Publication: Evolvability and robustness in a complex signalling circuit
Evolvability and robustness in a complex signalling circuit
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Raman, K., & Wagner, A. (2011). Evolvability and robustness in a complex signalling circuit. Molecular Biosystems, 7(4), 1081–1092. https://doi.org/10.1039/c0mb00165a
Abstract
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Biological systems at various levels of organisation exhibit robustness, as well as phenotypic variability or evolvability, the ability to evolve novel phenotypes. We still know very little about the relationship between robustness and phenotypic variability at levels of organisation beyond individual macromolecules, and especially for signalling circuits. Here, we examine multiple alternate topologies of the Saccharomyces cerevisiae target-of-rapamycin (TOR) signalling circuit, in order to understand the circuit's robustness and phen
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- Raman, K
- Wagner, A
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Citations
Raman, K., & Wagner, A. (2011). Evolvability and robustness in a complex signalling circuit. Molecular Biosystems, 7(4), 1081–1092. https://doi.org/10.1039/c0mb00165a
