannes; Heikenwalder, Mathias; Klevenz, Britta; Schwarz, Petra; Margalith, Ilan; Bridel, Claire; Mertz, Kirsten; Zirdum, Elizabeta; Petsch, Benjamin; Fuchs, Thomas J; Stitz, Lothar; Aguzzi, Adriano (2016). Correction: Aerosols transmit prions to immunocompetent and immunodeficient mice. PLoS Pathogens, 12(2):e1005463.

Frontzek, Karl; Lutz, Mirjam I; Aguzzi, Adriano; Kovacs, Gabor G; Budka, Herbert (2016). Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting. Swiss Medical Weekly, 146:w14287.

Aguzzi, Adriano; Lakkaraju, Asvin K K (2016). Cell biology of prions and prionoids: a status report. Trends in Cell Biology, 26(1):40-51.

Reimann, Regina R; Sonati, Tiziana; Hornemann, Simone; Herrmann, Uli S; Arand, Michael; Hawke, Simon; Aguzzi, Adriano (2016). Differential toxicity of antibodies to the prion protein. PLoS Pathogens, 12(1):e1005401.

Seredenina, Tamara; Nayernia, Zeynab; Sorce, Silvia; Maghzal, Ghassan J; Filippova, Aleksandra; Ling, Shuo-Chien; Basset, Olivier; Plastre, Olivier; Daali, Youssef; Rushing, Elisabeth J; Giordana, Maria T; Cleveland, Don W; Aguzzi, Adriano; Stocker, Roland; Krause, Karl-Heinz; Jaquet, Vincent (2016). Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radical Biology & Medicine, 97:95-108.

Nuvolone, Mario; Hermann, Mario; Sorce, Silvia; Russo, Giancarlo; Tiberi, Cinzia; Schwarz, Petra; Minikel, Eric; Sanoudou, Despina; Pelczar, Pawel; Aguzzi, Adriano (2016). Strictly co-isogenic C57BL/6J-Prnp−/−mice: A rigorous resource for prion science. Journal of Experimental Medicine, 213(3):313-327.

Kiessling, Michael K; Curioni-Fontecedro, Alessandra; Samaras, Panagiotis; Lang, Silvia; Scharl, Michael; Aguzzi, Adriano; Oldrige, Derek A; Maris, John M; Rogler, Gerhard (2016). Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma. PLoS ONE, 11(1):e0147682.

2015

Frontzek, Karl; Moos, Rita; Schaper, Elke; Jann, Lukas; Herfs, Gregor; Zimmermann, Dieter R; Aguzzi, Adriano; Budka, Herbert (2015). Iatrogenic and sporadic Creutzfeldt-Jakob disease in 2 sisters without mutation in the prion protein gene. Prion, 9(6):444-448.

Nuvolone, Mario; Aguzzi, Adriano (2015). Altered monoaminergic systems and depressive-like behavior in congenic prion protein nnock-out mice. Journal of Biological Chemistry, 290(43):26350.

Hruska-Plochan, Marian; Li, Bei; Kyburz, Diego; Krützfeldt, Jan; Landmesser, Ulf; Aguzzi, Adriano; Polymenidou, Magdalini (2015). New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases. Swiss Medical Weekly:w14192.

Schreiner, Bettina; Romanelli, Elisa; Liberski, Pawel; Ingold-Heppner, Barbara; Sobottka-Brillout, Bettina; Hartwig, Tom; Chandrasekar, Vijay; Johannssen, Helge; Zeilhofer, Hanns Ulrich; Aguzzi, Adriano; Heppner, Frank; Kerschensteiner, Martin; Becher, Burkhard (2015). Astrocyte depletion impairs redox homeostasis and triggers neuronal loss in the adult CNS. Cell Reports, 12(9):1377-1384.

Baral, Pravas Kumar; Swayampakula, Mridula; Aguzzi, Adriano; James, Michael N G (2015). X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. Journal of Structural Biology, 192(1):37-47.

Herrmann, Uli S; Schütz, Anne K; Shirani, Hamid; Huang, Danzhi; Saban, Dino; Nuvolone, Mario; Li, Bei; Ballmer, Boris; Aslund, Andreas; Mason, Jeffrey J; Rushing, Elisabeth J; Budka, Herbert; Nystrom, Sofie; Hammarstrom, Per; Böckmann, Anja; Caflisch, Amedeo; Meier, Beat H; Nilsson, K Peter R; Hornemann, Simone; Aguzzi, Adriano (2015). Structure-based drug design identifies polythiophenes as antiprion compounds. Science Translational Medicine, 7(299):299ra123.

Cudalbu, Cristina; Craveiro, Melanie; Mlynárik, Vladimir; Bremer, Juliane; Aguzzi, Adriano; Gruetter, Rolf (2015). In Vivo Longitudinal 1H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T. Neurochemical Research, 40(12):2639-2646.

Aguzzi, Adriano (2015). Authoring scientific papers: a perspective from the trenches. Swiss Medical Weekly, 145(w14107):online.

Aguzzi, Adriano (2015). Scientific publishing in the times of open access. Swiss Medical Weekly, 145(w14118):online.

Dametto, Paolo; Lakkaraju, Asvin K K; Bridel, Claire; Villiger, Lukas; O’Connor, Tracy; Herrmann, Uli S; Pelczar, Pawel; Rülicke, Thomas; McHugh, Donal; Adili, Arlind; Aguzzi, Adriano (2015). Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP. PLoS ONE, 10(2):e0117412.

Martínez, Javier; Sánchez, Rosa; Castellanos, Milagros; Makarava, Natallia; Aguzzi, Adriano; Baskakov, Ilia V; Gasset, María (2015). PrP charge structure encodes interdomain interactions. Scientific Reports, 5:13623.

Herrmann, Uli S; Sonati, Tiziana; Falsig, Jeppe; Reimann, Regina R; Dametto, Paolo; O’Connor, Tracy; Li, Bei; Lau, Agnes; Hornemann, Simone; Sorce, Silvia; Wagner, Uli; Sanoudou, Despina; Aguzzi, Adriano (2015). Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathogens, 11(2):e1004662.

Nuvolone, Mario; Sorce, Silvia; Schwarz, Petra; Aguzzi, Adriano (2015). Prion pathogenesis in the absence of NLRP3/ASC inflammasomes. PLoS ONE, 10(2):e0117208.

Zhu, Caihong; Herrmann, Uli S; Li, Bei; Abakumova, Irina; Moos, Rita; Schwarz, Petra; Rushing, Elisabeth J; Colonna, Marco; Aguzzi, Adriano (2015). Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of Aging, 36(5):1994-2003.

Zhu, Caihong; Schwarz, Petra; Abakumova, Irina; Aguzzi, Adriano (2015). Unaltered prion pathogenesis in a mouse model of high-fat diet-induced insulin resistance. PLoS ONE, 10(12):e0144983.

2014

Aguzzi, Adriano (2014). Neurodegeneration: Alzheimer's disease under strain. Nature, 512(7512):32-34.

Franklin, Bernardo S; Bossaller, Lukas; De Nardo, Dominic; Ratter, Jacqueline M; Stutz, Andrea; Engels, Gudrun; Brenker, Christoph; Nordhoff, Mark; Mirandola, Sandra R; Al-Amoudi, Ashraf; Mangan, Matthew S; Zimmer, Sebastian; Monks, Brian G; Fricke, Martin; Schmidt, Reinhold E; Espevik, Terje; Jones, Bernadette; Jarnicki, Andrew G; Hansbro, Philip M; Busto, Patricia; Marshak-Rothstein, Ann; Hornemann, Simone; Aguzzi, Adriano; Kastenmüller, Wolfgang; Latz, Eicke (2014). The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nature Immunology, 15(8):727-737.

Aguzzi, Adriano; Kranich, Jan; Krautler, Nike Julia (2014). Follicular dendritic cells: origin, phenotype, and function in health and disease. Trends in Immunology, 35(3):105-113.

Kurt, Timothy D; Bett, Cyrus; Fernández-Borges, Natalia; Joshi-Barr, Shivanjali; Hornemann, Simone; Rülicke, Thomas; Castilla, Joaquín; Wüthrich, Kurt; Aguzzi, Adriano; Sigurdson, Christina J (2014). Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC. Journal of Neuroscience, 34(3):1022-1027.

Ganzinger, Kristina A; Narayan, Priyanka; Qamar, Seema S; Weimann, Laura; Ranasinghe, Rohan T; Aguzzi, Adriano; Dobson, Christopher M; McColl, James; et al (2014). Single-molecule imaging reveals that small Amyloid-β1-42Oligomers interact with the Cellular Prion Protein (PrPC). Chembiochem, 15(17):2515-2521.

Baral, Pravas Kumar; Swayampakula, Mridula; Rout, Manoj Kumar; Kav, Nat N V; Spyracopoulos, Leo; Aguzzi, Adriano; James, Michael N G (2014). Structural basis of prion inhibition by phenothiazine compounds. Structure, 22(2):291-303.

Rauch, P J; Müllhaupt, B; Biedermann, L; Manz, M G; Ruschitzka, F; Flammer, A; Segerer, S T; Mohebbi, N; Jung, H H; Moch, H; Ikenberg, K; Aguzzi, A; Nuvolone, M; Distler, O; Rauch, A; Fehr, T H; Gerber, B (2014). Systemische Amyloidosen. Swiss Medical Forum, 14(50):943-948.

Sorce, Silvia; Nuvolone, Mario; Keller, Annika; Falsig, Jeppe; Varol, Ahmet; Schwarz, Petra; Bieri, Monika; Budka, Herbert; Aguzzi, Adriano (2014). The role of the NADPH oxidase NOX2 in prion pathogenesis. PLoS Pathogens, 10(12):e1004531.

2013

Tag, Brigitte; Aguzzi, Adriano; Papassotiropoulos, Andreas; Fuchs, Marita; Werner, David. "Wir erleben gerade eine Revolution" (Interview). In: Journal. Die Zeitung der Universität Zürich, 1 February 2013, p.8-9.

Aguzzi, Adriano; Gitler, Aaron D (2013). A template for new drugs against Alzheimer's Disease. Cell, 154(6):1182-1184.

Krasemann, Susanne; Mearini, Giulia; Krämer, Elisabeth; Wagenführ, Katja; Schulz-Schaeffer, Walter; Neumann, Melanie; Bodemer, Walter; Kaup, Franz-Josef; Beekes, Michael; Carrier, Lucie; Aguzzi, Adriano; Glatzel, Markus (2013). BSE-associated prion-amyloid cardiomyopathy in primates. Emerging Infectious Diseases, 19(6):985-988.

Sponarova, Jana; Nuvolone, Mario; Whicher, Charlotte; Frei, Nathalie; Kana, Veronika; Schwarz, Petra; Westermark, Gunilla T; Aguzzi, Adriano (2013). Efficient amyloid a clearance in the absence of immunoglobulins and complement factors. American Journal of Pathology, 182(4):1297-1307.

Aguzzi, Adriano; Barres, Ben A; Bennett, Mariko L (2013). Microglia: scapegoat, saboteur, or something else? Science, 339(6116):156-161.

Keller, Annika; Westenberger, Ana; Sobrido, Maria J; García-Murias, Maria; Domingo, Aloysius; Sears, Renee L; Lemos, Roberta R; Ordoñez-Ugalde, Andres; Nicolas, Gael; da Cunha, José E Gomes; Rushing, Elisabeth J; Hugelshofer, Michael; Wurnig, Moritz C; Kaech, Andres; Reimann, Regina; Lohmann, Katja; Dobričić, Valerija; Carracedo, Angel; Petrović, Igor; Miyasaki, Janis M; Abakumova, Irina; Mäe, Maarja Andaloussi; Raschperger, Elisabeth; Zatz, Mayana; Zschiedrich, Katja; Klepper, Jörg; Spiteri, Elizabeth; Prieto, Jose M; Navas, Inmaculada; Preuss, Michael; Dering, Carmen; Janković, Milena; Paucar, Martin; Svenningsson, Per; Saliminejad, Kioomars; Khorshid, Hamid R K; Novaković, Ivana; Aguzzi, Adriano; Boss, Andreas; Le Ber, Isabelle; Defer, Gilles; Hannequin, Didier; Kostić, Vladimir S; Campion, Dominique; Geschwind, Daniel H; Coppola, Giovanni; Betsholtz, Christer; Klein, Christine; Oliveira, Joao R M (2013). Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nature Genetics, 45(9):1077-1082.

O'Connor, Tracy; Aguzzi, Adriano (2013). Prions and lymphoid organs: Solved and remaining mysteries. Prion, 7(2):157-163.

