Publication: Synthesis and characterization of PEG-based drug-responsive biohybrid hydrogels
Synthesis and characterization of PEG-based drug-responsive biohybrid hydrogels
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Gübeli, R. J., Ehrbar, M., Fussenegger, M., Friedrich, C., & Weber, W. (2012). Synthesis and characterization of PEG-based drug-responsive biohybrid hydrogels. Macromolecular Rapid Communications, 33(15), 1280–1285. https://doi.org/10.1002/marc.201200203
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Interactive materials being responsive to a biocompatible stimulus represent a promising approach for future therapeutic applications. In this study, we present a novel biohybrid material synthesized from biocompatible components being stimulus-responsive to the pharmaceutically approved small-molecule novobiocin. The hydrogel design is based on the gyrase B (GyrB) protein, which is covalently grafted to multi-arm polyethylene glycol (PEG) using a Michael-type addition reaction. Upon addition of the GyrB-dimerizing substance coumermyc
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- Gübeli, Raphael J
- Fussenegger, Martin
- Friedrich, Christian
- Weber, Wilfried
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Gübeli, R. J., Ehrbar, M., Fussenegger, M., Friedrich, C., & Weber, W. (2012). Synthesis and characterization of PEG-based drug-responsive biohybrid hydrogels. Macromolecular Rapid Communications, 33(15), 1280–1285. https://doi.org/10.1002/marc.201200203
