Publication: Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy
Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy
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Gschwind, T., Lafourcade, C., Gfeller, T., Zaichuk, M., Rambousek, L., Knuesel, I., & Fritschy, J.-M. (2018). Contribution of early Alzheimer’s disease-related pathophysiology to the development of acquired epilepsy. European Journal of Neuroscience, 47(12), 1534–1562. https://doi.org/10.1111/ejn.13983
Abstract
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Abstract
Aberrant epileptic activity is detectable at early disease stages in Alzheimer's disease (AD) patients and in AD mouse models. Here, we investigated in young ArcticAβ mice whether AD-like pathology renders neuronal networks more susceptible to the development of acquired epilepsy induced by unilateral intrahippocampal injection of kainic acid (IHK). In this temporal lobe epilepsy model, IHK induces a status epilepticus followed after two weeks by spontaneous recurrent seizures (SRS). ArcticAβ mice exhibited more severe status epilepti
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- Gschwind, Tilo
- Lafourcade, Carlos
- Gfeller, Tim
- Zaichuk, Mariana
- Rambousek, Lukas
- Knuesel, Irene
- Fritschy, Jean-Marc
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Gschwind, T., Lafourcade, C., Gfeller, T., Zaichuk, M., Rambousek, L., Knuesel, I., & Fritschy, J.-M. (2018). Contribution of early Alzheimer’s disease-related pathophysiology to the development of acquired epilepsy. European Journal of Neuroscience, 47(12), 1534–1562. https://doi.org/10.1111/ejn.13983
