Publication: Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
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Baek, J. H., D’Agnillo, F., Vallelian, F., Pereira, C. P., Williams, M. C., Jia, Y., Schaer, D. J., & Buehler, P. W. (2012). Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. Journal of Clinical Investigation, 122(4), 1444–1458. https://doi.org/10.1172/JCI59770
Abstract
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Abstract
Massive transfusion of blood can lead to clinical complications, including multiorgan dysfunction and even death. Such severe clinical outcomes have been associated with longer red blood cell (rbc) storage times. Collectively referred to as the rbc storage lesion, rbc storage results in multiple biochemical changes that impact intracellular processes as well as membrane and cytoskeletal properties, resulting in cellular injury in vitro. However, how the rbc storage lesion triggers pathophysiology in vivo remains poorly defined. In thi
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Creators (Authors)
- Baek, Jin Hyen
- D'Agnillo, Felice
- Vallelian, Florence
- Pereira, Claudia P
- Williams, Matthew C
- Jia, Yiping
- Schaer, Dominik J
- Buehler, Paul W
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Citations
Baek, J. H., D’Agnillo, F., Vallelian, F., Pereira, C. P., Williams, M. C., Jia, Y., Schaer, D. J., & Buehler, P. W. (2012). Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. Journal of Clinical Investigation, 122(4), 1444–1458. https://doi.org/10.1172/JCI59770
