UZH-Logo

Maintenance Infos

Browse by Communities & Collections - Zurich Open Repository and Archive

Navigate back| Up a level
Export as
Number of items at this level: 607.

2017

Graf, Urs; Casanova, Elisa A; Wyck, Sarah; Dalcher, Damian; Gatti, Marco; Vollenweider, Eva; Okoniewski, Michal J; Weber, Fabienne A; Patel, Sameera S; Schmid, Marc W; Li, Jiwen; Sharif, Jafar; Wanner, Guido A; Koseki, Haruhiko; Wong, Jiemin; Pelczar, Pawel; Penengo, Lorenza; Santoro, Raffaella; Cinelli, Paolo (2017). Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nature Cell Biology, 19(7):763-773.

Di Marco, Stefano; Hasanova, Zdenka; Kanagaraj, Radhakrishnan; Chappidi, Nagaraja; Altmannova, Veronika; Menon, Shruti; Sedlackova, Hana; Langhoff, Jana; Surendranath, Kalpana; Hühn, Daniela; Bhowmick, Rahul; Marini, Victoria; Ferrari, Stefano; Hickson, Ian D; Krejci, Lumir; Janscak, Pavel (2017). RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Molecular Cell, 66(5):658-671.e8.

Parrotta, Rossella; Okonska, Agata; Ronner, Manuel; Weder, Walter; Stahel, Rolf; Penengo, Lorenza; Felley-Bosco, Emanuela (2017). A novel BRCA1-associated protein-1 isoform affects response of mesothelioma cells to drugs impairing BRCA1-mediated DNA repair. Journal of Thoracic Oncology:Epub ahead of print.

Levikova, Maryna; Pinto, Cosimo; Cejka, Petr (2017). The motor activity of DNA2 functions as an ssDNA translocase to promote DNA end resection. Genes and Development, 31(5):493-502.

Odermatt, Diana C; Gari, Kerstin (2017). The CIA targeting complex is highly regulated and provides two distinct binding sites for client iron-sulfur proteins. Cell Reports, 18(6):1434-1443.

Henrich, Sarah Marie; Usadel, Clemens; Werwein, Eugen; Burdova, Kamila; Janscak, Pavel; Ferrari, Stefano; Hess, Daniel; Klempnauer, Karl-Heinz (2017). Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling. Scientific Reports, 7:41663.

Mordasini, Vanessa; Ueda, Seigo; Aslandogmus, Roberta; Berger, Christoph; Gysin, Claudine; Hühn, Daniela; Sartori, Alessandro A; Bernasconi, Michele; Nadal, David (2017). Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells. OncoTarget, 8(4):6461-6474.

Duroc, Yann; Kumar, Rajeev; Ranjha, Lepakshi; Adam, Céline; Guérois, Raphaël; Md Muntaz, Khan; Marsolier-Kergoat, Marie-Claude; Dingli, Florent; Laureau, Raphaëlle; Loew, Damarys; Llorente, Bertrand; Charbonnier, Jean-Baptiste; Cejka, Petr; Borde, Valérie (2017). Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion. eLife, 6:e21900.

Uzozie, Anuli Christiana; Selevsek, Nathalie; Wahlander, Asa; Nanni, Paolo; Grossmann, Jonas; Weber, Achim; Buffoli, Federico; Marra, Giancarlo (2017). Targeted proteomics for multiplexed verification of markers of colorectal tumorigenesis. Molecular & Cellular Proteomics:1-48.

Vindigni, Alessandro; Lopes, Massimo (2017). Combining electron microscopy with single molecule DNA fiber approaches to study DNA replication dynamics. Biophysical Chemistry, 225:3-9.

Urban, Vaclav; Dobrovolna, Jana; Janscak, Pavel (2017). Distinct functions of human RecQ helicases during DNA replication. Biophysical Chemistry, 225:20-26.

Pinto, Cosimo. Functions of Human DNA2 and its Protein Partners in DNA End Resection. 2017, University of Zurich, Faculty of Science.

Kyburz, Andreas; Müller, Anne (2017). Helicobacter pylori and Extragastric Diseases. In: Tegtmeyer, Nicole; Backert, Steffen. Molecular Pathogenesis and Signal Transduction by Helicobacter pylori. Springer International Publishing: Springer, 325-347.

Schwendener, Reto A; Schott, Herbert (2017). Liposome formulations of hydrophobic drugs. In: D'Souza, Gerard G M. Liposomes, Methods and Protocols, Second Edition. New York, NY, USA: Springer, 73-82.

Mejías-Luque, Raquel; Zöller, Jessica; Anderl, Florian; Loew-Gil, Elena; Vieth, Michael; Adler, Thure; Engler, Daniela B; Urban, Sabine; Browning, Jeffrey L; Müller, Anne; Gerhard, Markus; Heikenwalder, Mathias (2017). Lymphotoxin β receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner. Gut, 66(8):1369-1381.

2016

Hess, Jeannine; Patra, Malay; Jabbar, Abdul; Pierroz, Vanessa; Konatschnig, Sandro; Spingler, Bernhard; Ferrari, Stefano; Gasser, Robin B; Gasser, Gilles (2016). Assessment of the nematocidal activity of metallocenyl analogues of monepantel. Dalton Transactions, 45(44):17662-17671.

Anand, Roopesh; Ranjha, Lepakshi; Cannavo, Elda; Cejka, Petr (2016). Phosphorylated CtIP functions as a co-factor of the MRE11-RAD50-NBS1 endonuclease in DNA end resection. Molecular Cell, 64(1):940-950.

Piwko, Wojciech; Mlejnkova, Lucie J; Mutreja, Karun; Ranjha, Lepakshi; Stafa, Diana; Smirnov, Alexander; Brodersen, Mia Ml; Zellweger, Ralph; Sturzenegger, Andreas; Janscak, Pavel; Lopes, Massimo; Peter, Matthias; Cejka, Petr (2016). The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress. EMBO Journal Online, 35:2584-2601.

Ölmezer, Gizem; Levikova, Maryna; Klein, Dominique; Falquet, Benoît; Fontana, Gabriele Alessandro; Cejka, Petr; Rass, Ulrich (2016). Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1. Nature Communications, 7:13157.

Oh, Julyun; Al-Zain, Amr; Cannavo, Elda; Cejka, Petr; Symington, Lorraine S (2016). Xrs2 dependent and independent functions of the Mre11-Rad50 complex. Molecular Cell, 64(2):405-415.

Pinto, Cosimo; Kasaciunaite, Kristina; Seidel, Ralf; Cejka, Petr (2016). Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases. eLife, 5:e18574.

Pierroz, Vanessa; Rubbiani, Riccardo; Gentili, Christian; Patra, Malay; Mari, Cristina; Gasser, Gilles; Ferrari, Stefano (2016). Dual mode of cell death upon the photo-irradiation of a Ru(II) polypyridyl complex in interphase or mitosis. Chemical Science, 7(9):6115-6124.

Urban, Vaclav; Dobrovolna, Jana; Hühn, Daniela; Fryzelkova, Jana; Bartek, Jiri; Janscak, Pavel (2016). RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. Journal of Cell Biology, 214(4):401-415.

Adam, Ronja; Spier, Isabel; Zhao, Bixiao; Kloth, Michael; Marquez, Jonathan; Hinrichsen, Inga; Kirfel, Jutta; Tafazzoli, Aylar; Horpaopan, Sukanya; Uhlhaas, Siegfried; Stienen, Dietlinde; Friedrichs, Nicolaus; Altmüller, Janine; Laner, Andreas; Holzapfel, Stefanie; Peters, Sophia; Kayser, Katrin; Thiele, Holger; Holinski-Feder, Elke; Marra, Giancarlo; Kristiansen, Glen; Nöthen, Markus M; Büttner, Reinhard; Möslein, Gabriela; Betz, Regina C; Brieger, Angela; Lifton, Richard P; Aretz, Stefan (2016). Exome sequencing identifies biallelic MSH3 germline mutations as a recessive subtype of colorectal adenomatous polyposis. American Journal of Human Genetics, 99(2):337-351.

Acosta-Ramirez, Elizabeth; Tram, Cynthia; Kampen, Rachel M; Tillman, Melanie R; Schwendener, Reto A; Xing, Zhou; Halperin, Scott A; Wang, Jun (2016). Respiratory macrophages regulate CD4 T memory responses to mucosal immunization with recombinant adenovirus-based vaccines. Cellular Immunology, 310:53-62.

Kemmerich, Felix E; Daldrop, Peter; Pinto, Cosimo; Levikova, Maryna; Cejka, Petr; Seidel, Ralf (2016). Force regulated dynamics of RPA on a DNA fork. Nucleic Acids Research, 44(12):5837-5848.

Galanos, Panagiotis; Vougas, Konstantinos; Walter, David; Polyzos, Alexander; Maya-Mendoza, Apolinar; Haagensen, Emma J; Kokkalis, Antonis; Roumelioti, Fani-Marlen; Gagos, Sarantis; Tzetis, Maria; Canovas, Begoña; Igea, Ana; Ahuja, Akshay K; Zellweger, Ralph; Havaki, Sofia; Kanavakis, Emanuel; Kletsas, Dimitris; Roninson, Igor B; Garbis, Spiros D; Lopes, Massimo; Nebreda, Angel; Thanos, Dimitris; Blow, J Julian; Townsend, Paul; Sørensen, Claus Storgaard; Bartek, Jiri; Gorgoulis, Vassilis G (2016). Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nature Cell Biology, 18(7):777-789.

Saredi, Giulia; Huang, Hongda; Hammond, Colin M; Alabert, Constance; Bekker-Jensen, Simon; Forne, Ignasi; Reverón-Gómez, Nazaret; Foster, Benjamin M; Mlejnkova, Lucie; Bartke, Till; Cejka, Petr; Mailand, Niels; Imhof, Axel; Patel, Dinshaw J; Groth, Anja (2016). H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex. Nature, 534(7609):714-718.

Lu, Huiming; Shamanna, Raghavendra A; Keijzers, Guido; Anand, Roopesh; Rasmussen, Lene Juel; Cejka, Petr; Croteau, Deborah L; Bohr, Vilhelm A (2016). RECQL4 promotes DNA end resection in repair of DNA double-strand breaks. Cell Reports, 16(1):161-173.

Budhathoki, Jagat B; Maleki, Parastoo; Roy, William A; Janscak, Pavel; Yodh, Jaya G; Balci, Hamza (2016). A comparative study of g-quadruplex unfolding and DNA reeling activities of human RECQ5 helicase. Biophysical Journal, 110(12):2585-2596.

Hermans, Nicolaas; Laffeber, Charlie; Cristovão, Michele; Artola-Borán, Mariela; Mardenborough, Yannicka; Ikpa, Pauline; Jaddoe, Aruna; Winterwerp, Herrie H K; Wyman, Claire; Jiricny, Josef; Kanaar, Roland; Friedhoff, Peter; Lebbink, Joyce H G (2016). Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair. Nucleic Acids Research, 44(14):6770-6786.

Ribeyre, Cyril; Zellweger, Ralph; Chauvin, Maeva; Bec, Nicole; Larroque, Christian; Lopes, Massimo; Constantinou, Angelos (2016). Nascent DNA proteomics reveals a chromatin remodeler required for topoisomerase i loading at replication forks. Cell Reports, 15(2):300-309.

Bregenhorn, Stephanie; Kallenberger, Lia; Artola-Borán, Mariela; Peña-Diaz, Javier; Jiricny, Josef (2016). Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination. Nucleic Acids Research, 44(6):2691-2705.

Smits, Hermelijn H; Hiemstra, Pieter S; Prazeres da Costa, Clarissa; Ege, Markus; Edwards, Michael; Garn, Holger; Howarth, Peter H; Jartti, Tuomas; de Jong, Esther C; Maizels, Rick M; Marsland, Ben J; McSorley, Henry J; Müller, Anne; Pfefferle, Petra I; Savelkoul, Huub; Schwarze, Jürgen; Unger, Wendy W J; von Mutius, Erika; Yazdanbakhsh, Maria; Taube, Christian (2016). Microbes and asthma: Opportunities for intervention. Journal of Allergy and Clinical Immunology, 137(3):690-697.

Flori, Michael; Schmid, Corina A; Sumrall, Eric T; Tzankov, Alexandar; Law, Charity W; Robinson, Mark D; Müller, Anne (2016). The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. Blood, 127(11):1438-1448.

Ahuja, Akshay K; Jodkowska, Karolina; Teloni, Federico; Bizard, Anna H; Zellweger, Ralph; Herrador, Raquel; Ortega, Sagrario; Hickson, Ian D; Altmeyer, Matthias; Mendez, Juan; Lopes, Massimo (2016). A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nature Communications, 7:10660-10671.

Pizzolato, Julia. Biochemical Characterization of FAN1 Nuclease. 2016, University of Zurich, Faculty of Science.

Himmels, Sarah-Felicitas; Sartori, Alessandro A (2016). Controlling DNA-end resection: an emerging task for ubiquitin and SUMO. Frontiers in Genetics, 7:152.

Ferretti, Lorenza P; Himmels, Sarah-Felicitas; Trenner, Anika; Walker, Christina; von Aesch, Christine; Eggenschwiler, Aline; Murina, Olga; Enchev, Radoslav I; Peter, Matthias; Freire, Raimundo; Porro, Antonio; Sartori, Alessandro A (2016). Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection. Nature Communications, 7:12628.

Mlejnkova, Lucie Jarmila. Elucidating the Role of MMS22L-TONSL Heterodimer in Homologous Recombination. 2016, University of Zurich, Faculty of Science.

Arnold, Isabelle C; Müller, Anne (2016). Helicobacter pylori: does gastritis prevent colitis? Inflammatory Intestinal Diseases, 1(3):102-112.

Pachathundikandi, Suneesh Kumar; Müller, Anne; Backert, Steffen (2016). Inflammasome activation by helicobacter pylori and its implications for persistence and immunity. In: Backert, Steffen. Inflammasome Signaling and Bacterial Infections. Germany: Springer, 117-131.

Ferrari, Stefano; Gentili, Christian (2016). Maintaining genome stability in defiance of mitotic DNA damage. Frontiers in Genetics, 7:128.

Vujanovic, Marko. Mechanistic Insight Into Replication Fork Reversal Under Genotoxic Stress. 2016, University of Zurich, Faculty of Science.

Di Marco, Stefano. Role of RECQ5 Helicase in MUS81-mediated Resolution of Aberrant Replication Intermediates. 2016, University of Zurich, Faculty of Science.

Lepakshi, Lepakshi. Role of Saccharomyces cerevisiae Mlh1-Mlh3 (MutLΥ) in Meiotic Homologous Recombination. 2016, University of Zurich, Faculty of Science.

Falke, Martin. Second Generation Protein Replacement System to Study MLH1 Missense Mutations. 2016, University of Zurich, Faculty of Science.

Sturzenegger, Andreas. Study of Mechanisms of Homologous Recombination in Mammalian Cells. 2016, University of Zurich, Faculty of Science.

Erzinger, Melanie M; Bovet, Cédric; Hecht, Katrin M; Senger, Sabine; Winiker, Pascale; Sobotzki, Nadine; Cristea, Simona; Beerenwinkel, Niko; Shay, Jerry W; Marra, Giancarlo; Wollscheid, Bernd; Sturla, Shana J (2016). Sulforaphane preconditioning sensitizes human colon cancer cells towards the bioreductive anticancer prodrug PR-104A. PLoS ONE, 11(3):e0150219.

Hess, Jeannine; Patra, Malay; Pierroz, Vanessa; Spingler, Bernhard; Jabbar, Abdul; Ferrari, Stefano; Gasser, Robin B; Gasser, Gilles (2016). Synthesis, Characterization, and Biological Activity of Ferrocenyl Analogues of the Anthelmintic Drug Monepantel. Organometallics, 35(19):3369-3377.

Weller, Marie-Christine. The Contribution of PARP-1 and ELG1/ATAD5 to Genomic Stability. 2016, University of Zurich, Faculty of Science.

Kyburz, Andreas; Müller, Anne (2016). The gastrointestinal tract microbiota and allergic diseases. Digestive Diseases, 34(3):230-243.

Flori, Michael. The hematopoietic oncoprotein FOXP1 promotes cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. 2016, University of Zurich, Faculty of Science.

Maglietta, Antonella; Maglietta, Rosalia; Staiano, Teresa; Bertoni, Ramona; Ancona, Nicola; Marra, Giancarlo; Resta, Leonardo (2016). The immune landscapes of polypoid and nonpolypoid precancerous colorectal lesions. PLoS ONE, 11(7):e0159373.

Lafranchi, Lorenzo; Sartori, Alessandro A (2016). The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection. Molecular & Cellular Oncology, 2(4):e1000696.

Imstepf, Sebastian; Pierroz, Vanessa; Raposinho, Paula; Felber, Michael; Fox, Thomas; Fernandes, Célia; Gasser, Gilles; Santos, Isabel R; Alberto, Roger (2016). Towards99mTc-based imaging agents with effective doxorubicin mimetics: a molecular and cellular study. Dalton Transactions, 45(33):13025-13033.

2015

Xu, Ren-Huan; Wong, Eric B; Rubio, Daniel; Roscoe, Felicia; Ma, Xueying; Nair, Savita; Remakus, Sanda; Schwendener, Reto; John, Shinu; Shlomchik, Mark; Sigal, Luis J (2015). Sequential activation of two pathogen-sensing pathways required for type I interferon expression and resistance to an acute DNA virus infection. Immunity, 43(6):1148-1159.

Koch, Katrin N; Müller, Anne (2015). Helicobacter pylori activates the TLR2/NLRP3/caspase-1/IL-18 axis to induce regulatory T-cells, establish persistent infection and promote tolerance to allergens. Gut Microbes, 6(6):382-387.

Hartung, Mara L; Gruber, Dorothea C; Koch, Katrin N; Grüter, Livia; Rehrauer, Hubert; Tegtmeyer, Nicole; Backert, Steffen; Müller, Anne (2015). H. pylori-induced DNA strand breaks are introduced by nucleotide excision repair endonucleases and promote nf-κb target gene expression. Cell Reports, 13(1):70-79.

Anstaett, Philipp; Pierroz, Vanessa; Ferrari, Stefano; Gasser, Gilles (2015). Two-photon uncageable enzyme inhibitors bearing targeting vectors. Photochemical & Photobiological Sciences, 14(10):1821-1825.

Fontana, Andrea O; Augsburger, Marc A; Grosse, Nicole; Guckenberger, Matthias; Lomax, Anthony J; Sartori, Alessandro A; Pruschy, Martin N (2015). Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation. Radiotherapy and Oncology, 116(3):374-380.

Burdova, Kamila; Mihaljevic, Boris; Sturzenegger, Andreas; Chappidi, Nagaraja; Janscak, Pavel (2015). The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks. Molecular Cell, 59(4):603-614.

Koch, Katrin N; Hartung, Mara L; Urban, Sabine; Kyburz, Andreas; Bahlmann, Anna S; Lind, Judith; Backert, Steffen; Taube, Christian; Müller, Anne (2015). Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma. Journal of Clinical Investigation, 125(8):3297-3302.

Bologna, Serena; Altmannova, Veronika; Valtorta, Emanuele; Koenig, Christiane; Liberali, Prisca; Gentili, Christian; Anrather, Dorothea; Ammerer, Gustav; Pelkmans, Lucas; Krejci, Lumir; Ferrari, Stefano (2015). Sumoylation regulates EXO1 stability and processing of DNA damage. Cell Cycle, 14(15):2439-2450.

