Publication: DNA hypermethylation within TERT promoter upregulates TERT expression in cancer
DNA hypermethylation within TERT promoter upregulates TERT expression in cancer
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Lee, D. D., Leão, R., Komosa, M., et al, Hermanns, T., & Wild, P. J. (2018). DNA hypermethylation within TERT promoter upregulates TERT expression in cancer. Journal of Clinical Investigation, 129(1), 1801. https://doi.org/10.1172/JCI121303
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Replicative immortality is a hallmark of cancer governed by telomere maintenance. About 90% of human cancers maintain their telomeres by activating telomerase, driven by transcriptional upregulation of telomerase reverse transcriptase (TERT). Although TERT promoter mutations (TPMs) are a major cancer-associated genetic mechanism of TERT upregulation, many cancers exhibit TERT upregulation without TPMs. In this study, we described TERT Hypermethylated Oncological Region (THOR), a 433-bp genomic region encompassing 52 CpG sites located
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- Lee, Donghyun D
- Leão, Ricardo
- Komosa, Martin
- Hermanns, Thomas
- Wild, Peter J
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Lee, D. D., Leão, R., Komosa, M., et al, Hermanns, T., & Wild, P. J. (2018). DNA hypermethylation within TERT promoter upregulates TERT expression in cancer. Journal of Clinical Investigation, 129(1), 1801. https://doi.org/10.1172/JCI121303
