Adipose-derived stem cells (ADSCs) and muscle precursor cells (MPCs) for the treatment of bladder voiding dysfunction

Tremp, Mathias; Salemi, Souzan; Largo, Remo; Andersson, Karl-Erik; Plock, Jan A; Aboushwareb, Tamer; Sulser, Tullio; Eberli, Daniel

doi:10.1007/s00345-013-1200-6

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Tremp, M., Salemi, S., Largo, R., Andersson, K.-E., Plock, J. A., Aboushwareb, T., Sulser, T., & Eberli, D. (2014). Adipose-derived stem cells (ADSCs) and muscle precursor cells (MPCs) for the treatment of bladder voiding dysfunction. World Journal of Urology, 32(5), 1241–1248. https://doi.org/10.1007/s00345-013-1200-6

Abstract

PURPOSE: Bladder outflow obstruction (BOO) is common in the elderly and can result in bladder voiding dysfunction (BVD) due to severe bladder muscle damage. The goal of this research was to evaluate the use of adult stem cells for the treatment of BVD due to decreased muscle contractility in a rat model. MATERIALS AND METHODS: Adipose-derived stem cells (ADSCs) and muscle precursor cells (MPCs) were harvested from male Lewis rats and expanded in culture. BOO was induced by tying a suture around the urethra. Six weeks after obstruction