Cejka, Petr (2015). DNA end resection: nucleases team up with the right partners to initiate homologous recombination. Journal of Biological Chemistry, 290:22931-22938.

Pizzolato, Julia; Mukherjee, Shivam; Schaerer, Orlando D; Jiricny, Josef (2015). FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro. Journal of Biological Chemistry, 290:22602-22611.

Levikova, Maryna; Cejka, Petr (2015). The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication. Nucleic Acids Research, 15(1):1-10.

Devaud, Christel; John, Liza B; Westwood, Jennifer A; Yong, Carmen Sm; Beavis, Paul A; Schwendener, Reto A; Darcy, Phillip K; Kershaw, Michael H (2015). Cross-talk between tumors can affect responses to therapy. OncoImmunology, 4(7):e975572.

Gemble, Simon; Ahuja, Akshay; Buhagiar-Labarchède, Géraldine; Onclercq-Delic, Rosine; Dairou, Julien; Biard, Denis S F; Lambert, Sarah; Lopes, Massimo; Amor-Guéret, Mounira (2015). Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA. PLoS Genetics, 11(7):e1005384.

Schmid, Corina A; Robinson, Mark D; Scheifinger, Nicole A; Müller, Sebastian; Cogliatti, Sergio; Tzankov, Alexandar; Müller, Anne (2015). DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma. Journal of Experimental Medicine:1-18.

Engler, Daniela B; Leonardi, Irina; Hartung, Mara L; Kyburz, Andreas; Spath, Sabine; Becher, Burkhard; Rogler, Gerhard; Müller, Anne (2015). Helicobacter pylori-specific Protection Against Inflammatory Bowel Disease Requires the NLRP3 Inflammasome and IL-18. Inflammatory Bowel Diseases, 21(4):854-861.

Fugger, Kasper; Mistrik, Martin; Neelsen, Kai J; Yao, Qi; Zellweger, Ralph; Kousholt, Arne Nedergaard; Haahr, Peter; Chu, Wai Kit; Bartek, Jiri; Lopes, Massimo; Hickson, Ian D; Sørensen, Claus Storgaard (2015). FBH1 Catalyzes Regression of Stalled Replication Forks. Cell Reports, 10(10):1749-1757.

Thangavel, Saravanabhavan; Berti, Matteo; Levikova, Maryna; Pinto, Cosimo; Gomathinayagam, Shivasankari; Vujanovic, Marko; Zellweger, Ralph; Moore, Hayley; Lee, Eu Han; Hendrickson, Eric A; Cejka, Petr; Stewart, Sheila; Lopes, Massimo; Vindigni, Alessandro (2015). DNA2 drives processing and restart of reversed replication forks in human cells. Journal of Cell Biology, 208(5):545-562.

Zellweger, Ralph; Dalcher, Damian; Mutreja, Karun; Berti, Matteo; Schmid, Jonas A; Herrador, Raquel; Vindigni, Alessandro; Lopes, Massimo (2015). Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. Journal of Cell Biology, 208(5):563-579.

Neelsen, Kai J; Lopes, Massimo (2015). Replication fork reversal in eukaryotes: from dead end to dynamic response. Nature Reviews. Molecular Cell Biology, 16(4):207-220.

Fasching, Clare L; Cejka, Petr; Kowalczykowski, Stephen C; Heyer, Wolf-Dietrich (2015). Top3-rmi1 dissolve rad51-mediated d loops by a topoisomerase-based mechanism. Molecular Cell, 57(4):595-606.

Repmann, Simone; Olivera-Harris, Maite; Jiricny, Josef (2015). Influence of oxidized purine processing on strand directionality of mismatch repair. Journal of Biological Chemistry, 290(16):9986-9999.

Symington, J W; Wang, C; Twentyman, J; Owusu-Boaitey, N; Schwendener, R; Núñez, G; Schilling, J D; Mysorekar, I U (2015). ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner. Mucosal immunology, 8:1388-1399.

Fumasoni, Marco; Zwicky, Katharina; Vanoli, Fabio; Lopes, Massimo; Branzei, Dana (2015). Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex. Molecular Cell:1-13.

Olivera Harris, Maite; Kallenberger, Lia; Artola Borán, Mariela; Enoiu, Milica; Costanzo, Vincenzo; Jiricny, Josef (2015). Mismatch repair-dependent metabolism of O(6)-methylguanine-containing DNA in Xenopus laevis egg extracts. DNA repair, 28C:1-7.

Lafranchi, Lorenzo. APC/CCdh1 Contributes to Maintenance of Genome Stability by Targeting the DNA-end Resection Factor CtIP. 2015, University of Zurich, Faculty of Science.

Levikova, Maryna. Biochemical Analysis and In Vivo Role of Dna2 Nuclease-Helicase. 2015, University of Zurich, Faculty of Science.

Gentili, Christian; Castor, Dennis; Kaden, Svenja; Lauterbach, David; Gysi, Mario; Steigemann, Patrick; Gerlich, Daniel W; Jiricny, Josef; Ferrari, Stefano (2015). Chromosome Missegregation Associated with RUVBL1 Deficiency. PLoS ONE, 10(7):e0133576.

Mari, Cristina; Pierroz, Vanessa; Ferrari, Stefano; Gasser, Gilles (2015). Combination of Ru(II) Complexes and Light: New Frontiers in Cancer Therapy. Chemical Science, 6:2660-2686.

Hartung, Mara L. Elucidating mechanisms leading to H. pylori-Induced DNA double strand breaks in host cells. 2015, University of Zurich, Faculty of Science.

Koch, Katrin N. Elucidating the mechanism of Helicobacter pylori-induced Caspase-1 activation and its role in immunity and immune tolerance. 2015, University of Zurich, Faculty of Science.

Aykut, Murat. Functional and physical interactions of 14-3-3 proteins with novel targets upon replication stress in S. cerevisiae. 2015, University of Zurich, Faculty of Science.

Csefalvay, Eva; Lapkouski, Mikalai; Guzanova, Alena; Csefalvay, Ladislav; Baikova, Tatsiana; Shevelev, Igor; Bialevich, Vitali; Shamayeva, Katsiaryna; Janscak, Pavel; Kuta Smatanova, Ivana; Panjikar, Santosh; Carey, Jannette; Weiserova, Marie; Ettrich, Rüdiger (2015). Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme. PLoS ONE, 10(6):e0128700.

Baker, Tiffany G; Roy, Soumen; Brandon, Carlene S; Kramarenko, Inga K; Francis, Shimon P; Taleb, Mona; Marshall, Keely M; Schwendener, Reto; Lee, Fu-Shing; Cunningham, Lisa L (2015). Heat shock protein-mediated protection against cisplatin-induced hair cell death. Journal of the Association for Research in Otolaryngology (JARO), 16(1):67-80.

Schmid, Corina A. Identification and Functional Analysis of Epigenetic Alterations in Diffuse Large B cell Lymphoma. 2015, University of Zurich, Faculty of Science.

Leonidova, Anna; Anstaett, Philipp; Pierroz, Vanessa; Spingler, Bernhard; Ferrari, Stefano; Gasser, Gilles (2015). Induction of Cytotoxicity through Photo-release of Aminoferrocene. Inorganic Chemistry, 54:9740-9748.

Moalli, Federica; Proulx, Steven T; Schwendener, Reto; Detmar, Michael; Schlapbach, Christoph; Stein, Jens V (2015). Intravital and whole-organ imaging reveals capture of melanoma-derived antigen by lymph node subcapsular macrophages leading to widespread deposition on follicular dendritic cells. Frontiers in Immunology, 6:114.

Ferretti, Lorenza P. Molecular and Cellular Aspects of CtIP Function in DNA Double-Strand Break Processing. 2015, University of Zurich, Faculty of Science.

Pierroz, Vanessa. Photo-induced activation of metal complexes in living cells for photodynamic therapy (PDT) and photo-activated chemotherapy (PACT). 2015, University of Zurich, Faculty of Science.

Mari, Cristina; Pierroz, Vanessa; Leonidova, Anna; Ferrari, Stefano; Gasser, Gilles (2015). Towards Selective Light Activated Ru(II)-based Prodrug Candidates. European Journal of Inorganic Chemistry, 23:3879-3891.

Engler-Anders, Daniela. Treatment with helicobacter pylorI extract protects against allergic asthma and inflammatory bowel disease. 2015, University of Zurich, Faculty of Science.

Hühn, D; Kousholt, A N; Sørensen, C S; Sartori, A A (2015). miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene, 34(30):3977-3984.

2014

Ray Chaudhuri, Arnab; Ahuja, Akshay Kumar; Herrador, Raquel; Lopes, Massimo (2014). Poly(ADP-ribosyl)gycohydrolase (PARG) prevents the accumulation of unusual replication structures during unperturbed S phase. Molecular and Cellular Biology:1-33.

Hannan, Thomas J; Roberts, Pacita L; Riehl, Terrence E; van der Post, Sjoerd; Binkley, Jana M; Schwartz, Drew J; Miyoshi, Hiroyuki; Mack, Matthias; Schwendener, Reto A; Hooton, Thomas M; Stappenbeck, Thaddeus S; Hansson, Gunnar C; Stenson, William F; Colonna, Marco; Stapleton, Ann E; Hultgren, Scott J (2014). Inhibition of cyclooxygenase-2 prevents chronic and recurrent cystitis. EBioMedicine, 1(1):46-57.

Schwendener, Reto A (2014). Liposomes as vaccine delivery systems: A review of the recent advances. Therapeutic Advances in Vaccines, 2(6):159-182.

Lafranchi, Lorenzo; de Boer, Harmen R; de Vries, Elisabeth Ge; Ong, Shao-En; Sartori, Alessandro A; van Vugt, Marcel Atm (2014). APC/CCdh1 controls CtIP stability during the cell cycle and in response to DNA damage. EMBO Journal Online, 33(23):2860-2879.

Ragusa, Simone; Cheng, Jianpin; Ivanov, Konstantin I; Zangger, Nadine; Ceteci, Fatih; Bernier-Latmani, Jeremiah; Milatos, Stavros; Joseph, Jean-Marc; Tercier, Stephane; Bouzourene, Hanifa; Bosman, Fredrik T; Letovanec, Igor; Marra, Giancarlo; Gonzalez, Michel; Cammareri, Patrizia; Sansom, Owen J; Delorenzi, Mauro; Petrova, Tatiana V (2014). PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells. Cell Reports, 8(6):1957-1973.

Cannavo, Elda; Cejka, Petr (2014). Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks. Nature, 514(7520):122-125.

Mari, Cristina; Pierroz, Vanessa; Rubbiani, Riccardo; Patra, Malay; Hess, Jeannine; Spingler, Bernhard; Oehninger, Luciano; Schur, Julia; Ott, Ingo; Salassa, Luca; Ferrari, Stefano; Gasser, Gilles (2014). DNA Intercalating Ru(II) Polypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy. Chemistry - A European Journal, 20(44):14421-14436.

Giannattasio, Michele; Zwicky, Katharina; Follonier, Cindy; Foiani, Marco; Lopes, Massimo; Branzei, Dana (2014). Visualization of recombination-mediated damage bypass by template switching. Nature Structural & Molecular Biology, 21(10):884-892.

Semper, Raphaela P; Mejías-Luque, Raquel; Groß, Christina; Anderl, Florian; Müller, Anne; Vieth, Michael; Busch, Dirk H; Prazeres da Costa, Clarissa; Ruland, Jürgen; Groß, Olaf; Gerhard, Markus (2014). Helicobacter pylori-Induced IL-1β Secretion in Innate Immune Cells Is Regulated by the NLRP3 Inflammasome and Requires the Cag Pathogenicity Island. Journal of Immunology, 193(7):3566-3576.

Sturzenegger, Andreas; Burdova, Kamila; Kanagaraj, Radhakrishnan; Levikova, Maryna; Pinto, Cosimo; Cejka, Petr; Janscak, Pavel (2014). DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA-end resection in human cells. Journal of Biological Chemistry, 289(39):27314-27326.

Engler, Daniela B; Reuter, Sebastian; van Wijck, Yolanda; Urban, Sabine; Kyburz, Andreas; Maxeiner, Joachim; Martin, Helen; Yogev, Nir; Waisman, Ari; Gerhard, Markus; Cover, Timothy L; Taube, Christian; Müller, Anne (2014). Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. Proceedings of the National Academy of Sciences of the United States of America:1-6.

Leonidova, Anna; Pierroz, Vanessa; Adams, Luke A; Barlow, Nicholas; Ferrari, Stefano; Graham, Bim; Gasser, Gilles (2014). Enhanced Cytotoxicity through Conjugation of a "Clickable" Luminescent Re(I) Complex to a Cell-Penetrating Lipopeptide. ACS Medicinal Chemistry Letters, 5(7):809-814.

Joshi, Tanmaya; Pierroz, Vanessa; Ferrari, Stefano; Gasser, Gilles (2014). Bis(dipyridophenazine)(2-(2'-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) hexafluorophosphate: a lesson in stubbornness. ChemMedChem, 9(7):1419-1427.

Gianferrara, Teresa; Spagnul, Cinzia; Alberto, Roger; Gasser, Gilles; Ferrari, Stefano; Pierroz, Vanessa; Bergamo, Alberta; Alessio, Enzo (2014). Towards matched pairs of porphyrin-Re(I) /(99m) Tc(I) conjugates that combine photodynamic activity with fluorescence and radio imaging. ChemMedChem, 9(6):1231-1237.

Hess, Jeannine; Konatschnig, Sandro; Morard, Sandra; Pierroz, Vanessa; Ferrari, Stefano; Spingler, Bernhard; Gasser, Gilles (2014). Novel, mercury-free synthetic pathway for trifluoromethylthio-substituted metallocenes. Inorganic Chemistry, 53(7):3662-3667.

Kitanovic, Igor; Can, Suzan; Alborzinia, Hamed; Kitanovic, Ana; Pierroz, Vanessa; Leonidova, Anna; Pinto, Antonio; Spingler, Bernhard; Ferrari, Stefano; Molteni, Roberto; Steffen, Andreas; Metzler-Nolte, Nils; Wölfl, Stefan; Gasser, Gilles (2014). A deadly organometallic luminescent probe: anticancer activity of a ReI bisquinoline complex. Chemistry - A European Journal, 20(9):2496-2507.

Kishore, Shivendra; Piscuoglio, Salvatore; Kovac, Michal B; Gylling, Annette; Wenzel, Friedel; Trapani, Francesca; Altermatt, Hans Joerg; Mele, Valentina; Marra, Giancarlo; Peltomäki, Päivi; Terracciano, Luigi; Zavolan, Mihaela; Heinimann, Karl (2014). 3'-UTR Poly(T/U) tract deletions and altered expression of EWSR1 are a hallmark of mismatch repair-deficient cancers. Cancer Research, 74(1):224-234.

Schwendener, Reto A; Mete, Sibel (2014). A New Approach to Cancer Therapy: The Tumor Microenvironment as Target. In: Atta-ur-Rahman. Frontiers in Clinical Drug Research - Anti-Cancer Agents. Bentham Science Publishers, P.O. Box 294, 1400 AG Bussum, The Netherlands: Bentham eBooks, 3-68.

Hess, Jeannine; Konatschnig, Sandro; Morard, Sanda; Pierroz, Vanessa; Ferrari, Stefano; Spingler, Bernhard; Gasser, Gilles (2014). A Novel, Mercury-Free Synthetic Pathway for Trifluoromethylthio-Subsituted Metallocenes. Inorganic Chemistry, 53(7):3662-3667.

Joshi, Tanmaya; Pierroz, Vanessa; Mari, Cristina; Gemperle, Lea; Ferrari, Stefano; Gasser, Gilles (2014). A bis(dipyridophenazine)(2-(2-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) complex with anticancer action upon photodeprotection. Angewandte Chemie Internationale Edition, 53(11):2960-2963.

Vonlanthen, Janine; Okoniewski, Michal J; Menigatti, Mirco; Cattaneo, Elisa; Pellegrini-Ochsner, Daniela; Haider, Ritva; Jiricny, Josef; Staiano, Teresa; Buffoli, Federico; Marra, Giancarlo (2014). A comprehensive look at transcription factor gene expression changes in colorectal adenomas. BMC Cancer, 14:46.

Uzozie, Anuli. Analysis of Proteomic Alterations during Human Colorectal Tumorigenesis. 2014, University of Zurich, Faculty of Science.

Riebler, Andrea; Menigatti, Mirco; Song, Jenny Z; Statham, Aaron L; Stirzaker, Clare; Mahmud, Nadiya; Mein, Charles A; Clark, Susan J; Robinson, Mark D (2014). BayMeth: improved DNA methylation quantification for affinity capture sequencing data using a flexible Bayesian approach. Genome Biology, 15(2):R35.

Bregenhorn, Stephanie; Jiricny, Josef (2014). Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1. Nucleic Acids Research, 42(11):7096-7103.

Follonier, Cindy; Lopes, Massimo (2014). Combined bidimensional electrophoresis and electron microscopy to study specific plasmid DNA replication intermediates in human cells. In: Stockert, Juan C; Espada, Jesús; Blázquez-Castro, Alfonso. Functional Analysis of DNA and Chromatin. New York, USA: Humana Press (Springer), 209-219.

Downey, Charlene M; Aghaei, Mehrnoosh; Schwendener, Reto A; Jirik, Frank R (2014). DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS ONE, 9(6):e99988.

Ahuja Kumar, Akshay. DNA Damage Response and Replication Stress in Mouse Embryonic Stem Cells. 2014, University of Zurich, Faculty of Science.

Grosse, Nicole; Fontana, Andrea O; Hug, Eugen B; Lomax, Antony; Coray, Adolf; Augsburger, Marc; Paganetti, Harald; Sartori, Alessandro A; Pruschy, Martin (2014). Deficiency in homologous recombination renders Mammalian cells more sensitive to proton versus photon irradiation. International Journal of Radiation Oncology, Biology, Physics, 88(1):175-181.

König, Simone; Nitzki, Frauke; Uhmann, Anja; Dittmann, Kai; Theiss-Suennemann, Jennifer; Herrmann, Markus; Reichardt, Holger M; Schwendener, Reto; Pukrop, Tobias; Schulz-Schaeffer, Walter; Hahn, Heidi (2014). Depletion of cutaneous macrophages and dendritic cells promotes growth of Basal cell carcinoma in mice. PLoS ONE, 9(4):e93555.

Epelman, Slava; Lavine, Kory J; Beaudin, Anna E; Sojka, Dorothy K; Carrero, Javier A; Calderon, Boris; Brija, Thaddeus; Gautier, Emmanuel L; Ivanov, Stoyan; Satpathy, Ansuman T; Schilling, Joel D; Schwendener, Reto; Sergin, Ismail; Razani, Babak; Forsberg, E Camilla; Yokoyama, Wayne M; Unanue, Emil R; Colonna, Marco; Randolph, Gwendalyn J; Mann, Douglas L (2014). Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity, 40(1):91-104.

Murina, Olga; von Aesch, Christine; Karakus, Ufuk; Ferretti, Lorenza P; Bolck, Hella A; Hänggi, Kay; Sartori, Alessandro A (2014). FANCD2 and CtIP Cooperate to Repair DNA Interstrand Crosslinks. Cell Reports, 7(4):1030-1038.

