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Items where Subject is "05 Vetsuisse Faculty > Department of Molecular Mechanisms of Disease
07 Faculty of Science > Department of Molecular Mechanisms of Disease"

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Lezaja, Aleksandra; Altmeyer, Matthias (2017). Inherited DNA lesions determine G1 duration in the next cell cycle. Cell Cycle:Epub ahead of print.

Graf, Urs; Casanova, Elisa A; Wyck, Sarah; Dalcher, Damian; Gatti, Marco; Vollenweider, Eva; Okoniewski, Michal J; Weber, Fabienne A; Patel, Sameera S; Schmid, Marc W; Li, Jiwen; Sharif, Jafar; Wanner, Guido A; Koseki, Haruhiko; Wong, Jiemin; Pelczar, Pawel; Penengo, Lorenza; Santoro, Raffaella; Cinelli, Paolo (2017). Corrigendum: Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nature Cell Biology, 19(8):1003.

Larsen, Sara C; Leutert, Mario; Bilan, Vera; Martello, Rita; Jungmichel, Stephanie; Young, Clifford; Hottiger, Michael O; Nielsen, Michael L (2017). Proteome-wide identification of in vivo ADP-ribose acceptor sites by liquid chromatography–tandem mass spectrometry. In: Tulin, Alexei V. Poly(ADP-Ribose) Polymerase. Switzerland: Springer, 149-162.

Graf, Urs; Casanova, Elisa A; Wyck, Sarah; Dalcher, Damian; Gatti, Marco; Vollenweider, Eva; Okoniewski, Michal J; Weber, Fabienne A; Patel, Sameera S; Schmid, Marc W; Li, Jiwen; Sharif, Jafar; Wanner, Guido A; Koseki, Haruhiko; Wong, Jiemin; Pelczar, Pawel; Penengo, Lorenza; Santoro, Raffaella; Cinelli, Paolo (2017). Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nature Cell Biology, 19(7):763-773.

Verdeguer, Francisco; Aouadi, Myriam (2017). Macrophage heterogeneity and energy metabolism. Experimental Cell Research, 360(1):35-40.

Hottiger, Michael O; De Carvalho, Daniel D; Bortoluci, Karina R; et al (2017). Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage. Scientific Reports, 7:41686.

Bisceglie, Lavinia; Bartolomei, Giody; Hottiger, Michael O (2017). ADP-ribose-specific chromatin-affinity purification for investigating genome-wide or locus-specific chromatin ADP-ribosylation. Nature Protocols, 12(9):1951-1961.

Hatting, Maximilian; Rines, Amy K; Luo, Chi; Tabata, Mitsuhisa; Sharabi, Kfir; Hall, Jessica A; Verdeguer, Francisco; Trautwein, Christian; Puigserver, Pere (2017). Adipose tissue CLK2 promotes energy expenditure during high-fat diet intermittent fasting. Cell Metabolism, 25(2):428-437.

Michelena, Jone; Altmeyer, Matthias (2017). Cell cycle resolved measurements of poly(ADP-ribose) formation and DNA damage signaling by quantitative image-based cytometry. In: Tulin, Alexei V.. Poly(ADP-Ribose) Polymerase. New York: Springer, 57-68.

Abplanalp, Jeannette; Hottiger, Michael O (2017). Cell fate regulation by chromatin ADP-ribosylation. Seminars in Cell & Developmental Biology, 63:114-122.

Bilan, Vera; Leutert, Mario; Nanni, Paolo; Panse, Christian; Hottiger, Michael O (2017). Combining higher-energy collision dissociation and electron-transfer/higher-energy collision dissociation fragmentation in a product-dependent manner confidently assigns proteomewide adp-ribose acceptor sites. Analytical Chemistry, 89(3):1523-1530.

Duda, Heike; Arter, Meret; Gloggnitzer, Jiradet; Teloni, Federico; Wild, Philipp; Blanco, Miguel G; Altmeyer, Matthias; Matos, Joao (2017). Correction: A mechanism for controlled breakage of under-replicated chromosomes during mitosis. Developmental Cell, 40(4):421-422.

Ambrosi, Christina; Manzo, Massimiliano; Baubec, Tuncay (2017). Dynamics and context-dependent roles of DNA methylation. Journal of Molecular Biology, 429(10):1459-1475.

Leutert, Mario; Bilan, Vera; Gehrig, Peter; Hottiger, Michael O (2017). Identification of ADP-Ribose acceptor sites on in vitro modified proteins by liquid chromatography–tandem mass spectrometry. Methods in Molecular Biology, 1608:137-148.

De Donato, Carlo; Barca, Donatella; Milazzo, Concetta; Santoro, Raffaella; Giglio, Gianni; Tripepi, Sandro; Sperone, Emilio (2017). Is trace element concentration correlated to parasite abundance? A case study in a population of the green frog Pelophylax synkl. hispanicus from the Neto River (Calabria, southern Italy). Parasitology Research, 116(6):1745-1753.

Bilan, Vera; Selevsek, Nathalie; Kistemaker, Hans A. V; Abplanalp, Jeannette; Feurer, Roxane; Filippov, Dmitri V; Hottiger, Michael O (2017). New quantitative mass spectrometry approaches reveal different ADP-ribosylation phases dependent on the levels of oxidative stress. Molecular & Cellular Proteomics, 16(5):949-958.

Pellegrino, Stefania; Michelena, Jone; Teloni, Federico; Imhof, Ralph; Altmeyer, Matthias (2017). Replication-coupled dilution of H4K20me2 guides 53BP1 to pre-replicative chromatin. Cell Reports, 19(9):1819-1831.

Leone, Sergio; Bär, Dominik; Slabber, Coenraad Frederik; Dalcher, Damian; Santoro, Raffaella (2017). The RNA helicase DHX9 establishes nucleolar heterochromatin, and this activity is required for embryonic stem cell differentiation. EMBO Reports, 18(7):1248-1262.

Leone, Sergio. Establishment of Heterochromatin at rRNA Genes Is Required for Embryonic Stem Cells Differentiation. 2016, University of Zurich, Vetsuisse Faculty.

Bilan, Vera. Mass spectrometry-based methods for analyzing oxidative stress-mediated cellular adp-ribosylation. 2016, University of Zurich, Faculty of Science.

Böhm, Maria; Wachtel, Marco; Marques, Joana G; Streiff, Natalie; Laubscher, Dominik; Nanni, Paolo; Mamchaoui, Kamel; Santoro, Raffaella; Schäfer, Beat W (2016). Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma. Journal of Clinical Investigation, 126(11):4237-4249.

Martello, Rita; Leutert, Mario; Jungmichel, Stephanie; Bilan, Vera; Larsen, Sara C; Young, Clifford; Hottiger, Michael O; Nielsen, Michael L (2016). Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue. Nature Communications, 7:12917.

Léger, Karolin; Hopp, Ann-Katrin; Fey, Monika; Hottiger, Michael O (2016). ARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells. Cell Cycle, 15(15):2042-2052.

Leutert, Mario; Pedrioli, Deena M Leslie; Hottiger, Michael O (2016). Identification of PARP-specific ADP-ribosylation targets reveals a regulatory function for ADP-ribosylation in transcription elongation. Molecular Cell, 63(2):181-183.

Hofer, Alexandre; Marques, Elia; Kieliger, Nicole; Gatter, Sarah-Kirsten N; Jordi, Sara; Ferrari, Elena; Hofmann, Manuel; Fitzpatrick, Teresa B; Hottiger, Michael O; Jessen, Henning J (2016). Chemoselective Dimerization of Phosphates. Organic Letters, 18(13):3222-3225.

Furrer, Antonia; Hottiger, Michael O; Valaperti, Alan (2016). Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation. Molecular Immunology, 74:47-58.

Watanabe, Yukihide; Papoutsoglou, Panagiotis; Maturi, Varun; Tsubakihara, Yutaro; Hottiger, Michael O; Heldin, Carl-Henrik; Moustakas, Aristidis (2016). Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation. Journal of Biological Chemistry, 291(24):12706-12723.

Hottiger, Michael O (2016). SnapShot: ADP-Ribosylation Signaling. Molecular Cell, 62(3):472.

Kresoja-Rakic, Jelena; Kapaklikaya, Esra; Ziltener, Gabriela; Dalcher, Damian; Santoro, Raffaella; Christensen, Brock C; Johnson, Kevin C; Schwaller, Beat; Weder, Walter; Stahel, Rolf A; Felley-Bosco, Emanuela (2016). Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells. OncoTarget, 7(16):21272-21286.

Aguzzi, Adriano; Altmeyer, Matthias (2016). Phase separation: linking cellular compartmentalization to disease. Trends in Cell Biology, 26(7):547-558.