Nuvolone, Mario; Kana, Veronika; Hutter, Gregor; Sakata, Daiji; Mortin-Toth, Steven M; Russo, Giancarlo; Danska, Jayne S; Aguzzi, Adriano (2013). SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells. Journal of Experimental Medicine, 210(12):2539-2552.

Swayampakula, Mridula; Baral, Pravas Kumar; Aguzzi, Adriano; Kav, Nat N V; James, Michael N G (2013). The crystal structure of an octapeptide repeat of the Prion protein in complex with a fab fragment of the POM2 antibody. Protein Science, 22(7):893-903.

Aguzzi, Adriano; Nuvolone, Mario; Zhu, Caihong (2013). The immunobiology of prion diseases. Nature Reviews. Immunology, 13(12):888-902.

Sonati, Tiziana; Reimann, Regina R; Falsig, Jeppe; Baral, Pravas Kumar; O'Connor, Tracy; Hornemann, Simone; Yaganoglu, Sine; Li, Bei; Herrmann, Uli S; Wieland, Barbara; Swayampakula, Mridula; Rahman, Muhammad Hafizur; Das, Dipankar; Kav, Nat; Riek, Roland; Liberski, Pawel P; James, Michael N G; Aguzzi, Adriano (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465):102-106.

2012

Hermann, Mario; Maeder, Morgan L; Rector, Kyle; Ruiz, Joseph; Becher, Burkhard; Bürki, Kurt; Khayter, Cyd; Aguzzi, Adriano; Joung, J Keith; Buch, Thorsten; Pelczar, Pawel (2012). Evaluation of OPEN Zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos. PLoS ONE, 7(9):e41796.

Stoeck, Katharina; Sanchez-Juan, Pascual; Gawinecka, Joanna; Green, Alison; Ladogana, Anna; Pocchiari, Maurizio; Sanchez-Valle, Raquel; Mitrova, Eva; Sklaviadis, Theodor; Kulczycki, Jerzy; Slivarichova, Dana; Saiz, Albert; Calero, Miguel; Knight, Richard; Aguzzi, Adriano; Laplanche, Jean-Louis; Peoc'h, Katell; Schelzke, Gabi; Karch, Andre; van Duijn, Cornelia M; Zerr, Inga (2012). Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years. Brain: A Journal of Neurology, 135(Pt 10):3051-3061.

Wolf, Monika Julia; Hoos, Alexandra; Bauer, Judith; Boettcher, Steffen; Knust, Markus; Weber, Achim; Simonavicius, Nicole; Schneider, Christoph; Lang, Matthias; Stürzl, Michael; Croner, Roland S; Konrad, Andreas; Manz, Markus G; Moch, Holger; Aguzzi, Adriano; van Loo, Geert; Pasparakis, Manolis; Prinz, Marco; Borsig, Lubor; Heikenwalder, Mathias (2012). Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell, 22(1):91-105.

Aguzzi, Adriano; Zhu, Caihong (2012). Five questions on prion diseases. PLoS Pathogens, 8(5):e1002651.

Krautler, Nike Julia; Kana, Veronika; Kranich, Jan; Tian, Yinghua; Perera, Dushan; Lemm, Doreen; Schwarz, Petra; Armulik, Annika; Browning, Jeffrey L; Tallquist, Michelle; Buch, Thorsten; Oliveira-Martins, José B; Zhu, Caihong; Hermann, Mario; Wagner, Ulrich; Brink, Robert; Heikenwalder, Mathias; Aguzzi, Adriano (2012). Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell, 150(1):194-206.

Michel, Brady; Ferguson, Adam; Johnson, Theodore; Bender, Heather; Meyerett-Reid, Crystal; Pulford, Bruce; von Teichman, Adriana; Seelig, Davis; Weis, John H; Telling, Glenn C; Aguzzi, Adriano; Zabel, Mark D (2012). Genetic Depletion of Complement Receptors CD21/35 Prevents Terminal Prion Disease in a Mouse Model of Chronic Wasting Disease. Journal of Immunology, 189(9):4520-4527.

Seleznik, Gitta M; Reding, Theresia; Romrig, Franziska; Saito, Yasuyuki; Mildner, Alexander; Segerer, Stephan; Sun, Li-Kang; Regenass, Stephan; Lech, Maciej; Anders, Hans-Joachim; McHugh, Donal; Kumagi, Teru; Hiasa, Yoichi; Lackner, Carolin; Haybaeck, Johannes; Angst, Eliane; Perren, Aurel; Balmer, Maria Luisa; Slack, Emma; Macpherson, Andrew; Manz, Markus; Weber, Achim; Browning, Jeffrey L; Arkan, Melek Canan; Rülicke, Thomas; Aguzzi, Adriano; Prinz, Marco; Graf, Rolf; Heikenwalder, Mathias (2012). Lymphotoxin β receptor signaling promotes development of autoimmune pancreatitis. Gastroenterology, 143(5):1361-1374.

O'Connor, Tracy; Frei, Nathalie; Sponarova, Jana; Schwarz, Petra; Heikenwalder, Mathias; Aguzzi, Adriano (2012). Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes. PLoS Pathogens, 8(8):e1002867.

Varvel, Nicholas H; Grathwohl, Stefan A; Baumann, Frank; Liebig, Christian; Bosch, Andrea; Brawek, Bianca; Thal, Dietmar R; Charo, Israel F; Heppner, Frank L; Aguzzi, Adriano; Garaschuk, Olga; Ransohoff, Richard M; Jucker, Mathias (2012). Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells. Proceedings of the National Academy of Sciences of the United States of America, 109(44):18150-18155.

Nystrom, Sofie; Mishra, Rajesh; Hornemann, Simone; Aguzzi, Adriano; Nilsson, K Peter R; Hammarstrom, Per (2012). Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway. Journal of Biological Chemistry, 287(31):25975-25984.

Jung, H H; Bremer, J; Streffer, J; Virdee, K; Spillantini, M G; Crowther, R A; Brugger, P; van Broekhoven, C; Aguzzi, A; Tolnay, M (2012). Phenotypic variation of autosomal-dominant corticobasal degeneration. European Neurology, 67(3):142-150.

Margalith, Ilan; Suter, Carlo; Ballmer, Boris; Schwarz, Petra; Tiberi, Cinzia; Sonati, Tiziana; Falsig, Jeppe; Nystrom, Sofie; Hammarstrom, Per; Aslund, Andreas; Nilsson, K Peter R; Yam, Alice; Whitters, Eric; Hornemann, Simone; Aguzzi, Adriano (2012). Polythiophenes inhibit prion propagation by stabilizing PrP aggregates. Journal of Biological Chemistry, 287(23):18872-18887.

Falsig, Jeppe; Sonati, Tiziana; Herrmann, Uli S; Saban, Dino; Li, Bei; Arroyo, Karina; Ballmer, Boris; Liberski, Pawel P; Aguzzi, Adriano (2012). Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures. PLoS Pathogens, 8(11):e1002985.

Aguzzi, Adriano; Falsig, Jeppe (2012). Prion propagation, toxicity and degradation. Nature Neuroscience, 15(7):936-939.

Ashe, Karen H; Aguzzi, Adriano (2012). Prions, prionoids and pathogenic proteins in Alzheimer disease. Prion, 7(1):1-5.

Ehling, Rainer; Helbok, Raimund; Beer, Ronny; Lackner, Peter; Broessner, Gregor; Pfausler, Bettina; Röcken, Christoph; Aguzzi, Adriano; Chemelli, Andreas; Schmutzhard, Erich (2012). Recurrent intracerebral haemorrhage after coitus: a case report of sporadic cerebral amyloid angiopathy in a younger patient. European Journal of Neurology, 19(3):e29-e31.

Baral, Pravas Kumar; Wieland, Barbara; Swayampakula, Mridula; Polymenidou, Magdalini; Rahman, Muhammad Hafiz; Kav, Nat N V; Aguzzi, Adriano; James, Michael N G (2012). Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1. Acta crystallographica. Section D, Biological crystallography, 68(Pt 11):1501-1512.

Larson, Megan; Sherman, Mathew A; Amar, Fatou; Nuvolone, Mario; Schneider, Julie A; Bennett, David A; Aguzzi, Adriano; Lesné, Sylvain E (2012). The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(47):16857-16871.

McHugh, Donal; O'Connor, Tracy; Bremer, Juliane; Aguzzi, Adriano (2012). ZyFISH: A simple, rapid and reliable zygosity assay for transgenic mice. PLoS ONE, 7(5):e37881.

2011

Aguzzi, Adriano; Kana, Veronika (2011). Introduction to Prion Disorders. In: Dickson, Dennis; Weller, Roy O. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, 2nd Edition. United Kingdom: Wiley-Blackwell, 315-321.

Aguzzi, Adriano; Kana, Veronika (2011). Protein Aggregation in Neurodegeneration. In: Dickson, Dennis; Weller, Roy O. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, 2nd Edition. United Kingdom: Wiley-Blackwell, 13-17.

Haybaeck, J; Heikenwalder, M; Klevenz, B; Schwarz, P; Margalith, I; Bridel, C; Mertz, K D; Zirdum, E; Petsch, B; Fuchs, T J; Stitz, L; Aguzzi, A (2011). Aerosols transmit prions to immunocompetent and immunodeficient mice. PLoS Pathogens, 7(1):e1001257.

Stitz, L; Aguzzi, A (2011). Aerosols: An underestimated vehicle for transmission of prion diseases? Prion, 5(3):138-141.

Polymenidou, M; Prokop, S; Jung, H H; Hewer, E; Peretz, D; Moos, R; Tolnay, M; Aguzzi, A (2011). Atypical prion protein conformation in familial prion disease with PRNP P105T mutation. Brain Pathology, 21(2):209-214.

Baral, P K; Wieland, B; Swayampakula, M; Polymenidou, M; Aguzzi, A; Kav, N N V; James, M N G (2011). Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 67(Pt 10):1211-1213.

Hafner-Bratkovic, I; Bester, R; Pristovsek, P; Gaedtke, L; Veranic, P; Gaspersic, J; Mancek-Keber, M; Avbelj, M; Polymenidou, M; Julius, C; Aguzzi, A; Vorberg, I; Jerala, R (2011). Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion. Journal of Biological Chemistry, 286(14):12149-12156.

Patzig, J; Jahn, O; Tenzer, S; Wichert, S P; de Monasterio-Schrader, P; Rosfa, S; Kuharev, J; Yan, K; Bormuth, I; Bremer, J; Aguzzi, A; Orfaniotou, F; Hesse, D; Schwab, M H; Möbius, W; Nave, K A; Werner, H B (2011). Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci. Journal of Neuroscience, 31(45):16369-16386.

Ligios, C; Cancedda, M G; Carta, A; Santucciu, C; Maestrale, C; Demontis, F; Sabat, M; Patta, C; Demartini, J C; Aguzzi, A; Sigurdson, C J (2011). Sheep with scrapie and mastitis transmit infectious prions through the milk. Journal of Virology, 85(2):1136-1139.

Sigurdson, C J; Joshi-Barr, S; Bett, C; Winson, O; Manco, G; Schwarz, P; Rülicke, T; Nilsson, K P R; Margalith, I; Raeber, A; Peretz, D; Hornemann, S; Wüthrich, K; Aguzzi, A (2011). Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein. Journal of Neuroscience, 31(39):13840-13847.

Schütz, A K; Soragni, A; Hornemann, S; Aguzzi, A; Ernst, M; Böckmann, A; Meier, B H (2011). The amyloid-congo red interface at atomic resolution. Angewandte Chemie Internationale Edition, 56(26):5956-5960.

Ayers, J I; Schutt, C R; Shikiya, R A; Aguzzi, A; Kincaid, A E; Bartz, J C (2011). The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease. PLoS Pathogens, 7(3):e1001317.

2010

Bremer, J; Baumann, F; Tiberi, C; Wessig, C; Fischer, H; Schwarz, P; Steele, A D; Toyka, K V; Nave, K A; Weis, J; Aguzzi, A (2010). Axonal prion protein is required for peripheral myelin maintenance. Nature Neuroscience, 13(3):310-318.

Sigurdson, C J; Nilsson, K P R; Hornemann, S; Manco, G; Fernández-Borges, N; Schwarz, P; Castilla, J; Wüthrich, K; Aguzzi, A (2010). A molecular switch controls interspecies prion disease transmission in mice. Journal of Clinical Investigation, 120(7):2590-2599.

Bremer, J; O'Connor, T; Tiberi, C; Rehrauer, H; Weissenberger, J; Aguzzi, A (2010). Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. PLoS ONE, 5(8):e12450.

Aguzzi, A; Krautler, N J (2010). Characterizing follicular dendritic cells: A progress report. European Journal of Immunology, 40(8):2134-2138.