Alvino, Ester; Passarelli, Francesca; Cannavò, Elda; Fortes, Cristina; Mastroeni, Simona; Caporali, Simona; Jiricny, Josef; Cappellini, Gian Carlo Antonini; Scoppola, Alessandro; Marchetti, Paolo; Modesti, Andrea; D'Atri, Stefania (2014). High expression of the mismatch repair protein MSH6 is associated with poor patient survival in melanoma. American Journal of Clinical Pathology, 142(1):121-132.

Paliwal, Shreya; Kanagaraj, Radhakrishnan; Sturzenegger, Andreas; Burdova, Kamila; Janscak, Pavel (2014). Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing. Nucleic Acids Research, 42(4):2380-2390.

Sabatino, Raffaella; Antonelli, Antonella; Battistelli, Serafina; Schwendener, Reto; Magnani, Mauro; Rossi, Luigia (2014). Macrophage depletion by free bisphosphonates and zoledronate-loaded red blood cells. PLoS ONE, 9(6):e101260.

Chatterjee, Sujoy; Zagelbaum, Jennifer; Savitsky, Pavel; Sturzenegger, Andreas; Huttner, Diana; Janscak, Pavel; Hickson, Ian D; Gileadi, Opher; Rothenberg, Eli (2014). Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures. Nature Communications, 5:5556.

Murina, Olga. Molecular and Cellular Aspects of DNA-end Resection by Human CtIP. 2014, University of Zurich, Faculty of Science.

Mejlvang, Jakob; Feng, Yunpeng; Alabert, Constance; Neelsen, Kai J; Jasencakova, Zuzana; Zhao, Xiaobei; Lees, Michael; Sandelin, Albin; Pasero, Philippe; Lopes, Massimo; Groth, Anja (2014). New histone supply regulates replication fork speed and PCNA unloading. Journal of Cell Biology, 204(1):29-43.

Ghodgaonkar, Medini Manohar; Kehl, Patrick; Ventura, Ilenia; Hu, Liyan; Bignami, Margherita; Jiricny, Josef (2014). Phenotypic characterization of missense polymerase-δ mutations using an inducible protein-replacement system. Nature Communications, 5:4990.

Leonidova, Anna; Pierroz, Vanessa; Rubbiani, Riccardo; Lan, Yanjun; Schmitz, Anita G; Kaech, Andres; Sigel, Roland K O; Ferrari, Stefano; Gasser, Gilles (2014). Photo-induced uncaging of a specific Re(I) organometallic complex in living cells. Chemical Science, 5:4044-4056.

Bologna, Serena. Post-translational modifications regulating Exonuclease 1 in response to replication forks stalling and double-strand breaks. 2014, University of Zurich, Faculty of Science.

Budhathoki, Jagat B; Ray, Sujay; Urban, Vaclav; Janscak, Pavel; Yodh, Jaya G; Balci, Hamza (2014). RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP. Nucleic Acids Research, 42(18):11528-45.

Uzozie, Anuli; Nanni, Paolo; Staiano, Teresa; Grossmann, Jonas; Barkow-Oesterreicher, Simon; Shay, Jerry W; Tiwari, Amit; Buffoli, Federico; Laczko, Endre; Marra, Giancarlo (2014). Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study. Molecular & Cellular Proteomics, 13(5):1198-1218.

Bocquet, Nicolas; Bizard, Anna H; Abdulrahman, Wassim; Larsen, Nicolai B; Faty, Mahamadou; Cavadini, Simone; Bunker, Richard D; Kowalczykowski, Stephen C; Cejka, Petr; Hickson, Ian D; Thomä, Nicolas H (2014). Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1. Nature Structural & Molecular Biology, 21(3):261-268.

Repmann, Simone. The Role of Mismatch Repair, Base Excision Repair and PARP-1 in the Processing of Oxidative DNA Damage. 2014, University of Zurich, Faculty of Science.

Ranjha, Lepakshi; Anand, Roopesh; Cejka, Petr (2014). The Saccaromyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctions. Journal of Biological Chemistry, 289(9):5674-5686.

Leonidova, Anna; Pierroz, Vanessa; Rubbiani, Riccardo; Heier, Jakob; Ferrari, Stefano; Gasser, Gilles (2014). Towards cancer cell-specific phototoxic organometallic rhenium(I) complexes. Dalton Transactions, 43(11):4287-4294.

Gianferrara, Teresa; Spagnul, Cinzia; Alberto, Roger; Gasser, Gilles; Ferrari, Stefano; Pierroz, Vanessa; Bergamo, Alberta; Alessio, Enzo (2014). Towards matched Pairs of Porphyrin-Re(I)/99mTc(I) Conjugates that combine Photodynamic Activity with Fluorescence- and Radio-Imaging. ChemMedChem, 9(6):1231-1237.

Constantinescu, Simona; Hecht, Katrin; Sobotzki, Nadine; Erzinger, Melanie M; Bovet, Cédric; Shay, Jerry W; Wollscheid, Bernd; Sturla, Shana J; Marra, Giancarlo; Beerenwinkel, Niko (2014). Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium. Chemical Research in Toxicology, 27(3):377-386.

Neelsen, Kai J; Chaudhuri, Arnab Ray; Follonier, Cindy; Herrador, Raquel; Lopes, Massimo (2014). Visualization and interpretation of eukaryotic DNA replication intermediates in vivo by electron microscopy. In: Stockert, Juan C; Espada, Jesús; Blázquez-Castro, Alfonso. Functional Analysis of DNA and Chromatin. New York, USA: Humana Press (Springer), 177-208.

2013

Ferretti, Lorenza P; Lafranchi, Lorenzo; Sartori, Alessandro A (2013). Controlling DNA-end resection: a new task for CDKs. Frontiers in Genetics, 4:99.

Patra, Malay; Joshi, Tanmaya; Pierroz, Vanessa; Ingram, Katrin; Kaiser, Marcel; Ferrari, Stefano; Spingler, Bernhard; Keiser, Jennifer; Gasser, Gilles (2013). DMSO-Mediated ligand dissociation: renaissance for biological activity of n-heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates. Chemistry - A European Journal:14768-14772.

Neelsen, Kai J; Zanini, Isabella M Y; Mijic, Sofija; Herrador, Raquel; Zellweger, Ralph; Ray Chaudhuri, Arnab; Creavin, Kevin D; Blow, J Julian; Lopes, Massimo (2013). Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template. Genes and Development, 27(23):2537-2542.

Tiwari, Amit; Schneider, Mirjam; Fiorino, Antonio; Haider, Ritva; Okoniewski, Michal J; Roschitzki, Bernd; Uzozie, Anuli; Menigatti, Mirco; Jiricny, Josef; Marra, Giancarlo (2013). Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors. PLoS ONE, 8(7):e69473.

König, Simone; Regen, Tommy; Dittmann, Kai; Engelke, Michael; Wienands, Jürgen; Schwendener, Reto; Hanisch, Uwe-Karsten; Pukrop, Tobias; Hahn, Heidi (2013). Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP). Cancer Immunology, Immunotherapy, 62(10):1587-1597.

Menigatti, M; Staiano, T; Manser, C N; Bauerfeind, P; Komljenovic, A; Robinson, M; Jiricny, J; Buffoli, F; Marra, G (2013). Epigenetic silencing of monoallelically methylated miRNA loci in precancerous colorectal lesions. Oncogenesis, 2:e56.

Lossaint, Gérald; Larroque, Marion; Ribeyre, Cyril; Bec, Nicole; Larroque, Christian; Décaillet, Chantal; Gari, Kerstin; Constantinou, Angelos (2013). FANCD2 binds MCM proteins and controls replisome function upon activation of S phase checkpoint signaling. Molecular Cell, 51(5):678-690.

Simandlova, Jitka; Zagelbaum, Jen; Payne, Miranda J; Chu, Wai Kit; Shevelev, Igor; Hanada, Katsuhiro; Chatterjee, Sujoy; Reid, Dylan A; Liu, Ying; Janscak, Pavel; Rothenberg, Eli; Hickson, Ian D (2013). FBH1 disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. Journal of Biological Chemistry, 288(47):34168-34180.

Schmid, Corina; Müller, Anne (2013). FoxD3 is a novel, epigenetically regulated tumor suppressor in gastric carcinogenesis. Gastroenterology, 144(1):22-25.

Follonier, Cindy; Oehler, Judith; Herrador, Raquel; Lopes, Massimo (2013). Friedreich's ataxia-associated GAA repeats induce replication-fork reversal and unusual molecular junctions. Nature Structural & Molecular Biology, 20(4):486-494.

Adelman, Carrie A; Lolo, Rafal L; Birkbak, Nicolai J; Murina, Olga; Matsuzaki, Kenichiro; Horejsi, Zuzana; Parmar, Kalindi; Borel, Valérie; Skehel, J Mark; Stamp, Gordon; D'Andrea, Alan; Sartori, Alessandro A; Swanton, Charles; Boulton, Simon J (2013). HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature, 502(7471):381-384.

Oertli, Mathias; Noben, Manuel; Engler, Daniela B; Semper, Raphaela P; Reuter, Sebastian; Maxeiner, Joachim; Gerhard, Markus; Taube, Christian; Müller, Anne (2013). Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance. Proceedings of the National Academy of Sciences of the United States of America, 110(8):3047-3052.

Berti, Matteo; Chaudhuri, Arnab Ray; Thangavel, Saravanabhavan; Gomathinayagam, Shivasankari; Kenig, Sasa; Vujanovic, Marko; Odreman, Federico; Glatter, Timo; Graziano, Simona; Mendoza-Maldonado, Ramiro; Marino, Francesca; Lucic, Bojana; Biasin, Valentina; Gstaiger, Matthias; Aebersold, Ruedi; Sidorova, Julia M; Monnat, Raymond J; Lopes, Massimo; Vindigni, Alessandro (2013). Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nature Structural & Molecular Biology, 20(3):347-354.

Patra, Malay; Ingram, Katrin; Leonidova, Anna; Pierroz, Vanessa; Ferrari, Stefano; Robertson, Murray N; Todd, Matthew H; Keiser, Jennifer; Gasser, Gilles (2013). In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-Praziquantel)Cr(CO)3 derivatives. Journal of Medicinal Chemistry, 56(22):9192-9198.

Bologna, Serena; Ferrari, Stefano (2013). It takes two to tango: Ubiquitin and SUMO in the DNA damage response. Frontiers in Genetics:4:106.

Salama, Nina R; Hartung, Mara L; Müller, Anne (2013). Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nature Reviews. Microbiology, 11(6):385-399.

Campo, Vanina A; Patenaude, Anne-Marie; Kaden, Svenja; Horb, Lori; Firka, Daniel; Jiricny, Josef; Di Noia, Javier M (2013). MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils. Nucleic Acids Research, 41(5):3032-3046.

Richter, Kirsten; Perriard, Guillaume; Behrendt, Rayk; Schwendener, Reto A; Sexl, Veronika; Dunn, Robert; Kamanaka, Masahito; Flavell, Richard A; Roers, Axel; Oxenius, Annette (2013). Macrophage and T cell produced IL-10 promotes viral chronicity. PLoS Pathogens, 9(11):e1003735.

Olivera-Harris, Maite. Mismatch repair dependent processing of o6-methylguanine adducts in xenopus egg extracts. 2013, University of Zurich, Faculty of Science.

Stölting, Meline N L; Ferrari, Stefano; Handschin, Christoph; Becskei, Attila; Provenzano, Maurizio; Sulser, Tullio; Eberli, Daniel (2013). Myoblasts inhibit prostate cancer growth by paracrine secretion of TNF alpha. Journal of Urology, 189(5):1952-1959.

Spagnul, Cinzia; Alberto, Roger; Gasser, Gilles; Ferrari, Stefano; Pierroz, Vanessa; Bergamo, Alberta; Gianferrara, Teresa; Alessio, Enzo (2013). Novel water-soluble Tc-99m(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging. Journal of Inorganic Biochemistry, 122:57-65.

Levikova, Maryna; Klaue, Daniel; Seidel, Ralf; Cejka, Petr (2013). Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity. Proceedings of the National Academy of Sciences of the United States of America, 110(22):E1992-E2001.

Neelsen, Kai J; Zanini, Isabella M Y; Herrador, Raquel; Lopes, Massimo (2013). Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates. Journal of Cell Biology, 200(6):699-708.

Paeschke, Katrin; Bochman, Matthew L; Garcia, P Daniela; Cejka, Petr; Friedman, Katherine L; Kowalczykowski, Stephen C; Zakian, Virginia A (2013). Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature, 497(7450):458-462.

Jiricny, Josef (2013). Postreplicative mismatch repair. Cold Spring Harbor Perspectives in Biology, 5(4):online.

Celesti, Giuseppe; Di Caro, Giuseppe; Bianchi, Paolo; Grizzi, Fabio; Basso, Gianluca; Marchesi, Federica; Doni, Andrea; Marra, Giancarlo; Roncalli, Massimo; Mantovani, Alberto; Malesci, Alberto; Laghi, Luigi (2013). Presence of twist1-positive neoplastic cells in the stroma of chromosome-unstable colorectal tumors. Gastroenterology, 145(3):647-657.e15.

Steger, Martin; Murina, Olga; Hühn, Daniela; Ferretti, Lorenza P; Walser, Reto; Hänggi, Kay; Lafranchi, Lorenzo; Neugebauer, Christine; Paliwal, Shreya; Janscak, Pavel; Gerrits, Bertran; Del Sal, Giannino; Zerbe, Oliver; Sartori, Alessandro A (2013). Prolyl isomerase PIN1 regulates DNA double-strand break repair by Counteracting DNA end resection. Molecular Cell, 50(3):333-343.

Sartori, Alessandro A; Steger, Martin (2013). Prolyl isomerization: A new PIN code for DSB repair. Cell Cycle, 12(17):2717-2718.

Chapman, J Ross; Barral, Patricia; Vannier, Jean-Baptiste; Borel, Valérie; Steger, Martin; Tomas-Loba, Antonia; Sartori, Alessandro A; Adams, Ian R; Batista, Facundo D; Boulton, Simon J (2013). RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Molecular Cell, 49(5):858-871.

Cannavo, Elda; Cejka, Petr; Kowalczykowski, Stephen C (2013). Relationship of DNA degradation by Saccharomyces cerevisiae Exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection. Proceedings of the National Academy of Sciences of the United States of America, 110(18):E1661-8.

Ghodgaonkar, Medini Manohar; Lazzaro, Federico; Olivera-Pimentel, Maite; Artola-Borán, Mariela; Cejka, Petr; Reijns, Martin A; Jackson, Andrew P; Plevani, Paolo; Muzi-Falconi, Marco; Jiricny, Josef (2013). Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Molecular Cell, 50(3):323-332.

Paliwal, Shreya. Role of RECQ5 DNA helicase in DNA double-strand break repair by homologous recombination. 2013, University of Zurich, Faculty of Science.

Hühn, Daniela; Bolck, Hella A; Sartori, Alessandro A (2013). Targeting DNA double-strand break signalling and repair: recent advances in cancer therapy. Swiss Medical Weekly, 143:w13837.

Schmid, Corina A; Craig, Vanessa J; Müller, Anne; Flori, Michael (2013). The role of microRNAs in the pathogenesis and treatment of hematopoietic malignancies. Current Pharmaceutical Design, 19(7):1201-1210.

Patra, Malay; Ingram, Katrin; Pierroz, Vanessa; Ferrari, Stefano; Spingler, Bernhard; Gasser, Robin B; Keiser, Jennifer; Gasser, Gilles (2013). [(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity. Chemistry - A European Journal, 19(7):2232-2235.

2012

Jurgeit, Andreas; McDowell, Robert; Moese, Stefan; Meldrum, Eric; Schwendener, Reto; Greber, Urs F (2012). Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects. PLoS Pathogens, 8(10):e1002976.

von Bueren, A O; Bacolod, M D; Hagel, C; Heinimann, K; Fedier, A; Kordes, U; Pietsch, T; Koster, J; Grotzer, M A; Friedman, H S; Marra, G; Kool, M; Rutkowski, S (2012). Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours. British Journal of Cancer, 107(8):1399-1408.

Dittrich, Christina M; Kratz, Katja; Sendoel, Ataman; Gruenbaum, Yosef; Jiricny, Josef; Hengartner, Michael O (2012). LEM-3 - A LEM domain containing nuclease involved in the DNA damage response in C. elegans. PLoS ONE, 7(2):e24555.

da Costa, Maria Helena Bueno; Sant'anna, Osvaldo A; Quintilio, Wagner; Schwendener, Reto Albert; de Araujo, Pedro Soares (2012). A Rational Design for the Nanoencapsulation of Poisonous Animal Venoms in Liposomes Prepared with Natural Phospholipids. Current Drug Delivery, 9(6):637-644.

Andersen, S D; Keijzers, G; Rampakakis, E; Engels, K; Luhn, P; El-Shemerly, M; Nielsen, F C; Du, Y; May, A; Bohr, V A; Ferrari, S; Zannis-Hadjopoulos, M; Fu, H; Rasmussen, L J (2012). 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. DNA Repair, 11(3):267-277.

Hitzler, Iris; Sayi, Ayca; Kohler, Esther; Engler, Daniela B; Koch, Katrin N; Hardt, Wolf-Dietrich; Müller, Anne (2012). Caspase-1 has both pro-inflammatory and regulatory properties in Helicobacter Infections, which are differentially mediated by its substrates IL-1β and IL-18. Journal of Immunology, 188(8):3594-3602.

Kousholt, Arne Nedergaard; Fugger, Kasper; Hoffmann, Saskia; Larsen, Brian D; Menzel, Tobias; Sartori, Alessandro A; Sørensen, Claus Storgaard (2012). CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation. Journal of Cell Biology, 197(7):869-876.

Oertli, M; Sundquist, M; Hitzler, I; Engler, D B; Arnold, I C; Reuter, S; Maxeiner, J; Hansson, M; Taube, C; Quiding-Järbrink, M; Müller, A (2012). DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection. Journal of Clinical Investigation, 122(3):1082-1096.

Cejka, Petr; Plank, Jody L; Dombrowski, Christopher C; Kowalczykowski, Stephen C (2012). Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA Complex: A Mechanism for Disentangling Chromosomes. Molecular Cell, 47(6):886-896.

Oertli, M. Dendritic Cells in Helicobacter Pylori-Specific Immune Tolerance and Asthma Protection. 2012, University of Zurich, Faculty of Science.

Warchol, Mark E; Schwendener, Reto A; Hirose, Keiko (2012). Depletion of resident macrophages does not alter sensory regeneration in the avian cochlea. PLoS ONE, 7(12):e51574.

Linkermann, Andreas; Bräsen, Jan H; De Zen, Federica; Weinlich, Ricardo; Schwendener, Reto A; Green, Douglas R; Kunzendorf, Ulrich; Krautwald, Stefan (2012). Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock. Molecular Medicine, 18(1):577-586.

Bregenhorn, Stephanie. Elucidating the role of mismatch repair in class switch recombination and chromatin assembly. 2012, University of Zurich, Faculty of Science.