Wang, C; Qu, C; Alippe, Y; Bonar, S L; Civitelli, R; Abu-Amer, Y; Hottiger, M O; Mbalaviele, G (2016). Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation. Cell Death and Disease, 7(3):e2153.

Schuster, Sabine; Roessler, Claudia; Meleshin, Marat; Zimmermann, Philipp; Simic, Zeljko; Kambach, Christian; Schiene-Fischer, Cordelia; Steegborn, Clemens; Hottiger, Michael O; Schutkowski, Mike (2016). A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions. Scientific Reports, 6:22643.

Becker, Annette; Zhang, Peng; Allmann, Lena; Meilinger, Daniela; Bertulat, Bianca; Eck, Daniel; Hofstaetter, Maria; Bartolomei, Giody; Hottiger, Michael O; Schreiber, Valérie; Leonhardt, Heinrich; Cardoso, M. Cristina (2016). Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure. Journal of Biological Chemistry, 291(10):4873-4881.

Bartolomei, Giody; Leutert, Mario; Manzo, Massimiliano; Baubec, Tuncay; Hottiger, Michael O (2016). Analysis of chromatin ADP-Ribosylation at the genome-wide level and at specific loci by ADPr-ChAP. Molecular Cell, 61(3):474-485.

Robaszkiewicz, Agnieszka; Qu, Chao; Wisnik, Ewelina; Ploszaj, Tomasz; Mirsaidi, Ali; Kunze, Friedrich A; Richards, Peter J; Cinelli, Paolo; Mbalaviele, Gabriel; Hottiger, Michael O (2016). ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β. Scientific Reports, 6:21131.

Ochs, Fena; Somyajit, Kumar; Altmeyer, Matthias; Rask, Maj-Britt; Lukas, Jiri; Lukas, Claudia (2016). 53BP1 fosters fidelity of homology-directed DNA repair. Nature Structural & Molecular Biology, 23(8):714-721.

Duda, Heike; Arter, Meret; Gloggnitzer, Jiradet; Teloni, Federico; Wild, Philipp; Blanco, Miguel G; Altmeyer, Matthias; Matos, Joao (2016). A mechanism for controlled breakage of under-replicated chromosomes during mitosis. Developmental Cell, 39(6):740-755.

Ahuja, Akshay K; Jodkowska, Karolina; Teloni, Federico; Bizard, Anna H; Zellweger, Ralph; Herrador, Raquel; Ortega, Sagrario; Hickson, Ian D; Altmeyer, Matthias; Mendez, Juan; Lopes, Massimo (2016). A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nature Communications, 7:10660-10671.

Barrow, Joeva J; Balsa, Eduardo; Verdeguer, Francisco; Tavares, Clint D J; Soustek, Meghan S; Hollingsworth, Louis R; Jedrychowski, Mark; Vogel, Rutger; Paulo, Joao A; Smeitink, Jan; Gygi, Steve P; Doench, John; Root, David E; Puigserver, Pere (2016). Bromodomain inhibitors correct bioenergetic deficiency caused by mitochondrial disease complex I mutations. Molecular Cell, 64(1):163-175.

Leone, Sergio; Santoro, Raffaella (2016). Challenges in the analysis of long noncoding RNA functionality. FEBS letters, 590(15):2342-2353.

Ma, Bin; Hottiger, Michael O (2016). Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation. Frontiers in Immunology, 7:378.

Hiragami-Hamada, Kyoko; Soeroes, Szabolcs; Nikolov, Miroslav; Wilkins, Bryan; Kreuz, Sarah; Chen, Carol; De La Rosa-Velázquez, Inti A; Zenn, Hans Michael; Kost, Nils; Pohl, Wiebke; Chernev, Aleksandar; Schwarzer, Dirk; Jenuwein, Thomas; Lorincz, Matthew; Zimmermann, Bastian; Walla, Peter Jomo; Neumann, Heinz; Baubec, Tuncay; Urlaub, Henning; Fischle, Wolfgang (2016). Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin. Nature Communications, 7:11310.

Pellegrino, Stefania; Altmeyer, Matthias (2016). Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress. Frontiers in Genetics:7:63.

Andersson, Anneli; Bluwstein, Andrej; Kumar, Nitin; Teloni, Federico; Traenkle, Jens; Baudis, Michael; Altmeyer, Matthias; Hottiger, Michael O (2016). PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation. Nucleic Acids Research, 44(16):7630-7645.

Becker, Annette; Zhang, Peng; Allmann, Lena; Meilinger, Daniela; Bertulat, Bianca; Eck, Daniel; Hofstaetter, Maria; Bartolomei, Giody; Hottiger, Michael O; Schreiber, Valérie; Leonhardt, Heinrich; Cardoso, M. Cristina (2016). Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure. Journal of Biological Chemistry, 291(17):9382.

Rosenthal, Florian; Nanni, Paolo; Barkow-Oesterreicher, Simon; Hottiger, Michael O (2015). Optimization of LTQ-Orbitrap mass spectrometer parameters for the identification of ADP-ribosylation sites. Journal of Proteome Research, 14(9):4072-4079.

Shakhova, Olga; Cheng, Phil; Mishra, Pravin J; Zingg, Daniel; Schaefer, Simon M; Debbache, Julien; Häusel, Jessica; Matter, Claudia; Guo, Theresa; Davis, Sean; Meltzer, Paul; Mihic-Probst, Daniela; Moch, Holger; Wegner, Michael; Merlino, Glenn; Levesque, Mitchell P; Dummer, Reinhard; Santoro, Raffaella; Cinelli, Paolo; Sommer, Lukas (2015). Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma. PLoS Genetics, 11(1):e1004877.

Zingg, Daniel; Debbache, Julien; Schaefer, Simon M; Tuncer, Eylul; Frommel, Sandra C; Cheng, Phil; Arenas-Ramirez, Natalia; Haeusel, Jessica; Zhang, Yudong; Bonalli, Mario; McCabe, Michael T; Creasy, Caretha L; Levesque, Mitchell P; Boyman, Onur; Santoro, Raffaella; Shakhova, Olga; Dummer, Reinhard; Sommer, Lukas (2015). The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors. Nature Communications, 6:6051.

Gu, Lei; Frommel, Sandra C; Oakes, Christopher C; Simon, Ronald; Grupp, Katharina; Gerig, Cristina Y; Bär, Dominik; Robinson, Mark D; Baer, Constance; Weiss, Melanie; Gu, Zuguang; Schapira, Matthieu; Kuner, Ruprecht; Sültmann, Holger; Provenzano, Maurizio; Yaspo, Marie-Laure; Brors, Benedikt; Korbel, Jan; Schlomm, Thorsten; Sauter, Guido; Eils, Roland; Plass, Christoph; Santoro, Raffaella (2015). BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence. Nature Genetics, 47(1):22-30.

Lehmann, Mareike; Pirinen, Eija; Mirsaidi, Ali; Kunze, Friedrich A; Richards, Peter J; Auwerx, Johan; Hottiger, Michael O (2015). ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange. Nucleic Acids Research, 43(1):129-142.

Cheng, Phil F; Shakhova, Olga; Widmer, Daniel S; Eichhoff, Ossia M; Zingg, Daniel; Frommel, Sandra C; Belloni, Benedetta; Raaijmakers, Marieke Ig; Goldinger, Simone M; Santoro, Raffaella; Hemmi, Silvio; Sommer, Lukas; Dummer, Reinhard; Levesque, Mitchell P (2015). Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma. Genome Biology, 16:42.

Miranda, Melroy X; van Tits, Lambertus J; Lohmann, Christine; Arsiwala, Tasneem; Winnik, Stephan; Tailleux, Anne; Stein, Sokrates; Gomes, Ana P; Suri, Vipin; Ellis, James L; Lutz, Thomas A; Hottiger, Michael O; Sinclair, David A; Auwerx, Johan; Schoonjans, Kristina; Staels, Bart; Lüscher, Thomas F; Matter, Christian M (2015). The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. European Heart Journal, 36(1):51-59.

Savić, Nataša; Bär, Dominik; Leone, Sergio; Frommel, Sandra C; Weber, Fabienne A; Vollenweider, Eva; Ferrari, Elena; Ziegler, Urs; Kaech, Andres; Shakhova, Olga; Cinelli, Paolo; Santoro, Raffaella (2014). lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs. Cell Stem Cell, 15(6):720-734.

