Publication: Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo
Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo
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Herzog, C., Pons Garcia, L., Keatinge, M., Greenald, D., Moritz, C., Peri, F., & Herrgen, L. (2019). Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo. Development, 146(9), dev174698. https://doi.org/10.1242/dev.174698
Abstract
Abstract
Abstract
Moderate or severe traumatic brain injury (TBI) causes widespread neuronal cell death. Microglia, the resident macrophages of the brain, react to injury by migrating to the lesion site, where they phagocytose cellular debris. Microglial phagocytosis can have both beneficial (e.g. debris clearance) and detrimental (e.g. respiratory burst, phagoptosis) consequences. Hence, whether the overall effect of microglial phagocytosis after brain injury in vivo is neuroprotective or neurotoxic is not known. Here, we establish a system with which
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- Herzog, Chiara
- Pons Garcia, Laura
- Keatinge, Marcus
- Greenald, David
- Moritz, Christian
- Peri, Francesca
- Herrgen, Leah
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Herzog, C., Pons Garcia, L., Keatinge, M., Greenald, D., Moritz, C., Peri, F., & Herrgen, L. (2019). Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo. Development, 146(9), dev174698. https://doi.org/10.1242/dev.174698