Panigrahy, D; Edin, M L; Lee, C R; Huang, S; Bielenberg, D R; Butterfield, C E; Barnés, C M; Mammoto, A; Mammoto, T; Luria, A; Benny, O; Chaponis, D M; Dudley, A C; Greene, E R; Vergilio, J A; Pietramaggiori, G; Scherer-Pietramaggiori, S S; Short, S M; Seth, M; Lih, F B; Tomer, K B; Yang, J; Schwendener, R A; Hammock, B D; Falck, J R; Manthati, V L; Ingber, D E; Kaipainen, A; D'Amore, P A; Kieran, M W; Zeldin, D C (2012). Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. Journal of Clinical Investigation, 122(1):178-191.

Buerki, Nicole; Gautier, Lucienne; Kovac, Michal; Marra, Giancarlo; Buser, Mauro; Mueller, Hansjakob; Heinimann, Karl (2012). Evidence for breast cancer as an integral part of Lynch syndrome. Genes, Chromosomes & Cancer, 51(1):83-91.

Steger, M. Factors and Mechanisms Governing CtlP Regulation in DNA Double Strand Break Repair. 2012, University of Zurich, Faculty of Science.

Patra, Malay; Ingram, Katrin; Pierroz, Vanessa; Ferrari, Stefano; Spingler, Bernhard; Keiser, Jennifer; Gasser, Gilles (2012). Ferrocenyl Derivatives of the Anthelmintic Praziquantel: Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry, 55(20):8790-8798.

Oertli, Mathias; Müller, Anne (2012). Helicobacter pylori targets dendritic cells to induce immune tolerance, promote persistence and confer protection against allergic asthma. Gut Microbes, 3(6):566-571.

Kuonen, François; Laurent, Julien; Secondini, Chiara; Lorusso, Girieca; Stehle, Jean-Christophe; Rausch, Thierry; Faes-Van't Hull, Eveline; Bieler, Grégory; Alghisi, Gian-Carlo; Schwendener, Reto; Andrejevic-Blant, Snezana; Mirimanoff, René-Olivier; Rüegg, Curzio (2012). Inhibition of the Kit Ligand/c-Kit Axis Attenuates Metastasis in a Mouse Model Mimicking Local Breast Cancer Relapse after Radiotherapy. Clinical Cancer Research, 18(16):4365-4374.

Schöpf, B; Bregenhorn, S; Quivy, J P; Kadyrov, F A; Almouzni, G; Jiricny, J (2012). Interplay between mismatch repair and chromatin assembly. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 109(6):1895-1900.

Bonde, Anne-Katrine; Tischler, Verena; Kumar, Sushil; Soltermann, Alex; Schwendener, Reto (2012). Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors. BMC Cancer, 12:35.

Kanagaraj, Radhakrishnan; Parasuraman, Prasanna; Mihaljevic, Boris; van Loon, Barbara; Burdova, Kamila; König, Christiane; Furrer, Antonia; Bohr, Vilhelm A; Hübscher, Ulrich; Janscak, Pavel (2012). Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage. Nucleic Acids Research, 40(17):8449-8459.

Schilling, Joel D; Machkovech, Heather M; Kim, Alfred H J; Schwendener, Reto; Schwedwener, Reto; Schaffer, Jean E (2012). Macrophages modulate cardiac function in lipotoxic cardiomyopathy. American Journal of Physiology - Heart and Circulatory Physiology, 303(11):H1366-H1373.

Peña-Diaz, Javier; Jiricny, Josef (2012). Mammalian mismatch repair: error-free or error-prone? Trends in Biochemical Sciences, 37(5):206-214.

Zhang, Yi; Zhang, Ruihua; Zhang, Huafeng; Liu, Jing; Yang, Zhuoshun; Xu, Pingwei; Cai, Wenqian; Lu, Geming; Cui, Miao; Schwendener, Reto A; Shi, Huang-Zhong; Xiong, Huabao; Huang, Bo (2012). Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity. Cellular & Molecular Immunology, 9(6):489-496.

Pierroz, Vanessa; Joshi, Tanmaya; Leonidova, Anna; Mari, Cristina; Schur, Julia; Ott, Ingo; Spiccia, Leone; Ferrari, Stefano; Gasser, Gilles (2012). Molecular and cellular characterization of the biological effects of ruthenium(II) complexes incorporating 2-Pyridyl-2-Pyrimidine-4-Carboxylic acid. Journal of the American Chemical Society, 134(50):20376-20387.

Müller, Anne (2012). Multistep activation of the Helicobacter pylori effector CagA. Journal of Clinical Investigation, 122(4):1192-1195.

Peña-Diaz, Javier; Bregenhorn, Stephanie; Ghodgaonkar, Medini; Follonier, Cindy; Artola-Borán, Mariela; Castor, Dennis; Lopes, Massimo; Sartori, Alessandro A; Jiricny, Josef (2012). Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells. Molecular Cell, 47(5):669-680.

Enoiu, Milica; Jiricny, Josef; Schärer, Orlando D (2012). Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis. Nucleic Acids Research, 40(18):8953-8964.

Nasser, M W; Qamri, Z; Deol, Y S; Ravi, J; Powell, C A; Trikha, P; Schwendener, R A; Bai, X F; Shilo, K; Zou, X; Leone, G; Wolf, R; Yuspa, S H; Ganju, R K (2012). S100A7 Enhances Mammary Tumorigenesis through Upregulation of Inflammatory Pathways. Cancer Research, 72(3):604-615.

Craig, V J; Tzankov, A; Flori, M; Schmid, C A; Bader, A G; Müller, A (2012). Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo. Leukemia, 26(11):2421-2424.

Arnold, Isabelle C; Hitzler, Iris; Müller, Anne (2012). The Immunomodulatory Properties of Helicobacter pylori Confer Protection Against Allergic and Chronic Inflammatory Disorders. Frontiers in Cellular and Infection Microbiology:2:10.

Brachner, Andreas; Braun, Juliane; Ghodgaonkar, Medini; Castor, Dennis; Zlopasa, Livija; Ehrlich, Veronika; Jiricny, Josef; Gotzmann, Josef; Knasmüller, Siegfried; Foisner, Roland (2012). The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. Journal of Cell Science, 125(Pt 4):1048-1057.

Piepoli, Ada; Palmieri, Orazio; Maglietta, Rosalia; Panza, Anna; Cattaneo, Elisa; Latiano, Anna; Laczko, Endre; Gentile, Annamaria; Carella, Massimo; Mazzoccoli, Gianluigi; Ancona, Nicola; Marra, Giancarlo; Andriulli, Angelo (2012). The expression of leucine-rich repeat gene family members in colorectal cancer. Experimental Biology and Medicine, 237(10):1123-1128.

Singh, Dharmendra Kumar; Popuri, Venkateswarlu; Kulikowicz, Tomasz; Shevelev, Igor; Ghosh, Avik K; Ramamoorthy, Mahesh; Rossi, Marie L; Janscak, Pavel; Croteau, Deborah L; Bohr, Vilhelm A (2012). The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability. Nucleic Acids Research, 40(14):6632-6648.

Taube, Christian; Müller, Anne (2012). The role of Helicobacter pylori infection in the development of allergic asthma. Expert Review of Respiratory Medicine, 6(4):441-449.

Hitzler, Iris; Kohler, Esther; Engler, Daniela B; Yazgan, Ayca S; Müller, Anne (2012). The role of Th cell subsets in the control of Helicobacter infections and in T cell-driven gastric immunopathology. Frontiers in Immunology:3:142.

Ray Chaudhuri, Arnab; Hashimoto, Yoshitami; Herrador, Raquel; Neelsen, Kai J; Fachinetti, Daniele; Bermejo, Rodrigo; Cocito, Andrea; Costanzo, Vincenzo; Lopes, Massimo (2012). Topoisomerase I poisoning results in PARP-mediated replication fork reversal. Nature Structural and Molecular Biology, 19(4):417-423.

Vasovcak, P; Krepelova, A; Menigatti, M; Puchmajerova, A; Skapa, P; Augustinakova, A; Amann, G; Wernstedt, A; Jiricny, J; Marra, G; Wimmer, K (2012). Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency. DNA Repair, 11(7):616-623.

2011

Sharma, A; Bode, B; Wenger, R H; Lehmann, K; Sartori, A A; Moch, H; Knuth, A; von Boehmer, L; van den Broek, Maries (2011). Gamma-radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo. PLoS ONE, 6(11):e28217.

Engels, K; Giannattasio, M; Muzi-Falconi, M; Lopes, M; Ferrari, S (2011). 14-3-3 proteins regulate exonuclease 1-dependent processing of stalled replication forks. PLoS Genetics, 7(4):e1001367.

Vuarchey, C; Kumar, S; Schwendener, R A (2011). Albumin coated liposomes: a novel platform for macrophage specific drug delivery. Nanotechnology Development, 1(1):e2.

Pocsfalvi, G; Votta, G; De Vincenzo, A; Fiume, I; Raj, D A A; Marra, G; Stoppelli, M P; Iaccarino, I (2011). Analysis of secretome changes uncovers an autocrine/paracrine component in the ability of c -Myc to modulate cell proliferation and motility. Journal of Proteome Research, 10(12):5326-5337.

Zattoni, M; Mura, M L; Deprez, F; Schwendener, R A; Engelhardt, B; Frei, K; Fritschy, J M (2011). Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. Journal of Neuroscience, 31(11):4037-4050.

Toller, I M; Neelsen, K J; Steger, M; Hartung, M L; Hottiger, M O; Stucki, M; Kalali, B; Gerhard, M; Sartori, A A; Lopes, M; Müller, A (2011). Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 108(36):14944-14949.

Bijnsdorp, I V; Schwendener, R A; Schott, H; Fichtner, I; Smid, K; Laan, A C; Schott, S; Losekoot, N; Honeywell, R J; Peters, G J (2011). Cellular pharmacology of multi- and duplex drugsconsisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine. Investigational New Drugs, 29(2):248-257.

Veljkovic, E; Jiricny, J; Menigatti, M; Rehrauer, H; Han, W (2011). Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B. Toxicology in Vitro, 25(2):446-453.

Arnold, I C; Zigova, Z; Holden, M; Lawley, T D; Rademakers, R; Dougan, G; Falkow, S; Bentley, S D; Müller, A (2011). Comparative whole genome sequence analysis of the carcinogenic bacterial model pathogen helicobacter felis. Genome Biology and Evolution, 3:302-308.

Hitzler, I; Oertli, M; Becher, B; Agger, E M; Müller, A (2011). Dendritic cells prevent rather than promote immunity conferred by a helicobacter vaccine using a mycobacterial adjuvant. Gastroenterology, 141(1):186-196.e1.

Cortázar, D; Kunz, C; Selfridge, J; Lettieri, T; Saito, Y; Macdougall, E; Wirz, A; Schuermann, D; Jacobs, A L; Siegrist, F; Steinacher, R; Jiricny, J; Bird, A; Schär, P (2011). Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature, 470(7334):419-423.

Craig, V J; Cogliatti, S B; Rehrauer, H; Wündisch, T; Müller, A (2011). Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric lymphomagenesis. Cancer Research, 71(10):3616-3624.

Kovac, M; Laczko, E; Haider, R; Jiricny, J; Mueller, H; Heinimann, K; Marra, G (2011). Familial colorectal cancer: eleven years of data from a registry program in Switzerland. Familial Cancer, 10(3):605-616.

Tiwari, A. Functional characterization of KIAA1199. 2011, University of Zurich, Faculty of Science.

Müller, A; Oertli, M; Arnold, I C (2011). H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection. Cell Communication and Signaling, 9(1):25.

Arnold, I C; Dehzad, N; Reuter, S; Martin, H; Becher, B; Taube, C; Müller, A (2011). Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. Journal of Clinical Investigation, 121(8):3088-3093.

Hitzler, I. Immune mechanisms governing infection control and pathogenesis of helicobacter pylori and prospects for a human vaccine. 2011, University of Zurich, Faculty of Science.

Lee, Y S; Li, P; Huh, J Y; Hwang, I J; Lu, M; Kim, J I; Ham, M; Talukdar, S; Chen, A; Lu, W J; Bandyopadhyay, G K; Schwendener, R; Olefsky, J; Kim, J B (2011). Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes, 60(10):2474-2483.

Müller, A; Solnick, J V (2011). Inflammation, immunity, and vaccine development for Helicobacter pylori. Helicobacter, 16(Sup 1):26-32.

Rizzo, A; Monteleone, I; Fina, D; Stolfi, C; Caruso, R; Fantini, M C; Franzè, E; Schwendener, R; Pallone, F; Monteleone, G (2011). Inhibition of colitis by IL-25 associates with induction of alternatively activated macrophages. Inflammatory Bowel Diseases, 18(3):449-459.

Yamamoto, K N; Kobayashi, S; Tsuda, M; Kurumizaka, H; Takata, M; Kono, K; Jiricny, J; Takeda, S; Hirota, K (2011). Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 108(16):6492-6496.

Oertli, M; Engler, D B; Kohler, E; Koch, M; Meyer, T F; Müller, A (2011). MicroRNA-155 is essential for the T cell-mediated control of Helicobacter pylori infection and for the induction of chronic gastritis and colitis. Journal of Immunology, 187(7):3578-3586.

Craig, V J; Cogliatti, S B; Imig, J; Renner, C; Neuenschwander, S; Rehrauer, H; Schlapbach, R; Dirnhofer, S; Tzankov, A; Müller, A (2011). Myc-mediated repression of microRNA-34a promotes high grade transformation of B-cell lymphoma by dysregulation of FoxP1. Blood, 117(23):6227-6236.

Schott, H; Goltz, D; Schott, T C; Jauch, C; Schwendener, R A (2011). N(4)-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine-new drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate). Bioorganic & Medicinal Chemistry, 19(11):3520-3526.

Egilmez, N K; Harden, J L; Virtuoso, L P; Schwendener, R A; Kilinc, M O (2011). Nitric oxide short-circuits interleukin-12-mediated tumor regression. Cancer Immunology, Immunotherapy, 60(6):839-845.

Cattaneo, E; Baudis, M; Buffoli, F; Bianco, M A; Zorzi, F; Marra, G (2011). Pathways and crossroads to colorectal cancer. In: Fitzgerald, R C. Pre-Invasive Disease: Pathogenesis and Clinical Management. New York: Springer, 369-394.

Cattaneo, E; Laczko, E; Buffoli, F; Zorzi, F; Bianco, M A; Menigatti, M; Bartosova, Z; Haider, R; Helmchen, B; Sabates-Bellver, J; Tiwari, A; Jiricny, J; Marra, G (2011). Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid). EMBO Molecular Medicine, 3(6):334-347.

Begemann, M; Spengler, S; Kanber, D; Haake, A; Baudis, M; Leisten, I; Binder, G; Markus, S; Rupprecht, T; Segerer, H; Fricke-Otto, S; Mühlenberg, R; Siebert, R; Buiting, K; Eggermann, T (2011). Silver-Russell patients showing a broad range of ICR1 and ICR2 hypomethylation in different tissues. Clinical Genetics, 80(1):83-88.

Yang, H; Kim, C; Kim, M J; Schwendener, R A; Alitalo, K; Heston, W; Kim, I; Kim, W J; Koh, G Y (2011). Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. Molecular Cancer, 10:36.

Sayi, A; Kohler, E; Toller, I M; Flavell, R A; Müller, W; Roers, A; Müller, A (2011). TLR-2-Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells. Journal of Immunology, 186(2):878-890.

Mete, S. Targeting tumor microenvironment by zoledronate as a novel therapeutic approach in cancer. 2011, University of Zurich, Faculty of Science.

Arnold, I C; Hitzler, I; Engler, D; Oertli, M; Agger, E M; Müller, A (2011). The C-terminally encoded, MHC class II-restricted T cell antigenicity of the helicobacter pylori virulence factor CagA promotes gastric preneoplasia. Journal of Immunology, 186(11):6165-6172.

Eid, Wassim. The Role of Exonuclease-1 and its Interaction Partners in Genome Stability. 2011, University of Zurich, Faculty of Science.

Meerang, M; Ritz, D; Paliwal, S; Garajova, Z; Bosshard, M; Mailand, N; Janscak, P; Hübscher, U; Meyer, H; Ramadan, K (2011). The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nature Cell Biology, 13(11):1376-1382.

Arnold, I; Lee, J Y; Amieva, M R; Roers, A; Flavell, R A; Sparwasser, T; Müller, A (2011). Tolerance rather than immunity protects from Helicobacter pylori -induced gastric preneoplasia. Gastroenterology, 140(1):199-209.

Treiger Borema, S E; Schwendener, R A; Osso, J A; de Andrade, H F; Nascimento, N (2011). Uptake and antileishmanial activity of meglumine antimoniate-containing liposomes in Leishmania (Leishmania) major-infected macrophages. International Journal of Antimicrobial Agents, 38(4):341-347.

Ruiz-Sánchez, P; König, C J; Ferrari, S; Alberto, R (2011). Vitamin B₁₂ as a carrier for targeted platinum delivery: in vitro cytotoxicity and mechanistic studies. Journal of Biological Inorganic Chemistry, 16(1):33-44.

2010

Craig, V J; Arnold, I; Gerke, C; Huynh, M Q; Wundisch, T; Neubauer, A; Renner, C; Falkow, S; Mueller, A (2010). Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins. Blood, 115(3):581-591.

Hashimoto, Y; Chaudhuri, A R; Lopes, M; Costanzo, V (2010). Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nature Structural and Molecular Biology, 17(11):1305-1311.

Haynes, N M; Hawkins, E D; Li, M; McLaughlin, N M; Hämmerling, G J; Schwendener, R; Winoto, A; Wensky, A; Yagita, H; Takeda, K; Kershaw, M H; Darcy, P K; Smyth, M J (2010). CD11c(+) dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors. Journal of Immunology, 185(1):532-541.

Toller, I M; Altmeyer, M; Kohler, E; Hottiger, M O; Müller, A (2010). Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia. Cancer Research, 70(14):5912-5922.

Schwendener, S; Raynard, S; Paliwal, S; Cheng, A; Kanagaraj, R; Shevelev, I; Stark, J M; Sung, P; Janscak, P (2010). Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity. Journal of Biological Chemistry, 285(21):15739-15745.

Speina, E; Dawut, L; Hedayati, M; Wang, Z; May, A; Schwendener, S; Janscak, P; Croteau, D L; Bohr, V A (2010). Human RECQL5{beta} stimulates flap endonuclease 1. Nucleic Acids Research, 38(9):2904-2916.

Hofer, U; Schlaepfer, E; Baenziger, S; Nischang, M; Regenass, S; Schwendener, R; Kempf, W; Nadal, D; Speck, R F (2010). Inadequate clearance of translocated bacterial products in HIV-infected humanized mice. PLoS Pathogens, 6(4):e1000867.

Ibrahim-Granet, O; Jouvion, G; Hohl, T M; Droin-Bergère, S; Philippart, F; Kim, O Y; Adib-Conquy, M; Schwendener, R; Cavaillon, J-M; Brock, M (2010). In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis. BMC Microbiology, 10:105.

Jiricny, J (2010). DNA repair: how MutM finds the needle in a haystack. Current Biology, 20(4):R145-R147.

Eggermann, T; Schönherr, N; Spengler, S; Jäger, S; Denecke, B; Binder, G; Baudis, M (2010). Identification of a 21q22 duplication in a Silver-Russell syndrome patient further narrows down the Down syndrome critical region. American Journal of Medical Genetics. Part A, 152A(2):356-359.