Ryu, Dongryeol; Jo, Young Suk; Lo Sasso, Giuseppe; Stein, Sokrates; Zhang, Hongbo; Perino, Alessia; Lee, Jung Uee; Zeviani, Massimo; Romand, Raymond; Hottiger, Michael O; Schoonjans, Kristina; Auwerx, Johan (2014). A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. Cell Metabolism, 20(5):856-869.

Larsen, Dorthe H; Hari, Flurina; Clapperton, Julie A; Gwerder, Myriam; Gutsche, Katrin; Altmeyer, Matthias; Jungmichel, Stephanie; Toledo, Luis I; Fink, Daniel; Rask, Maj-Britt; Grøfte, Merete; Lukas, Claudia; Nielsen, Michael L; Smerdon, Stephen J; Lukas, Jiri; Stucki, Manuel (2014). The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. Nature Cell Biology, 16(8):792-803.

Pirinen, Eija; Cantó, Carles; Jo, Young Suk; Morato, Laia; Zhang, Hongbo; Menzies, Keir J; Williams, Evan G; Mouchiroud, Laurent; Moullan, Norman; Hagberg, Carolina; Li, Wei; Timmers, Silvie; Imhof, Ralph; Verbeek, Jef; Pujol, Aurora; van Loon, Barbara; Viscomi, Carlo; Zeviani, Massimo; Schrauwen, Patrick; Sauve, Anthony A; Schoonjans, Kristina; Auwerx, Johan (2014). Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metabolism, 19(6):1034-1041.

Lehmann, Mareike. ARTD1 and poly-ADP-ribosylation enhance PPARγ-dependent adipogenesis in vitro and in vivo. 2014, University of Zurich, Faculty of Science.

Léger, Karolin; Bär, Dominik; Savić, Nataša; Santoro, Raffaella; Hottiger, Michael O (2014). ARTD2 activity is stimulated by RNA. Nucleic Acids Research, 42(8):5072-5082.

Santoro, Raffaella (2014). Analysis of chromatin composition of repetitive sequences: the ChIP-Chop assay. In: Santoro, Raffaella. Functional Analysis of DNA and Chromatin. University of Zurich, Switzerland: Humana Press (Springer), 319-28.

Grosse, Nicole; van Loon, Barbara; Rohrer Bley, Carla (2014). DNA damage response and DNA repair - dog as a model? BMC Cancer, 14:203.

Bachmann, Samia B; Frommel, Sandra C; Camicia, Rosalba; Winkler, Hans C; Santoro, Raffaella; Hassa, Paul O (2014). DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. Molecular Cancer, 13:125.

Dahl, Markus; Maturi, Varun; Lönn, Peter; Papoutsoglou, Panagiotis; Zieba, Agata; Vanlandewijck, Michael; van der Heide, Lars P; Watanabe, Yukihide; Söderberg, Ola; Hottiger, Michael O; Heldin, Carl-Henrik; Moustakas, Aristidis (2014). Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling. PLoS ONE, 9(8):e103651.

Furrer, Antonia; van Loon, Barbara (2014). Handling the 3-methylcytosine lesion by six human DNA polymerases members of the B-, X- and Y-families. Nucleic Acids Research, 42(1):553-566.

Rosenthal, Florian; Hottiger, Michael O (2014). Identification of ADP-ribosylated peptides and ADP-ribose acceptor sites. Frontiers in Bioscience, 19:1041-1056.

Bachmann, Samia Beatrice. LinkFunctional roles of DTX3L and ARTD9 in prostate cancer. 2014, University of Zurich, Vetsuisse Faculty.

Lo Sasso, Giuseppe; Ryu, Dongryeol; Mouchiroud, Laurent; Fernando, Samodha C; Anderson, Christopher L; Katsyuba, Elena; Piersigilli, Alessandra; Hottiger, Michael O; Schoonjans, Kristina; Auwerx, Johan (2014). Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. PLoS ONE, 9(7):e102495.

van Loon, Barbara; Samson, Leona D (2013). Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB). DNA repair, 12(3):177-187.

Weber, Fabienne A; Bartolomei, Giody; Hottiger, Michael O; Cinelli, Paolo (2013). Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation. Stem Cells, 31(11):2364-2373.

Rosenthal, Florian. Biochemical and mass spectrometric characterization of protein ADP-ribosylation. 2013, University of Zurich, Faculty of Science.

Kassner, Ingrid; Barandun, Marc; Fey, Monika; Rosenthal, Florian; Hottiger, Michael O (2013). Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4. Epigenetics & Chromatin, 6:1.

Maga, Giovanni; Crespan, Emmanuele; Markkanen, Enni; Imhof, Ralph; Furrer, Antonia; Villani, Giuseppe; Hübscher, Ulrich; van Loon, Barbara (2013). DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass. Proceedings of the National Academy of Sciences of the United States of America, 110(47):18850-18855.

Léger, Karolin. Distinct functions of ARTD1 and ARTD2 in cell cycle entry and the genotoxic stress response. 2013, University of Zurich, Faculty of Science.

Simonelli, Valeria; Camerini, Serena; Mazzei, Filomena; Van Loon, Barbara; Allione, Alessandra; D'Errico, Mariarosaria; Barone, Flavia; Minoprio, Anna; Ricceri, Fulvio; Guarrera, Simonetta; Russo, Alessia; Dalhus, Bjørn; Crescenzi, Marco; Hübscher, Ulrich; Bjørås, Magnar; Matullo, Giuseppe; Dogliotti, Eugenia (2013). Genotype-phenotype analysis of S326C OGG1 polymorphism: a risk factor for oxidative pathologies. Free Radical Biology & Medicine, 63:401-409.

Crespan, Emmanuele; Pasi, Emanuela; Imoto, Shuhei; Hübscher, Ulrich; Greenberg, Marc M; Maga, Giovanni (2013). Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen. ACS Chemical Biology, 8(2):336-344.

Quero, Lilian; Klawitter, Marina; Schmaus, Anja; Rothley, Melanie; Sleeman, Jonathan; Tiaden, André N; Klasen, Juergen; Boos, Norbert; Hottiger, Michael O; Wuertz, Karin; Richards, Peter (2013). Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways. Arthritis Research & Therapy, 15(4):R94.

Markkanen, Enni; Dorn, Julia; Hübscher, Ulrich (2013). MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA. Frontiers in Genetics:4:18.

Rosenthal, Florian; Feijs, Karla L H; Frugier, Emilie; Bonalli, Mario; Forst, Alexandra H; Imhof, Ralph; Winkler, Hans C; Fischer, David; Caflisch, Amedeo; Hassa, Paul O; Lüscher, Bernhard; Hottiger, Michael O (2013). Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Nature Structural & Molecular Biology, 20(4):502-507.

Dianov, Grigory L; Hübscher, Ulrich (2013). Mammalian base excision repair: the forgotten archangel. Nucleic Acids Research, 41(6):3483-3490.

Lindgren, Anders E G; Karlberg, Tobias; Thorsell, Ann-Gerd; Hesse, Mareike; Spjut, Sara; Ekblad, Torun; Andersson, C David; Pinto, Ana Filipa; Weigelt, Johan; Hottiger, Michael O; Linusson, Anna; Elofsson, Mikael; Schüler, Herwig (2013). PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chemical Biology, 8(8):1698-1703.

Kraus, W Lee; Hottiger, Michael O (2013). PARP-1 and gene regulation: progress and puzzles. Molecular Aspects of Medicine, 34(6):1109-1123.

Bluwstein, A; Kumar, N; Léger, K; Traenkle, J; van Oostrum, J; Rehrauer, H; Baudis, M; Hottiger, M O (2013). PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts. Cell Death and Disease, 4:e498.

Jungmichel, Stephanie; Rosenthal, Florian; Altmeyer, Matthias; Lukas, Jiri; Hottiger, Michael O; Nielsen, Michael L (2013). Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. Molecular Cell, 52(2):272-285.

Kassner, Ingrid; Andersson, Anneli; Fey, Monika; Tomas, Martin; Ferrando-May, Elisa; Hottiger, Michael O (2013). SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress. Open Biology, 3(10):120173.

Zucca, Elisa; Bertoletti, Federica; Wimmer, Ursula; Ferrari, Elena; Mazzini, Giuliano; Khoronenkova, Svetlana; Grosse, Nicole; van Loon, Barbara; Dianov, Grigory; Hübscher, Ulrich; Maga, Giovanni (2013). Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint. Nucleic Acids Research, 41(1):229-241.

Bluwstein, Andrej. Systemic analysis of the radiation and oxidation induced cellular signaling response. 2013, University of Zurich, Faculty of Science.

