Publication: Redox-Neutral Syntheses and Electrochemical Studies of 10-Bromo-Substituted Light-Stable Antivitamin B12 Candidates
Redox-Neutral Syntheses and Electrochemical Studies of 10-Bromo-Substituted Light-Stable Antivitamin B12 Candidates
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Brenig, C., Mosberger, L., Baumann, K., Blacque, O., & Zelder, F. (2021). Redox-Neutral Syntheses and Electrochemical Studies of 10-Bromo-Substituted Light-Stable Antivitamin B12 Candidates. Helvetica Chimica Acta, 104, e21000. https://doi.org/10.1002/hlca.202100067
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This publication describes the straightforward and redox-neutral synthesis of 10-bromophenylethynylcobalamin and its facile conversion to 10-bromoaquacobalamin. In this approach, the phenylethynyl ligand acts as convenient light-stable protecting group that is removed in quantitative yield under acidic conditions. The proteolytic cleavage at pH 2.0 was studied under pseudo-first-order conditions and is 1.5 times slower than that of phenylethynylcobalamin with a hydrogen instead of a bromine at C(10). Preliminary electrochemical studie
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- Brenig, Christopher
- Mosberger, Leila
- Baumann, Katja
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Brenig, C., Mosberger, L., Baumann, K., Blacque, O., & Zelder, F. (2021). Redox-Neutral Syntheses and Electrochemical Studies of 10-Bromo-Substituted Light-Stable Antivitamin B12 Candidates. Helvetica Chimica Acta, 104, e21000. https://doi.org/10.1002/hlca.202100067