Craig, V J; Cogliatti, S B; Arnold, I; Gerke, C; Balandat, J-E; Wündisch, T; Müller, A (2010). B-cell receptor signaling and CD40 ligand-independent T cell help cooperate in Helicobacter-induced MALT lymphomagenesis. Leukemia, (24):1186-1196.

Kratz, K. Biochemical characterization of KIAA1018/FAN1, a novel endonuclease involved in interstrand cross-link repair. 2010, University of Zurich, Faculty of Science.

Eid, W; Steger, M; El-Shemerly, M; Ferretti, L P; Pena-Diaz, J; König, C J; Valtorta, E; Sartori, A A; Ferrari, S (2010). DNA end resection by CtIP and exonuclease 1 prevents genomic instability. EMBO Reports, 11(12):962-968.

Cejka, Petr; Cannavo, Elda; Polaczek, Piotr; Masuda-Sasa, Taro; Pokharel, Subhash; Campbell, Judith L; Kowalczykowski, Stephen C (2010). DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2. Nature, 467(7311):112-116.

Schöpf, B. DNA mismatch repair and chromatin & functional characterisation of the zinc finger of KIAA1018. 2010, University of Zurich, Faculty of Science.

Kratz, K; Schöpf, B; Kaden, S; Sendoel, A; Eberhard, R; Lademann, C; Cannavó, E; Sartori, A A; Hengartner, M O; Jiricny, J (2010). Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell, 142(1):77-88.

Giannattasio, M; Follonier, C; Tourrière, H; Puddu, F; Lazzaro, F; Pasero, P; Lopes, M; Plevani, P; Muzi-Falconi, M (2010). Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation. Molecular Cell, 40(1):50-62.

Engels, K. Functional characterization of 14-3-3 proteins and exonuclease1 at stalled replication forks. 2010, University of Zurich, Faculty of Science.

Hühn, D. Functional characterization of the human RECQ5 helicase. 2010, University of Zurich, Faculty of Science.

Kaden, S. In vivo characterisaton of KIAA1018/FAN1 and its role in DNA repair. 2010, University of Zurich, Faculty of Science.

Peralta, R; Baudis, M; Vazquez, G; Juárez, S; Ortiz, R; Decanini, H; Hernandez, D; Gallegos, F; Valdivia, A; Piña, P; Salcedo, M (2010). Increased expression of cellular retinol-binding protein 1 in laryngeal squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology, 136(6):931-938.

Yoshikiyo, K; Kratz, K; Hirota, K; Nishihara, K; Takata, M; Kurumizaka, H; Horimoto, S; Takeda, S; Jiricny, J (2010). KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(50):21553-21557.

Schwendener, R A; Schott, H (2010). Liposome formulations of hydrophobic drugs. In: Weissig, V. Liposomes, Methods and Protocols, Vol. 1: Pharmaceutical Nanocarriers. New York, NY, USA: Humana Press, 129-138.

Schwendener, R A; Ludewig, B; Cerny, A; Engler, O (2010). Liposome-based vaccines. In: Weissig, V. Liposomes, Methods and Protocols, Vol. 1: Pharmaceutical Nanocarriers. New York, NY, USA: Springer, 163-175.

Bhatia, P. Mechanism of regulation of protein Kinase Aurora A in response to Mitotic DNA damage. 2010, University of Zurich, Faculty of Science.

Bhatia, P; Menigatti, M; Brocard, M; Morley, S J; Ferrari, S (2010). Mitotic DNA damage targets the Aurora A/TPX2 complex. Cell Cycle, 9(22):4592-4599.

Toller, I M. Molecular Mechanisms of Inflammation-Induced Cancer: T-cells as Targets for Prevention and Cure of Helicobacter-Related Gastric Preneoplasia. 2010, University of Zurich, Faculty of Science.

Craig, V J. Novel insights into the molecular pathogenesis of gastric MALT lymphoma. 2010, University of Zurich, Faculty of Science.

Peña-Diaz, J; Jiricny, J (2010). PCNA and MutLα: partners in crime in triplet repeat expansion? Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(38):16409-16410.

Toller, I M; Hitzler, I; Sayi, A; Mueller, A (2010). Prostaglandin E2 prevents Helicobacter-induced gastric preneoplasia and facilitates persistent infection in a mouse model. Gastroenterology, 138(4):1455-1467.e4 .

Kanagaraj, R; Huehn, D; MacKellar, A; Menigatti, M; Zheng, L; Urban, V; Shevelev, I; Greenleaf, A L; Janscak, P (2010). RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription. Nucleic Acids Research, 38(22):8131-8140.

Ferrari, S. Regulation of cell cycle transitions. 2010, University of Zurich, Faculty of Science.

Gillessen, S; Templeton, A; Marra, G; Kuo, Y F; Valtorta, E; Shahinian, V B (2010). Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer. Journal of the National Cancer Institute, 102(23):1760-1770.

Cejka, Petr; Plank, Jody L; Bachrati, Csanad Z; Hickson, Ian D; Kowalczykowski, Stephen C (2010). Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3. Nature Structural & Molecular Biology, 17(11):1377-1382.

Spengler, S; Schönherr, N; Binder, G; Wollmann, H; Fricke-Otto, S; Mühlenberg, R; Denecke, B; Baudis, M; Eggermann, T (2010). Submicroscopic chromosomal imbalances in idiopathic Silver-Russell syndrome (SRS): the SRS phenotype overlaps with the 12q14 microdeletion syndrome. Journal of Medical Genetics, 47(5):356-360.

Arnold, I. The Balance Between Immunity nad Tolerance Determines the Outcome of H. pylori Infection. 2010, University of Zurich, Faculty of Science.

Cejka, Petr; Kowalczykowski, Stephen C (2010). The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds Holliday junctions. Journal of Biological Chemistry, 285(11):8290-8301.

Cattaneo, E. The transcriptomic profiling of human colorectal precancerous lesions. 2010, University of Zurich, Faculty of Science.

Bonde, A K. Tumor associated macrophages regulate epithelial to mesenchymal transition in tumor cells in a TGF-β dependent manner. 2010, University of Zurich, Faculty of Science.

2009

Liu, J; Bandyopadhyay, N; Ranka, S; Baudis, M; Kahveci, T (2009). Inferring Progression Models for CGH data. Bioinformatics, 25(17):2208-2215.

Andrés, G; Leali, D; Mitola, S; Coltrini, D; Camozzi, M; Corsini, M; Belleri, M; Hirsch, E; Schwendener, R; Christofori, G; Alcamí, A; Presta, M (2009). A pro-inflammatory signature mediates FGF2-induced angiogenesis. Journal of Cellular and Molecular Medicine, 13(8b):2083-2108.

Torroella-Kouri, M; Silvera, R; Rodriguez, D; Caso, R; Shatry, A; Opiela, S; Ilkovitch, D; Schwendener, R; Iragavarapu-Charyulu, V; Cardentey, Y; Strbo, N; Lopez, D M (2009). Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated. Cancer Research, 69(11):4800-4809.

Zheng, L; Kanagaraj, R; Mihaljevic, B; Schwendener, S; Sartori, A A; Gerrits, B; Shevelev, I; Janscak, P (2009). MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Research, 37(8):2645-2657.

Dietschy, T; Shevelev, I; Pena-Diaz, J; Hühn, D; Kuenzle, S; Mak, R; Miah, M F; Hess, D; Fey, M; Hottiger, M O; Janscak, P; Stagljar, I (2009). p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization. Journal of Cell Science, 122(Pt. 8):1258-1267.

Schanz, S; Castor, D; Fischer, F; Jiricny, J (2009). Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(14):5593-5598.

Gunsten, S; Mikols, C L; Grayson, M H; Schwendener, R; Agapov, E; Tidwell, R M; Cannon, C L; Brody, S L; Walter, M J (2009). IL-12 p80-dependent macrophage recruitment primes the host for increased survival following a lethal respiratory viral infection. Immunology, 126(4):500-513.

Boerma, E G; Siebert, R; Kluin, P M; Baudis, M (2009). Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge. Leukemia, 23(2):225-234.

Menigatti, M; Truninger, K; Gebbers, J O; Marbet, U; Marra, G; Schär, P (2009). Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters. Oncogene, 28(6):899-909.

Siehler, S Y; Schrauder, M; Gerischer, U; Cantor, S; Marra, G; Wiesmüller, L (2009). Human MutL-complexes monitor homologous recombination independently of mismatch repair. DNA Repair, 8(2):242-252.

Güthlein, C; Wanner, R M; Sander, P; Davis, E O; Bosshard, M; Jiricny, J; Böttger, E C; Springer, B (2009). Characterisation of the mycobacterial NER system reveals novel functions of uvrD1 helicase. Journal of Bacteriology, 191(2):555-562.

Schott, H; Hamprecht, K; Schott, S; Schott, T C; Schwendener, R (2009). Synthesis and in vitro activities of a new antiviral duplex drug linking Zidovudine (AZT) and Foscarnet (PFA) via an octadecylglycerol residue. Bioorganic & Medicinal Chemistry, 17(1):303-310.

Yodh, J G; Stevens, B C; Kanagaraj, R; Janscak, P; Ha, T (2009). BLM helicase measures DNA unwound before switching strands and hRPA promotes unwinding reinitiation. The EMBO Journal, 28(4):405-416.

Templeton, A; Marra, G; Valtorta, E; Heinimann, K; Müller, H; Köberle, D; Gillessen, S (2009). Concordant colon tumors in monozygotic twins previously treated for prostate cancer. Familial Cancer, 8(2):167-171.

Kataru, R P; Jung, K; Jang, C; Yang, H; Schwendener, R; Baik, J E; Han, S H; Alitalo, K; Koh, G Y (2009). Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood, 113(22):5650-5659.

Lopes, M (2009). Electron microscopy methods for studying in vivo DNA replication intermediates. Methods in Molecular Biology, 521:605-631.

Castor, D. Functional characterization of RuvB-like 1 during cell division. 2009, University of Zurich, Faculty of Science.

Schwendener, S. Functional characterization of the human RECQ5 protein. 2009, University of Zurich, Faculty of Science.

Angelov, Todor; Guainazzi, Angelo; Schärer, Orlando D (2009). Generation of DNA interstrand cross-links by post-synthetic reductive amination. Organic Letters, 11(3):661-664.

Kehl, P. Inducible Gene Replacement of DNA Polymerase Delta. 2009, University of Zurich, Faculty of Science.

Zumsteg, A; Baeriswyl, V; Imaizumi, N; Schwendener, R; Rüegg, C; Christofori, G (2009). Myeloid cells contribute to tumor lymphangiogenesis. PLoS ONE, 4(9):e7067.

Mueller, A; Sayi, A; Hitzler, I (2009). Protective and pathogenic functions of T-cells are inseparable during the Helicobacter-host interaction. Discovery medicine, 8(41):68-73.

Gerstung, M; Baudis, M; Moch, H; Beerenwinkel, N (2009). Quantifying cancer progression with conjunctive Bayesian networks. Bioinformatics, 25(21):2809-2815.

Bug, S; Dürig, J; Oyen, F; Klein-Hitpass, L; Martin-Subero, J I; Harder, L; Baudis, M; Arnold, N; Kordes, U; Dührsen, U; Schneppenheim, R; Siebert, R (2009). Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition. Cancer Genetics and Cytogenetics, 192(1):44-47.

Kim, K E; Koh, Y J; Jeon, B H; Jang, C; Han, J; Kataru, R P; Schwendener, R; Kim, J M; Koh, G Y (2009). Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm. American Journal of Pathology, 175(4):1733-1745.

Lapkouski, M; Panjikar, S; Janscak, P; Smatanova, I K; Carey, J; Ettrich, R; Csefalvay, E (2009). Structure of the motor subunit of type I restriction-modification complex EcoR124I. Nature Structural and Molecular Biology, 16(1):94-95.

Schott, H; Schott, S; Schwendener, R (2009). Synthesis and in vitro activities of new anticancer duplex drugs linking 2'-deoxy-5-fluorouridine (5-FdU) with 3'-C-ethynylcytidine (ECyd) via a phosphodiester bonding. Bioorganic & Medicinal Chemistry, 17(19):6824-6831.

Sayi, A; Kohler, E; Hitzler, I; Arnold, I; Schwendener, R; Rehrauer, H; Müller, A (2009). The CD4+ T cell-mediated IFN-gamma response to Helicobacter infection is essential for clearance and determines gastric cancer risk. Journal of Immunology, 182(11):7085-7101.

Menigatti, M; Cattaneo, E; Sabates-Bellver, J; Ilinsky, V V; Went, P; Buffoli, F; Marquez, V E; Jiricny, J; Marra, G (2009). The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis. Molecular Cancer Therapeutics, 8:124.

Wanner, R M; Castor, D; Güthlein, C; Böttger, E C; Springer, B; Jiricny, J (2009). The uracil DNA glycosylase UdgB of Mycobacterium smegmatis protects the organism from the mutagenic effects of cytosine and adenine deamination. Journal of Bacteriology, 191(20):6312-6319.

Westwood, J A; Haynes, N M; Sharkey, J; McLaughlin, N; Pegram, H J; Schwendener, R A; Smyth, M J; Darcy, P K; Kershaw, M H (2009). Toll-like receptor triggering and T-cell costimulation induce potent antitumor immunity in mice. Clinical Cancer Research, 15(24):7624-7633.

Marra, G. Understanding tumorigenesis of the large intestine: The cornerstone of effective cancer prevention strategies. 2009, University of Zurich, Faculty of Science.

2008

Roos, A; Elbracht, M; Baudis, M; Senderek, J; Schönherr, N; Eggermann, T; Schüler, H M (2008). A 10.7 Mb interstitial deletion of 13q21 without phenotypic effect defines a further non-pathogenic euchromatic variant. American Journal of Medical Genetics. Part A, 146A(18):2417-2420.

Vlasic, I; Ivancic-Bace, I; Imesek, M; Mihaljevic, B; Brcic-Kostic, K (2008). RecJ nuclease is required for SOS induction after introduction of a double-strand break in a RecA loading deficient recB mutant of Escherichia coli. Biochimie, 90(9):1347-1355.

Huertas, P; Cortés-Ledesma, F; Sartori, A A; Aguilera, A; Jackson, S P (2008). CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature, 455:689-692.

Cejka, P; Jiricny, J (2008). Interplay of DNA repair pathways controls methylation damage toxicity in Saccharomyces cerevisiae. Genetics, 179(4):1835-1844.

Hoischen, A; Ehrler, M; Fassunke, J; Simon, M; Baudis, M; Landwehr, C; Radlwimmer, B; Lichter, P; Schramm, J; Becker, A J; Weber, R G (2008). Comprehensive characterization of genomic aberrations in gangliogliomas by CGH, array-based CGH and interphase FISH. Brain Pathology, 18(3):326-337.

Zheng, L. The role of human RECQ5 helicase in the maintenance of genomic stability revealed by protein-protein interaction study. 2008, University of Zurich, Faculty of Science.

Ren, H; Dou, S X; Zhang, X D; Wang, P Y; Kanagaraj, R; Liu, J L; Janscak, P; Hu, J S; Xi, X G (2008). The zinc-binding motif of human RECQ5beta suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme. Biochemical Journal, 412(3):425-433.

Schanz, S. Involvement of mismatch repair proteins in activation-induced deaminase-mediated antibody diversification. 2008, University of Zurich, Faculty of Science.

Neelsen, K J. A novel gene therapy approach for the treatment of tumours with microsatellite instability. 2008, University of Zurich, Faculty of Science.

El-Shemerly, M; Hess, D; Pyakurel, A K; Moselhy, S; Ferrari, S (2008). ATR-dependent pathways control hEXO1 stability in response to stalled forks. Nucleic Acids Research, 36(2):511-519.

Radhakrishnan, Kanagaraj. Biochemistry of Human RecQ DNA Helicases and their Role in DNA Repair. 2008, University of Zurich, Faculty of Science.

Bauer, V L; Braselmann, H; Henke, M; Mattern, D; Walch, A; Unger, K; Baudis, M; Lassmann, S; Huber, R; Wienberg, J; Werner, M; Zitzelsberger, H F (2008). Chromosomal changes characterize head and neck cancer with poor prognosis. Journal of Molecular Medicine, 86(12):1353-1365.

Matthews, J M; Bhati, M; Craig, V J; Deane, J E; Jeffries, C; Lee, C; Nancarrow, A L; Ryan, D P; Sunde, M (2008). Competition between LIM-binding domains. Biochemical Society Transactions, 36(Pt 6):1393-1397.

Spycher, C; Miller, E S; Townsend, K; Pavic, L; Morrice, N A; Janscak, P; Stewart, G S; Stucki, M (2008). Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. Journal of Cell Biology, 181(2):227-240.

Jiricny, J; Menigatti, M (2008). DNA Cytosine demethylation: are we getting close? Cell, 135(7):1167-1169.

Kim, D D; Miwa, T; Kimura, Y; Schwendener, R; van Lookeren Campagne, M; Song, W C (2008). Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood, 112(4):1109-1119.

Hippert, C; Dubois, G; Morin, C; Disson, O; Ibanes, S; Jacquet, C; Schwendener, R; Antignac, C; Kremer, E J; Kalatzis, V (2008). Gene transfer may be preventive but not curative for a lysosomal transport disorder. Molecular Therapy, 16(8):1372-81.

Haugen, A C; Goel, A; Yamada, K; Marra, G; Nguyen, T P; Nagasaka, T; Kanazawa, S; Koike, J; Kikuchi, Y; Zhong, X; Arita, M; Shibuya, K; Oshimura, M; Hemmi, H; Boland, C R; Koi, M (2008). Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. Cancer Research, 68(20):8465-8472.

Bhati, M; Lee, C; Nancarrow, A L; Lee, M; Craig, V J; Bach, I; Guss, J M; Mackay, J P; Matthews, J M (2008). Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. The EMBO journal, 27(14):2018-29.

Bijnsdorp, I V; Schwendener, R; Schott, H; Schott, S; Fichtner, I; Honeywell, R J; Losekoot, N; Laan, A C; Peters, G J (2008). In vitro activity and mechanism of action of a duplex and multidrug of ethynylcytidine and 5-fluorodeoxyuridine. Nucleic Acids Symposium Series (2004), (52):651.

Shen, W; Liu, Y; Zhu, J; Schwendener, R; Huard, J (2008). Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury. Journal of Cellular Physiology, 214(2):405-412.

Ren, W; Markel, D C; Schwendener, R; Ding, Y; Wu, B; Wooley, P H (2008). Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model. Journal of Biomedical Materials Research Part A, 85(4):1043-1051.

Räschle, M; Knipsheer, P; Enoiu, M; Angelov, T; Sun, J; Griffith, J D; Ellenberger, T E; Schärer, O D; Walter, J C (2008). Mechanism of replication-coupled DNA interstrand crosslink repair. Cell, 134(6):969-980.

Ollila, S; Dermadi Bebek, D; Jiricny, J; Nyström, M (2008). Mechanisms of pathogenicity in human MSH2 missense mutants. Human Mutation, 29(11):1355-63.

Wang, J; Barke, R A; Charboneau, R; Schwendener, R; Roy, S (2008). Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kappaB signaling. Journal of Immunology, 180(5):3594-3600.