Ziesché, Elisabeth; Kettner-Buhrow, Daniela; Weber, Axel; Wittwer, Tobias; Jurida, Liane; Soelch, Johanna; Müller, Helmut; Newel, Doris; Kronich, Petra; Schneider, Heike; Dittrich-Breiholz, Oliver; Bhaskara, Srividya; Hiebert, Scott W; Hottiger, Michael O; Li, Haiying; Burstein, Ezra; Schmitz, M Lienhard; Kracht, Michael (2013). The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. Nucleic Acids Research, 41(1):90-109.

Dantzer, Françoise; Santoro, Raffaella (2013). The expanding role of PARPs in the establishment and maintenance of heterochromatin. FEBS Journal, 280(15):3508-3018.

Aria, Valentina; De Felice, Mariarita; Di Perna, Roberta; Uno, Shuji; Masai, Hisao; Syväoja, Juhani E; van Loon, Barbara; Hübscher, Ulrich; Pisani, Francesca M (2013). The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity. Journal of Biological Chemistry, 288(18):12742-12752.

Eisele, Petra S; Salatino, Silvia; Sobek, Jens; Hottiger, Michael O; Handschin, Christoph (2013). The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. Journal of Biological Chemistry, 288(4):2246-2260.

Guetg, Claudio. Role of non-coding RNA in epigenetic inheritance of ribosomal RNA gene silencing. 2012, University of Zurich, Faculty of Science.

Raffaella, Santoro. Evolutionary diversity and developmental regulation of gene dosage compensation i XX female and XY male animals. 2012, University of Zurich, Vetsuisse Faculty.

Razumenko, Mikhailo. Oxygen-dependent regulation of base excision repair and its role in oxidative stress tolerance and tumor therapy resistance. 2012, University of Zurich, Faculty of Science.

Kassner, Ingrid. Regulation of ARTD1 by SET7/9 - dependent Methylation. 2012, University of Zurich, Faculty of Science.

Crespan, Emmanuele; Maga, Giovanni; Hübscher, Ulrich (2012). A new proofreading mechanism for lesion bypass by DNA polymerase-λ. EMBO Reports, 13(1):68-74.

Markkanen, Enni Emilia; Castrec, Benoit; Villani, Giuseppe; Hübscher, Ulrich (2012). A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesions. Proceedings of the National Academy of Sciences of the United States of America, 109(50):20401-20406.

Erener, Süheda; Mirsaidi, Ali; Hesse, Mareike; Tiaden, André N; Ellingsgaard, Helga; Kostadinova, Radina; Donath, Marc Y; Richards, Peter J; Hottiger, Michael O (2012). ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation. FASEB Journal, 26(6):2631-2638.

Bosshard, Matthias; Markkanen, Enni; van Loon, Barbara (2012). Base excision repair in physiology and pathology of the central nervous system. International Journal of Molecular Sciences, 13(12):16172-16222.

Guetg, Claudio; Santoro, Raffaella (2012). Formation of nuclear heterochromatin: the nucleolar point of view. Epigenetics, 7(8):811-814.

Erener, Süheda; Pétrilli, Virginie; Kassner, Ingrid; Minotti, Roberta; Castillo, Rosa; Santoro, Raffaella; Hassa, Paul O; Tschopp, Jürg; Hottiger, Michael O (2012). Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes. Molecular Cell, 46(2):200-211.

Guetg, Claudio; Scheifele, Fabian; Rosenthal, Florian; Hottiger, Michael O; Santoro, Raffaella (2012). Inheritance of silent rDNA chromatin is mediated by PARP1 via noncoding RNA. Molecular Cell, 45(6):790-800.

Kanagaraj, Radhakrishnan; Parasuraman, Prasanna; Mihaljevic, Boris; van Loon, Barbara; Burdova, Kamila; König, Christiane; Furrer, Antonia; Bohr, Vilhelm A; Hübscher, Ulrich; Janscak, Pavel (2012). Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage. Nucleic Acids Research, 40(17):8449-8459.

Crespan, Emmanuele; Czabany, Tibor; Maga, Giovanni; Hübscher, Ulrich (2012). Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences. Nucleic Acids Research, 40(12):5577-5590.

Guetg, Claudio; Santoro, Raffaella (2012). Noncoding RNAs link PARP1 to heterochromatin. Cell Cycle, 11(12):2217-2218.

Erener, Süheda; Hesse, Mareike; Kostadinova, Radina; Hottiger, Michael O (2012). Poly(ADP-ribose)polymerase-1 (PARP1) controls adipogenic gene expression and adipocyte function. Molecular Endocrinology, 26(1):79-86.

Markkanen, E; van Loon, B; Ferrari, E; Parsons, J L; Dianov, G L; Hübscher, U (2012). Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 109(2):437-442.

Markkanen, Enni; Hübscher, Ulrich; van Loon, Barbara (2012). Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem. Cell Cycle, 11(6):1070-1075.

Ali, Ammar A E; Timinszky, Gyula; Arribas-Bosacoma, Raquel; Kozlowski, Marek; Hassa, Paul O; Hassler, Markus; Ladurner, Andreas G; Pearl, Laurence H; Oliver, Antony W (2012). The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Nature Structural & Molecular Biology, 19(7):685-692.

Markkanen, Enni Emilia. Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of posttranslational modifications. 2011, University of Zurich, Faculty of Science.

Hottiger, M O (2011). ADP-ribosylation of histones by ARTD1: an additional module of the histone code? FEBS Letters, 585(11):1595-1599.

Hübscher, U; Maga, G (2011). DNA replication and repair bypass machines. Current Opinion in Chemical Biology, 15(5):627-635.

Eger, S; Castrec, B; Hübscher, U; Scheffner, M; Rubini, M; Marx, A (2011). Generation of a mono-ubiquitinated PCNA mimic by click chemistry. ChemBioChem, 12(18):2807-2812.

Chen, Y; Wang, H; Yoon, S O; Xu, X; Hottiger, M O; Svaren, J; Nave, K A; Kim, H A; Olson, E N; Lu, Q R (2011). HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination. Nature Neuroscience, 14(4):437-441.

Messner, S; Hottiger, M O (2011). Histone ADP-ribosylation in DNA repair, replication and transcription. Trends in Cell Biology, 21(9):534-542.

Villani, G; Hübscher, U; Gironis, N; Parkkinen, S; Pospiech, H; Shevelev, I; di Cicco, G; Markkanen, E; Syväoja, J E; Tanguy Le Gac, N (2011). In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta. Journal of Biological Chemistry, 286(37):32094-32104.

Hottiger, M O (2011). Mehr als nur synthetische Lethalität mit BRCA1/2. Vet-MedReport, 38(V4):4.

Valovka, T; Hottiger, M O (2011). P65 controls NF-κB activity by regulating cellular localization of IκBβ. Biochemical Journal, 434(2):253-263.

Gebhard, C; Stähli, B E; Shi, Y; Camici, G G; Akhmedov, A; Hoegger, L; Lohmann, C; Matter, C M; Hassa, P O; Hottiger, M O; Malinski, T; Lüscher, T F; Tanner, F C (2011). Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction. Biochemical and Biophysical Research Communications (BBRC), 414(4):641-646.

Hottiger, M O; Boothby, M; Koch-Nolte, F; Lüscher, B; Martin, N M B; Plummer, R; Wang, Z Q; Ziegler, M (2011). Progress in the function and regulation of ADP-Ribosylation. Science Signaling, 4(174):mr5.

Santoro, R (2011). The epigenetics of the nucleolus: structure and function of active and silent ribosomal RNA genes. In: Olson, M O J. The Nucleolus. New York [etc.]: Springer, 57-82.

Markkanen, E; van Loon, B; Ferrari, E; Hübscher, U (2011). Ubiquitylation of DNA polymerase λ. FEBS Letters, 585(18):2826-2830.

Notz, C. Zur Wirksamkeit einer komplementärmedizinischen (homöopathischen) Mastitisprophylaxe zum Trockenstellen und zum Abkalben beim Rind. 2011, University of Zurich, Vetsuisse Faculty.

Santoro, R; Schmitz, K M; Sandoval, J; Grummt, I (2010). Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans. EMBO Reports, (11):52-58.

Asher, G; Reinke, H; Altmeyer, M; Gutierrez-Arcelus, M; Hottiger, M O; Schibler, U (2010). Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell, 142(6):943-953.

Altmeyer, M; Barthel, M; Eberhard, M; Rehrauer, H; Hardt, W D; Hottiger, M O (2010). Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation. Infection and Immunity, 78(8):3420-3431.

Toller, I M; Altmeyer, M; Kohler, E; Hottiger, M O; Müller, A (2010). Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia. Cancer Research, 70(14):5912-5922.

