Publication: Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes.
Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes.
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Schittenhelm, R. B., Heeger, S., Althoff, F., Walter, A., Heidmann, S., Mechtler, K., & Lehner, C. F. (2007). Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes. Chromosoma, 116(4), 385–402. https://doi.org/10.1007/s00412-007-0103-y
Abstract
Abstract
Abstract
Chromosome segregation during meiosis and mitosis depends on the assembly of functional kinetochores within centromeric regions. Centromeric DNA and kinetochore proteins show surprisingly little sequence conservation despite their fundamental biological role. However, our identification in Drosophila melanogaster of the most diverged orthologs identified so far, which encode components of a kinetochore protein network including the Ndc80 and Mis complexes, further emphasizes the notion of a shared eukaryotic kinetochore design. To det
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Creators (Authors)
- Schittenhelm, R B
- Heeger, S
- Althoff, F
- Walter, A
- Heidmann, S
- Mechtler, K
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Citations
Schittenhelm, R. B., Heeger, S., Althoff, F., Walter, A., Heidmann, S., Mechtler, K., & Lehner, C. F. (2007). Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes. Chromosoma, 116(4), 385–402. https://doi.org/10.1007/s00412-007-0103-y