Peters, Rowayda; Wolf, Monika J; van den Broek, Maries; Nuvolone, Mario; Dannenmann, Stefanie; Stieger, Bruno; Rapold, Reto; Konrad, Daniel; Rubin, Arnold; Bertino, Joseph R; Aguzzi, Adriano; Heikenwalder, Mathias; Knuth, Alexander K (2010). Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture. PLoS ONE, 5(12):e15689.

Kranich, J; Krautler, N J; Falsig, J; Ballmer, B; Li, S; Hutter, G; Schwarz, P; Moos, R; Julius, C; Miele, G; Aguzzi, A (2010). Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner. Journal of Experimental Medicine, 207(10):2271-2281.

Kobayashi, A; Sakuma, N; Matsuura, Y; Mohri, S; Aguzzi, A; Kitamoto, T (2010). Experimental verification of a traceback phenomenon in prion infection. Journal of Virology, 84(7):3230-3238.

Krasemann, S; Neumann, M E; Geissen, M; Bodemer, W; Kaup, F J; Schulz-Schaeffer, W; Morel, N; Aguzzi, A; Glatzel, M (2010). Preclinical deposition of pathological prion protein in muscle of experimentally infected primates. PLoS ONE, 5(11):e13906.

Calella, A M; Farinelli, M; Nuvolone, M; Mirante, O; Moos, R; Falsig, J; Mansuy, I M; Aguzzi, A (2010). Prion protein and Abeta-related synaptic toxicity impairment. EMBO Molecular Medicine, 2(8):306-314.

Aguzzi, A; O'Connor, T (2010). Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nature Reviews. Drug Discovery, 9(3):237-248.

Nilsson, K P R; Ikenberg, K; Aslund, A; Fransson, S; Konradsson, P; Röcken, C; Moch, H; Aguzzi, A (2010). Structural typing of systemic amyloidoses by luminescent-conjugated polymer spectroscopy. American Journal of Pathology, 176(2):563-574.

Oliveira-Martins, J B; Yusa, S I; Calella, A M; Bridel, C; Baumann, F; Dametto, P; Aguzzi, A (2010). Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations. PLoS ONE, 5(2):e9107.

2009

Ladogana, A; Sanchez-Juan, P; Mitrová, E; Green, A; Cuadrado-Corrales, N; Sánchez-Valle, R; Koscova, S; Aguzzi, A; Sklaviadis, T; Kulczycki, J; Gawinecka, J; Saiz, A; Calero-Lara, M; van Duijn, C M; Pocchiari, M; Knight, R; Zerr, I (2009). Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies. Journal of Neurology, Epub a:1-9.

Weller, M; Aguzzi, A (2009). Movement disorders reveal Creutzfeldt-Jakob disease. Nature Reviews. Neurology, 5(4):185-186.

Sigurdson, C J; Nilsson, K P R; Hornemann, S; Heikenwalder, M; Manco, G; Schwarz, P; Ott, D; Rülicke, T; Liberski, P P; Julius, C; Falsig, J; Stitz, L; Wüthrich, K; Aguzzi, A (2009). De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(1):304-309.

Ruegger, J; Stoeck, K; Amsler, L; Blaettler, T; Zwahlen, M; Aguzzi, A; Glatzel, M; Hess, K; Eckert, T (2009). A case-control study of sporadic Creutzfeldt-Jakob disease in Switzerland: analysis of potential risk factors with regard to an increased CJD incidence in the years 2001-2004. BMC Public Health, 9:18.

Haybaeck, J; Zeller, N; Wolf, M J; Weber, A; Wagner, U; Kurrer, M O; Bremer, J; Iezzi, G; Graf, R; Clavien, P A; Thimme, R; Blum, H; Nedospasov, S A; Zatloukal, K; Ramzan, M; Ciesek, S; Pietschmann, T; Marche, P N; Karin, M; Kopf, M; Browning, J L; Aguzzi, A; Heikenwalder, M (2009). A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell, 16(4):295-308.

Knowles, T P J; Waudby, C A; Devlin, G L; Cohen, S I A; Aguzzi, A; Vendruscolo, M; Terentjev, E M; Welland, M E; Dobson, C M (2009). An analytical solution to the kinetics of breakable filament assembly. Science, 326(5959):1533-1537.

Sigurdson, C J; Heikenwalder, M; Manco, G; Barthel, M; Schwarz, P; Stecher, B; Krautler, N J; Hardt, W D; Seifert, B; MacPherson, A J S; Corthesy, I; Aguzzi, A (2009). Bacterial Colitis Increases Susceptibility to Oral Prion Disease. Journal of Infectious Diseases, 199(2):243-252.

Aguzzi, A (2009). Cell biology: Beyond the prion principle. Nature, 459(7249):924-925.

Nuvolone, M; Aguzzi, A; Heikenwalder, M (2009). Cells and prions: A license to replicate. FEBS Letters, 583(16):2674-2684 .

Grathwohl, S A; Kälin, R E; Bolmont, T; Prokop, S; Winkelmann, G; Kaeser, S A; Odenthal, J; Radde, R; Eldh, T; Gandy, S; Aguzzi, A; Staufenbiel, M; Mathews, P M; Wolburg, H; Heppner, F L; Jucker, M (2009). Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience, 12(11):1361-1363.

Baumann, F; Pahnke, J; Radovanovic, I; Rülicke, T; Bremer, J; Tolnay, M; Aguzzi, A (2009). Functionally relevant domains of the prion protein identified in vivo. PLoS ONE, 4(9):e6707.

Nazabal, A; Hornemann, S; Aguzzi, A; Zenobi, R (2009). Hydrogen/deuterium exchange mass spectrometry identifies two highly protected regions in recombinant full-length prion protein amyloid fibrils. Journal of Mass Spectrometry, 44(6):965-977.

Eisele, Y S; Bolmont, T; Heikenwalder, M; Langer, F; Jacobson, L H; Yan, Z X; Roth, K; Aguzzi, A; Staufenbiel, M; Walker, L C; Jucker, M (2009). Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(31):12926-12931.

Aslund, A; Sigurdson, C J; Klingstedt, T; Grathwohl, S; Bolmont, T; Dickstein, D L; Glimsdal, E; Prokop, S; Lindgren, M; Konradsson, P; Holtzman, D M; Hof, P R; Heppner, F L; Gandy, S; Jucker, M; Aguzzi, A; Hammarström, P; Nilsson, K P R (2009). Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chemical Biology, 4(8):673-684.

Race, B; Meade-White, K; Race, R; Baumann, F; Aguzzi, A; Chesebro, B (2009). Prion protein on astrocytes or in extracellular fluid impedes neurodegeneration induced by truncated prion protein. Experimental Neurology, 217(2):347-352.

Aguzzi, A; Steele, A D (2009). Prion topology and toxicity. Cell, 137(6):994-996.

Aguzzi, A; Calella, A M (2009). Prions: protein aggregation and infectious diseases. Physiological Reviews, 89(4):1105-1152.

Fuchs, T J; Haybaeck, J; Wild, P J; Heikenwalder, M; Moch, H; Aguzzi, A; Buhmann, J M (2009). Randomized tree ensembles for object detection in computational pathology. In: Bebis, G; et al. Advances in Visual Computing : 5th International Symposium, ISVC 2009, Las Vegas, NV, USA, November 30 - December 2, 2009, Proceedings, Part 1. Berlin: Springer, 367-380.

Bremer, J; Heikenwalder, M; Haybaeck, J; Tiberi, C; Krautler, N J; Kurrer, M O; Aguzzi, A (2009). Repetitive immunization enhances the susceptibility of mice to peripherally administered prions. PLoS ONE, 4(9):e7160.

Rutishauser, D; Mertz, K D; Moos, R; Brunner, E; Rülicke, T; Calella, A M; Aguzzi, A (2009). The comprehensive native interactome of a fully functional tagged prion protein. PLoS ONE, 4(2):e4446.

Aguzzi, A; Rajendran, L (2009). The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron, 64(6):783-790.

Baenziger, S; Heikenwalder, M; Johansen, P; Schlaepfer, E; Hofer, U; Miller, R; Diemand, S; Honda, K; Kundig, T M; Aguzzi, A; Speck, R F (2009). Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology. Blood, 113(2):377-388.

2008

Miele, G; Seeger, H; Marino, D; Eberhard, R; Heikenwalder, M; Stoeck, K; Basagni, M; Knight, R; Green, A; Chianini, F; Wüthrich, R P; Hock, C; Zerr, I; Aguzzi, A (2008). Urinary alpha1-antichymotrypsin: a biomarker of prion infection. PLoS ONE, 3(12):e3870.

Seeger, H; Julius, C; Cozzari, C; Calella, A M; Dattilo, M; Aguzzi, A (2008). Prion depletion and preservation of biological activity by preparative chaotrope ultracentrifugation. Biologicals, 36(6):403-411.

Ott, D; Taraborrelli, C; Aguzzi, A (2008). Novel dominant-negative prion protein mutants identified from a randomized library. Protein Engineering Design and Selection : PEDS, 21(10):623-629.

Steele, A D; Hutter, G; Jackson, W S; Heppner, F L; Borkowski, A W; King, O D; Raymond, G J; Aguzzi, A; Lindquist, S (2008). Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(36):13626-13631.

Chen, D; Steele, A D; Hutter, G; Bruno, J; Govindarajan, A; Easlon, E; Lin, S J; Aguzzi, A; Lindquist, S; Guarente, L (2008). The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Experimental Gerontology, 43(12):1086-1093.

Kranich, J; Krautler, N J; Heinen, E; Polymenidou, M; Bridel, C; Schildknecht, A; Huber, C; Kosco-Vilbois, M H; Zinkernagel, R; Miele, G; Aguzzi, A (2008). Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8. Journal of Experimental Medicine, 205(6):1293-1302.

Heikenwalder, M; Prinz, M; Zeller, N; Lang, K S; Junt, T; Rossi, S; Tumanov, A; Schmidt, H; Priller, J; Flatz, L; Rülicke, T; Macpherson, A J; Holländer, G A; Nedospasov, S A; Aguzzi, A (2008). Overexpression of lymphotoxin in T cells induces fulminant thymic involution. American Journal of Pathology, 172(6):1555-1570.

von Poser-Klein, C; Flechsig, E; Hoffmann, T; Schwarz, P; Harms, H; Bujdoso, R; Aguzzi, A; Klein, M A (2008). Alteration of B-cell subsets enhances neuroinvasion in mouse scrapie infection. Journal of Virology, 82(7):3791-3795.

Debatin, L; Streffer, J; Geissen, M; Matschke, J; Aguzzi, A; Glatzel, M (2008). Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease. Neurodegenerative Diseases, 5(6):347-354.

Falsig, J; Julius, C; Margalith, I; Schwarz, P; Heppner, F L; Aguzzi, A (2008). A versatile prion replication assay in organotypic brain slices. Nature Neuroscience, 11(1):109-117.

Genoud, N; Ott, D; Braun, N; Prinz, M; Schwarz, P; Suter, U; Trono, D; Aguzzi, A (2008). Antiprion prophylaxis by gene transfer of a soluble prion antagonist. American Journal of Pathology, 172(5):1287-1296.

Polymenidou, M; Trusheim, H; Stallmach, L; Moos, R; Julius, C; Miele, G; Lenz-Bauer, C; Aguzzi, A (2008). Canine MDCK cell lines are refractory to infection with human and mouse prions. Vaccine, 26(21):2601-2614.

Falsig, J; Nilsson, K P R; Knowles, T P J; Aguzzi, A (2008). Chemical and biophysical insights into the propagation of prion strains. HFSP Journal, 2(6):332-341.

Gavín, R; Ureña, J M; Rangel, A; Pastrana, M A; Requena, J R; Soriano, E; Aguzzi, A; Del Río, J A (2008). Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and A beta production in cortical neurons. Neurobiology of Disease, 30(2):243-254.

Stoeck, K; Hess, K; Amsler, L; Eckert, T; Zimmermann, D R; Aguzzi, A; Glatzel, M (2008). Heightened incidence of sporadic Creutzfeldt-Jakob disease is associated with a shift in clinicopathological profiles. Journal of Neurology, 255(10):1464-1472.

Heikenwalder, M; Kurrer, M O; Margalith, I; Kranich, J; Zeller, N; Haybaeck, J; Polymenidou, M; Matter, M; Bremer, J; Jackson, W S; Lindquist, S; Sigurdson, C J; Aguzzi, A (2008). Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity, 29(6):998-1008.

Aguzzi, A; Sigurdson, C; Heikenwaelder, M (2008). Molecular mechanisms of prion pathogenesis. Annual Review of Pathology, 3:11-40.