Messner, S; Altmeyer, M; Zhao, H; Pozivil, A; Roschitzki, B; Gehrig, P; Rutishauser, D; Huang, D; Caflisch, A; Hottiger, M O (2010). PARP1 ADP-ribosylates lysine residues of the core histone tails. Nucleic Acids Research, 38(19):6350-6362.

Hari, F J; Spycher, Christoph; Jungmichel, S; Pavic, L; Stucki, M (2010). A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin. EMBO Reports, 11(5):387-392.

Rothgiesser, K M; Fey, M; Hottiger, M O (2010). Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression. BMC Genomics, 11:22.

Parasuraman, P. Artificially engineered and WRN protein bridged DNA polymerase lambda leads to improved translesion synthesis. 2010, University of Zurich, Faculty of Science.

DNA Polymerases Discovery,Characterizations and Functions in Cellular DNA Transactions. Edited by: Hübscher, U; Spadari, S; Villani, G; Maga, G (2010). Singapure, Singapure: World Scientific Publishing Co. PTE. Ltd..

Locatelli, G A; Pospiech, H; Tanguy Le Gac, N; van Loon, B; Hubscher, U; Parkkinen, S; Syväoja, J E; Villani, G (2010). Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase in the presence of replication protein A and proliferating-cell nuclear antigen. Biochemical Journal, 429(3):573-582.

van Loon, Barbara. Faithful DNA repair of 7,8-dihydro-8oxo-guanine lesions by human enzymes. 2010, University of Zurich, Faculty of Science.

Furter, L M. Geopathische Störzonen und ihre Auswirkungen auf die Gesundheit von Milchkühen. 2010, University of Zurich, Vetsuisse Faculty.

Pozivil, A U. Identification of lysine residues as ADP-ribose acceptor sites in core histone tails. 2010, University of Zurich, Vetsuisse Faculty.

Bosshard, M L. Involvement of the AAA ATPase p97/VCP in DNA metabolism. 2010, University of Zurich, Vetsuisse Faculty.

Jungmichel, S; Stucki, M (2010). MDC1: The art of keeping things in focus. Chromosoma, 119(4):337-349.

Jungmichel, S. Mechanism of DNA damage-induced MDC1 dimerization. 2010, University of Zurich, Faculty of Science.

Altmeyer, M. Mechanism of poly(ADP-Ribose) formation and the role of PARP1 in inflammation. 2010, University of Zurich, Faculty of Science.

Osorio, F G; Varela, I; Lara, E; Puente, X S; Espada, J; Santoro, R; Freije, J M P; Fraga, M F; López-Otín, C (2010). Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease. Aging Cell, 9(6):947-957.

van Loon, B; Markkanen, E; Hübscher, U (2010). Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine. DNA Repair, 9(6):604-616.

Erener, S. Regulation of inflammation and glucose homeostasis by poly(ADP-ribose) polymerase 1 (PARP). 2010, University of Zurich, Faculty of Science.

Messner, S. Regulation of poly(ADP-ribose) polymerase 1 by sumoylation and investigation of histone poly(ADP-ribosyl)ation. 2010, University of Zurich, Faculty of Science.

Rothgiesser, K M; Erener, S; Waibel, S; Lüscher, B; Hottiger, M O (2010). SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310. Journal of Cell Science, 123(Pt 24):4251-4258.

Guetg, C; Lienemann, P; Sirri, V; Grummt, I; Hernandez-Verdun, D; Hottiger, M O; Fussenegger, M; Santoro, R (2010). The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. The EMBO Journal, 29(13):2135-2146.

Larsen, D H; Poinsignon, C; Gudjonsson, T; Dinant, C; Payne, M R; Hari, F J; Danielsen, J M R; Menard, P; Sand, J C; Stucki, M; Lukas, C; Bartek, J; Andersen, J S; Lukas, J (2010). The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. Journal of Cell Biology, 190(5):731-740.

Hottiger, M O; Hassa, P O; Lüscher, B; Schüler, H; Koch-Nolte, F (2010). Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends in Biochemical Sciences, 35(4):208-219.

Poveda, L; Hottiger, M; Boos, N; Wuertz, K (2009). Peroxynitrite induces gene expression in intervertebral disc cells. Spine, 34(11):1127-1133.

Dietschy, T; Shevelev, I; Pena-Diaz, J; Hühn, D; Kuenzle, S; Mak, R; Miah, M F; Hess, D; Fey, M; Hottiger, M O; Janscak, P; Stagljar, I (2009). p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization. Journal of Cell Science, 122(Pt. 8):1258-1267.

Chapman, S W; Metzger, N; Grest, P; Feige, K; von Rechenberg, B; Auer, J A; Hottiger, M O (2009). Isolation, establishment, and characterization of ex vivo equine melanoma cell cultures. In Vitro Cellular & Developmental Biology - Animal, 45(3-4):152-162.

Hübscher, U (2009). DNA Replication Fork Proteins. In: Vengrova, S; Dalgaard, J Z. DNA Replication Methods and Protocols. Totowa, NJ , USA: Humana Press.

Timinszky, G; Till, S; Hassa, P O; Hothorn, M; Kustatscher, G; Nijmeijer, B; Colombelli, J; Altmeyer, M; Stelzer, E H K; Scheffzek, K; Hottiger, M O; Ladurner, A G (2009). A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nature Structural and Molecular Biology, 16(9):923-929.

van Loon, B; Hübscher, U (2009). An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(43):18201-18206.

Jayne, S; Rothgiesser, K M; Hottiger, M O (2009). CARM1 but not its enzymatic activity is required for transcriptional coactivation of NF-kappaB-dependent gene expression. Journal of Molecular Biology, 394(3):485-495.

Hothorn, M; Neumann, H; Lenherr, E D; Wehner, M; Rybin, V; Hassa, P O; Uttenweiler, A; Reinhardt, M; Schmidt, A; Seiler, J; Ladurner, A G; Herrmann, C; Scheffzek, K; Mayer, A (2009). Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science, 324(5926):513-516.

Buob, R. DNA repair mechanism in the radioresistant bacterium Deinococcus radiodurans and in human. 2009, University of Zurich, Faculty of Science.

Stucki, M (2009). Histone H2A.X Tyr142 phosphorylation: a novel sWItCH for apoptosis? DNA Repair, 8(7):873-876.

Spycher, C. Identification and functional characterization of novel phosphorylation sites in MDC1. 2009, University of Zurich, Faculty of Science.

Clemenz, C. Interface between science and art: can art predict functions of enzymes? 2009, University of Zurich, Vetsuisse Faculty.

Bonalli, Mario-Emanuel. Investigation on phosphospecitic interactions in the DNA damage response. 2009, University of Zurich, Vetsuisse Faculty.

Bäckert, S. Involvement of PARP1 in NF-kB-dependent gene expression during the cell cycle. 2009, University of Zurich, Vetsuisse Faculty.

van Loon, B; Ferrari, E; Hübscher, U (2009). Isolation of recombinant DNA elongation proteins. Methods in Molecular Biology, 521:345-359.

Altmeyer, M; Messner, S; Hassa, P O; Fey, M; Hottiger, M O (2009). Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Research, 37(11):3723-3738.

Altmeyer, M; Hottiger, M O (2009). Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging, 1(5):458-469.

Rothgiesser, K. Role of p65 acetylation on NF-kB-dependent gene expression. 2009, University of Zurich, Faculty of Science.

Rajamohan, S B; Pillai, V B; Gupta, M; Sundaresan, N R; Birukov, K G; Samant, S; Hottiger, M O; Gupta, M P (2009). SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Molecular and Cellular Biology, 29(15):4116-4129.

Messner, S; Schuermann, D; Altmeyer, M; Kassner, I; Schmidt, D; Schär, P; Müller, S; Hottiger, M O (2009). Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function. FASEB Journal, 23(11):3978-3989.

Maga, G; van Loon, B; Crespan, E; Villani, G; Hübscher, U (2009). The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1. Journal of Biological Chemistry, 284(21):14267-1475.

Stucki, M. The discovery of MDC1 and its role in the DNA damage response. 2009, University of Zurich, Vetsuisse Faculty.

Hassa, P O (2009). The molecular "Jekyll and Hyde" duality of PARP1 in cell death and cell survival. Frontiers in Bioscience, 14:72-111.

Haenni, S S; Altmeyer, M; Hassa, P O; Valovka, T; Fey, M; Hottiger, M O (2008). Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS. BMC Cell Biology, 9:39.

Amoroso, A; Crespan, E; Wimmer, U; Hubscher, U; Maga, G (2008). DNA Polymerases and Oxidative Damage: Friends or Foes? Current Molecular Pharmacology, 1(2):162-170.

