Publication: Gauging circadian variation in ketamine metabolism by real-time breath analysis
Gauging circadian variation in ketamine metabolism by real-time breath analysis
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Martinez-Lozano Sinues, P., Kohler, M., Brown, S. A., Zenobi, R., & Dallmann, R. (2017). Gauging circadian variation in ketamine metabolism by real-time breath analysis. Chemical Communications, 53(14), 2264–2267. https://doi.org/10.1039/c6cc09061c
Abstract
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Abstract
The time-of-day of drug application is an important factor in maximizing efficacy and minimizing toxicity. Real-time in vivo mass spectrometric breath analysis of mice was deployed to investigate time-of-day variation in ketamine metabolism. Different production rates of ketamine metabolites, including the recently described anti-depressant hydroxynorketamine, were found in opposite circadian phases. Thus, breath analysis has potential as a rapid and 3Rs (Replacement, Reduction and Refinement) conforming screening method to estimate t
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- Martinez-Lozano Sinues, P
- Kohler, M
- Brown, S A
- Zenobi, R
- Dallmann, R
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Citations
Martinez-Lozano Sinues, P., Kohler, M., Brown, S. A., Zenobi, R., & Dallmann, R. (2017). Gauging circadian variation in ketamine metabolism by real-time breath analysis. Chemical Communications, 53(14), 2264–2267. https://doi.org/10.1039/c6cc09061c