Le Pichon, C E; Valley, M T; Polymenidou, M; Chesler, A T; Sagdullaev, B T; Aguzzi, A; Firestein, S (2008). Olfactory behavior and physiology are disrupted in prion protein knockout mice. Nature Neuroscience, 12(1):60-69.

Julius, C; Heikenwalder, M; Schwarz, P; Marcel, A; Karin, M; Prinz, M; Pasparakis, M; Aguzzi, A (2008). Prion propagation in mice lacking central nervous system NF-kappaB signalling. Journal of General Virology, 89(6):1545-1550.

Aguzzi, A (2008). Staining, straining and restraining prions. Nature Neuroscience, 11(11):1239-1240.

Polymenidou, M; Moos, R; Scott, M; Sigurdson, C; Shi, Y Z; Yajima, B; Hafner-Bratkovic, I; Jerala, R; Hornemann, S; Wuthrich, K; Bellon, A; Vey, M; Garen, G; James, M N G; Kav, N; Aguzzi, A (2008). The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS ONE, 3(12):e3872.

Falsig, J; Aguzzi, A (2008). The prion organotypic slice culture assay-POSCA. Nature Protocols, 3(4):555-562.

Aguzzi, A; Baumann, F; Bremer, J (2008). The prion's elusive reason for being. Annual Review of Neuroscience, 31:439-477.

Julius, C; Hutter, G; Wagner, U; Seeger, H; Kana, V; Kranich, J; Klöhn, P C; Weissmann, C; Miele, G; Aguzzi, A (2008). Transcriptional stability of cultured cells upon prion infection. Journal of Molecular Biology, 375(5):1222-1233.

Aguzzi, A (2008). Unraveling prion strains with cell biology and organic chemistry. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(1):11-12.

2007

Aguzzi, A (2007). Prion biology: the quest for the test. Nature Methods, 4(8):614-616.

Sigurdson, C J; Aguzzi, A (2007). Chronic wasting disease. Biochimica et Biophysica Acta, 1772(6):610-618.

Steele, A D; Lindquist, S; Aguzzi, A (2007). The prion protein knockout mouse: a phenotype under challenge. Prion, 1(2):83-93.

Nicolas, O; Gavín, R; Braun, N; Ureña, J M; Fontana, X; Soriano, E; Aguzzi, A; del Río, J A (2007). Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion. FASEB Journal, 21(12):3107-3117.

Rangel, A; Burgaya, F; Gavín, R; Soriano, E; Aguzzi, A; Del Río, J A (2007). Enhanced susceptibility of Prnp-deficient mice to kainate-induced seizures, neuronal apoptosis, and death: Role of AMPA/kainate receptors. Journal of Neuroscience Research, 85(12):2741-2755.

Marruchella, G; Ligios, C; Albanese, V; Cancedda, M G; Madau, L; Lalatta-Costerbosa, G; Mazzoni, M; Clavenzani, P; Chiocchetti, R; Sarli, G; De Grossi, L; Agrimi, U; Aguzzi, A; Di Guardo, G (2007). Enteroglial and neuronal involvement without apparent neuron loss in ileal enteric nervous system plexuses from scrapie-affected sheep. Journal of General Virology, 88(Pt 10):2899-2904.

Heikenwalder, Mathias; Federau, Christian; Boehmer, Lotta von; Schwarz, Petra; Wagner, Mareike; Zeller, Nicolas; Haybaeck, Johannes; Prinz, Marco; Becher, Burkhard; Aguzzi, Adriano (2007). Germinal center B cells are dispensable in prion transport and neuroinvasion. Journal of Neuroimmunology, 192(1-2):113-123.

Aguzzi, A; Heikenwalder, M; Polymenidou, M (2007). Insights into prion strains and neurotoxicity. Nature Reviews. Molecular Cell Biology, 8(7):552-561.

Baumann, F; Tolnay, M; Brabeck, C; Pahnke, J; Kloz, U; Niemann, H H; Heikenwalder, M; Rülicke, T; Bürkle, A; Aguzzi, A (2007). Lethal recessive myelin toxicity of prion protein lacking its central domain. EMBO Journal, 26(2):538-547.

Sigurdson, Christina J; Nilsson, K Peter R; Hornemann, Simone; Manco, Giuseppe; Polymenidou, Magdalini; Schwarz, Petra; Leclerc, Mario; Hammarström, Per; Wüthrich, Kurt; Aguzzi, Adriano (2007). Prion strain discrimination using luminescent conjugated polymers. Nature Methods, 4(12):1023-1030.

Heikenwalder, M; Julius, C; Aguzzi, A (2007). Prions and peripheral nerves: a deadly rendezvous. Journal of Neuroscience Research, 85(12):2714-2725.

Zabel, M D; Heikenwalder, M; Prinz, M; Arrighi, I; Schwarz, P; Kranich, J; von Teichman, A; Haas, K M; Zeller, N; Tedder, T F; Weis, J H; Aguzzi, A (2007). Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. Journal of Immunology, 179(9):6144-6152.

2006

Sigurdson, C J; Manco, G J; Schwarz, P; Liberski, P; Hoover, E A; Hornemann, S; Polymenidou, M; Miller, M W; Glatzel, M; Aguzzi, A (2006). Strain fidelity of chronic wasting disease upon murine adaptation. Journal of Virology, 80(24):12303-12311.

Junt, T; Tumanov, A V; Harris, N; Heikenwalder, M; Zeller, N; Kuprash, D V; Aguzzi, A; Ludewig, B; Nedospasov, S A; Zinkernagel, R M (2006). Expression of lymphotoxin beta governs immunity at two distinct levels. European Journal of Immunology, 36(8):2061-2075.

Aguzzi, A (2006). Prion diseases of humans and farm animals: epidemiology, genetics, and pathogenesis. Journal of Neurochemistry, 97(6):1726-1739.

Landolt, H P; Glatzel, M; Blättler, T; Achermann, P; Roth, C; Mathis, J; Weis, J; Tobler, I; Aguzzi, A; Bassetti, C L (2006). Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease. Neurology, 66(9):1418-1424.

Vogelgesang, S; Glatzel, M; Walker, L C; Kroemer, H K; Aguzzi, A; Warzok, R W (2006). Cerebrovascular P-glycoprotein expression is decreased in Creutzfeldt-Jakob disease. Acta Neuropathologica, 111(5):436-443.

Schoch, G; Seeger, H; Bogousslavsky, J; Tolnay, M; Janzer, R C; Aguzzi, A; Glatzel, M (2006). Analysis of prion strains by PrPSc profiling in sporadic Creutzfeldt-Jakob disease. PLoS Medicine, 3(2):e14.

Baenziger, S; Tussiwand, R; Schlaepfer, E; Mazzucchelli, L; Heikenwalder, M; Kurrer, M O; Behnke, S; Frey, J; Oxenius, A; Joller, H; Aguzzi, A; Manz, M G; Speck, R F (2006). Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 103(43):15951-15956.

Priller, J; Prinz, M; Heikenwalder, M J; Zeller, N; Schwarz, P; Heppner, F L; Aguzzi, A (2006). Early and rapid engraftment of bone marrow-derived microglia in scrapie. Journal of Neuroscience, 26(45):11753-11762.

Aguzzi, A; Heikenwalder, M (2006). Pathogenesis of prion diseases: current status and future outlook. Nature Reviews. Microbiology, 4(10):765-775.

Aguzzi, A; Glatzel, M (2006). Prion infections, blood and transfusions. Nature Reviews. Neurology, 2(6):321-329.

2005

Polymenidou, M; Stoeck, K; Glatzel, M; Vey, M; Bellon, A; Aguzzi, A (2005). Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease. Lancet Neurology, 4(12):805-814.

Kovács, G G; et al; Aguzzi, A (2005). Genetic prion disease: the EUROCJD experience. Human Genetics, 118(2):166-174.

Galvan, C; Camoletto, P G; Dotti, C G; Aguzzi, A; Ledesma, M D (2005). Proper axonal distribution of PrP(C) depends on cholesterol-sphingomyelin-enriched membrane domains and is developmentally regulated in hippocampal neurons. Molecular and Cellular Neuroscience, 30(3):304-315.

Seeger, Harald; Heikenwalder, Mathias; Zeller, Nicolas; Kranich, Jan; Schwarz, Petra; Gaspert, Ariana; Seifert, Burkhardt; Miele, Gino; Aguzzi, Adriano (2005). Coincident scrapie infection and nephritis lead to urinary prion excretion. Science, 310(5746):324-326.

Gavín, R; Braun, N; Nicolas, O; Parra, B; Ureña, J M; Mingorance, A; Soriano, E; Torres, J M; Aguzzi, A; del Río, J A (2005). PrP(106-126) activates neuronal intracellular kinases and Egr1 synthesis through activation of NADPH-oxidase independently of PrPc. FEBS Letters, 579(19):4099-4106.

Papassotiropoulos, A; Wollmer, M A; Aguzzi, A; Hock, Christoph; Nitsch, R M; de Quervain, D J F (2005). The prion gene is associated with human long-term memory. Human Molecular Genetics, 14(15):2241-2246.

Donofrio, G; Heppner, F L; Polymenidou, M; Musahl, C; Aguzzi, A (2005). Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies. Journal of Virology, 79(13):8330-8338.

Glatzel, M; Mohajeri, M H; Poirier, R; Nitsch, R M; Schwarz, Petra; Lu, B; Aguzzi, A (2005). No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis. Journal of General Virology, 8(6):1861-1867.

Radovanovic, I; Braun, N; Giger, O T; Mertz, K; Miele, G; Prinz, M; Navarro, B; Aguzzi, A (2005). Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC. Journal of Neuroscience, 25(19):4879-4888.

Ladogana, A; Puopolo, M; Croes, E A; Budka, H; Jarius, C; Collins, S; Klug, G M; Sutcliffe, T; Giulivi, A; Alperovitch, A; Delasnerie-Laupretre, N; Brandel, J-P; Poser, S; Kretzschmar, H A; Rietveld, I; Mitrova, E; Cuesta, J de Pedro; Martinez-Martin, P; Glatzel, M; Aguzzi, A; Knight, R; Ward, H; Pocchiari, M; van Duijn, C M; Will, R G; Zerr, I (2005). Mortality from Creutzfeldt-Jakob disease and related disorders in Europe, Australia, and Canada. Neurology, 64(9):1586-1591.

Frappart, P O; Tong, W M; Demuth, I; Radovanovic, I; Herceg, Z; Aguzzi, A; Digweed, M; Wang, Z Q (2005). An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nature Medicine, 11(5):538-544.

Huber, C; Thielen, C; Seeger, H; Schwarz, Petra; Montrasio, F; Wilson, M R; Heinen, E; Fu, Yang-Xin; Miele, G; Aguzzi, A (2005). Lymphotoxin-beta receptor-dependent genes in lymph node and follicular dendritic cell transcriptomes. Journal of Immunology, 174(9):5526-5536.

Nikles, D; Bach, P; Boller, K; Merten, C A; Montrasio, F; Heppner, F L; Aguzzi, A; Cichutek, K; Kalinke, U; Buchholz, C J (2005). Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP. Journal of Virology, 79(7):4033-4042.

Glatzel, M; Stoeck, K; Seeger, H; Lührs, T; Aguzzi, A (2005). Human prion diseases: molecular and clinical aspects. Archives of Neurology, 62(4):545-552.

Russmann, H; Vingerhoets, F; Miklossy, J; Maeder, P; Glatzel, M; Aguzzi, A; Bogousslavsky, J (2005). Sporadic Creutzfeldt-Jakob disease: a comparison of pathological findings and diffusion weighted imaging. Journal of Neurology, 252(3):338-342.

Uelhoff, A; Tatzelt, J; Aguzzi, A; Winklhofer, K F; Haass, C (2005). A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. Journal of Biological Chemistry, 280(7):5137-5140.

Heikenwalder, M; Zeller, N; Seeger, H; Prinz, M; Klöhn, P C; Schwarz, Petra; Ruddle, N H; Weissmann, Charles; Aguzzi, A (2005). Chronic lymphocytic inflammation specifies the organ tropism of prions. Science, 307(5712):1107-1110.

Masel, J; Genoud, Nicolas; Aguzzi, A (2005). Efficient inhibition of prion replication by PrP-Fc(2) suggests that the prion is a PrP(Sc) oligomer. Journal of Molecular Biology, 345(5):1243-1251.

Heppner, F L; Greter, M; Marino, D; Falsig, J; Raivich, G; Hövelmeyer, N; Waisman, A; Rülicke, T; Prinz, M; Priller, J; Becher, B; Aguzzi, A (2005). Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nature Medicine, 11(2):146-152.