Maga, G; Hübscher, U (2008). Repair and Translesion DNA Polymerases as Anticancer Drug Targets. Anti-Cancer Agents in Medicinal Chemistry, 8(4):431-447.

Kamau Chapman, S; Hassa, P; Koch, S; von Rechenberg, Brigitte; Hofmann-Amtenbrink, M; Steitz, B; Petri-Fink, A; Hofmann, H; Hottiger, M O (2008). Application of pulsed magnetic field enhances non-viral gene delivery in primary cells from different origins. Journal of Magnetism and Magnetic Materials, 320(8):1517-1527.

Hassa, P O; Covic, M; Bedford, M T; Hottiger, M O (2008). Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. Journal of Molecular Biology, 377(3):668-678.

Buerki, C; Rothgiesser, K M; Valovka, T; Owen, H R; Rehrauer, H; Fey, M; Lane, W S; Hottiger, M O (2008). Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Research, 36(5):1665-1680.

Belousova, E A; Crespan, E; Lebedeva, N A; Rechunova, N J; Hübscher, U; Maga, G; Lavrik, O I (2008). Photoreactive DNA Probes as a Tool for Studying the Translesion Synthesis System in Mammalian Cell Extracts. Medicinal Chemistry, 4(2):155-162.

Elser, M; Borsig, L; Hassa, P O; Erener, S; Messner, S; Valovka, T; Keller, S; Gassmann, M; Hottiger, M O (2008). Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression. Molecular Cancer Research, 6(2):282-290.

Hassa, P O; Hottiger, M O (2008). The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Frontiers in Bioscience, 13:3046-3082.

Spycher, C; Miller, E S; Townsend, K; Pavic, L; Morrice, N A; Janscak, P; Stewart, G S; Stucki, M (2008). Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. Journal of Cell Biology, 181(2):227-240.

Wimmer, U; Ferrari, E; Hunziker, P; Hübscher, U (2008). Control of DNA polymerase lambda stability by phosphorylation and ubiquitination during the cell cycle. EMBO Reports, 9(10):1027-1033.

Blasius, M; Sommer, S; Hubscher, U (2008). Deinococcus radiodurans: What Belongs to the Survival Kit? Critical Reviews in Biochemistry and Molecular Biology, 43(3):221-238.

Haenni, S S; Hassa, P O; Altmeyer, M; Fey, M; Imhof, R; Hottiger, M O (2008). Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation. International Journal of Biochemistry & Cell Biology, 40(10):2274-2283.

Hübscher, Ulrich (2008). Obituary; Arthur Kornberg (1918-2007). Angewandte Chemie Internationale Edition, 47(7):1172.

von Lukowicz, T; Hassa, P O; Lohmann, C; Borén, J; Braunersreuther, V; Mach, F; Odermatt, B; Gersbach, M; Camici, G G; Stähli, B E; Tanner, F C; Hottiger, M O; Lüscher, T F; Matter, C M (2008). PARP1 is required for adhesion molecule expression in atherogenesis. Cardiovascular Research, 78(1):158-166.

Poveda, L. Pathophysiological Pro-Inflammatory and Pain-Inducing Mechanisms in Degenerative Intervertebral Discs. 2008, University of Zurich, Faculty of Science.

Hänni, S. Regulation of PARP-1 and PARP-2 by lysine acetylation. 2008, University of Zurich, Faculty of Science.

Crespan, M; Cancio, E; Spadari, S; Hübscher, U; Maga, G (2008). Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the “primer grip” region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. Biochemical Pharmacology, 76(2):156-168.

Kleine, H; Poreba, E; Lesniewicz, K; Hassa, P O; Hottiger, M O; Litchfield, D W; Shilton, B H; Lüscher, B (2008). Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. Molecular Cell, 32(1):57-69.

Selak, N; Bachrati, C Z; Shevelev, I; Dietschy, T; van Loon, B; Jacob, A; Hübscher, U; Hoheisel, J D; Hickson, I D; Stagljar, I (2008). The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta. Nucleic Acids Research, 36(16):5166-5179.

Gembka, A; Smirnova, E; Hübscher, U (2008). The checkpoint sensors, the 9-1-1 complex and the Rad17-RF-C2-5 complex: at the crossroads of DNA damage checkpoint and DNA repair. In: Maga, G; Hübscher, U; Villani, G; Baldacci, G. DNA Replication, Repair and Recombination at the Crossroad Between Genome Integrity and Genomic Instability : A Biochemical Perspective. Kerala: Research Signpost, 77-86.

Blasius, M; Buob, R; Shevelev, I V; Hubscher, U (2007). Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radiodurans. BMC Molecular Biology, 8:69.

Crespan, E; Hübscher, U; Maga, G (2007). Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. Nucleic Acids Research, 35(15):5173-5181.

Maga, G; Amacker, M; Hübscher, U; Gosselin, G; Imbach, J L; Mathé, C; Faraj, A; Sommadossi, J P; Spadari, S (2006). Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy. Nucleosides, Nucleotides and Nucleic Acids, 18(4-5):795-805.

El-Andaloussi, N; Valovka, T; Toueille, M; Steinacher, R; Focke, F; Gehrig, P; Covic, M; Hassa, P O; Schär, P; Hübscher, U; Hottiger, M O (2006). Arginine methylation regulates DNA polymerase beta. Molecular Cell, 22(1):51-62.

Blasius, M; Shevelev, I V; Jolivet, E; Sommer, Suzanne; Hübscher, U (2006). DNA polymerase X from Deinococcus radiodurans possesses a structure-modulated 3'-->5' exonuclease activity involved in radioresistance. Molecular Microbiology, 60(1):165-176.

Maga, G; Shevelev, I V; Villani, G; Spadari, S; Hübscher, U (2006). Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. Nucleic Acids Research, 34(5):1405-1415.

Hassa, P O; et al (2005). Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. Journal of Biological Chemistry, 280(49):40450-40464.

Sharma, S; Sommers, J A; Gary, R K; Friedrich-Heineken, E; Hübscher, U; Brosh, R M (2005). The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Research, 33(21):6769-6781.

Friedrich-Heineken, E; Toueille, M; Tännler, B; Bürki, C; Ferrari, E; Hottiger, M O; Hübscher, U (2005). The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity. Journal of Molecular Biology, 353(5):980-989.

Cancio, R; Silvestri, R; Ragno, R; Artico, M; De Martino, G; La Regina, G; Crespan, E; Zanoli, S; Hübscher, U; Spadari, S; Maga, G (2005). High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme. Antimicrobial Agents and Chemotherapy, 49(11):4546-4554.

Frouin, I; Toueille, M; Ferrari, E; Shevelev, I V; Hübscher, U (2005). Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen. Nucleic Acids Research, 33(16):5354-5361.

Cramer, Mirjam; Nagy, Ivana; Murphy, Brian J; Gassmann, Max; Hottiger, Michael O; Georgiev, Oleg; Schaffner, Walter (2005). NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biological Chemistry, 386(9):865-872.

Locatelli, G A; Di Santo, R; Crespan, E; Costi, R; Roux, A; Hübscher, U; Shevelev, I V; Blanca, G; Villani, G; Spadari, S; Maga, G (2005). Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. Molecular Pharmacology, 68(2):538-550.

Crespan, E; Zanoli, S; Khandazhinskaya, A; Shevelev, I V; Jasko, M; Alexandrova, L; Kukhanova, M; Blanca, G; Villani, G; Hübscher, U; Spadari, S; Maga, G (2005). Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. Nucleic Acids Research, 33(13):4117-4127.

Locatelli, G A; Savio, M; Forti, L; Shevelev, I V; Ramadan, K; Stivala, L A; Vannini, V; Hübscher, U; Spadari, S; Maga, G (2005). Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. Biochemical Journal, 389(2):259-268.

Smirnova, E; Toueille, M; Markkanen, E; Hübscher, U (2005). The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery. Biochemical Journal, 389(1):13-17.

Henneke, G; Flament, D; Hübscher, U; Querellou, J; Raffin, J P (2005). The hyperthermophilic euryarchaeota Pyrococcus abyssi likely requires the two DNA polymerases D and B for DNA replication. Journal of Molecular Biology, 350(1):53-64.

Boudsocq, F; Benaim, P; Canitrot, Y; Knibiehler, M; Ausseil, F; Capp, J P; Bieth, A; Long, C; David, B; Shevelev, I V; Frierich-Heinecken, E; Hübscher, U; Amalric, F; Massiot, G; Hoffmann, J S; Cazaux, C (2005). Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta. Molecular Pharmacology, 67(5):1485-1492.