Bujalkova, M; Zavodna, K; Krivulcik, T; Ilencikova, D; Wolf, B; Kovac, M; Karner-Hanusch, J; Heinimann, K; Marra, G; Jiricny, J; Bartosova, Z (2008). Multiplex SNaPshot genotyping for detecting loss of heterozygosity in the mismatch-repair genes MLH1 and MSH2 in microsatellite-unstable tumors. Clinical Chemistry, 54:1844-1854.

Hauk, T G; Müller, A; Lee-Thorp, J; Schwendener, R; Fischer, D (2008). Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages. Experimental Neurology, 209(2):469-482.

Kim, E Y; Battaile, J T; Patel, A C; You, Y; Agapov, E; Grayson, M H; Benoit, L A; Byers, D E; Alevy, Y; Tucker, J; Swanson, S; Tidwell, R; Tyner, J W; Morton, J D; Castro, M; Polineni, D; Patterson, G A; Schwendener, R; Allard, J D; Peltz, G; Holtzman, M J (2008). Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nature Medicine, 14(6):633-640.

Pani, E; Menigatti, M; Schubert, S; Hess, D; Gerrits, B; Klempnauer, K H; Ferrari, S (2008). Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity. Biochimica et Biophysica Acta, 1783(6):1121-1128.

Jeon, B H; Jang, C; Han, J; Kataru, R P; Piao, L; Jung, K; Cha, H J; Schwendener, R; Jang, K Y; Kim, K S; Alitalo, K; Koh, G Y (2008). Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer. Cancer Research, 68(4):1100-9.

Nieländer, I; Martín-Subero, J I; Wagner, F; Baudis, M; Gesk, S; Harder, L; Hasenclever, D; Klapper, W; Kreuzer, M; Pott, C; Martinez-Climent, J A; Dreyling, M; Arnold, N; Siebert, R (2008). Recurrent loss of the Y chromosome and homozygous deletions within the pseudoautosomal region 1: association with male predominance in mantle cell lymphoma. Haematologica, 93(6):949-950.

Bathia, P; Ferrari, S (2008). Role of cell cycle controllers in the development of cancer. In: Mondello, C. Multiple Pathways in Cancer Development. Kerala, India: Transworld Research Network, 69-86.

Pani, E; Ferrari, S (2008). p38MAPK delta controls c-Myb degradation in response to stress. Blood Cells Molecules and Diseases, 40(3):388-394.

2007

Baudis, M (2007). Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data. BMC Cancer, 7 : 22:1-15.

Dürig, J; Bug, S; Klein-Hitpass, L; Boes, T; Jöns, T; Martin-Subero, J I; Harder, L; Baudis, M; Dührsen, U; Siebert, R (2007). Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32). Leukemia, 21(10):2153-2163.

Zehnder-Fjällman, A H M; Marty, C; Halin, C; Hohn, A; Schibli, R; Ballmer-Hofer, K; Schwendener, R (2007). Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis. Oncology Reports, 18(4):933-941.

Cho, C H; Koh, Y J; Han, J; Sung, H K; Jong Lee, H; Morisada, T; Schwendener, R; Brekken, R A; Kang, G; Oike, Y; Choi, T S; Suda, T; Yoo, O J; Koh, G Y (2007). Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circulation Research, 100(4):e47-e57.

Sammalkorpi, H; Alhopuro, P; Lehtonen, R; Tuimala, J; Mecklin, J-P; Järvinen, H J; Jiricny, J; Karhu, A; Aaltonen, L A (2007). Background mutation frequency in microsatellite-unstable colorectal cancer. Cancer Research, 67(12):5691-5698.

Cannavo, E; Gerrits, B; Marra, G; Schlapbach, R; Jiricny, J (2007). Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS. Journal of Biological Chemistry, 282(5):2976-86.

Schwendener, R (2007). Delivery Systems for Peptides/Oligonucleotides and Lipophilic Nucleoside Analogs. In: Gad, S C. Handbook of Pharmaceutical Biotechnology. Hoboken, New Jersey, USA: John Wiley & Sons, 1149-1172.

Hohl, Marcel; Dunand-Sauthier, Isabelle; Staresincic, Lidija; Jaquier-Gubler, Pascale; Thorel, Fabrizio; Modesti, Mauro; Clarkson, Stuart G; Schärer, Orlando D (2007). Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity. Nucleic Acids Research, 35(9):3053-3063.

Stella, A; Surdo, N C; Lastella, P; Barana, D; Oliani, C; Tibiletti, M G; Viel, A; Natale, C; Piepoli, A; Marra, G; Guanti, G (2007). Germline novel MSH2 deletions and a founder MSH2 deletion associated with anticipation effects in HNPCC. Clinical Genetics, 71(2):130-139.

Rechner, C; Kühlewein, C; Müller, A; Schild, H; Rudel, T (2007). Host glycoprotein Gp96 and scavenger receptor SREC interact with PorB of disseminating Neisseria gonorrhoeae in an epithelial invasion pathway. Cell Host & Microbe, 2(6):393-403.

Sartori, A A; Lukas, C; Coates, J; Mistrik, M; Fu, S; Bartek, J; Baer, R; Lukas, J; Jackson, S P (2007). Human CtIP promotes DNA end resection. Nature, 450(7169):509-514.

Bijnsdorp, I V; Schwendener, R; Schott, H; Fichtner, I; Smid, K; Schott, S; Laan, A C; Peters, G J (2007). In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine. Nucleosides, Nucleotides and Nucleic Acids, 26(10-12):1619-1624.

Schwendener, R (2007). Liposomes in biology and medicine. In: Chan, W C W. Bio-Applications of Nanoparticles. New York: Springer, 117-128.

Pani, E; Stojic, L; El-Shemerly, M; Jiricny, J; Ferrari, S (2007). Mismatch repair status and the response of human cells to cisplatin. Cell Cycle, 6(14):1796-1802.

Mojas, N; Lopes, M; Jiricny, J (2007). Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA. Genes and Development, 21(24):3342-55.

Menigatti, M; Pedroni, M; Verrone, A M; Borghi, F; Scarselli, A; Benatti, P; Losi, L; Di Gregorio, C; Schär, P; Marra, G; Ponz de Leon, M; Roncucci, L (2007). O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis. Oncology Reports, 17(6):1421-1427.

Weiss, M B; Vitolo, M I; Baerenfaller, K; Marra, G; Park, B H; Bachman, K E (2007). Persistent mismatch repair deficiency following targeted correction of hMLH1. Cancer Gene Therapy, 14(1):98-104.

Saydam, N; Kanagaraj, R; Dietschy, T; Garcia, P L; Peña-Diaz, J; Shevelev, I; Stagljar, I; Janscak, P (2007). Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Research, 35(17):5706-5716.

Hu, Y; Raynard, S; Sehorn, M G; Lu, X; Bussen, W; Zheng, L; Stark, J M; Barnes, E L; Chi, P; Janscak, P; Jasin, M; Vogel, H; Sung, P; Luo, G (2007). RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes and Development, 21(23):3073-3084.

Dietschy, T. Regulation of RECQL4, the Rothmund-Thomson-, RAPADILINO- and Baller-Gerold-Syndrome Gene Product, by p300 Mediated Acetylation. 2007, University of Zurich, Faculty of Science.

Kais, S. Regulatory aspects of DNA double-strand break repair in the yeast saccharomyces cerevisiae. 2007, University of Zurich, Faculty of Science.

Fischer, F. The Function of Mismatch Repair Proteins in Response to DNA Damage caused by Chemotherapeutic Agents. 2007, University of Zurich, Faculty of Science.

Van der Flier, L G; Sabates-Bellver, J; Oving, I; Haegebarth, A; De Palo, M; Anti, M; Van Gijn, M E; Suijkerbuijk, S; Van de Wetering, M; Marra, G; Clevers, H (2007). The Intestinal Wnt/TCF Signature. Gastroenterology, 132(2):628-632.

Jiao, R; Harrigan, J A; Shevelev, I; Dietschy, T; Selak, N; Indig, F E; Piotrowski, J; Janscak, P; Bohr, V A; Stagljar, I (2007). The Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage. Oncogene, 26(26):3811-3822.

Sabates-Bellver, J; Van der Flier, L G; de Palo, M; Cattaneo, E; Maake, C; Rehrauer, H; Laczko, E; Kurowski, M A; Bujnicki, J M; Menigatti, M; Luz, J; Ranalli, T V; Gomes, V; Pastorelli, A; Faggiani, R; Anti, M; Jiricny, J; Clevers, H; Marra, G (2007). Transcriptome profile of human colorectal adenomas. Molecular Cancer Research, 5(12):1263-1275.

2006

Plasilova, M; Zhang, J; Okhowat, R; Marra, G; Mettler, M; Mueller, H; Heinimann, K (2006). A de novo MLH1 germ line mutation in a 31-year-old colorectal cancer patient. Genes, Chromosomes & Cancer, 45(12):1106-1110.

Alzeer, Jawad; Schärer, Orlando D (2006). A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks. Nucleic Acids Research, 34(16):4458-4466.

Alvino, E; Castiglia, D; Caporali, S; Pepponi, R; Caporaso, P; Lacal, P M; Marra, G; Fischer, F; Zambruno, G; Bonmassar, E; Jiricny, J; D'Atri, S (2006). A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system. International Journal of Oncology, 29(4):785-797.

Baerenfaller, K; Fischer, F; Jiricny, J (2006). Characterization of the "mismatch repairosome" and its role in the processing of modified nucleosides in vitro. Methods in Enzymology, 408:285-303.

Zeisberger, S M; Odermatt, B; Marty, C; Zehnder-Fjällman, A H M; Ballmer-Hofer, K; Schwendener, R (2006). Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach. British Journal of Cancer, 95(3):272-281.

Liu, J; Mohammed, J; Carter, J; Ranka, S; Kahveci, T; Baudis, M (2006). Distance-based clustering of CGH data. Bioinformatics, 22(16):1971-1978.

Zhang, J; Lindroos, A; Ollila, S; Russell, A; Marra, G; Mueller, H; Peltomaki, P; Plasilova, M; Heinimann, K (2006). Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers. Cancer Research, 66(2):659-664.

Kanagaraj, R; Saydam, N; Garcia, P L; Zheng, L; Janscak, P (2006). Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Research, 34(18):5217-5231.

Krystyniak, A; Garcia-Echeverria, C; Prigent, C; Ferrari, S (2006). Inhibition of Aurora A in response to DNA damage. Oncogene, 25(3):338-348.

Mojas, N. Interplay between Mismatch Repair and other Pathways of DNA Metabolism. 2006, University of Zurich, Faculty of Science.

Marty, C; Langer-Machova, Z; Sigrist, S; Schott, H; Schwendener, R; Ballmer-Hofer, K (2006). Isolation and characterization of a scFv antibody specific for tumor endothelial marker 1 (TEM1), a new reagent for targeted tumor therapy. Cancer Letters, 235(2):298-308.

Liberi, G; Cotta-Ramusino, C; Lopes, M; Sogo, J; Conti, C; Bensimon, A; Foiani, M (2006). Methods to study replication fork collapse in budding yeast. Methods in Enzymology, 409:442-62.

Gillet, Ludovic C J; Schärer, Orlando D (2006). Molecular mechanisms of mammalian global genome nucleotide excision repair. Chemical Reviews, 106(2):253-276.

Lopes, M; Foiani, M; Sogo, J M (2006). Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Molecular Cell, 21(1):15-27.

Jiricny, J (2006). MutLalpha: at the cutting edge of mismatch repair. Cell, 126(2):239-241.

Zavodna, K; Bujalkova, M; Krivulcik, T; Alemayehu, A; Skorvaga, M; Marra, G; Fridrichova, I; Jiricny, J; Bartosova, Z (2006). Novel and recurrent germline alterations in the MLH1 and MSH2 genes identified in hereditary nonpolyposis colorectal cancer patients in Slovakia. Neoplasma, 53(4):269-276.

Baudis, Michael (2006). Online database and bioinformatics toolbox to support data mining in cancer cytogenetics. BioTechniques, 40(3):269-272.

Ferrari, S (2006). Protein kinases controlling the onset of mitosis. Cellular and Molecular Life Sciences, 63(7-8):781-795.

Lasbury, M E; Durant, P J; Ray, C A; Tschang, D; Schwendener, R; Lee, C H (2006). Suppression of alveolar macrophage apoptosis prolongs survival of rats and mice with pneumocystis pneumonia. Journal of Immunology, 176(11):6443-6453.

Cannavo, E. The Role of Human MutL proteins in DNA Repair. 2006, University of Zurich, Faculty of Science.

Sabates-Bellver, J. The Transcriptome of Epithelial Transformation in the Distal Gastrointestinal Tract. 2006, University of Zurich, Faculty of Science.

Krystyniak, A. The involvement of the mitotic kinase aurora A in the DNA damage response. 2006, University of Zurich, Faculty of Science.

Jiricny, J (2006). The multifaceted mismatch-repair system. Nature Reviews. Molecular Cell Biology, 7(5):335-346.

2005

Lingaraju, G M; Sartori, A A; Kostrewa, D; Prota, A E; Jiricny, J; Winkler, F K (2005). A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure. Structure, 13(1):87-98.

Beck-Schimmer, B; Schwendener, R; Pasch, T; Reyes, L; Booy, C; Schimmer, R C (2005). Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury. Respiratory Research, 6:61.

Anstett, A. Approach of combined cancer gene therapy and radiation: response of promoters to ionizing radiation. 2005, University of Zurich, Faculty of Science.

Ferrari, S; Marin, O; Pagano, M A; Meggio, F; Hess, D; El-Shemerly, M; Krystyniak, A; Pinna, L A (2005). Aurora-A site specificity: a study with synthetic peptide substrates. Biochemical Journal, 390(1):293-302.

Tyner, J W; Uchida, O; Kajiwara, N; Kim, E Y; Patel, A C; O'Sullivan, M P; Walter, M J; Schwendener, R; Cook, D N; Danoff, T M; Holtzman, M J (2005). CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nature Medicine, 11(11):1180-1187.

Bärenfaller, K. Characterisation of protein/protein interactions during mismatch repair in human cells. 2005, University of Zurich, Faculty of Science.

Szadkowski, M; Iaccarino, I; Heinimann, K; Marra, G; Jiricny, J (2005). Characterization of the mismatch repair defect in the human lymphoblastoid MT1 cells. Cancer Research, 65(11):4525-4529.

Marty, C; Schwendener, R (2005). Cytotoxic tumor targeting with scFv antibody-modified liposomes. In: Ludewig, B; Hoffmann, M W. Adoptive Immunotherapy: Methods and Protocols. Springer: Humana Press, 389-401.

Schärer, Orlando D (2005). DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses. ChemBioChem, 6(1):27-32.

Marra, G; Jiricny, J (2005). DNA mismatch repair and colon cancer. In: Nigg, E A. Genome Instability in Cancer Development. Netherland: Springer, 85-123.

di Pietro, M; Sabates-Bellver, J; Menigatti, M; Bannwart, F; Schnider, A; Russell, A; Truninger, K; Jiricny, J; Marra, G (2005). Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers. Gastroenterology, 129(3):1047-1059.

El-Shemerly, M; Janscak, P; Hess, D; Jiricny, J; Ferrari, S (2005). Degradation of human exonuclease 1b upon DNA synthesis inhibition. Cancer Research, 65(9):3604-3609.

Cotta-Ramusino, C; Fachinetti, D; Lucca, C; Doksani, Y; Lopes, M; Sogo, J; Foiani, M (2005). Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Molecular Cell, 17(1):153-159.

Cannavo, E; Marra, G; Sabates-Bellver, J; Menigatti, M; Lipkin, S M; Fischer, F; Cejka, P; Jiricny, J (2005). Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair. Cancer Research, 65(23):10759-10766.

Mueller, A; Falkow, S; Amieva, M R (2005). Helicobacter pylori and gastric cancer: what can be learned by studying the response of gastric epithelial cells to the infection? Cancer Epidemiology Biomarkers & Prevention, 14(8):1859-1864.

Stojic, L; Cejka, P; Jiricny, J (2005). High doses of SN1 type methylating agents activate DNA damage signaling cascades that are largely independent of mismatch repair. Cell Cycle, 4(3):473-477.

Probst, H C; Tschannen, K; Odermatt, B; Schwendener, R; Zinkernagel, R M; van den Broek, Maries (2005). Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clinical and Experimental Immunology, 141(3):398-404.

Cejka, P; Mojas, N; Gillet, L; Schär, P; Jiricny, J (2005). Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae. Current Biology, 15(15):1395-1400.

Truninger, K; Menigatti, M; Luz, J; Russell, A; Haider, R; Gebbers, J-O; Bannwart, F; Yurtsever, H; Neuweiler, J; Riehle, H-M; Cattaruzza, M S; Heinimann, K; Schär, P; Jiricny, J; Marra, G (2005). Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer. Gastroenterology, 128(5):1160-1171.

Schwendener, R; Schott, H (2005). Lipophilic arabinofuranosyl cytosine derivatives in liposomes. Methods in Enzymology, 391:58-70.

Stojic, L. Mismatch Repair and DNA Damage Signalling. 2005, University of Zurich, Faculty of Science.

Gillet, L C J. New Photoreactive DNA Substrates to Study Damage Recognition in Nucleotide Excision Repair. 2005, University of Zurich, Faculty of Science.

Buchholz, Julia; Kaser-Hotz, Barbara; Khan, Tania; Rohrer Bley, Carla; Melzer, Katja; Schwendener, Reto; Roos, Malgorzata; Walter, Heinrich (2005). Optimizing photodynamic therapy: in vivo pharmacokinetics of liposomal meta-(tetrahydroxyphenyl)chlorin in feline squamous cell carcinoma. Clinical Cancer Research, 11(20):7538-7544.

Robinson, J A; Shankaramma, S C; Jetter, P; Kienzl, U; Schwendener, R; Vrijbloed, J W; Obrecht, D (2005). Properties and structure-activity studies of cyclic beta-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I. Bioorganic & Medicinal Chemistry, 13(6):2055-2064.

Beck-Schimmer, B; Rosenberger, D S; Neff, S B; Jamnicki, M; Suter, D; Fuhrer, T; Schwendener, R; Booy, C; Reyes, L; Pasch, T; Schimmer, R C (2005). Pulmonary aspiration: new therapeutic approaches in the experimental model. Anesthesiology, 103(3):556-566.

Liberi, G; Maffioletti, G; Lucca, C; Chiolo, I; Baryshnikova, A; Cotta-Ramusino, C; Lopes, M; Pellicioli, A; Harber, J E; Foiani, M (2005). Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes and Development, 19(3):339-350.

Gillet, Ludovic C J; Alzeer, Jawad; Schärer, Orlando D (2005). Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified 'ultra-mild' DNA synthesis. Nucleic Acids Research, 33(6):1961-1969.

Klasen, M; Spillmann, F; Marra, G; Cejka, P; Wabl, M (2005). Somatic hypermutation and mismatch repair in non-B cells. European Journal of Immunology, 35(7):2222-2229.

Garcia, P L. Structure and function of the human RecQ DNA helicases. 2005, University of Zurich, Faculty of Science.

Ludwig, P S; Schwendener, R; Schott, H (2005). Synthesis and anticancer activities of amphiphilic 5-fluoro-2'-deoxyuridylic acid prodrugs. European Journal of Medicinal Chemistry, 40(5):494-504.

Rubio Demirovic, A; Marty, C; Console, S; Zeisberger, S M; Ruch, C; Jaussi, R; Schwendener, R; Ballmer-Hofer, K (2005). Targeting human cancer cells with VEGF receptor-2-directed liposomes. Oncology Reports, 13(2):319-324.

