Publication: Blood pressure normalization-independent cardioprotective effects of endogenous, physical activity-induced alpha Calcitonin Gene-Related Peptide (αCGRP) in chronically hypertensive mice
Blood pressure normalization-independent cardioprotective effects of endogenous, physical activity-induced alpha Calcitonin Gene-Related Peptide (αCGRP) in chronically hypertensive mice
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Skaria, T., Mitchell, K. J., Vogel, O., Wälchli, T., Gassmann, M., & Vogel, J. (2019). Blood pressure normalization-independent cardioprotective effects of endogenous, physical activity-induced alpha Calcitonin Gene-Related Peptide (αCGRP) in chronically hypertensive mice. Circulation Research, 125(12), 1124–1140. https://doi.org/10.1161/CIRCRESAHA.119.315429
Abstract
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Abstract
Rationale: α-calcitonin gene related peptide (αCGRP), one of the strongest vasodilators, is cardioprotective in hypertension by reducing the elevated blood pressure (BP). Objective: However, we hypothesize that endogenous, physical activity-induced αCGRP has BP-independent cardioprotective effects in chronic hypertension. MMethods and Results: Chronically hypertensive (one-kidney-one-clip surgery) WT and αCGRP-/- sedentary or voluntary wheel running mice were treated with vehicle, αCGRP, or the αCGRP receptor antagonist CGRP8-37. Card
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Creators (Authors)
- Skaria, Tom
- Mitchell, Katharyn J
- Vogel, Olga
- Wälchli, Thomas
- Gassmann, Max
- Vogel, Johannes
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Skaria, T., Mitchell, K. J., Vogel, O., Wälchli, T., Gassmann, M., & Vogel, J. (2019). Blood pressure normalization-independent cardioprotective effects of endogenous, physical activity-induced alpha Calcitonin Gene-Related Peptide (αCGRP) in chronically hypertensive mice. Circulation Research, 125(12), 1124–1140. https://doi.org/10.1161/CIRCRESAHA.119.315429
