Publication: Supporting Cell-Based Tendon Therapy: Effect of PDGF-BB and Ascorbic Acid on Rabbit Achilles Tenocytes in Vitro
Supporting Cell-Based Tendon Therapy: Effect of PDGF-BB and Ascorbic Acid on Rabbit Achilles Tenocytes in Vitro
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Citations
Evrova, O., Kellenberger, D., Calcagni, M., Vogel, V., & Buschmann, J. (2020). Supporting Cell-Based Tendon Therapy: Effect of PDGF-BB and Ascorbic Acid on Rabbit Achilles Tenocytes in Vitro. International Journal of Molecular Sciences, 21(2), E458. https://doi.org/10.3390/ijms21020458
Abstract
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Abstract
Cell-based tendon therapies with tenocytes as a cell source need effective tenocyte in vitro expansion before application for tendinopathies and tendon injuries. Supplementation of tenocyte culture with biomolecules that can boost proliferation and matrix synthesis is one viable option for supporting cell expansion. In this in vitro study, the impacts of ascorbic acid or PDGF-BB supplementation on rabbit Achilles tenocyte culture were studied. Namely, cell proliferation, changes in gene expression of several ECM and tendon markers (co
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Creators (Authors)
- Evrova, Olivera
- Kellenberger, Damian
- Calcagni, Maurizio
- Vogel, Viola
- Buschmann, Johanna
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Citations
Evrova, O., Kellenberger, D., Calcagni, M., Vogel, V., & Buschmann, J. (2020). Supporting Cell-Based Tendon Therapy: Effect of PDGF-BB and Ascorbic Acid on Rabbit Achilles Tenocytes in Vitro. International Journal of Molecular Sciences, 21(2), E458. https://doi.org/10.3390/ijms21020458