Cheok, C F; Wu, L; Garcia, P L; Janscak, P; Hickson, I D (2005). The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA. Nucleic Acids Research, 33(12):3932-3941.

Wu, L; Chan, K L; Ralf, C; Bernstein, D A; Garcia, P L; Bohr, V; Vindigni, A; Janscak, P; Keck, J L; Hickson, I D (2005). The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO Journal, 24(14):2679-2687.

Mueller, A; Schäfer, B W; Ferrari, S; Weibel, M; Makek, M; Höchli, M; Heizmann, C W (2005). The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity. Journal of Biological Chemistry, 280(32):29186-29193.

Mueller, A; Dixon, M F; Bouley, D M; Lee, A; Falkow, S; et al (2005). The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of helicobacter-induced mucosa-associated lymphoid tissue lymphoma. American Journal of Pathology, 167(3):797-812.

Cejka, P. Therapy of cancers with microsatellite instability. 2005, University of Zurich, Faculty of Science.

Vandesompele, J; Baudis, M; De Preter, K; Van Roy, N; Ambros, P; Bown, N; Brinkschmidt, C; Christiansen, H; Combaret, V; Lastowska, M; Nicholson, J; O'Meara, A; Plantaz, D; Stallings, R; Brichard, B; Van den Broecke, C; De Bie, S; De Paepe, A; Laureys, G; Speleman, F (2005). Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma. Journal of Clinical Oncology, 23(10):2280-2299.

2004

Engler, O B; Schwendener, R; Dai, W J; Wölk, B; Pichler, W; Moradpour, D; Brunner, T; Cerny, A (2004). A liposomal peptide vaccine inducing CD8+ T cells in HLA-A2.1 transgenic mice, which recognise human cells encoding hepatitis C virus (HCV) proteins. Vaccine, 23(1):58-68.

Chastel, C; Jiricny, J; Jaussi, R (2004). Activation of stress-responsive promoters by ionizing radiation for deployment in targeted gene therapy. DNA Repair, 3(3):201-215.

Enzlin, J H. Biochemical Studies of Xeroderma Pigmentosum Group F Protein Active Site and Patient Mutants. 2004, University of Zurich, Faculty of Science.

Caporali, S; Falcinelli, S; Starace, G; Russo, M T; Bonmassar, E; Jiricny, J; D'Atri, S (2004). DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system. Molecular Pharmacology, 66(3):478-491.

Papouli, E; Cejka, P; Jiricny, J (2004). Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells. Cancer Research, 64(10):3391-3394.

Marty, C; Meylan, C; Schott, H; Ballmer-Hofer, K; Schwendener, R (2004). Enhanced heparan sulfate proteoglycan-mediated uptake of cell-penetrating peptide-modified liposomes. Cellular and Molecular Life Sciences, 61(14):1785-1794.

Garcia, P L; Liu, Y; Jiricny, J; West, S C; Janscak, P (2004). Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO Journal, 23(14):2882-2891.

Hohl, M. Insight into DNA Binding and Catalysis by the Human XPG Endonuclease. 2004, University of Zurich, Faculty of Science.

Cejka, P; Stojic, L; Marra, G; Jiricny, J (2004). Is mismatch repair really required for ionizing radiation-induced DNA damage signaling? Nature Genetics, 36(5):432-3; author reply 434.

Plaschke, J; Krüger, S; Jeske, B; Theissig, F; Kreuz, F R; Pistorius, S; Saeger, H D; Iaccarino, I; Marra, G; Schackert, H K (2004). Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression. Cancer Research, 64(3):864-870.

Stojic, L; Brun, R; Jiricny, J (2004). Mismatch repair and DNA damage signalling. DNA Repair, 3(8-9):1091-1101.

Stojic, L; Mojas, N; Cejka, P; Di Pietro, M; Ferrari, S; Marra, G; Jiricny, J (2004). Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes and Development, 18(11):1331-1344.

Grimm, J; Mueller, A; Hefti, F; Rosenthal, A (2004). Molecular basis for catecholaminergic neuron diversity. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 101(38):13891-13896.

Storni, T; Ruedl, C; Schwarz, K; Schwendener, R; Renner, W A; Bachmann, M F (2004). Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects. Journal of Immunology, 172(3):1777-1785.

Sartori, A A; Lingaraju, G M; Hunziker, P; Winkler, F K; Jiricny, J (2004). Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases. Nucleic Acids Research, 32(22):6531-6539.

Monack, D M; Mueller, A; Falkow, S (2004). Persistent bacterial infections: the interface of the pathogen and the host immune system. Nature Reviews. Microbiology, 2(9):747-765.

El-Etr, A H; Mueller, A; Tompkins, L S; Falkow, S; Merrell, D S (2004). Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers. Journal of Infectious Diseases, 190(8):1516-23.

Grossi, S; Puglisi, A; Dmitriev, P V; Lopes, M; Shore, D (2004). Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes and Development, 18(9):992-1006.

Mueller, A; Merrell, D S; Grimm, J; Falkow, S (2004). Profiling of microdissected gastric epithelial cells reveals a cell type-specific response to Helicobacter pylori infection. Gastroenterology, 127(5):1446-1462.

Garcia, P L; Bradley, G; Hayes, C H; Krintel, S J; Soultanas, P; Janscak, P (2004). RPA alleviates the inhibitory effect of vinylphosphonate internucleotide linkages on DNA unwinding by BLM and WRN helicases. Nucleic Acids Research, 32(12):3771-3778.

Muheim-Lenz, R; Buterin, T; Marra, G; Naegeli, H (2004). Short-patch correction of C/C mismatches in human cells. Nucleic Acids Research, 32(22):6696-6705.

Jiricny, J (2004). Unfaithful DNA polymerase caught in the act. Molecular Cell, 13(6):768-769.

2003

Lopes, M; Cotta-Ramusino, C; Liberi, G; Foiani, M (2003). Branch migrating sister chromatid junctions form at replication origins through Rad51/Rad52-independent mechanisms. Molecular Cell, 12(6):1499-1510.

Janscak, P; Garcia, P L; Hamburger, F; Makuta, Y; Shiraishi, K; Imai, Y; Ikeda, H; Bickle, T A (2003). Characterization and mutational analysis of the RecQ core of the bloom syndrome protein. Journal of Molecular Biology, 330(1):29-42.

Metzger, E; Müller, J M; Ferrari, S; Buettner, R; Schüle, R (2003). A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer. EMBO Journal, 22(2):270-280.

Console, S; Marty, C; García-Echeverría, C; Schwendener, R; Ballmer-Hofer, K (2003). Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans. Journal of Biological Chemistry, 278(37):35109-35114.

Castiglia, D; Pagani, E; Alvino, E; Vernole, P; Marra, G; Cannavò, E; Jiricny, J; Zambruno, G; D'Atri, S (2003). Biallelic somatic inactivation of the mismatch repair gene MLH1 in a primary skin melanoma. Genes, Chromosomes & Cancer, 37(2):165-175.

Abadjieva, A; Scarlett, G; Janscák, P; Dutta, C F; Firman, K (2003). Characterization of an EcoR124I restriction-modification enzyme produced from a deleted form of the DNA-binding subunit, which results in a novel DNA specificity. Folia Microbiologica, 48(3):319-328.

Sartori, A A. DNA Repair in the Hyperthermophilic Archaeon Pyrobaculum aerophilum. 2003, University of Zurich, Faculty of Science.

Jiricny, J; Marra, G (2003). DNA repair defects in colon cancer. Current Opinion in Genetics & Development, 13(1):61-69.

Madjdpour, C; Jewell, U R; Kneller, S; Ziegler, U; Schwendener, R; Booy, C; Kläusli, L; Pasch, T; Schimmer, R C; Beck-Schimmer, B (2003). Decreased alveolar oxygen induces lung inflammation. American Journal of Physiology: Lung Cellular and Molecular Physiology, 284(2):L360-L367.

Cejka, P; Marra, G; Hemmerle, C; Cannavó, E; Storchova, Z; Jiricny, J (2003). Differential killing of mismatch repair-deficient and -proficient cells: towards the therapy of tumors with microsatellite instability. Cancer Research, 63(23):8113-8117.

Mueller, A; O'Rourke, J; Grimm, J; Guillemin, K; Dixon, M F; Lee, A; Falkow, S (2003). Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 100(3):1292-1297.

Sartori, A A; Jiricny, J (2003). Enzymology of base excision repair in the hyperthermophilic archaeon Pyrobaculum aerophilum. Journal of Biological Chemistry, 278(27):24563-24576.

Steinacher, R. Exploring regulatory mechanisms of DNA base excision mediated by human thymine-DNA glycosylase. 2003, University of Zurich, Faculty of Science.

Aichele, P; Zinke, J; Grode, L; Schwendener, R; Kaufmann, S H E; Seiler, P (2003). Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses. Journal of Immunology, 171(3):1148-1155.

Cejka, P; Stojic, L; Mojas, N; Russell, A F; Heinimann, K; Cannavó, E; di Pietro, M; Marra, G; Jiricny, J (2003). Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1. EMBO Journal, 22(9):2245-2254.

di Pietro, M; Marra, G; Cejka, P; Stojic, L; Menigatti, M; Cattaruzza, M S; Jiricny, J (2003). Mismatch repair-dependent transcriptome changes in human cells treated with the methylating agent N-methyl-n'-nitro-N-nitrosoguanidine. Cancer Research, 63(23):8158-8166.

Marra, G; Jiricny, J (2003). Multiple colorectal adenomas--is their number up? New England Journal of Medicine, 348(9):845-847.

Bartosova, Z; Fridrichova, I; Bujalkova, M; Wolf, B; Ilencikova, D; Krizan, P; Hlavcak, P; Palaj, J; Lukac, L; Lukacova, M; Böör, A; Haider, R; Jiricny, J; Nyström-Lahti, M; Marra, G (2003). Novel MLH1 and MSH2 germline mutations in the first HNPCC families identified in Slovakia. Human Mutation, 21(4):449.

Mueller, A; O'Rourke, J; Chu, P; Kim, C C; Sutton, Philip; Lee, A; Falkow, S (2003). Protective immunity against Helicobacter is characterized by a unique transcriptional signature. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 100(21):12289-12294.

Peakman, L J; Antognozzi, M; Bickle, T A; Janscak, P; Szczelkun, M D (2003). S-adenosyl methionine prevents promiscuous DNA cleavage by the EcoP1I type III restriction enzyme. Journal of Molecular Biology, 333(2):321-235.

Pedrazzi, G; Bachrati, C Z; Selak, N; Studer, I; Petkovic, M; Hickson, I D; Jiricny, J; Stagljar, I (2003). The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6. Biological Chemistry, 384(8):1155-1164.

Pepponi, R; Marra, G; Fuggetta, M P; Falcinelli, S; Pagani, E; Bonmassar, E; Jiricny, J; D'Atri, S (2003). The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin. Journal of Pharmacology and Experimental Therapeutics, 304(2):661-668.

Hardeland, U; Bentele, M; Jiricny, J; Schär, P (2003). The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs. Nucleic Acids Research, 31(9):2261-2271.

2002

Hasan, S; El-Andaloussi, N; Hardeland, U; Hassa, P O; Bürki, C; Imhof, R; Schär, P; Hottiger, M O (2002). Acetylation regulates the DNA end-trimming activity of DNA polymerase beta. Molecular Cell, 10(5):1213-1222.

Sartori, A A; Fitz-Gibbon, S; Yang, H; Miller, J H; Jiricny, J (2002). A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site. EMBO Journal, 21(12):3182-3191.

Hinks, J A; Evans, M C W; De Miguel, Y; Sartori, A A; Jiricny, J; Pearl, L H (2002). An iron-sulfur cluster in the family 4 uracil-DNA glycosylases. Journal of Biological Chemistry, 277(19):16936-19640.

Marty, C; Odermatt, B; Schott, H; Neri, D; Ballmer-Hofer, K; Klemenz, R; Schwendener, R (2002). Cytotoxic targeting of F9 teratocarcinoma tumours with anti-ED-B fibronectin scFv antibody modified liposomes. British Journal of Cancer, 87(1):106-112.

Jiricny, J (2002). DNA repair: An APE that proofreads. Nature, 415(6872):593-594.

Jiricny, J (2002). DNA repair: bioinformatics helps reverse methylation damage. Current Biology, 12(24):R846-R848.

Yang, H; Chiang, J-H; Fitz-Gibbon, S; Lebel, M; Sartori, A A; Jiricny, J; Slupska, M M; Miller, J H (2002). Direct interaction between uracil-DNA glycosylase and a proliferating cell nuclear antigen homolog in the crenarchaeon Pyrobaculum aerophilum. Journal of Biological Chemistry, 277(25):22271-22278.

Kuismanen, S A; Moisio, A-L; Schweizer, P; Truninger, K; Salovaara, R; Arola, J; Butzow, R; Jiricny, J; Nyström-Lahti, M; Peltomäki, P (2002). Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. American Journal of Pathology, 160(6):1953-1958.

Klingler, H; Hemmerle, C; Bannwart, F; Haider, R; Cattaruzza, M S; Marra, G (2002). Expression of the hMSH6 mismatch-repair protein in colon cancer and HeLa cells. Swiss Medical Weekly, 132(5-6):57-63.

Sogo, J M; Lopes, M; Foiani, M (2002). Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science, 297(5581):599-602.

Nyström-Lahti, M; Perrera, C; Räschle, M; Panyushkina-Seiler, E; Marra, G; Curci, A; Quaresima, B; Costanzo, F; D'Urso, M; Venuta, S; Jiricny, J (2002). Functional analysis of MLH1 mutations linked to hereditary nonpolyposis colon cancer. Genes, Chromosomes & Cancer, 33(2):160-167.

Trojan, J; Zeuzem, S; Randolph, A; Hemmerle, C; Brieger, A; Raedle, J; Plotz, G; Jiricny, J; Marra, G (2002). Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system. Gastroenterology, 122(1):211-219.

Alvino, E; Marra, G; Pagani, E; Falcinelli, S; Pepponi, R; Perrera, C; Haider, R; Castiglia, D; Ferranti, G; Bonmassar, E; Jiricny, J; Zambruno, G; D'Atri, S (2002). High-frequency microsatellite instability is associated with defective DNA mismatch repair in human melanoma. Journal of Investigative Dermatology, 118(1):79-86.

Szadkowski, M; Jiricny, J (2002). Identification and functional characterization of the promoter region of the human MSH6 gene. Genes, Chromosomes & Cancer, 33(1):36-46.

Godthelp, B C; Wiegant, W W; van Duijn-Goedhart, A; Schärer, O D; van Buul, P P W; Kanaar, R; Zdzienicka, M Z (2002). Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Nucleic Acids Research, 30(10):2172-2182.

Hardeland, U; Steinacher, R; Jiricny, J; Schär, P (2002). Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. EMBO Journal, 21(6):1456-1464.

Räschle, M; Dufner, P; Marra, G; Jiricny, J (2002). Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha. Journal of Biological Chemistry, 277(24):21810-21820.

Chang, C L; Marra, G; Chauhan, D P; Ha, H T; Chang, D K (2002). Oxidative stress inactivates the human DNA mismatch repair system. American Journal of Physiology. Cell Physiology, 283(1):C148-C154.

Gillet, L C J; Schärer, O D (2002). Preparation of C8-amine and acetylamine adducts of 2'-deoxyguanosine suitably protected for DNA synthesis. Organic Letters, 4(24):4205-4208.

Enzlin, J H; Schärer, O D (2002). The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif. EMBO Journal, 21(8):2045-2053.

Bentele, M. The role of uracil repair in the maintenance of genome stability in fission yeast. 2002, University of Zurich, Faculty of Science.

Müller, A; Rassow, J; Grimm, J; Machuy, N; Meyer, T F; Rudel, T (2002). VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways. EMBO Journal, 21(8):1916-1929.

2001

Sartori, A A; Schär, P; Fitz-Gibbon, S; Miller, J H; Jiricny, J (2001). Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum. Journal of Biological Chemistry, 276(32):29979-29986.

Pedrazzi, G; Perrera, C; Blaser, H; Kuster, P; Marra, G; Davies, S L; Ryu, G H; Freire, R; Hickson, I D; Jiricny, J; Stagljar, I (2001). Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1. Nucleic Acids Research, 29(21):4378-4386.

Rajalingam, K; Al-Younes, H; Müller, A; Meyer, T F; Szczepek, A J; Rudel, T (2001). Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis. Infection and Immunity, 69(12):7880-7888.

Bentz, M; Barth, T F; Brüderlein, S; Bock, D; Schwerer, M J; Baudis, M; Joos, S; Viardot, A; Feller, A C; Müller-Hermelink, H K; Lichter, P; Döhner, H; Möller, P (2001). Gain of chromosome arm 9p is characteristic of primary mediastinal B-cell lymphoma (MBL): comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell line. Genes, Chromosomes & Cancer, 30(4):393-401.

Szadkowski, M. Genetic Analysis of the Human Mismatch Repair Gene MSH6 and Phenotypic Study of Cell Lines Mutated at this Locus. 2001, University of Zurich, Faculty of Science.

Schwendener, R; Friedl, K; Depenbrock, H; Schott, H; Hanauske, A R (2001). In vitro activity of liposomal N4octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC), a new lipophilic derivative of 1-beta-D-arabinofuranocylcytosine on biopsized clonogenic human tumor cells and hematopoietic precursor cells. Investigational New Drugs, 19(3):203-210.

Hill, M M; Andjelkovic, M; Brazil, D P; Ferrari, S; Fabbro, D; Hemmings, B A (2001). Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase. Journal of Biological Chemistry, 276(28):25643-25646.

Schweizer, P; Moisio, A L; Kuismanen, S A; Truninger, K; Vierumäki, R; Salovaara, R; Arola, J; Butzow, R; Jiricny, J; Peltomäki, P; Nyström-Lahti, M (2001). Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer. Cancer Research, 61(7):2813-2815.

Seiler, P; Schwendener, R; Bandermann, S; Brinkmann, V; Grode, L; Kaufmann, S H E; Aichele, P (2001). Limited mycobacterial infection of the liver as a consequence of its microanatomical structure causing restriction of mycobacterial growth to professional phagocytes. Infection and Immunity, 69(12):7922-7926.

Müller, A; Rudel, T (2001). Modification of host cell apoptosis by viral and bacterial pathogens. International Journal of Medical Microbiology, 291(3):197-207.

Percesepe, A; Borghi, F; Menigatti, M; Losi, L; Foroni, M; Di Gregorio, C; Rossi, G; Pedroni, M; Sala, E; Vaccina, F; Roncucci, L; Benatti, P; Viel, A; Genuardi, M; Marra, G; Kristo, P; Peltomäki, P; Ponz de Leon, M (2001). Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study. Journal of Clinical Oncology, 19(19):3944-3950.

Heinimann, K; Thompson, A; Locher, A; Furlanetto, T; Bader, E; Wolf, A; Meier, R; Walter, K; Bauerfeind, P; Marra, G; Müller, H; Foernzler, D; Dobbie, Z (2001). Nontruncating APC germ-line mutations and mismatch repair deficiency play a minor role in APC mutation-negative polyposis. Cancer Research, 61(20):7616-7622.