Steinacker, P; Schwarz, P; Reim, K; Brechlin, P; Jahn, O; Kratzin, H; Aitken, A; Wiltfang, J; Aguzzi, A; Bahn, E; Baxter, H C; Brose, Nils; Otto, M (2005). Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein. Molecular and Cellular Biology, 25(4):1339-1346.

Weissmann, Charles; Aguzzi, A (2005). Approaches to therapy of prion diseases. Annual Review of Medicine, 56:321-344.

Aguzzi, A (2005). Cell biology. Prion toxicity: all sail and no anchor. Science, 308(5727):1420-1421.

Sigurdson, C A; Glatzel, M A; Aguzzi, A (2005). Comment on "Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy". Veterinary Pathology, 42(1):107.

Ligios, C B; Sigurdson, C W; Santucciu, C; Carcassola, G; Manco, G; Basagni, M; Maestrale, C; Cancedda, M G; Madau, L; Aguzzi, A (2005). PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nature Medicine, 11(11):1137-1138.

Aguzzi, A; Heikenwalder, M (2005). Prions, cytokines, and chemokines: a meeting in lymphoid organs. Immunity, 22(2):145-154.

Sigurdson, C B; Polymenidou, M; Aguzzi, A (2005). Reconstructing prions: fibril assembly from simple yeast to complex mammals. Neurodegenerative Diseases, 2(1):1-5.

2004

Hugel, B; Martínez, M C; Kunzelmann, C; Blättler, T; Aguzzi, A; Freyssinet, J M (2004). Modulation of signal transduction through the cellular prion protein is linked to its incorporation in lipid rafts. Cellular and Molecular Life Sciences, 61(23):2998-3007.

Spaeth, N; Wyss, M T; Weber, B; Scheidegger, S; Lutz, A; Verwey, J; Radovanovic, I; Pahnke, J; Wild, D; Westera, G; Weishaupt, D; Hermann, D M; Kaser-Hotz, B; Aguzzi, A; Buck, A (2004). Uptake of 18F-fluorocholine, 18F-fluoroethyl-L-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat: implications for separation of radiation necrosis from tumor recurrence. Journal of Nuclear Medicine, 45(11):1931-1938.

Polymenidou, M; Heppner, F L; Pellicioli, E C; Urich, E; Miele, G; Braun, N; Wopfner, F; Schätzl, H M; Becher, B; Aguzzi, A (2004). Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 101(S2):14670-14676.

Pocchiari, M; Puopolo, M; Croes, E A; Budka, H; Gelpi, E; Collins, S; Lewis, V; Sutcliffe, T; Guilivi, A; Delasnerie-Laupretre, N; Brandel, J-P; Alperovitch, A; Zerr, I; Poser, S; Kretzschmar, H A; Ladogana, A; Rietvald, I; Mitrova, E; Martinez-Martin, P; de Pedro-Cuesta, J; Glatzel, M; Aguzzi, A; Cooper, S; Mackenzie, J; van Duijn, C M; Will, R G (2004). Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. Brain: A Journal of Neurology, 127(10):2348-2359.

Heppner, F L; Aguzzi, A (2004). Recent developments in prion immunotherapy. Current Opinion in Immunology, 16(5):594-598.

Aguzzi, A; Sigurdson, C J (2004). Antiprion immunotherapy: to suppress or to stimulate? Nature Reviews. Immunology, 4(9):725-736.

Raivich, G; Bohatschek, M; Da Costa, C; Iwata, O; Galiano, M; Hristova, M; Nateri, A S; Makwana, M; Riera-Sans, L; Wolfer, D P; Lipp, H P; Aguzzi, A; Wagner, E F; Behrens, A (2004). The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron, 43(1):57-67.

Aguzzi, A; Heikenwalder, M; Miele, G (2004). Progress and problems in the biology, diagnostics, and therapeutics of prion diseases. Journal of Clinical Investigation, 114(2):153-160.

Prinz, M; Montrasio, F; Furukawa, H; van der Haar, M E; Schwarz, Petra; Rülicke, T; Giger, O T; Häusler, K G; Perez, D; Glatzel, M; Aguzzi, A (2004). Intrinsic resistance of oligodendrocytes to prion infection. Journal of Neuroscience, 24(26):5974-5981.

Glatzel, M; Giger, O; Braun, N; Aguzzi, A (2004). The peripheral nervous system and the pathogenesis of prion diseases. Current Molecular Medicine, 4(4):355-359.

Weissenberger, J; Loeffler, S; Kappeler, A; Kopf, M; Lukes, A; Afanasieva, T A; Aguzzi, A; Weis, J (2004). IL-6 is required for glioma development in a mouse model. Oncogene, 23(19):3308-3316.

Genoud, Nicolas; Behrens, A; Miele, G; Robay, D; Heppner, F L; Freigang, S; Aguzzi, A (2004). Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 101(12):4198-4203.

Aguzzi, A; Glatzel, M (2004). vCJD tissue distribution and transmission by transfusion--a worst-case scenario coming true? Lancet, 363(9407):411-412.

Gandy, S; DeMattos, R B; Lemere, C A; Heppner, F L; Leverone, J; Aguzzi, A; Ershler, W B; Dai, J; Fraser, P; St George Hyslop, P; Holtzman, D M; Walker, L C; Keller, E T (2004). Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mechanisms of Ageing and Development, 125(2):149-151.

Heikenwalder, M; Polymenidou, M; Junt, T; Sigurdson, C J; Wagner, H; Akira, S; Zinkernagel, R M; Aguzzi, A (2004). Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nature Medicine, 10(2):187-192.

Glatzel, M; Giger, Olivier; Seeger, H; Aguzzi, A (2004). Variant Creutzfeldt-jakob disease: between lymphoid organs and brain. Trends in Microbiology, 12(2):51-53.

Aguzzi, A; Polymenidou, M (2004). Mammalian prion biology: one century of evolving concepts. Cell, 116(2):313-327.

Kovacs, G G; Lindeck-Pozza, E; Chimelli, L; Araújo, A Q C; Gabbai, A A; Ströbel, T; Glatzel, M; Aguzzi, A; Budka, H (2004). Creutzfeldt-Jakob disease and inclusion body myositis: abundant disease-associated prion protein in muscle. Annals of Neurology, 55(1):121-125.

Gandy, S; DeMattos, R B; Lemere, C A; Heppner, F L; Leverone, J; Aguzzi, A; Ershler, W B; Dai, J; Fraser, P; Hyslop, P S; Holtzman, D M; Walker, L C; Keller, E T (2004). Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Disease and Associated Disorders, 18(1):44-46.

Radovanovic, I; D'Angelo, M G; Aguzzi, A (2004). Angiogenesis in transgenic models of multistep angiogenesis. Journal of Neuro-Oncology, 50(1-2):89-98.

Heikenwalder, M; Prinz, M; Heppner, F L; Aguzzi, A (2004). Current concepts and controversies in prion immunopathology. Journal of Molecular Neuroscience, 23(1-2):3-12.

Aguzzi, A (2004). Host-microbe interactions: viruses a never-ending creativity contest. Current Opinion in Microbiology, 7(4):397-399.

Rossetti, A O; Bogousslavsky, J; Glatzel, M; Aguzzi, A (2004). Mimicry of variant Creutzfeldt-Jakob disease by sporadic Creutzfeldt-Jakob disease: importance of the pulvinar sign. Archives of Neurology, 61(3):445-446.

Aguzzi, A; Miele, G (2004). Recent advances in prion biology. Current Opinion in Neurology, 17(3):337-342.

Aguzzi, A (2004). Understanding the diversity of prions. Nature Cell Biology, 6(4):290-292.

2003

Glatzel, M; Ott, P M; Linder, T; Gebbers, J O; Gmür, A; Wüst, W; Huber, G; Moch, H; Podvinec, M; Stamm, B; Aguzzi, A (2003). Human prion diseases: epidemiology and integrated risk assessment. Lancet Neurology, 2(12):757-763.

Glatzel, M; Abela, E; Maissen, M; Aguzzi, A (2003). Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease. New England Journal of Medicine, 349(19):1812-1820.

Aguzzi, A; Haass, C (2003). Games played by rogue proteins in prion disorders and Alzheimer's disease. Science, 302(5646):814-818.

Prinz, M; Heikenwalder, M; Junt, T; Schwarz, Petra; Glatzel, M; Heppner, F L; Fu, Y X; Lipp, M; Aguzzi, A (2003). Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion. Nature, 425(6961):957-962.

Hutter, G; Heppner, F L; Aguzzi, A (2003). No superoxide dismutase activity of cellular prion protein in vivo. Biological Chemistry, 384(9):1279-1285.

Flechsig, E; Hegyi, I; Leimeroth, R; Zuniga, A; Rossi, D; Cozzio, A; Schwarz, Petra; Rülicke, T; Götz, J; Aguzzi, A; Weissmann, Charles (2003). Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia. The EMBO Journal, 22(12):3095-3101.

Lampe, J B; Schneider-Schaulies, S; Aguzzi, A (2003). Expression of the interferon-induced MxA protein in viral encephalitis. Neuropathology and Applied Neurobiology, 29(3):273-279.

Radovanovic, I; Casse, H; Aguzzi, A; Wang, Z Q; Zhang, C X (2003). Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mechanisms of Development, 120(5):549-560.

Praus, M; Kettelgerdes, G; Baier, M; Holzhütter, H G; Jungblut, P R; Maissen, M; Epple, G; Schleuning, W D; Köttgen, E; Aguzzi, A; Gessner, R (2003). Stimulation of plasminogen activation by recombinant cellular prion protein is conserved in the NH2-terminal fragment PrP23-110. Thrombosis and Haemostasis, 89(5):812-819.

Meier, Philipp; Genoud, Nicolas; Prinz, M; Maissen, M; Rülicke, T; Zurbriggen, A; Raeber, A J; Aguzzi, A (2003). Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease. Cell, 113(1):49-60.

Prinz, M; Huber, G; Macpherson, A J S; Heppner, F L; Glatzel, M; Eugster, H P; Wagner, N; Aguzzi, A (2003). Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes. American Journal of Pathology, 162(4):1103-1111.

Prinz, M; Heikenwalder, M; Schwarz, Petra; Takeda, K; Akira, S; Aguzzi, A (2003). Prion pathogenesis in the absence of Toll-like receptor signalling. EMBO Reports, 4(2):195-199.

Rossetti, A O; Glatzel, M; Aguzzi, A; Janzer, R; Bogousslavsky, J (2003). Clinical and radiological mimicry of vCJD in a valine homozygous PrP(Sc) type 1 sCJD patient. Journal of Neurology, 250(4):491-493.

Aguzzi, A; Hardt, W-D (2003). Dangerous liaisons between a microbe and the prion protein. Journal of Experimental Medicine, 198(1):1-4.

Aguzzi, A; Heppner, F L; Heikenwalder, M; Prinz, M; Mertz, K; Seeger, H; Glatzel, M (2003). Immune system and peripheral nerves in propagation of prions to CNS. British Medical Bulletin, 66(1):141-159.

Aguzzi, A; Heikenwalder, M (2003). Prion diseases: Cannibals and garbage piles. Nature, 423(6936):127-129.

Genoud, N; Behrens, A; Arrighi, I; Aguzzi, A (2003). Prion proteins and infertility: insight from mouse models. Cytogenetic and Genome Research, 103(3-4):285-289.

Aguzzi, A (2003). Prions and the immune system: a journey through gut, spleen, and nerves. Advances in Immunology, 81:123-171.

2002

Künzi, V; Glatzel, M; Nakano, M Y; Greber, U F; Van Leuven, F; Aguzzi, A (2002). Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau. Journal of Neuroscience, 22(17):7471-7477.

Thackray, A M; Klein, M A; Aguzzi, A; Bujdoso, R (2002). Chronic subclinical prion disease induced by low-dose inoculum. Journal of Virology, 76(5):2510-2517.

Prinz, M; Montrasio, F; Klein, M A; Schwarz, P; Priller, J P; Odermatt, B; Pfeffer, K; Aguzzi, A (2002). Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 99(2):919-924.

Sisó, S; Puig, B; Varea, R; Vidal, E; Acín, C; Prinz, M; Montrasio, F; Badiola, J; Aguzzi, A; Pumarola, M; Ferrer, I (2002). Abnormal synaptic protein expression and cell death in murine scrapie. Acta Neuropathologica, 103(6):615-626.

Behrens, A; Genoud, N; Naumann, H; Rülicke, T J; Janett, F; Heppner, F L; Ledermann, B; Aguzzi, A (2002). Absence of the prion protein homologue Doppel causes male sterility. EMBO Journal, 21(14):3652-3658.

Glatzel, M; Pekarik, V; Lührs, T; Dittami, J; Aguzzi, A (2002). Analysis of the prion protein in primates reveals a new polymorphism in codon 226 (Y226F). Biological Chemistry, 383(6):1021-1025.

