Publication: New Insights into Tumor Heterogeneity: A Case of Solid-Oncocytic Epithelial-Myoepithelial Carcinoma of the Parotid Gland Harboring a HRAS and Heterogeneous Terminating ARID1A Mutation
New Insights into Tumor Heterogeneity: A Case of Solid-Oncocytic Epithelial-Myoepithelial Carcinoma of the Parotid Gland Harboring a HRAS and Heterogeneous Terminating ARID1A Mutation
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Rupp, N. J., Brada, M., Skálová, A., Bode, B., Broglie, M. A., Morand, G. B., Rechsteiner, M., & Freiberger, S. N. (2020). New Insights into Tumor Heterogeneity: A Case of Solid-Oncocytic Epithelial-Myoepithelial Carcinoma of the Parotid Gland Harboring a HRAS and Heterogeneous Terminating ARID1A Mutation. Head and Neck Pathology, 14(2), 554–558. https://doi.org/10.1007/s12105-019-01055-9
Abstract
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Abstract
Epithelial-myoepithelial carcinoma (EMC) can be a challenging diagnosis due to a lack of obvious invasion and bland cytology. We report an unusual case of a low-grade EMC with prominent fibrous stroma, an extensive solid-oncocytic differentiation and limited areas of morphological clearly identifiable characteristic biphasic (tubular) differentiation, clear cells and PAS-positive secretions/calcifications. Both areas were investigated by next generation sequencing (Oncomine comprehensive assay) and revealed a typical concordant HRAS p
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Creators (Authors)
- Rupp, Niels J
- Brada, Muriel
- Skálová, Alena
- Bode, Beata
- Broglie, Martina A
- Morand, Grégoire B
- Rechsteiner, Markus
- Freiberger, Sandra N
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Citations
Rupp, N. J., Brada, M., Skálová, A., Bode, B., Broglie, M. A., Morand, G. B., Rechsteiner, M., & Freiberger, S. N. (2020). New Insights into Tumor Heterogeneity: A Case of Solid-Oncocytic Epithelial-Myoepithelial Carcinoma of the Parotid Gland Harboring a HRAS and Heterogeneous Terminating ARID1A Mutation. Head and Neck Pathology, 14(2), 554–558. https://doi.org/10.1007/s12105-019-01055-9
