Publication: Synthetic virus-like particles and conformationally constrained peptidomimetics in vaccine design
Synthetic virus-like particles and conformationally constrained peptidomimetics in vaccine design
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Riedel, T., Ghasparian, A., Moehle, K., Rusert, P., Trkola, A., & Robinson, J. A. (2011). Synthetic virus-like particles and conformationally constrained peptidomimetics in vaccine design. ChemBioChem, 12(18), 2829–2836. https://doi.org/10.1002/cbic.201100586
Abstract
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Conformationally constrained peptidomimetics could be of great value in the design of vaccines targeting protective epitopes on viral and bacterial pathogens. But the poor immunogenicity of small synthetic molecules represents a serious obstacle for their use in vaccine development. Here, we show how a constrained epitope mimetic can be rendered highly immunogenic through multivalent display on the surface of synthetic virus-like nanoparticles. The target epitope is the V3 loop from the gp120 glycoprotein of HIV-1 bound to the neutral
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- Riedel, T
- Ghasparian, A
- Moehle, K
- Rusert, P
- Trkola, A
- Robinson, J A
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Citations
Riedel, T., Ghasparian, A., Moehle, K., Rusert, P., Trkola, A., & Robinson, J. A. (2011). Synthetic virus-like particles and conformationally constrained peptidomimetics in vaccine design. ChemBioChem, 12(18), 2829–2836. https://doi.org/10.1002/cbic.201100586
