Publication: Effect of Roux-en-Y gastric bypass and diet-induced weight loss on diabetic kidney disease in the Zucker diabetic fatty rat
Effect of Roux-en-Y gastric bypass and diet-induced weight loss on diabetic kidney disease in the Zucker diabetic fatty rat
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Neff, K. J., Elliott, J. A., Corteville, C., Abegg, K., Boza, C., Lutz, T. A., Docherty, N. G., & le Roux, C. W. (2017). Effect of Roux-en-Y gastric bypass and diet-induced weight loss on diabetic kidney disease in the Zucker diabetic fatty rat. Surgery for Obesity and Related Diseases, 13, 21–27. https://doi.org/10.1016/j.soard.2016.08.026
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BACKGROUND Reductions in urinary protein excretion after Roux-en-Y gastric bypass (RYGB) surgery in patients with diabetic kidney disease have been reported in multiple studies. OBJECTIVES To determine the weight loss dependence of the effect of RYGB on urinary protein excretion by comparing renal outcomes in Zucker diabetic fatty rats undergoing either gastric bypass surgery or a sham operation with or without weight matching. SETTING University laboratories. METHODS Zucker diabetic fatty rats underwent surgery at 18 weeks of
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- Neff, Karl J
- Elliott, Jessie A
- Corteville, Caroline
- Abegg, Kathrin
- Boza, Camilo
- Lutz, Thomas A
- Docherty, Neil G
- le Roux, Carel W
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Neff, K. J., Elliott, J. A., Corteville, C., Abegg, K., Boza, C., Lutz, T. A., Docherty, N. G., & le Roux, C. W. (2017). Effect of Roux-en-Y gastric bypass and diet-induced weight loss on diabetic kidney disease in the Zucker diabetic fatty rat. Surgery for Obesity and Related Diseases, 13, 21–27. https://doi.org/10.1016/j.soard.2016.08.026
