Publication: DELay of Appearance of sYmptoms of Canine Degenerative Mitral Valve Disease Treated with Spironolactone and Benazepril: the DELAY Study
DELay of Appearance of sYmptoms of Canine Degenerative Mitral Valve Disease Treated with Spironolactone and Benazepril: the DELAY Study
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Borgarelli, M., Ferasin, L., Lamb, K., Bussadori, C., Chiavegato, D., D’Agnolo, G., Migliorini, F., Poggi, M., Santilli, R. A., Guillot, E., Garelli-Paar, C., Toschi Corneliani, R., Farina, F., Zani, A., Dirven, M., Smets, P., Guglielmini, C., Oliveira, P., Di Marcello, M., … Baron Toaldo, M. (2020). DELay of Appearance of sYmptoms of Canine Degenerative Mitral Valve Disease Treated with Spironolactone and Benazepril: the DELAY Study. Journal of Veterinary Cardiology, 27, 34–53. https://doi.org/10.1016/j.jvc.2019.12.002
Abstract
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INTRODUCTION: Efficacy of renin-angiotensin-aldosterone system (RAAS) blockade using angiotensin-converting enzyme inhibitors (ACEi) in dogs with preclinical myxomatous mitral valve disease (MMVD) is controversial. HYPOTHESIS: Administration of spironolactone (2-4 mg q 24 h) and benazepril (0.25-0.5 mg q 24 h) in dogs with preclinical MMVD, not receiving any other cardiac medications, delays the onset of heart failure (HF) and cardiac-related death. Moreover, it reduces the progression of the disease as indicated by echocardiographic
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- Borgarelli, M
- Ferasin, L
- Lamb, K
- Bussadori, C
- Chiavegato, D
- Migliorini, F
- Poggi, M
- Santilli, R A
- Guillot, E
- Garelli-Paar, C
- Toschi Corneliani, R
- Farina, F
- Zani, A
- Dirven, M
- Smets, P
- Guglielmini, C
- Oliveira, P
- Di Marcello, M
- Porciello, F
- Crosara, S
- Ciaramella, P
- Piantedosi, D
- Vannini, S
- Dall’Aglio, E
- Savarino, P
- Quintavalla, C
- Patteson, M
- Silva, J
- Locatelli, C
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Borgarelli, M., Ferasin, L., Lamb, K., Bussadori, C., Chiavegato, D., D’Agnolo, G., Migliorini, F., Poggi, M., Santilli, R. A., Guillot, E., Garelli-Paar, C., Toschi Corneliani, R., Farina, F., Zani, A., Dirven, M., Smets, P., Guglielmini, C., Oliveira, P., Di Marcello, M., … Baron Toaldo, M. (2020). DELay of Appearance of sYmptoms of Canine Degenerative Mitral Valve Disease Treated with Spironolactone and Benazepril: the DELAY Study. Journal of Veterinary Cardiology, 27, 34–53. https://doi.org/10.1016/j.jvc.2019.12.002
