Publication: Beta-adrenergic blockade increases pulmonary vascular resistance and causes exaggerated hypoxic pulmonary vasoconstriction at high altitude: a physiological study
Beta-adrenergic blockade increases pulmonary vascular resistance and causes exaggerated hypoxic pulmonary vasoconstriction at high altitude: a physiological study
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Hilty, M. P., Siebenmann, C., Rasmussen, P., Keiser, S., Müller, A., Lundby, C., & Maggiorini, M. (2024). Beta-adrenergic blockade increases pulmonary vascular resistance and causes exaggerated hypoxic pulmonary vasoconstriction at high altitude: a physiological study. European Heart Journal : Cardiovascular Pharmacotherapy, 10(4), 316–328. https://doi.org/10.1093/ehjcvp/pvae004
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BACKGROUND: An increasing number of hypertensive persons travel to high altitude while using antihypertensive medications such as betablockers. Nevertheless, while hypoxic exposure initiates an increase in pulmonary artery pressure (Ppa) and pulmonary vascular resistance (PVR), the contribution of the autonomic nervous system is unclear. In animals, $\beta$
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Hilty, M. P., Siebenmann, C., Rasmussen, P., Keiser, S., Müller, A., Lundby, C., & Maggiorini, M. (2024). Beta-adrenergic blockade increases pulmonary vascular resistance and causes exaggerated hypoxic pulmonary vasoconstriction at high altitude: a physiological study. European Heart Journal : Cardiovascular Pharmacotherapy, 10(4), 316–328. https://doi.org/10.1093/ehjcvp/pvae004
