Publication: Experimental tissue engineering of fetal skin
Experimental tissue engineering of fetal skin
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Mazzone, L., Pontiggia, L., Reichmann, E., Ochsenbein-Kölble, N., Moehrlen, U., & Meuli, M. (2014). Experimental tissue engineering of fetal skin. Pediatric Surgery International, 30(12), 1241–1247. https://doi.org/10.1007/s00383-014-3614-7
Abstract
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PURPOSE: In some human fetuses undergoing prenatal spina bifida repair, the skin defect is too large for primary closure. The aim of this study was to engineer an autologous fetal skin analogue suitable for in utero skin reconstruction during spina bifida repair. METHODS: Keratinocytes (KC) and fibroblasts (FB) isolated from skin biopsies of 90-day-old sheep fetuses were cultured. Thereafter, plastically compressed collagen hydrogels and fibrin gels containing FB were prepared. KC were seeded onto these dermal constructs and allowed t
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- Mazzone, L
- Reichmann, E
- Ochsenbein-Kölble, N
- Moehrlen, U
- Meuli, M
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Mazzone, L., Pontiggia, L., Reichmann, E., Ochsenbein-Kölble, N., Moehrlen, U., & Meuli, M. (2014). Experimental tissue engineering of fetal skin. Pediatric Surgery International, 30(12), 1241–1247. https://doi.org/10.1007/s00383-014-3614-7