Svetlova, M; Solovjeva, L; Blasius, M; Shevelev, I V; Hubscher, U; Hanawalt, P; Tomilin, N (2005). Differential incorporation of halogenated deoxyuridines during UV-induced DNA repair synthesis in human cells. DNA Repair, 4(3):359-366.

Maga, G; Ramadan, K; Locatelli, G A; Shevelev, I V; Spadari, S; Hübscher, U (2005). DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. Journal of Biological Chemistry, 280(3):1971-1981.

Crespan, E; Locatelli, G A; Cancio, R; Hübscher, U; Spadari, S; Maga, G (2005). Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz. Antimicrobial Agents and Chemotherapy, 49(1):342-349.

Ramadan, K; Shevelev, I V; Hübscher, U (2004). The DNA-polymerase-X family: controllers of DNA quality? Nature Reviews. Molecular Cell Biology, 5(12):43.

Maga, G; Blanca, G; Shevelev, I V; Frouin, I; Ramadan, K; Spadari, S; Villani, G; Hübscher, U (2004). The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. FASEB Journal, 18(14):1743-1745.

Blanca, G; Villani, G; Shevelev, I V; Ramadan, K; Spadari, S; Hübscher, U; Maga, G (2004). Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Biochemistry, 43(36):11605-11615.

Lecointe, F; Shevelev, I V; Bailone, A; Sommer, Suzanne; Hübscher, U (2004). Involvement of an X family DNA polymerase in double-stranded break repair in the radioresistant organism Deinococcus radiodurans. Molecular Microbiology, 53(6):1721-1730.

Toueille, M; Hübscher, U (2004). Regulation of the DNA replication fork: a way to fight genomic instability. Chromosoma, 113(3):113-125.

Toueille, M; El-Andaloussi, N; Frouin, I; Freire, R; Funk, D; Shevelev, I V; Friedrich-Heineken, E; Villani, G; Hottiger, M O; Hübscher, U (2004). The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair. Nucleic Acids Research, 32(11):3316-3324.

Ramadan, K; Shevelev, I V; Maga, G; Hübscher, U (2004). De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase. Journal of Molecular Biology, 339(2):395-404.

Locatelli, G A; Campiani, Giuseppe; Cancio, R; Morelli, E; Ramunno, A; Gemma, S; Hübscher, U; Spadari, S; Maga, G (2004). Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. Antimicrobial Agents and Chemotherapy, 48(5):1570-1580.

Friedrich-Heineken, E; Hübscher, U (2004). The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity. Nucleic Acids Research, 32(8):2520-2528.

Shevelev, I V; Blanca, G; Villani, G; Ramadan, K; Spadari, S; Hübscher, U; Maga, G (2003). Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Nucleic Acids Research, 31(23):6916-6925.

Bergoglio, V; Ferrari, E; Hübscher, U; Cazaux, C; Hoffmann, J S (2003). DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA. Journal of Molecular Biology, 331(5):1017-1023.

Maga, G; Hubscher, U (2003). Proliferating cell nuclear antigen (PCNA): a dancer with many partners. Journal of Cell Science, 116(15):3051-3060.

Henneke, G; Koundrioukoff, S; Hübscher, U (2003). Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Oncogene, 22(28):4301-4313.

Baldanti, F; Paolucci, S; Maga, G; Labo, N; Hübscher, U; Skoblov, A Y; Victorova, L; Spadari, S; Minoli, L; Gerna, G (2003). Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine. AIDS, 17(10):1568-1570.

Henneke, G; Friedrich-Heineken, E; Hübscher, U (2003). Flap endonuclease 1: a novel tumour suppresser protein. Trends in Biochemical Sciences, 28(7):384-390.

Blanca, G; Shevelev, I V; Ramadan, K; Villani, G; Spadari, S; Hübscher, U; Maga, G (2003). Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. Biochemistry, 42(24):7467-7476.

Tasara, T; Angerer, B; Damond, M; Winter, H; Dörhöfer, S; Hübscher, U; Amacker, M (2003). Incorporation of reporter molecule-labeled nucleotides by DNA polymerases. II. High-density labeling of natural DNA. Nucleic Acids Research, 31(10):2636-2646.

Blanca, G; Baldanti, F; Paolucci, S; Skoblov, A Y; Victorova, L; Hübscher, U; Gerna, G; Spadari, S; Maga, G (2003). Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. Journal of Biological Chemistry, 278(18):15469-15472.

Ramadan, K; Maga, G; Shevelev, I V; Villani, G; Blanco, L; Hübscher, U (2003). Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions. Journal of Molecular Biology, 328(1):63-72.

Friedrich-Heineken, E; Henneke, G; Ferrari, E; Hübscher, U (2003). The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities. Journal of Molecular Biology, 328(1):73-84.

Henneke, G; Koundrioukoff, S; Hübscher, U (2003). Multiple roles for kinases in DNA replication. EMBO Reports, 4(3):252-256.

Maga, G; Villani, G; Ramadan, K; Shevelev, I V; Tanguy Le Gac, N; Blanco, L; Blanca, G; Spadari, S; Hübscher, U (2002). Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. Journal of Biological Chemistry, 277(50):48434-48440.

Henneke, G; Gueguen, Y; Flament, D; Azam, P; Querellou, J; Dietrich, J; Hübscher, U; Raffin, J P (2002). Replication factor C from the hyperthermophilic archaeon Pyrococcus abyssi does not need ATP hydrolysis for clamp-loading and contains a functionally conserved RFC PCNA-binding domain. Journal of Molecular Biology, 323(5):795-810.

Storici, F; Henneke, G; Ferrari, E; Gordenin, D A; Hübscher, U; Resnick, M A (2002). The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair. The EMBO Journal, 21(21):5930-5942.

Dahm, K; Hübscher, U (2002). Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block. Oncogene, 21(50):7710-7719.

Maga, G; Shevelev, I V; Ramadan, K; Spadari, S; Hübscher, U (2002). DNA polymerase theta purified from human cells is a high-fidelity enzyme. Journal of Molecular Biology, 319(2):359-369.

Ramadan, K; Shevelev, I V; Maga, G; Hübscher, U (2002). DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. Journal of Biological Chemistry, 277(21):18454-18458.

Frouin, I; Montecucco, A; Biamonti, G; Hübscher, U; Spadari, S; Maga, G (2002). Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. The EMBO Journal, 21(10):2485-2495.

Pascucci, B; Maga, G; Hübscher, U; Bjoras, M; Seeberg, E; Hickson, I D; Villani, G; Giordano, C; Cellai, L; Dogliotti, E (2002). Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins. Nucleic Acids Research, 30(10):2124-2130.

Shevelev, I V; Hübscher, U (2002). The 3' 5' exonucleases. Nature Reviews. Molecular Cell Biology, 3(5):364-376.

Hubscher, U; Maga, G; Spadari, S (2002). Eukaryotic DNA polymerases. Annual Review of Biochemistry, 71:133-163.

Ducoux, M; Urbach, S; Baldacci, G; Hübscher, U; Koundrioukoff, S; Christensen, J; Hughes, P (2001). Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. Journal of Biological Chemistry, 276(52):49258-49266.

Maga, G; Villani, G; Tillement, V; Stucki, M; Locatelli, G A; Frouin, I; Spadari, S; Hübscher, U (2001). Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 98(25):14298-14303.

Maga, G; Ramunno, A; Nacci, V; Locatelli, G A; Spadari, S; Fiorini, I; Baldanti, F; Paolucci, S; Zavattoni, M; Bergamini, A; Galletti, B; Muck, S; Hubscher, U; Giorgi, G; Guiso, G; Caccia, S; Campiani, G (2001). The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors. Journal of Biological Chemistry, 276(48):44653-44662.

Ziemienowicz, A; Konieczny, I; Hübscher, U (2001). Calf thymus Hsc70 and Hsc40 can substitute for DnaK and DnaJ function in protein renaturation but not in bacteriophage DNA replication. FEBS Letters, 507(1):11-15.

Tasara, T; Maga, G; Hottiger, M O; Hübscher, U (2001). HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other. FEBS Letters, 507(1):39-44.

Miller, J T; Ehresmann, B; Hübscher, U; Le Grice, S F (2001). A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis. Journal of Biological Chemistry, 276(29):27721-27730.

Missura, M; Buterin, T; Hindges, R; Hübscher, U; Kaspárková, J; Brabec, V; Naegeli, H (2001). Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair. The EMBO Journal, 20(23):3554-3564.

Tasara, T; Hottiger, M O; Hübscher, U (2001). Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation. Biological Chemistry, 382(7):993-999.

Hasan, S; Stucki, M; Hassa, P O; Imhof, R; Gehrig, P; Hunziker, P; Hübscher, U; Hottiger, M O (2001). Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Molecular Cell, 7(6):1221-1231.