Wischhusen, J; Jung, G; Radovanovic, I; Beier, C; Steinbach, J P; Rimner, A; Huang, H; Schulz, J B; Ohgaki, H; Aguzzi, A; Rammensee, H G; Weller, M (2002). Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma. Cancer Research, 62(9):2592-2599.

Heppner, F L; Aguzzi, A (2002). Immunität gegen Prionen? Deutsche Medizinische Wochenschrift, 127(7):328-330.

Glatzel, M; Rogivue, C; Ghani, A; Streffer, J R; Amsler, L; Aguzzi, A (2002). Incidence of Creutzfeldt-Jakob disease in Switzerland. Lancet, 360(9327):139-141.

Glatzel, M; Gottwein, J; Aguzzi, A (2002). Prionen als Motor der transmissiblen spongiformen Enzephalopathien. Schweizer Archiv für Tierheilkunde, 144(12):633-638.

Glatzel, M; Brandner, S; Klein, M A; Horstmann, S K; Aguzzi, A (2002). Prions--role of the peripheral nervous system. Virus Research, 82(1-2):53.

Behrens, A; Aguzzi, A (2002). Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl. Trends in Neurosciences, 25(3):150-154.

Rogivue, C; Gottwein, J; Aguzzi, A; Glatzel, M (2002). Transmissible spongiforme Enzephalopathien beim Menschen. Schweizer Archiv für Tierheilkunde, 144(12):685-690.

Aguzzi, A (2002). [The prion hypothesis and the human prion diseases.]. Berliner und Münchener Tierärztliche Wochenschrift, 115(3-4):91-98.

Zatloukal, K; Stumptner, C; Fuchsbichler, A; Heid, H; Schnoelzer, M; Kenner, L; Kleinert, R; Prinz, M G; Aguzzi, A; Denk, H (2002). p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. American Journal of Pathology, 160(1):255-263.

2001

Parizek, P; Roeckl, C; Weber, J; Flechsig, E; Aguzzi, A; Raeber, A J (2001). Similar turnover and shedding of the cellular prion protein in primary lymphoid and neuronal cells. Journal of Biological Chemistry, 276(48):44627-44632.

Birchler, T; Seibl, R; Büchner, K; Loeliger, S; Seger, R; Hossle, J P; Aguzzi, A; Lauener, R P (2001). Human Toll-like receptor 2 mediates induction of the antimicrobial peptide human beta-defensin 2 in response to bacterial lipoprotein. European Journal of Immunology, 31(11):3131-3137.

Montesinos-Rongen, M; Hans, V H; Eis-Hübinger, A M; Prinz, M; Schaller, C; Van Roost, D; Aguzzi, A; Wiestler, O D; Deckert, M (2001). Human herpes virus-8 is not associated with primary central nervous system lymphoma in HIV-negative patients. Acta Neuropathologica, 102(5):489-495.

Glatzel, M; Aguzzi, A (2001). Sympathetic prions. The Scientific World Journal, 1:555-556.

Heppner, F L; Musahl, C; Arrighi, I; Klein, M A; Rülicke, T; Oesch, B; Zinkernagel, R M; Kalinke, U; Aguzzi, A (2001). Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science, 294(5540):178-182.

Aguzzi, A; Glatzel, M; Montrasio, F; Prinz, M; Heppner, F L (2001). Interventional strategies against prion diseases. Nature Reviews. Neuroscience, 2(10):745-749.

Glatzel, M; Aguzzi, A (2001). The shifting biology of prions. Brain Research Reviews, 36(2-3):241-248.

Steinbach, J P; Kozmik, Z; Pfeffer, P; Aguzzi, A (2001). Overexpression of Pax5 is not sufficient for neoplastic transformation of mouse neuroectoderm. International Journal of Cancer, 93(4):459-467.

Kaeser, P S; Klein, M A; Schwarz, P; Aguzzi, A (2001). Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells. Journal of Virology, 75(15):7097-7106.

Glatzel, M; Heppner, F L; Albers, K M; Aguzzi, A (2001). Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion. Neuron, 31(1):25-34.

Klein, M A; Kaeser, P S; Schwarz, P; Weyd, H; Xenarios, I; Zinkernagel, R M; Carroll, M C; Verbeek, J S; Botto, M; Walport, M J; Molina, H; Kalinke, U; Acha-Orbea, H; Aguzzi, A (2001). Complement facilitates early prion pathogenesis. Nature Medicine, 7(4):488-492.

Afanasieva, T A; Pekarik, V; Grazia D'Angelo, M; Klein, M A; Voigtländer, T; Stocking, C; Aguzzi, A (2001). Insertional mutagenesis of preneoplastic astrocytes by Moloney murine leukemia virus. Journal of NeuroVirology, 7(2):169-181.

Behrens, A; Brandner, S; Genoud, N; Aguzzi, A (2001). Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel. EMBO Reports, 2(4):347-352.

Montrasio, F; Cozzio, A; Flechsig, E; Rossi, D; Klein, M A; Rülicke, T; Raeber, A J; Vosshenrich, C A; Proft, J; Aguzzi, A; Weissmann, C (2001). B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 98(7):4034-4037.

Weissmann, C; Raeber, A J; Montrasio, F; Hegyi, I; Frigg, R; Klein, M A; Aguzzi, A (2001). Prions and the lymphoreticular system. Philosophical Transactions of the Royal Society B: Biological Sciences, 356(1406):177-184.

Rossi, D; Cozzio, A; Flechsig, E; Klein, M A; Rülicke, T; Aguzzi, A; Weissmann, C (2001). Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. The EMBO Journal, 20(4):694-702.

Aguzzi, A; Montrasio, F; Kaeser, P S (2001). Prions: health scare and biological challenge. Nature Reviews. Molecular Cell Biology, 2(2):118-126.

Aguzzi, A (2001). Blood simple prion diagnostics. Nature Medicine, 7(3):289-290.

Hainfellner, J A; Voigtländer, T; Ströbel, T; Mazal, P R; Maddalena, A S; Aguzzi, A; Budka, H (2001). Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo. Journal of Neuropathology and Experimental Neurology, 60(5):449-461.

Heppner, F L; Arrighi, I; Kalinke, U; Aguzzi, A (2001). Immunity against prions? Trends in Molecular Medicine, 7(11):477-479.

Heppner, F L; Prinz, M; Aguzzi, A (2001). Pathogenesis of prion diseases: possible implications of microglial cells. Progress in Brain Research, 132:737-750.

Aguzzi, A (2001). Peripheral prion pursuit. Journal of Clinical Investigation, 108(5):661-662.

Maissen, M; Roeckl, C; Glatzel, M; Goldmann, W; Aguzzi, A (2001). Plasminogen binds to disease-associated prion protein of multiple species. Lancet, 357(9273):2026-2028.

Blattler, T; Siegel, A M; Jochum, W; Aguzzi, A; Hess, K (2001). Primary cerebral amyloidoma. Neurology, 56(6):777.

Aguzzi, A; Brandner, S; Fischer, M B; Furukawa, H; Glatzel, M; Hawkins, C; Heppner, F L; Montrasio, F; Navarro, B; Parizek, P; Pekarik, V; Prinz, M; Raeber, A J; Röckl, C; Klein, M A (2001). Spongiform encephalopathies: insights from transgenic models. Advances in Virus Research, 56:313-352.

Raeber, A J; Montrasio, F; Hegyi, I; Frigg, R; Klein, M A; Aguzzi, A; Weissmann, C (2001). Studies on prion replication in spleen. Developmental Immunology, 8(3-4):291-304.

Heppner, F L; Christ, A D; Klein, M A; Prinz, M; Fried, M; Kraehenbuhl, J P; Aguzzi, A (2001). Transepithelial prion transport by M cells. Nature Medicine, 7(9):976-977.

2000

Fischer, M B; Roeckl, C; Parizek, P; Schwarz, H P; Aguzzi, A (2000). Binding of disease-associated prion protein to plasminogen. Nature, 408(6811):479-483.

Klein, M A; Rüedi, D; Nozaki, M; Dell, E W; Diserens, A C; Seelentag, W; Janzer, R C; Aguzzi, A; Hegi, M E (2000). Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant. Oncogene, 19(47):5329-5337.

Heber, S; Herms, J; Gajic, V; Hainfellner, J A; Aguzzi, A; Rülicke, T; von Kretzschmar, H; von Koch, C; Sisodia, S; Tremml, P; Lipp, H P; Wolfer, D P; Müller, U (2000). Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. Journal of Neuroscience, 20(21):7951-7963.

Brandner, S; Klein, M A; Frigg, R; Pekarik, V; Parizek, P; Raeber, A; Glatzel, M; Schwarz, P; Rülicke, T; Weissmann, C; Aguzzi, A (2000). Neuroinvasion of prions: insights from mouse models. Experimental Physiology, 85(6):705-712.

Glatzel, M; Aguzzi, A (2000). PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion. Journal of General Virology, 81(11):2813-2821.

Aguzzi, A; Heppner, F L (2000). Pathogenesis of prion diseases: a progress report. Cell Death and Differentiation, 7(10):889-902.

Biffiger, K; Bartsch, S; Montag, D; Aguzzi, A; Schachner, M; Bartsch, U (2000). Severe hypomyelination of the murine CNS in the absence of myelin-associated glycoprotein and fyn tyrosine kinase. Journal of Neuroscience, 20(19):7430-7437.

Klein, M A; Aguzzi, A (2000). The neuroimmune interface in prion diseases. News in Physiological Sciences, 15(5):250-255.

Flechsig, E; Shmerling, D; Hegyi, I; Raeber, A J; Fischer, M B; Cozzio, A; von Mering, C; Aguzzi, A; Weissmann, C (2000). Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. Neuron, 27(2):399-408.

Chrast, R; Scott, H S; Madani, R; Huber, L; Wolfer, D P; Prinz, M; Aguzzi, A; Lipp, H P; Antonarakis, S E (2000). Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Human Molecular Genetics, 9(12):1853-1864.

Loup, F; Wieser, H G; Yonekawa, Y; Aguzzi, A; Fritschy, J M (2000). Selective alterations in GABAA receptor subtypes in human temporal lobe epilepsy. Journal of Neuroscience, 20(14):5401-5419.

Benninger, Y; Marino, S; Hardegger, R; Weissmann, C; Aguzzi, A; Brandner, S (2000). Differentiation and histological analysis of embryonic stem cell-derived neural transplants in mice. Brain Pathology, 10(3):330-341.

Gao, B; Hagenbuch, B; Kullak-Ublick, G A; Benke, D; Aguzzi, A; Meier, P J (2000). Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. Journal of Pharmacology and Experimental Therapeutics, 249(1):73-79.

Politopoulou, G; Seebach, J D; Schmugge, M; Schwarz, H P; Aguzzi, A (2000). Age-related expression of the cellular prion protein in human peripheral blood leukocytes. Haematologica / The Hematology Journal, 85(6):580-587.

Hegi, M E; Klein, M A; Rüedi, D; Chène, P; Hamou, M F; Aguzzi, A (2000). p53 transdominance but no gain of function in mouse brain tumor model. Cancer Research, 60(11):3019-3024.

Montrasio, F; Frigg, R; Glatzel, M; Klein, M A; Mackay, F; Aguzzi, A; Weissmann, C (2000). Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science, 288(5469):1257-1259.

Glatzel, M; Aguzzi, A (2000). Peripheral pathogenesis of prion diseases. Microbes and Infection, 2(6):613-619.

Brandner, S; Klein, M A; Aguzzi, A (2000). Mechanisms of neuroinvasion by prions: molecular principles and present state of research. Swiss Medical Weekly, 130(12):435-442.

Glatzel, M; Flechsig, E; Navarro, B; Klein, M A; Paterna, J C; Büeler, H; Aguzzi, A (2000). Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 97(1):442-447.

Nedelcu, J; Klein, M A; Aguzzi, A; Martin, E (2000). Resuscitative hypothermia protects the neonatal rat brain from hypoxic-ischemic injury. Brain Pathology, 10(1):61-71.

D'Angelo, M G; Afanasieva, T A; Aguzzi, A (2000). Angiogenesis in transgenic models of multistep carcinogenesis. Journal of Neuro-Oncology, 50(1-2):89-98.

Hergersberg, M; Glatzel, M; Capone, A; Achermann, S; Hagmann, A; Fischer, J; Ersch, J; Aguzzi, A; Boltshauser, E (2000). Deletions in the spinal muscular atrophy gene region in a newborn with neuropathy and extreme generalized muscular weakness. European Journal of Paediatric Neurology, 4(1):35-38.

