Publication: EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation
EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation
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Zingg, D., Debbache, J., Peña-Hernández, R., Antunes, A. T., Schaefer, S. M., Cheng, P. F., Zimmerli, D., Haeusel, J., Calçada, R. R., Tuncer, E., Zhang, Y., Bossart, R., Wong, K.-K., Basler, K., Dummer, R., Santoro, R., Levesque, M. P., & Sommer, L. (2018). EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation. Cancer Cell, 34(1), 69–84. https://doi.org/10.1016/j.ccell.2018.06.001
Abstract
Abstract
Abstract
Human melanomas frequently harbor amplifications of EZH2. However, the contribution of EZH2 to melanoma formation has remained elusive. Taking advantage of murine melanoma models, we show that EZH2 drives tumorigenesis from benign BrafV600E- or NrasQ61K-expressing melanocytes by silencing of genes relevant for the integrity of the primary cilium, a signaling organelle projecting from the surface of vertebrate cells. Consequently, gain of EZH2 promotes loss of primary cilia in benign melanocytic lesions. In contrast, blockade of EZH2 a
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- Zingg, Daniel
- Debbache, Julien
- Peña-Hernández, Rodrigo
- Antunes, Ana T
- Schaefer, Simon M
- Zimmerli, Dario
- Haeusel, Jessica
- Calçada, Raquel R
- Tuncer, Eylul
- Zhang, Yudong
- Bossart, Raphaël
- Wong, Kwok-Kin
- Dummer, Reinhard
- Santoro, Raffaella
- Levesque, Mitchell P
- Sommer, Lukas
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Zingg, D., Debbache, J., Peña-Hernández, R., Antunes, A. T., Schaefer, S. M., Cheng, P. F., Zimmerli, D., Haeusel, J., Calçada, R. R., Tuncer, E., Zhang, Y., Bossart, R., Wong, K.-K., Basler, K., Dummer, R., Santoro, R., Levesque, M. P., & Sommer, L. (2018). EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation. Cancer Cell, 34(1), 69–84. https://doi.org/10.1016/j.ccell.2018.06.001