Maga, G; Frouin, I; Spadari, S; Hubscher, U (2001). Replication protein A as a "fidelity clamp" for DNA polymerase alpha. Journal of Biological Chemistry, 276(21):18235-18242.

Maga, G; Hübscher, U; Pregnolato, M; Ubiali, D; Gosselin, G; Spadari, S (2001). Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs. Antimicrobial Agents and Chemotherapy, 45(4):1192-1200.

Stucki, M; Jónsson, Z O; Hübscher, U (2001). In eukaryotic flap endonuclease 1, the C terminus is essential for substrate binding. Journal of Biological Chemistry, 276(11):7843-7849.

Hobi, R; Hübscher, U; Neftel, K; Alteri, E; Poncioni, B; Walker, M R; Woods-Cook, K; Schneider, P; Lazdins, J K (2001). Anti-HIV-1 activity in vitro of ceftazidime degradation products. Antiviral Chemistry & Chemotherapy, 12(2):109-118.

Stucki, M; Stagljar, I; Jónsson, Z O; Hübscher, U (2001). A coordinated interplay: proteins with multiple functions in DNA replication, DNA repair, cell cycle/checkpoint control, and transcription. Progress in Nucleic Acid Research and Molecular Biology, 65:261-298.

Rülicke, T; Hübscher, U (2000). Germ line transformation of mammals by pronuclear microinjection. Experimental Physiology, 85(6):859-601.

Henneke, G; Raffin, J P; Ferrari, E; Jónsson, Z O; Dietrich, J; Hübscher, U (2000). The PCNA from Thermococcus fumicolans functionally interacts with DNA polymerase delta. Biochemical and Biophysical Research Communications (BBRC), 276(2):600-6.

Koundrioukoff, S; Jónsson, Z O; Hasan, S; de Jong, R N; van der Vliet, P C; Hottiger, M O; Hübscher, U (2000). A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation. Journal of Biological Chemistry, 275(30):22882-22887.

Georlette, D; Jónsson, Z O; Van Petegem, F; Chessa, J; Van Beeumen, J; Hübscher, U; Gerday, C (2000). A DNA ligase from the psychrophile Pseudoalteromonas haloplanktis gives insights into the adaptation of proteins to low temperatures. FEBS Journal, 267(12):3502-3512.

Hübscher, U; Nasheuer, H P; Syväoja, J E (2000). Eukaryotic DNA polymerases, a growing family. Trends in Biochemical Sciences, 25(3):143-147.

Moggs, J G; Grandi, P; Quivy, J P; Jónsson, Z O; Hübscher, U; Becker, P B; Almouzni, G (2000). A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage. Molecular and Cellular Biology, 20(4):1206-1218.

Araújo, S J; Tirode, F; Coin, F; Pospiech, H; Syväoja, J E; Stucki, M; Hübscher, U; Egly, J M; Wood, R D (2000). Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK. Genes and Development, 14(3):349-359.

Maga, G; Stucki, M; Spadari, S; Hübscher, U (2000). DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Journal of Molecular Biology, 295(4):801.

Mossi, R; Keller, R C; Ferrari, E; Hübscher, U (2000). DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase alpha at a critical length. Journal of Molecular Biology, 295(4):803-814.

Schumacher, S B; Stucki, M; Hübscher, U (2000). The N-terminal region of DNA polymerase delta catalytic subunit is necessary for holoenzyme function. Nucleic Acids Research, 28(2):620-625.

Pascucci, B; Stucki, M; Jónsson, Z O; Dogliotti, E; Hübscher, U (1999). Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon. Journal of Biological Chemistry, 274(47):33696-33702.

Keller, R C; Mossi, R; Maga, G; Wellinger, R E; Hübscher, U; Sogo, J M (1999). Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA. Nucleic Acids Research, 27(17):3433-3437.

Stagljar, I; Hübscher, U; Barberis, A (1999). Activation of DNA replication in yeast by recruitment of the RNA polymerase II transcription complex. Biological Chemistry, 380(5):525-30.

Maga, G; Amacker, M; Hübscher, U; Gosselin, G; Imbach, J L; Mathé, C; Faraj, A; Sommadossi, J P; Spadari, S (1999). Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs. Nucleic Acids Research, 27(4):972-978.

Tasara, T; Amacker, M; Hübscher, U (1999). Intramolecular chimeras of the p51 subunit between HIV-1 and FIV reverse transcriptases suggest a stabilizing function for the p66 subunit in the heterodimeric enzyme. Biochemistry, 35(5):1633-1642.

Marx, A; Spichty, M; Amacker, M; Schwitter, U; Hübscher, U; Bickle, T A; Maga, G; Giese, B (1999). Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides. Chemistry & Biology, 6(2):111-116.

Maga, G; Jónsson, Z O; Stucki, M; Spadari, S; Hübscher, U (1999). Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. Journal of Molecular Biology, 285(1):259-267.

Shivji, M K; Ferrari, E; Ball, K; Hübscher, U; Wood, R D (1998). Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1. Oncogene, 17(22):2827-2835.

Perderiset, M; Maga, G; Piard, K; Francesconi, S; Tratner, I; Hübscher, U; Baldacci, G (1998). Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen. Biochemical Journal, 335(3):581-588.

Marx, A; Amacker, M; Stucki, M; Hübscher, U; Bickle, T A; Giese, B (1998). 4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase. Nucleic Acids Research, 26(17):4063-4069.

Stucki, M; Pascucci, B; Parlanti, E; Fortini, P; Wilson, S H; Hübscher, U; Dogliotti, E (1998). Mammalian base excision repair by DNA polymerases delta and epsilon. Oncogene, 17(7):835-843.

Mossi, R; Ferrari, E; Hübscher, U (1998). DNA ligase I selectively affects DNA synthesis by DNA polymerases delta and epsilon suggesting differential functions in DNA replication and repair. Journal of Biological Chemistry, 273(23):14322-14330.

von Janta-Lipinski, M; Costisella, B; Ochs, H; Hübscher, U; Hafkemeyer, P; Matthes, E (1998). Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. Journal of Medicinal Chemistry, 41(12):2040-2046.

Mossi, R; Hübscher, U (1998). Clamping down on clamps and clamp loaders--the eukaryotic replication factor C. FEBS Journal, 254(2):209-216.

Amacker, M; Hübscher, U (1998). Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases. Journal of Molecular Biology, 278(4):757-765.

Schurtenberger, P; Egelhaaf, S U; Hindges, R; Maga, G; Jónsson, Z O; May, R P; Glatter, O; Hübscher, U (1998). The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering. Journal of Molecular Biology, 275(1):123-132.

Maga, G; Amacker, M; Ruel, N; Hübscher, U; Spadari, S (1997). Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions. Journal of Molecular Biology, 274(5):738-747.

Jónsson, Z O; Hübscher, U (1997). Proliferating cell nuclear antigen: more than a clamp for DNA polymerases. BioEssays, 19(11):967-975.

Mossi, R; Jónsson, Z O; Allen, B L; Hardin, S H; Hübscher, U (1997). Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. Journal of Biological Chemistry, 272(3):1769-1776.

Jessberger, R; Schär, P; Robins, P; Ferrari, E; Riwar, B; Hübscher, U (1997). Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: up-regulation of DNA polymerase delta. Nucleic Acids Research, 25(2):289-296.

Lutz, M J; Held, H A; Hottiger, M O; Hübscher, U; Benner, S A (1996). Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet. Nucleic Acids Research, 24(7):1308-1313.

Amacker, M; Hottiger, M O; Hübscher, U (1995). Feline immunodeficiency virus reverse transcriptase: expression, functional characterization, and reconstitution of the 66- and 51-kilodalton subunits. Journal of Virology, 69(10):6273-6279.

Horlacher, J; Hottiger, M O; Podust, V N; Hübscher, U; Benner, S A (1995). Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 92(14):6329-6333.

Ziemienowicz, A; Zylicz, M; Floth, C; Hübscher, U (1995). Calf thymus Hsc70 protein protects and reactivates prokaryotic and eukaryotic enzymes. Journal of Biological Chemistry, 270(26):15479-15484.

Hoffmann, J S; Pillaire, M J; Maga, G; Podust, V N; Hübscher, U; Villani, G (1995). DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 92(12):5356-5360.

Hottiger, M O; Gramatikoff, K; Georgiev, O; Chaponnier, C; Schaffner, W; Hübscher, U (1995). The large subunit of HIV-1 reverse transcriptase interacts with beta-actin. Nucleic Acids Research, 23(5):736-741.

This list was generated on Wed Nov 22 22:11:06 2017 CET.