Marra, G; D'Atri, S; Yan, H; Perrera, C; Cannavo', E; Vogelstein, B; Jiricny, J (2001). Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes. Cancer Research, 61(21):7719-7721.

Marty, C; Scheidegger, P; Ballmer-Hofer, K; Klemenz, R; Schwendener, R (2001). Production of functionalized single-chain Fv antibody fragments binding to the ED-B domain of the B-isoform of fibronectin in Pichia pastoris. Protein Expression and Purification, 21(1):156-164.

Schärer, O D; Jiricny, J (2001). Recent progress in the biology, chemistry and structural biology of DNA glycosylases. BioEssays, 23(3):270-281.

Roscic-Mrkic, B; Schwendener, R; Odermatt, B; Zuniga, A; Pavlovic, J; Billeter, M A; Cattaneo, R (2001). Roles of macrophages in measles virus infection of genetically modified mice. Journal of Virology, 75(7):3343-3351.

Schär, P (2001). Spontaneous DNA damage, genome instability, and cancer--when DNA replication escapes control. Cell, 104(3):329-332.

Janscak, P; Sandmeier, U; Szczelkun, M D; Bickle, T A (2001). Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I. Journal of Molecular Biology, 306(3):417-431.

Hardeland, U; Bentele, M; Lettieri, T; Steinacher, R; Jiricny, J; Schär, P (2001). Thymine DNA glycosylase. In: Moldave, K; Mitra, S; McCullough, A K; Lloyd, R S; Wilson, S H. Base Excision Repair. New York: Elsevier, 235-253.

Marra, G; D'Atri, S; Corti, C; Bonmassar, L; Cattaruzza, M S; Schweizer, P; Heinimann, K; Bartosova, Z; Nyström-Lahti, M; Jiricny, J (2001). Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 98(13):7164-7169.

Kleczkowska, H E; Marra, G; Lettieri, T; Jiricny, J (2001). hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. Genes and Development, 15(6):724-736.

Pepponi, R; Graziani, G; Falcinelli, S; Vernole, P; Levati, L; Lacal, P M; Pagani, E; Bonmassar, E; Jiricny, J; D'Atri, S (2001). hMSH3 overexpression and cellular response to cytotoxic anticancer agents. Carcinogenesis, 22(8):1131-1137.

2000

Jiricny, J (2000). Mismatch repair: the praying hands of fidelity. Current Biology, 10(21):R788-R790.

Hardeland, U. Biochemical Investigation into Structural and Functional Aspects of Thymine-DNA Glycosylases and the MBD4 Protein. 2000, University of Zurich, Faculty of Science.

Cattaneo-Pangrazzi, R M; Schott, H; Wunderli-Allenspach, H; Rothen-Rutishauser, B; Guenthert, M; Schwendener, R (2000). Cell-cycle arrest and p53-independent induction of apoptosis in vitro by the new anticancer drugs 5-FdUrd-P-FdCydOct and dCydPam-P-FdUrd in DU-145 human prostate cancer cells. Journal of Cancer Research and Clinical Oncology, 126(5):247-256.

Räschle, M. Characterization of the human mismatch repair proteins hMLH1, hPMS1 nad hPMS2. 2000, University of Zurich, Faculty of Science.

Yan, H; Papadopoulos, N; Marra, G; Perrera, C; Jiricny, J; Boland, C R; Lynch, H T; Chadwick, R B; de la Chapelle, A; Berg, K; Eshleman, J R; Yuan, W; Markowitz, S; Laken, S J; Lengauer, C; Kinzler, K W; Vogelstein, B (2000). Conversion of diploidy to haploidy. Nature, 403(6771):723-724.

Horber, D H; Cattaneo-Pangrazzi, R M; von Ballmoos, P; Schott, H; Ludwig, P S; Eriksson, S; Fichtner, I; Schwendener, R (2000). Cytotoxicity, cell-cycle perturbations and apoptosis in human tumor cells by lipophilic N4-alkyl-1-beta-D-arabinofuranosylcytosine derivatives and the new heteronucleoside phosphate dimer arabinocytidylyl-(5'-->5')-N4-octadecyl-1-beta-D-arabinofuranosylcytosi ne. Journal of Cancer Research and Clinical Oncology, 126(6):311-319.

Janscak, P; Bickle, T A (2000). DNA supercoiling during ATP-dependent DNA translocation by the type I restriction enzyme EcoAI. Journal of Molecular Biology, 295(4):1089-1099.

Ichikawa, M; Nakane, H; Marra, G; Corti, C; Jiricny, J; Fitch, M; Ford, J M; Ikejima, M; Shimada, T; Yoshino, M; Takeuchi, S; Nakatsu, Y; Tanaka, K (2000). Decreased UV sensitivity, mismatch repair activity and abnormal cell cycle checkpoints in skin cancer cell lines derived from UVB-irradiated XPA-deficient mice. Mutation Research, 459(4):285-298.

Charrasse, S; Carena, I; Brondani, V; Klempnauer, K H; Ferrari, S (2000). Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway. Oncogene, 19(26):2986-2995.

Bearzatto, A; Szadkowski, M; Macpherson, P; Jiricny, J; Karran, P (2000). Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents. Cancer Research, 60(12):3262-3270.

Ludewig, B; Barchiesi, F; Pericin, M; Zinkernagel, R M; Hengartner, H; Schwendener, R (2000). In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity. Vaccine, 19(1):23-32.

Cattaneo-Pangrazzi, R M; Schott, H; Wunderli-Allenspach, H; Derighetti, M; Schwendener, R (2000). Induction of cell cycle-dependent cytotoxicity and apoptosis by new heterodinucleoside phosphate dimers of 5-fluorodeoxyuridine in PC-3 human prostate cancer cells. Biochemical Pharmacology, 60(12):1887-96.

Jiricny, J (2000). Mediating mismatch repair. Nature Genetics, 24(1):6-8.

Dufner, P; Marra, G; Räschle, M; Jiricny, J (2000). Mismatch recognition and DNA-dependent stimulation of the ATPase activity of hMutSalpha is abolished by a single mutation in the hMSH6 subunit. Journal of Biological Chemistry, 275(47):36550-36555.

Jiricny, J; Nyström-Lahti, M (2000). Mismatch repair defects in cancer. Current Opinion in Genetics & Development, 10(2):157-161.

Zhang, H; Marra, G; Jiricny, J; Maher, V M; McCormick, J J (2000). Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts. Carcinogenesis, 21(9):1639-1646.

Iaccarino, I; Marra, G; Dufner, P; Jiricny, J (2000). Mutation in the magnesium binding site of hMSH6 disables the hMutSalpha sliding clamp from translocating along DNA. Journal of Biological Chemistry, 275(3):2080-2086.

Hardeland, U; Bentele, M; Jiricny, J; Schär, P (2000). Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis. Journal of Biological Chemistry, 275(43):33449-33456.

Müller, A; Günther, D; Brinkmann, V; Hurwitz, R; Meyer, T F; Rudel, T (2000). Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells. EMBO Journal, 19(20):5332-543.

Lamers, M H; Perrakis, A; Enzlin, J H; Winterwerp, H H; de Wind, N; Sixma, T K (2000). The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature, 407(6805):711-717.

Cattaneo-Pangrazzi, R M; Schott, H; Schwendener, R (2000). The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145. Prostate, 45(1):8-18.

1999

Barrett, T E; Schärer, O D; Savva, R; Brown, T; Jiricny, J; Verdine, G L; Pearl, L H (1999). Crystal structure of a thwarted mismatch glycosylase DNA repair complex. EMBO Journal, 18(23):6599-6609.

Räschle, M; Marra, G; Nyström-Lahti, M; Schär, P; Jiricny, J (1999). Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. Journal of Biological Chemistry, 274(45):32368-32375.

Koller-Lucae, S K; Schott, H; Schwendener, R (1999). Low density lipoprotein and liposome mediated uptake and cytotoxic effect of N4-octadecyl-1-beta-D-arabinofuranosylcytosine in Daudi lymphoma cells. British Journal of Cancer, 80(10):1542-9.

Koller-Lucae, S K; Suter, M J; Rentsch, K M; Schott, H; Schwendener, R (1999). Metabolism of the new liposomal anticancer drug N4-octadecyl-1-beta-D-arabinofuranosylcytosine in mice. Drug Metabolism and Disposition, 27(3):342-350.

Müller, A; Günther, D; Düx, F; Naumann, M; Meyer, T F; Rudel, T (1999). Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases. EMBO Journal, 18(2):339-352.

Ludewig, B; Oehen, S; Barchiesi, F; Schwendener, R; Hengartner, H; Zinkernagel, R M (1999). Protective antiviral cytotoxic T cell memory is most efficiently maintained by restimulation via dendritic cells. Journal of Immunology, 163(4):1839-1844.

Schwendener, R; Peghini, P A; Ludwing, P S; Schott, H (1999). Synthesis, in vitro anti-HIV and anti-hepatitis B activities and pharmacokinetic properties of amphiphilic heterodinucleoside phosphates containing ddC and AZT. Nucleosides and Nucleotides, 18(4-5):949-950.

Hendrich, B; Hardeland, U; Ng, H H; Jiricny, J; Bird, A (1999). The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature, 401(6750):301-304.

1998

Barrett, T E; Savva, R; Panayotou, G; Barlow, T; Brown, T; Jiricny, J; Pearl, L H (1998). Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell, 92(1):117-129.

Peghini, P A; Zahner, R; Kuster, H; Schott, H; Schwendener, R (1998). In vitro anti-human immunodeficiency virus and anti-hepatitis B virus activities and pharmacokinetic properties of heterodinucleoside phosphates containing AZT or ddC. Antiviral Chemistry & Chemotherapy, 9(2):117-126.

Marra, G; Iaccarino, I; Lettieri, T; Roscilli, G; Delmastro, P; Jiricny, J (1998). Mismatch repair deficiency associated with overexpression of the MSH3 gene. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 95(15):8568-8573.

Rentsch, K M; Schwendener, R; Pestalozzi, B C; Sauter, C; Wunderli-Allenspach, H; Hänseler, E (1998). Pharmacokinetic studies of mitoxantrone and one of its metabolites in serum and urine in patients with advanced breast cancer. European Journal of Clinical Pharmacology, 54(1):83-89.

Jiricny, J (1998). Replication errors: cha(lle)nging the genome. EMBO Journal, 17(22):6427-6436.

van Borssum Waalkes, M; Goris, H; Dontje, B H; Schwendener, R; Scherphof, G; Nijhof, W (1998). Toxicity of liposomal 3'-5'-O-dipalmitoyl-5-fluoro-2'-deoxyuridine in mice. Anti-Cancer Drug Design, 13(4):291-305.

Iaccarino, I; Marra, G; Palombo, F; Jiricny, J (1998). hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha. EMBO Journal, 17(9):2677-2686.

1997

Rentsch, K M; Horber, D H; Schwendener, R; Wunderli-Allenspach, H; Hänseler, E (1997). Comparative pharmacokinetic and cytotoxic analysis of three different formulations of mitoxantrone in mice. British Journal of Cancer, 75(7):986-992.

Seiler, P; Aichele, P; Odermatt, B; Hengartner, H; Zinkernagel, R M; Schwendener, R (1997). Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection. European Journal of Immunology, 27(10):2626-2633.

Werner, C A; Döhner, H; Joos, S; Trümper, L H; Baudis, M; Barth, T F; Ott, G; Möller, P; Lichter, P; Bentz, M (1997). High-level DNA amplifications are common genetic aberrations in B-cell neoplasms. American Journal of Pathology, 151(2):335-342.

Koller-Lucae, S K; Schott, H; Schwendener, R (1997). Interactions with human blood in vitro and pharmacokinetic properties in mice of liposomal N4-octadecyl-1-beta-D-arabinofuranosylcytosine, a new anticancer drug. Journal of Pharmacology and Experimental Therapeutics, 282(3):1572-1580.

Frankenberger, M; Hofmann, B; Emmerich, B; Nerl, C; Schwendener, R; Ziegler-Heitbrock, H W (1997). Liposomal 1,25 (OH)2 vitamin D3 compounds block proliferation and induce differentiation in myelomonocytic leukaemia cells. British Journal of Haematology, 98(1):186-194.

Rentsch, K M; Schwendener, R; Schott, H; Hänseler, E (1997). Pharmacokinetics of N4-octadecyl-1-beta-D-arabinofuranosylcytosine in plasma and whole blood after intravenous and oral administration to mice. Journal of Pharmacy and Pharmacology, 49(11):1076-1081.

1996

Gallinari, P; Jiricny, J (1996). A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase. Nature, 383(6602):735-738.

Neddermann, P; Gallinari, P; Lettieri, T; Schmid, D; Truong, O; Hsuan, J J; Wiebauer, K; Jiricny, J (1996). Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. Journal of Biological Chemistry, 271(22):12767-12774.

Rentsch, K M; Schwendener, R; Hänseler, E (1996). Determination of mitoxantrone in mouse whole blood and different tissues by high-performance liquid chromatography. Journal of Chromatography. B, Biomedical Applications, 679(1-2):185-192.

Müller, A; Hacker, J; Brand, B C (1996). Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection. Infection and Immunity, 64(12):4900-4906.

Marra, G; Chang, C L; Laghi, L A; Chauhan, D P; Young, D; Boland, C R (1996). Expression of human MutS homolog 2 (hMSH2) protein in resting and proliferating cells. Oncogene, 13(10):2189-2196.

Schwendener, R; Schott, H (1996). Lipophilic 1-beta-D-arabinofuranosyl cytosine derivatives in liposomal formulations for oral and parenteral antileukemic therapy in the murine L1210 leukemia model. Journal of Cancer Research and Clinical Oncology, 122(12):723-726.

Schwendener, R; Horber, D H; Odermatt, B; Schott, H (1996). Oral antitumour activity in murine L1210 leukaemia and pharmacological properties of liposome formulations of N4-alkyl derivatives of 1-beta-D-arabinofuranosylcytosine. Journal of Cancer Research and Clinical Oncology, 122(2):102-108.

Schott, H; Schwendener, R (1996). Synthesis and structure-activity studies in vivo of liposomal phospholipid-N4-palmitoyl- and N4-hexadecyl-1-beta-D-arabinofuranosylcytosine conjugates. Anti-Cancer Drug Design, 11(6):451-62.

Palombo, F; Iaccarino, I; Nakajima, E; Ikejima, M; Shimada, T; Jiricny, J (1996). hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Current Biology, 6(9):1181-1184.

1995

Marra, G; Boland, C R (1995). Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. Journal of the National Cancer Institute, 87(15):1114-1125.

Horber, D H; von Ballmoos, P; Schott, H; Schwendener, R (1995). Cell cycle-dependent cytotoxicity and induction of apoptosis by liposomal N4-hexadecyl-1-beta-D-arabinofuranosylcytosine. British Journal of Cancer, 72(5):1067-1073.

Horber, D H; Schott, H; Schwendener, R (1995). Cellular pharmacology of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine in the human leukemic cell lines K-562 and U-937. Cancer Chemotherapy and Pharmacology, 36(6):483-492.

Horber, D H; Schott, H; Schwendener, R (1995). Cellular pharmacology of a liposomal preparation of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine, a lipophilic derivative of 1-beta-D-arabinofuranosylcytosine. British Journal of Cancer, 71(5):957-962.

Palombo, F; Gallinari, P; Iaccarino, I; Lettieri, T; Hughes, M; D'Arrigo, A; Truong, O; Hsuan, J J; Jiricny, J (1995). GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science, 268(5219):1912-1914.

Horber, D H; Ottiger, C; Schott, H; Schwendener, R (1995). Pharmacokinetic properties and interactions with blood components of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC) incorporated into liposomes. Journal of Pharmacy and Pharmacology, 47(4):282-288.

Pestalozzi, B C; Vass, A; Adam, H; Horber, D H; Schwendener, R; Sauter, C (1995). Phase II study of liposome-complexed mitoxantrone in patients with advanced breast cancer. European Journal of Cancer, 31A(6):1024.

Rentsch, K M; Schwendener, R; Schott, H; Hänseler, E (1995). Sensitive high-performance liquid chromatographic method for the determination of N4-hexadecyl- and N4-octadecyl-1-beta-D-arabinofuranosylcytosine in plasma and erythrocytes. Journal of Chromatography. B, Biomedical Applications, 673(2):259-266.

1994

Marra, G; Anti, M; Percesepe, A; Armelao, F; Ficarelli, R; Coco, C; Rinelli, A; Vecchio, F M; D'Arcangelo, E (1994). Circadian variations of epithelial cell proliferation in human rectal crypts. Gastroenterology, 106(4):982-987.

Anti, M; Armelao, F; Marra, G; Percesepe, A; Bartoli, G M; Palozza, P; Parrella, P; Canetta, C; Gentiloni, N; De Vitis, I (1994). Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Gastroenterology, 107(6):1709-1718.

Schwendener, R; Gowland, P; Horber, D H; Zahner, R; Schertler, A; Schott, H (1994). New lipophilic alkyl/acyl dinucleoside phosphates as derivatives of 3'-azido-3'-deoxythymidine: inhibition of HIV-1 replication in vitro and antiviral activity against Rauscher leukemia virus infected mice with delayed treatment regimens. Antiviral Research, 24(1):79-93.

Condrau, M A; Schwendener, R; Niederer, P; Anliker, M (1994). Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: I. Concept and theoretical evaluation. Cytometry Part A, 16(3):187-194.

Condrau, M A; Schwendener, R; Zimmermann, M; Muser, M H; Graf, U; Niederer, P; Anliker, M (1994). Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: II. Instrument design and experimental results. Cytometry Part A, 16(3):195-205.

1992

Anti, M; Marra, G; Armelao, F; Bartoli, G M; Ficarelli, R; Percesepe, A; De Vitis, I; Maria, G; Sofo, L; Rapaccini, G L (1992). Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. Gastroenterology, 103(3):883-891.

Pestalozzi, B; Schwendener, R; Sauter, C (1992). Phase I/II study of liposome-complexed mitoxantrone in patients with advanced breast cancer. Annals of Oncology, 3(6):445-449.

Schwendener, R; Schott, H (1992). Treatment of L1210 murine leukemia with liposome-incorporated N4-hexadecyl-1-beta-D-arabinofuranosyl cytosine. International Journal of Cancer, 51(3):466-469.

1991

Schwendener, R; Fiebig, H H; Berger, M R; Berger, D P (1991). Evaluation of incorporation characteristics of mitoxantrone into unilamellar liposomes and analysis of their pharmacokinetic properties, acute toxicity, and antitumor efficacy. Cancer Chemotherapy and Pharmacology, 27(6):429-439.

1990

Schwendener, R; Wüthrich, R; Duewell, S; Wehrli, E; von Schulthess, G K (1990). A pharmacokinetic and MRI study of unilamellar gadolinium-, manganese-, and iron-DTPA-stearate liposomes as organ-specific contrast agents. Investigative Radiology, 25(8):922-932.

1989

Wiebauer, K; Jiricny, J (1989). In vitro correction of G.T mispairs to G.C pairs in nuclear extracts from human cells. Nature, 339(6221):234-236.

1988

Brown, T C; Jiricny, J (1988). Different base/base mispairs are corrected with different efficiencies and specificities in monkey kidney cells. Cell, 54(5):705-711.

1987

Brown, T C; Jiricny, J (1987). A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine. Cell, 50(6):945-950.

This list was generated on Mon Jul 24 01:18:59 2017 CEST.