Publication: Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate ENaC: Role in Rapid Renal Responses to Dietary Potassium
Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate ENaC: Role in Rapid Renal Responses to Dietary Potassium
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Saha, B., Shabbir, W., Takagi, E., Duan, X.-P., Almeida Leite Dellova, D. C., Demko, J., Manis, A., Loffing-Cueni, D., Loffing, J., Sørensen, M. V., Wang, W.-H., & Pearce, D. (2023). Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate ENaC: Role in Rapid Renal Responses to Dietary Potassium. Journal of the American Society of Nephrology (JASN), 34(6), 1019–1038. https://doi.org/10.1681/ASN.0000000000000109
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BACKGROUND: Increasing evidence implicates the signaling kinase mTOR complex-2 (mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+]. However, the underlying cellular and molecular mechanisms that are relevant in vivo for these responses remain controversial.
METHODS: We used Cre-Lox-mediated knockout of rapamycin-insensitive companion of TOR (Rictor) to inactivate mTORC2 in kidney tubule cells of mice. In a series of time-course experiments in wild-type and knockout mice, we assessed urinary and blood p
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Saha, B., Shabbir, W., Takagi, E., Duan, X.-P., Almeida Leite Dellova, D. C., Demko, J., Manis, A., Loffing-Cueni, D., Loffing, J., Sørensen, M. V., Wang, W.-H., & Pearce, D. (2023). Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate ENaC: Role in Rapid Renal Responses to Dietary Potassium. Journal of the American Society of Nephrology (JASN), 34(6), 1019–1038. https://doi.org/10.1681/ASN.0000000000000109
