Publication: Repetitions and Iterations: Novel Approaches to Characterize Protein-Peptide Interactions of Designed Armadillo Repeat Proteins by Solution NMR
Repetitions and Iterations: Novel Approaches to Characterize Protein-Peptide Interactions of Designed Armadillo Repeat Proteins by Solution NMR
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Cucuzza, S. (2021). Repetitions and Iterations: Novel Approaches to Characterize Protein-Peptide Interactions of Designed Armadillo Repeat Proteins by Solution NMR. (Dissertation, University of Zurich)
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About 15-40% of all interactions in the cell are estimated to be peptide-protein interactions and consequently designing a scaffold able to interact with a target peptide through a conserved binding mode has potentially many applications in the field of research, diagnostic and therapeutics. The Armadillo project aims to generate a modular binding technology based on natural Armadillo repeat proteins (nArmRPs). The idea is to build a repetitive protein based on modules able to bind a specific dipeptide each, thus simplifying the probl
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Cucuzza, S. (2021). Repetitions and Iterations: Novel Approaches to Characterize Protein-Peptide Interactions of Designed Armadillo Repeat Proteins by Solution NMR. (Dissertation, University of Zurich)