Publication: Selective monoderivatization of propane-1,3-diamine with acid chlorides: ‘Hexahydropyrimidine method’ vs. statistic methods
Selective monoderivatization of propane-1,3-diamine with acid chlorides: ‘Hexahydropyrimidine method’ vs. statistic methods
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Jentgens, C., Bienz, S., & Hesse, M. (1997). Selective monoderivatization of propane-1,3-diamine with acid chlorides: ‘Hexahydropyrimidine method’ vs. statistic methods. Helvetica Chimica Acta, 80(4), 1133–1143. https://doi.org/10.1002/hlca.19970800410
Abstract
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Abstract
The selective N-monoderivatization of propane-1,3-diamine (5) with carbonyl and sulfonyl chlorides via2-phenylhexahydropyrimidine (6) was compared with the direct statistic monoderivatization. It was found that, under optimized conditions, both methods are competitive to one another, depending, however, strongly on the reactivity of the eleclrophile used. The ‘hexahydropyrimidine method’ is more reliable with respect to yields, which are moderate but invariably between 54 and 69%, whereas the ‘statistic method’ leads in certain cases
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- Jentgens, Christian
- Bienz, Stefan
- Hesse, Manfred
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Jentgens, C., Bienz, S., & Hesse, M. (1997). Selective monoderivatization of propane-1,3-diamine with acid chlorides: ‘Hexahydropyrimidine method’ vs. statistic methods. Helvetica Chimica Acta, 80(4), 1133–1143. https://doi.org/10.1002/hlca.19970800410
