NbCSPR underlies age-dependent immune responses to bacterial cold shock protein in Nicotiana benthamiana

Saur, Isabel M L; Kadota, Yasuhiro; Sklenar, Jan; Holton, Nicholas J; Smakowska, Elwira; Belkhadir, Youssef; Zipfel, Cyril; Rathjen, John P

doi:10.5167/uzh-260317

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Saur, I. M. L., Kadota, Y., Sklenar, J., Holton, N. J., Smakowska, E., Belkhadir, Y., Zipfel, C., & Rathjen, J. P. (2016). NbCSPR underlies age-dependent immune responses to bacterial cold shock protein in Nicotiana benthamiana. Proceedings of the National Academy of Sciences of the United States of America, 113(12), 3389–3394. https://doi.org/10.1073/pnas.1511847113

Abstract

Plants use receptor kinases (RKs) and receptor-like proteins (RLPs) as pattern recognition receptors (PRRs) to sense pathogen-associated molecular patterns (PAMPs) that are typical of whole classes of microbes. After ligand perception, many leucine-rich repeat (LRR)-containing PRRs interact with the LRR-RK BRI1-ASSOCIATED KINASE 1 (BAK1). BAK1 is thus expected to interact with unknown PRRs. Here, we used BAK1 as molecular bait to identify a previously unknown LRR-RLP required for the recognition of the csp22 peptide derived from bacte