Publication: Cysteine and glutathione trigger the Cu-Zn swap between Cu(ii)-amyloid-β4-16 peptide and Zn7-metallothionein-3
Cysteine and glutathione trigger the Cu-Zn swap between Cu(ii)-amyloid-β4-16 peptide and Zn7-metallothionein-3
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Santoro, A., Ewa Wezynfeld, N., Vašák, M., Bal, W., & Faller, P. (2017). Cysteine and glutathione trigger the Cu-Zn swap between Cu(ii)-amyloid-β4-16 peptide and Zn7-metallothionein-3. Chemical Communications, 53(85), 11634–11637. https://doi.org/10.1039/c7cc06802f
Abstract
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Abstract
Cysteine and glutathione are able to reduce Cu(ii) coordinated to the peptide amyloidβ4-16, and shuttle the resulting Cu(i) to partially replace Zn(ii) in the protein Zn7-metallothionein-3. The released Zn(ii) in turn binds to amyloid-β4-16. Thus cysteine and glutathione are modulators of Cu/Zn-distribution between metallothionein-3 and amyloid-β4-16.
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- Santoro, Alice
- Ewa Wezynfeld, Nina
- Vašák, Milan
- Bal, Wojciech
- Faller, Peter
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Citations
Santoro, A., Ewa Wezynfeld, N., Vašák, M., Bal, W., & Faller, P. (2017). Cysteine and glutathione trigger the Cu-Zn swap between Cu(ii)-amyloid-β4-16 peptide and Zn7-metallothionein-3. Chemical Communications, 53(85), 11634–11637. https://doi.org/10.1039/c7cc06802f