Raeber, A J; Aguzzi, A (2000). Engulfment of prions in the germinal centre. Immunology Today, 21(2):66-67.

Aguzzi, A (2000). Prion diseases, blood and the immune system: concerns and reality. Haematologica / The Hematology Journal, 81(1):3-10.

Glatzel, M; Klein, M A; Brandner, S; Aguzzi, A (2000). Prions: from neurografts to neuroinvasion. Archives of virology. Supplementum, 16(3):3-12.

Aguzzi, A; Klein, M A; Montrasio, F; Pekarik, V; Brandner, S; Furukawa, H; Käser, P; Röckl, C; Glatzel, M (2000). Prions: pathogenesis and reverse genetics. Annals of the New York Academy of Sciences, 920:140-157.

1999

Steinbach, J P; Weissenberger, J; Aguzzi, A (1999). Distinct phases of cryogenic tissue damage in the cerebral cortex of wild-type and c-fos deficient mice. Neuropathology and Applied Neurobiology, 25(6):468-480.

Frigg, R; Klein, M A; Hegyi, I; Zinkernagel, R M; Aguzzi, A (1999). Scrapie pathogenesis in subclinically infected B-cell-deficient mice. Journal of Virology, 73(11):9584-9588.

Maddalena, A S; Hainfellner, J A; Hegi, M E; Glatzel, M; Aguzzi, A (1999). No complementation between TP53 or RB-1 and v-src in astrocytomas of GFAP-v-src transgenic mice. Brain Pathology, 9(4):627-637.

Sancho, S; Magyar, J P; Aguzzi, A; Suter1, U (1999). Distal axonopathy in peripheral nerves of PMP22-mutant mice. Brain: A Journal of Neurology, 122(8):1563-1577.

Hefti, H P; Frese, M; Landis, H; Di Paolo, C; Aguzzi, A; Haller, O; Pavlovic, J (1999). Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. Journal of Virology, 73(8):6984-6991.

Calogero, S; Grassi, F; Aguzzi, A; Voigtländer, T; Ferrier, P; Ferrari, S; Bianchi, M E (1999). The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nature Genetics, 22(3):276-280.

Lichtlen, P; Georgiev, O; Schaffner, W; Aguzzi, A; Brandner, S (1999). The heavy metal-responsive transcription factor-1 (MTF-1) is not required for neural differentiation. Biological Chemistry, 380(6):711-715.

Raeber, A J; Klein, M A; Frigg, R; Flechsig, E; Aguzzi, A; Weissmann, C (1999). PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice. The EMBO Journal, 18(10):2702-2706.

Raeber, A J; Sailer, A; Hegyi, I; Klein, M A; Rülicke, T; Fischer, M B; Brandner, S; Aguzzi, A; Weissmann, C (1999). Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 96(7):3987-3992.

Brandner, S; Klein, M A; Aguzzi, A (1999). A crucial role for B cells in neuroinvasive scrapie. Transfusion Clinique et Biologique, 6(1):17-23.

Theurillat, J P; Hainfellner, J A; Maddalena, A; Weissenberger, J; Aguzzi, A (1999). Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice. American Journal of Pathology, 154(2):581-590.

Nedelcu, J; Klein, M A; Aguzzi, A; Boesiger, P; Martin, E (1999). Biphasic edema after hypoxic-ischemic brain injury in neonatal rats reflects early neuronal and late glial damage. Pediatric Research, 46(3):297-304.

Pohl, U; Wick, W; Weissenberger, J; Steinbach, J P; Dichgans, J; Aguzzi, A; Weller, M (1999). Characterization of Tu-2449, a glioma cell line derived from a spontaneous tumor in GFAP-v-src-transgenic mice: comparison with established murine glioma cell lines. International Journal of Oncology, 15(4):829-834.

Weissmann, C; Aguzzi, A (1999). Perspectives: neurobiology. PrP's double causes trouble. Science, 286(5441):914-915.

Aguzzi, A; Brandner, S (1999). Shrinking prions: new folds to old questions. Nature Medicine, 5(5):486-487.

Shepherd, E J; Brettle, R P; Liberski, P P; Aguzzi, A; Ironside, J W; Simmonds, P; Bell, J E (1999). Spinal cord pathology and viral burden in homosexuals and drug users with AIDS. Neuropathology and Applied Neurobiology, 25(1):2-10.

Aguzzi, A; Brandner, S (1999). The genetics of prions--a contradiction in terms? Lancet, 354(S1):S122-S125.

1998

Klein, M A; Frigg, R; Raeber, A J; Flechsig, E; Hegyi, I; Zinkernagel, R M; Weissmann, C; Aguzzi, A (1998). PrP expression in B lymphocytes is not required for prion neuroinvasion. Nature Medicine, 4(12):1429-1433.

Aguzzi, A (1998). Grafting mouse brains: from neurocarcinogenesis to neurodegeneration. EMBO Journal, 17(21):6107-6114.

Loup, F; Weinmann, O; Yonekawa, Y; Aguzzi, A; Wieser, H G; Fritschy, J M (1998). A highly sensitive immunofluorescence procedure for analyzing the subcellular distribution of GABA A receptor subunits in the human brain. Journal of Histochemistry and Cytochemistry, 46(10):1129-1139.

Raeber, A J; Brandner, S; Klein, M A; Benninger, Y; Musahl, C; Frigg, R; Roeckl, C; Fischer, M B; Weissmann, C; Aguzzi, A (1998). Transgenic and knockout mice in research on prion diseases. Brain Pathology, 8(4):715-733.

Mrkic, B; Pavlovic, J; Rülicke, T; Volpe, P; Buchholz, C J; Hourcade, D; Atkinson, J P; Aguzzi, A; Cattaneo, R (1998). Measles virus spread and pathogenesis in genetically modified mice. Journal of Virology, 72(9):7420-7427.

Zanusso, G; Liu, D; Ferrari, S; Hegyi, I; Yin, X; Aguzzi, A; Hornemann, S; Liemann, S; Glockshuber, R; Manson, J C; Brown, P; Petersen, R B; Gambetti, P; Sy, M S (1998). Prion protein expression in different species: analysis with a panel of new mAbs. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 95(15):8812-8816.

Cathomen, T; Mrkic, B; Spehner, D; Drillien, R; Naef, R; Pavlovic, J; Aguzzi, A; Billeter, M A; Cattaneo, R (1998). A matrix-less measles virus is infectious and elicits extensive cell fusion: consequences for propagation in the brain. The EMBO Journal, 17(14):3899-3908.

Aguzzi, A; Weissmann, C (1998). Prion diseases. Haemophilia, 4(4):619-627.

Günes, C; Heuchel, R; Georgiev, O; Müller, K H; Lichtlen, P; Blüthmann, H; Marino, S; Aguzzi, A; Schaffner, W (1998). Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. The EMBO Journal, 17(10):2846-2854.

Shmerling, D; Hegyi, I; Fischer, M B; Blättler, T; Brandner, S; Götz, J; Rülicke, T; Flechsig, E; Cozzio, A; von Mering, C; Hangartner, C; Aguzzi, A; Weissmann, C (1998). Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell, 93(2):203-214.

Lampe, J B; Marino, S; Rethwilm, A; Aguzzi, A (1998). Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus. Neuropathology and Applied Neurobiology, 24(1):36-43.

Brandner, S; Isenmann, S; Kühne, G; Aguzzi, A (1998). Identification of the end stage of scrapie using infected neural grafts. Brain Pathology, 8(1):19-27.

Sibilia, M; Steinbach, J P; Stingl, L; Aguzzi, A; Wagner, E F (1998). A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. EMBO Journal, 17(3):719-731.

Vingerhoets, F J; Hegyi, I; Aguzzi, A; Myers, P; Pizzolato, G; Landis, T (1998). An unusual case of Creutzfeldt-Jakob disease. Neurology, 51(2):617-619.

Kurz, D; Aguzzi, A; Scherer, T A (1998). Decompensated cor pulmonaleas the first manifestation of adult-onset myopathy. Respiration, 65(4):317-319.

Aguzzi, A; Huber, G F (1998). How to fight brain cell suicide, and feel good at it. Cell Death and Differentiation, 5(10):803-804.

Steinbach, J P; Müller, U; Leist, M; Li, Z W; Nicotera, P; Aguzzi, A (1998). Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice. Cell Death and Differentiation, 5(10):858-866.

Aguzzi, A (1998). Protein conformation dictates prion strain. Nature Medicine, 4(10):1125-1126.

Aguzzi, A; Weissmann, C (1998). Spongiform encephalopathies. The prion's perplexing persistence. Nature, 392(6678):763-764.

Weissmann, C; Fischer, M; Raeber, A; Bueler, H; Sailer, A; Shmerling, D; Rülicke, T; Brandner, S; Aguzzi, A (1998). The use of transgenic mice in the investigation of transmissible spongiform encephalopathies. Revue scientifique et technique, 17(1):278-290.

Rovigatti, U; Afanasieva, T A; Brandner, S; Hainfellner, J A; Kiess, M; Maddalena, A; Malin, G; Rülicke, T; Steinbach, J; Weissenberger, J; Aguzzi, A (1998). Transgenic mice as research tools in neurocarcinogenesis. Journal of Neurovirology, 4(2):159-174.

Aguzzi, A; Raeber, A J (1998). Transgenic models of neurodegeneration. Neurodegeneration: of (transgenic) mice and men. Brain Pathology, 8(4):695-697.

Aguzzi, A; Klein, M A; Musahl, C; Raeber, A J; Blättler, T; Hegyi, I; Frigg, R; Brandner, S (1998). Use of brain grafts to study the pathogenesis of prion diseases. Essays in Biochemistry, 33:133-147.

Raeber, A J; Klein, M A; Frigg, R; Brandner, S; Blättler, T; Aguzzi, A (1998). [Significance of prion protein in transmission of prions and in pathogenesis of spongiform encephalopathies]. Wiener Medizinische Wochenschrift, 148(4):74-77.

Aguzzi, A; D'Angelo, M G; Klein, M A; Frigg, R; Fischer, M B; Raeber, A J; Röckl, C; Musahl, C; Hegyi, I; Brandner, S (1998). [The new research frontier on prion disease.]. Pathologica, 90(6):743-752.

1997

Pruschy, M; Shi, Y Q; Crompton, N E; Steinbach, J P; Aguzzi, A; Glanzmann, C; Bodis, S (1997). The proto-oncogene c-fos mediates apoptosis in murine T-lymphocytes induced by ionizing radiation and dexamethasone. Biochemical and Biophysical Research Communications (BBRC), 241(2):519-524.

Weissmann, C; Aguzzi, A (1997). Bovine spongiform encephalopathy and early onset variant Creutzfeldt-Jakob disease. Current Opinion in Neurobiology, 7(5):695-700.

Blättler, T; Brandner, S; Raeber, A J; Klein, M A; Voigtländer, T; Weissmann, C; Aguzzi, A (1997). PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature, 389(6646):69-73.

Jochum, W; Weber, T; Frye, S; Hunsmann, G; Lüke, W; Aguzzi, A (1997). Detection of JC virus by anti-VP1 immunohistochemistry in brains with progressive multifocal leukoencephalopathy. Acta Neuropathologica, 94(3):226-231.

Bieniasz, P D; Erlwein, O; Aguzzi, A; Rethwilm, A; McClure, M O (1997). Gene transfer using replication-defective human foamy virus vectors. Virology, 235(1):65-72.

Schmidt, M; Niewiesk, S; Heeney, J; Aguzzi, A; Rethwilm, A (1997). Mouse model to study the replication of primate foamy viruses. Journal of General Virology, 78(8):1929-1933.

Aguzzi, A; Blättler, T; Klein, M A; Räber, A J; Hegyi, I; Frigg, R; Brandner, S; Weissmann, C (1997). Tracking prions: the neurografting approach. Cellular and Molecular Life Sciences, 53(6):485-495.

Weissenberger, J; Steinbach, J P; Malin, G; Spada, S; Rülicke, T; Aguzzi, A (1997). Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice. Oncogene, 14(17):2005-2013.

Ozsahin, H; Arredondo-Vega, F X; Santisteban, I; Fuhrer, H; Tuchschmid, P; Jochum, W; Aguzzi, A; Lederman, H M; Fleischman, A; Winkelstein, J A; Seger, R A; Hershfield, M S (1997). Adenosine deaminase deficiency in adults. Blood, 89(8):2849-2855.

Hafezi, F; Steinbach, J P; Marti, A; Munz, K; Wang, Z Q; Wagner, E F; Aguzzi, A; Remé, C E (1997). The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nature Medicine, 3(3):346-349.

Sartoretti-Schefer, S; Wichmann, W; Aguzzi, A; Valavanis, A (1997). MR differentiation of adamantinous and squamous-papillary craniopharyngiomas. American Journal of Neuroradiology : AJNR, 18(1):77-87.

Klein, M A; Frigg, R; Flechsig, E; Raeber, A J; Kalinke, U; Bluethmann, H; Bootz, F; Suter, M; Zinkernagel, R M; Aguzzi, A (1997). A crucial role for B cells in neuroinvasive scrapie. Nature, 390(6661):687-690.

Raeber, A J; Race, R E; Brandner, S; Priola, S A; Sailer, A; Bessen, R A; Mucke, L; Manson, J C; Aguzzi, A; Oldstone, M B; Weissmann, C; Chesebro, B (1997). Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO Journal, 16(20):6057-6065.

Sherman, L; Jacoby, L B; Lampe, J; Pelton, P; Aguzzi, A; Herrlich, P; Ponta, H (1997). CD44 expression is aberrant in benign Schwann cell tumors possessing mutations in the neurofibromatosis type 2, but not type 1, gene. Cancer Research, 57(21):4889-4897.

Beutler, A S; Banck, M S; Aguzzi, A (1997). Curing rat glioblastoma: immunotherapy or graft rejection? Science, 276(5309):20-21.

Rumpel, H; Nedelcu, J; Aguzzi, A; Martin, E (1997). Late glial swelling after acute cerebral hypoxia-ischemia in the neonatal rat: a combined magnetic resonance and histochemical study. Pediatric Research, 42(1):54-59.

Aguzzi, A (1997). Neuro-immune connection in spread of prions in the body? Lancet, 349(9054):742-743.

Aguzzi, A; Raeber, A; Blättler, T; Flechsig, E; Klein, M; Weissmann, C; Brandner, S (1997). Neurotoxicity and neuroinvasiveness of prions. Journal of NeuroVirology, 3(S1):S23-S24.

Vajtai, I; Varga, Z; Aguzzi, A (1997). Pleomorphic xanthoastrocytoma with gangliogliomatous component. Pathology, Research and Practice, 193(9):617-621.

Aguzzi, A; Collinge, J (1997). Post-exposure prophylaxis after accidental prion inoculation. Lancet, 350(9090):1519-1520.

Aguzzi, A; Weissmann, C (1997). Prion research: the next frontiers. Nature, 389(6653):795-798.

Aguzzi, A (1997). Prions and antiprions. Biological Chemistry, 378(12):1393-1395.

Baerlocher, K E; Steinmann, B; Aguzzi, A; Krähenbühl, S; Roe, C R; Vianey-Saban, C (1997). Short-chain acyl-CoA dehydrogenase deficiency in a 16-year-old girl with severe muscle wasting and scoliosis. Journal of Inherited Metabolic Disease, 20(3):427-431.

Serio, G; Aguzzi, A (1997). Spindle and giant cell carcinoma of the colon. Histopathology, 30(4):383-385.

Weber, T; Aguzzi, A (1997). The spectrum of transmissible spongiform encephalopathies. Intervirology, 40(2-3):198-212.

Aguzzi, A; Maddalena, A; Brandner, S; Klein, M (1997). [Molecular pathogenesis of spongiform encephalopathy.]. Pathologica, 89(5):481-490.

1996

Brandner, S; Raeber, A; Sailer, A; Blättler, T; Fischer, M B; Weissmann, C; Aguzzi, A (1996). Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 93(23):13148-13151.

Ogata, N; Jochum, W; Aguzzi, A; Fournier, J Y; Yonekawa, Y (1996). Total removal of a primary intracranial squamous cell carcinoma invading the brain stem. Surgical Neurology, 46(5):477-480.

Magyar, J P; Martini, R; Ruelicke, T; Aguzzi, A; Adlkofer, K; Dembic, Z; Zielasek, J; Toyka, K V; Suter, U (1996). Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage. Journal of Neuroscience, 16(17):5351-5360.

Fritschy, J M; Brandner, S; Aguzzi, A; Koedood, M; Luscher, B; Mitchell, P J (1996). Brain cell type specificity and gliosis-induced activation of the human cytomegalovirus immediate-early promoter in transgenic mice. Journal of Neuroscience, 16(7):2275-2282.

Isenmann, S; Brandner, S; Kühne, G; Boner, J; Aguzzi, A (1996). Comparative in vivo and pathological analysis of the blood-brain barrier in mouse telencephalic transplants. Neuropathology and Applied Neurobiology, 22(2):118-128.

Isenmann, S; Brandner, S; Sure, U; Aguzzi, A (1996). Telencephalic transplants in mice: characterization of growth and differentiation patterns. Neuropathology and Applied Neurobiology, 22(2):108-117.

Tief, K; Schmidt, A; Aguzzi, A; Beermann, F (1996). Tyrosinase is a new marker for cell populations in the mouse neural tube. Developmental Dynamics, 205(4):445-456.

Fischer, M B; Rülicke, T; Raeber, A; Sailer, A; Moser, M; Oesch, B; Brandner, S; Aguzzi, A; Weissmann, C (1996). Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. The EMBO Journal, 15(6):1255-1264.

Tschopp, R R; Brandner, S; Marino, S; Bothe, K; Horak, I; Rethwilm, A; Aguzzi, A (1996). Analysis of the determinants of neurotropism and neurotoxicity of HFV in transgenic mice. Virology, 216(2):338-346.

Brandner, S; Isenmann, S; Raeber, A; Fischer, M B; Sailer, A; Kobayashi, Y; Marino, S; Weissmann, C; Aguzzi, A (1996). Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature, 379(6563):339-343.

Aguzzi, A (1996). Between cows and monkeys. Nature, 381(6585):734-735.

Pergami, P; Arbustini, E; Butti, G; Karau, J; Aguzzi, A; Poloni, T E; Montalbetti, L; Egitto, M G; Simonetti, F; Savoldi, F; Ceroni, M (1996). Disseminated encephalitis following streptococcal infection. Italian Journal of Neurological Sciences, 17(1):87-91.

Vajtai, I; Varga, Z; Aguzzi, A (1996). MIB-1 immunoreactivity reveals different labelling in low-grade and in malignant epithelial neoplasms of the choroid plexus. Histopathology, 29(2):147-151.

Müller, U; Cristina, N; Li, Z W; Wolfer, D P; Lipp, H P; Rülicke, T; Brandner, S; Aguzzi, A; Weissman, C (1996). Mice homozygous for a modified beta-amyloid precursor protein (beta APP) gene show impaired behavior and high incidence of agenesis of the corpus callosum. Annals of the New York Academy of Sciences, 777:65-73.

Isenmann, S; Brandner, S; Aguzzi, A (1996). Neuroectodermal grafting: a new tool for the study of neurodegenerative diseases. Histology and Histopathology, 11(4):1063-1073.

Chazot, G; Broussolle, E; Lapras, C l; Blättler, T; Aguzzi, A; Kopp, N (1996). New variant of Creutzfeldt-Jakob disease in a 26-year-old French man. Lancet, 347(9009):1181.

Aguzzi, A (1996). Pathogenesis of spongiform encephalopathies: an update. International Archives of Allergy and Immunology, 110(2):99-106.

Lindberg, R L; Porcher, C; Grandchamp, B; Ledermann, B; Bürki, K; Brandner, S; Aguzzi, A; Meyer, U A (1996). Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria. Nature Genetics, 12(2):195-199.

Aguzzi, A; Marino, S; Tschopp, R; Rethwilm, A (1996). Regulation of expression and pathogenic potential of human foamy virus in vitro and in transgenic mice. Current Topics in Microbiology and Immunology, 206:243-273.

Aguzzi, A; Weissmann, C (1996). Sleepless in Bologna: transmission of fatal familial insomnia. Trends in Microbiology, 4(4):129-132.

Aguzzi, A; Weissmann, C (1996). Spongiform encephalopathies: a suspicious signature. Nature, 383(6602):666-667.

Weissmann, C; Fischer, M; Raeber, A; Büeler, H; Sailer, A; Shmerling, D; Rülicke, T; Brandner, S; Aguzzi, A (1996). The role of PrP in pathogenesis of experimental scrapie. Cold Spring Harbor Symposia on Quantitative Biology, 61:511-522.

Varga, Z; Vajtai, I; Aguzzi, A (1996). The standard isoform of CD44 is preferentially expressed in atypical papillomas and carcinomas of the choroid plexus. Pathology, Research and Practice, 192(12):1225-1231.

Weissmann, C; Fischer, M; Raeber, A; Büeler, H; Sailer, A; Shmerling, D; Rülicke, T; Brandner, S; Aguzzi, A (1996). The use of transgenic mice in the investigation of transmissible spongiform encephalopathies. International Journal of Experimental Pathology, 77(6):283-293.

Aguzzi, A; Brandner, S; Marino, S; Steinbach, J P (1996). Transgenic and knockout mice in the study of neurodegenerative diseases. Journal of Molecular Medicine, 74(3):111-126.

Varga, Z; Vajtai, I; Marino, S; Schäuble, B; Yonekawa, Y; Aguzzi, A (1996). Tubular adenoma of the choroid plexus: evidence for glandular differentiation of the neuroepithelium. Pathology, Research and Practice, 192(8):840-844.

Steinbach, J P; Aguzzi, A (1996). XVI Winter meeting of the Swiss Society of Neuropathology, St Moritz, 20-23 March 1996. Neuropathology and Applied Neurobiology, 22(3):261-263.

Budka, H; Aguzzi, A; Brown, P; Brucher, J M; Bugiani, O; Collinge, J; Diringer, H; Gullotta, F; Haltia, M; Hauw, J J; Ironside, J W; Kretzschmar, H A; Lantos, P L; Masullo, C; Pocchiari, M; Schlote, W; Tateishi, J; Will, R G (1996). [Consensus report: tissue handling in suspected Creutzfeldt-Jakob disease and other spongiform encephalopathies (prion diseases) in the human. European Union Biomed-1 Concerted Action]. Der Pathologe, 17(2):171-175.

1995

Isenmann, S; Molthagen, M; Brandner, S; Bartsch, U; Kühne, G; Magyar, J P; Sure, U; Schachner, M; Aguzzi, A (1995). The AMOG/beta 2 subunit of Na,K-ATPase is not necessary for long-term survival of telencephalic grafts. Glia, 15(4):377-388.

Adlkofer, K; Martini, R; Aguzzi, A; Zielasek, J; Toyka, K V; Suter, U (1995). Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice. Nature Genetics, 11(3):274-280.

Aguzzi, A; Brandner, S; Isenmann, S; Steinbach, J P; Sure, U (1995). Transgenic and gene disruption techniques in the study of neurocarcinogenesis. Glia, 15(3):348-364.

Bladt, F; Riethmacher, D; Isenmann, S; Aguzzi, A; Birchmeier, C (1995). Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature, 376(6543):768-771.

Marino, S; Kretschmer, C; Brandner, S; Cavard, C; Zider, A; Briand, P; Isenmann, S; Wagner, E F; Aguzzi, A (1995). Activation of HIV transcription by human foamy virus in transgenic mice. Laboratory Investigation, 73(1):103-110.

Kozmik, Z; Sure, U; Rüedi, D; Busslinger, M; Aguzzi, A (1995). Deregulated expression of PAX5 in medulloblastoma. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 92(12):5709-5713.

Weller, M; Malipiero, U; Aguzzi, A; Reed, J C; Fontana, A (1995). Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. Journal of Clinical Investigation, 95(6):2633-2643.

Rainov, N G; Lübbe, J; Renshaw, J; Pritchard-Jones, K; Lüthy, A R; Aguzzi, A (1995). Association of Wilms' tumor with primary brain tumor in siblings. Journal of Neuropathology and Experimental Neurology, 54(2):214-223.

Hergersberg, M; Matsuo, K; Gassmann, M; Schaffner, W; Lüscher, B; Rülicke, T; Aguzzi, A (1995). Tissue-specific expression of a FMR1/beta-galactosidase fusion gene in transgenic mice. Human Molecular Genetics, 4(3):359-366.

Stuart, E T; Kioussi, C; Aguzzi, A; Gruss, P (1995). PAX5 expression correlates with increasing malignancy in human astrocytomas. Clinical Cancer Research, 1(2):207-214.

Sure, U; Bertalanffy, H; Isenmann, S; Brandner, S; Berghorn, W J; Seeger, W; Aguzzi, A (1995). Secondary manifestation of medulloblastoma: metastases and local recurrences in 66 patients. Acta Neurochirurgica, 136(3-4):117-126.

1994

Aguzzi, A; Theuring, F (1994). Improved in situ beta-galactosidase staining for histological analysis of transgenic mice. Histochemistry and Cell Biology, 102(6):477-481.

This list was generated on Tue Oct 17 08:09:11 2017 CEST.